[go: up one dir, main page]

NO963138L - L-Nukleosider for behandling av hepatitt-B-virus og Epstein-bar-virus - Google Patents

L-Nukleosider for behandling av hepatitt-B-virus og Epstein-bar-virus

Info

Publication number
NO963138L
NO963138L NO963138A NO963138A NO963138L NO 963138 L NO963138 L NO 963138L NO 963138 A NO963138 A NO 963138A NO 963138 A NO963138 A NO 963138A NO 963138 L NO963138 L NO 963138L
Authority
NO
Norway
Prior art keywords
virus
fluoro
beta
treatment
arabinofuranosyl
Prior art date
Application number
NO963138A
Other languages
English (en)
Other versions
NO306408B1 (no
NO963138D0 (no
Inventor
Chung K Chu
Yung-Chi Cheng
Balakrishna S Pai
Gang-Qing Yao
Original Assignee
Univ Georgia
Univ Yale
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22695792&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO963138(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Georgia, Univ Yale filed Critical Univ Georgia
Publication of NO963138D0 publication Critical patent/NO963138D0/no
Publication of NO963138L publication Critical patent/NO963138L/no
Publication of NO306408B1 publication Critical patent/NO306408B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
NO963138A 1994-01-28 1996-07-26 L-nukleosidforbindelse, anvendelse derav og farmasöytisk sammensetning NO306408B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/189,070 US5587362A (en) 1994-01-28 1994-01-28 L-nucleosides
PCT/US1995/001253 WO1995020595A1 (en) 1994-01-28 1995-01-30 L-nucleosides for the treatment of hepatitis b-virus and epstein-bar virus

Publications (3)

Publication Number Publication Date
NO963138D0 NO963138D0 (no) 1996-07-26
NO963138L true NO963138L (no) 1996-09-26
NO306408B1 NO306408B1 (no) 1999-11-01

Family

ID=22695792

Family Applications (1)

Application Number Title Priority Date Filing Date
NO963138A NO306408B1 (no) 1994-01-28 1996-07-26 L-nukleosidforbindelse, anvendelse derav og farmasöytisk sammensetning

Country Status (23)

Country Link
US (3) US5587362A (no)
EP (2) EP0748330B1 (no)
JP (1) JP3899440B2 (no)
KR (1) KR100321209B1 (no)
CN (1) CN1043769C (no)
AT (2) ATE328889T1 (no)
AU (1) AU710262B2 (no)
BG (1) BG62571B1 (no)
BR (1) BRPI9506596B8 (no)
CA (1) CA2182273C (no)
CZ (1) CZ292574B6 (no)
DE (2) DE69530192T2 (no)
DK (2) DK1283211T3 (no)
ES (2) ES2194902T3 (no)
FI (4) FI117475B (no)
HK (1) HK1014716A1 (no)
HU (1) HU228135B1 (no)
NO (1) NO306408B1 (no)
NZ (2) NZ330137A (no)
PT (2) PT748330E (no)
RO (1) RO116623B1 (no)
SK (1) SK285191B6 (no)
WO (1) WO1995020595A1 (no)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5728575A (en) * 1990-02-01 1998-03-17 Emory University Method of resolution of 1,3-oxathiolane nucleoside enantiomers
US5444063A (en) * 1990-12-05 1995-08-22 Emory University Enantiomerically pure β-D-dioxolane nucleosides with selective anti-Hepatitis B virus activity
US5817667A (en) * 1991-04-17 1998-10-06 University Of Georgia Research Foudation Compounds and methods for the treatment of cancer
US20020120130A1 (en) * 1993-09-10 2002-08-29 Gilles Gosselin 2' or 3' -deoxy and 2', 3' -dideoxy-beta-L-pentofuranonucleo-side compounds, method of preparation and application in therapy, especially as anti- viral agents
US5587362A (en) * 1994-01-28 1996-12-24 Univ. Of Ga Research Foundation L-nucleosides
IL115156A (en) * 1994-09-06 2000-07-16 Univ Georgia Pharmaceutical compositions for the treatment of cancer comprising 1-(2-hydroxymethyl-1,3-dioxolan-4-yl) cytosines
US5703058A (en) * 1995-01-27 1997-12-30 Emory University Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent
US6391859B1 (en) 1995-01-27 2002-05-21 Emory University [5-Carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides
US5808040A (en) * 1995-01-30 1998-09-15 Yale University L-nucleosides incorporated into polymeric structure for stabilization of oligonucleotides
WO1996040164A1 (en) 1995-06-07 1996-12-19 Emory University Nucleosides with anti-hepatitis b virus activity
US6025335A (en) * 1995-09-21 2000-02-15 Lipitek International, Inc. L-Nucleoside Dimer Compounds and therapeutic uses
US5753789A (en) * 1996-07-26 1998-05-19 Yale University Oligonucleotides containing L-nucleosides
HUP0001186A3 (en) * 1996-10-16 2002-04-29 Icn Pharmaceuticals Inc Costa Purine l-nucleosides,analogs and pharmaceutical compositions thereof
EP1072607A3 (en) * 1996-10-16 2001-09-12 ICN Pharmaceuticals, Inc. Purine L-nucleosides, analogs and uses therof
EP1254911A1 (en) * 1996-10-16 2002-11-06 ICN Pharmaceuticals, Inc. Monocyclic L-nucleosides, analogs and uses thereof
BR9712527A (pt) * 1996-10-16 2000-03-08 Icn Pharmaceuticals L-nucleosìdeos monocìclicos, análogos e seus empregos
US6509320B1 (en) * 1996-10-16 2003-01-21 Icn Pharmaceuticals, Inc. Purine L-nucleosides, analogs and uses thereof
TW434252B (en) 1997-07-23 2001-05-16 Univ Georgia Res Found Process for the preparation of 2'-fluoro-5-methyl-β-L-arabino-furanosyluridine
GB9716567D0 (en) * 1997-08-05 1997-10-08 Pfizer Process
US6090602A (en) * 1998-02-18 2000-07-18 Promelas Research Corporation Levo-monosaccharide in a nucleoside analog for use as an anti-retroviral agent
DK1058686T3 (da) * 1998-02-25 2007-03-05 Univ Emory 2'-fluornukleosider
KR100449618B1 (ko) * 1998-03-27 2004-11-16 부광약품 주식회사 2'-플루오로-5-메틸-β-L-아라비노푸라노실유리딘의 제조방법
CA2326823A1 (en) * 1998-04-20 1999-10-28 Ribozyme Pharmaceuticals, Inc. Nucleic acid molecules with novel chemical compositions capable of modulating gene expression
PT1431304E (pt) 1998-08-10 2015-03-09 Novartis Ag Beta-l-2'-desoxi-nucleosidos para o tratamento da hepatite b
US6444652B1 (en) 1998-08-10 2002-09-03 Novirio Pharmaceuticals Limited β-L-2'-deoxy-nucleosides for the treatment of hepatitis B
US6528515B1 (en) * 1998-11-02 2003-03-04 Triangle Pharmaceuticals, Inc. Combination therapy to treat hepatitis B virus
US6407077B1 (en) 1998-11-05 2002-06-18 Emory University β-L nucleosides for the treatment of HIV infection
US6653318B1 (en) 1999-07-21 2003-11-25 Yale University 5-(E)-Bromovinyl uracil analogues and related pyrimidine nucleosides as anti-viral agents and methods of use
EP1214074B1 (en) * 1999-09-24 2004-06-16 Shire Biochem Inc. Dioxolane nucleoside analogs for the treatment or prevention of viral infection
US6436948B1 (en) 2000-03-03 2002-08-20 University Of Georgia Research Foundation Inc. Method for the treatment of psoriasis and genital warts
CN1268345C (zh) * 2000-03-29 2006-08-09 乔治敦大学 治疗丁型肝炎病毒感染的核苷化合物
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
US6787526B1 (en) 2000-05-26 2004-09-07 Idenix Pharmaceuticals, Inc. Methods of treating hepatitis delta virus infection with β-L-2′-deoxy-nucleosides
KR20080021797A (ko) 2000-05-26 2008-03-07 이데닉스(케이만)리미티드 플라비바이러스 및 페스티바이러스의 치료방법 및 조성물
US6875751B2 (en) * 2000-06-15 2005-04-05 Idenix Pharmaceuticals, Inc. 3′-prodrugs of 2′-deoxy-β-L-nucleosides
WO2002006296A1 (fr) * 2000-07-19 2002-01-24 Mitsui Chemicals, Inc. Procedes de preparation de derives de compose d'acide nucleique 2,2'-anhydro
US20030087873A1 (en) 2000-10-18 2003-05-08 Lieven Stuyver Modified nucleosides for the treatment of viral infections and abnormal cellular proliferation
ES2253544T3 (es) * 2001-03-01 2006-06-01 Gilead Sciences, Inc. Formas poliformicas y otras cristalinas de cis-ftc.
CN101117346B (zh) * 2001-03-30 2012-12-12 富光药品株式会社 2'-卤代-β-L-阿拉伯呋喃糖基核苷的制备方法
GB0112617D0 (en) 2001-05-23 2001-07-18 Hoffmann La Roche Antiviral nucleoside derivatives
JP2005503358A (ja) 2001-06-22 2005-02-03 フアーマセツト・リミテツド β−２’−または３’−ハロヌクレオシド
KR100487992B1 (ko) * 2001-10-25 2005-05-09 부광약품 주식회사 2'-플루오로-5-메틸-β-엘-아라비노푸라노실유리딘의 황유도체
AU2002360697B2 (en) 2001-12-20 2009-04-23 Beth Israel Deaconess Medical Center Treatment of EBV and KHSV infection and associated abnormal cellular proliferation
SE521676C2 (sv) * 2002-01-02 2003-11-25 Dilafor Ab Användning av glykosaminoglykaner för prevention och behandling av värksvaghet vid fullgången graviditet
US7662798B2 (en) 2002-06-28 2010-02-16 Idenix Pharmaceuticals, Inc. 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
US7608600B2 (en) * 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
CN101172993A (zh) 2002-06-28 2008-05-07 埃迪尼克斯(开曼)有限公司 用于治疗黄病毒感染的2′－c－甲基－3′－o－l－缬氨酸酯核糖呋喃基胞苷
TWI244393B (en) * 2002-08-06 2005-12-01 Idenix Pharmaceuticals Inc Crystalline and amorphous forms of beta-L-2'-deoxythymidine
CA2498731C (en) * 2002-09-13 2012-10-30 Idenix (Cayman) Limited .beta.-l-2'-deoxynucleosides for the treatment of resistant hbv strains and combination therapies
US7824851B2 (en) 2002-11-15 2010-11-02 Idenix Pharmaceuticals, Inc. 2′-branched nucleosides and Flaviviridae mutation
EP1585529A4 (en) 2002-12-12 2008-05-28 Idenix Cayman Ltd PROCESS FOR PREPARING 2'-BRANCHED NUCLEOSIDES
WO2004084453A2 (en) * 2003-03-20 2004-09-30 Microbiologica Quimica E Farmaceutica Ltd. METHODS OF MANUFACTURE OF 2'-DEOXY-β-L-NUCLEOSIDES
PT2604620T (pt) 2003-05-30 2016-08-18 Gilead Pharmasset Llc Analogos de nucleósido fluorados modificados
EP1794172B1 (en) * 2004-08-23 2009-07-15 F.Hoffmann-La Roche Ag Antiviral 4'-azido-nucleosides
JP2006265156A (ja) * 2005-03-23 2006-10-05 Ajinomoto Co Inc ２−デオキシ−ｌ−リボフラノシルクロリド化合物の製造方法
EP1890537B1 (en) * 2005-06-07 2012-08-08 Yale University Methods of treating cancer and other conditions or disease states using lfmau and ldt
EP1968595A4 (en) 2005-12-02 2014-05-21 Univ Yale METHOD FOR THE TREATMENT OF CANCER AND OTHER CONDITIONS OR DISEASES WITH L-CYTOSINE NUCLEOSIDE ANALOGUE
US8076303B2 (en) 2005-12-13 2011-12-13 Spring Bank Pharmaceuticals, Inc. Nucleotide and oligonucleotide prodrugs
US7781576B2 (en) 2005-12-23 2010-08-24 Idenix Pharmaceuticals, Inc. Process for preparing a synthetic intermediate for preparation of branched nucleosides
US8895531B2 (en) * 2006-03-23 2014-11-25 Rfs Pharma Llc 2′-fluoronucleoside phosphonates as antiviral agents
MY145314A (en) * 2006-10-10 2012-01-13 Medivir Ab Hcv nucleoside inhibtor
EP2105445A4 (en) 2006-12-08 2014-01-22 Api Corp PROCESS FOR THE PREPARATION OF A FURANOSEDERIVATE
EP2189161B1 (en) * 2007-09-10 2012-08-08 Yamasa Corporation Medicinal agent for disease associated with epstein-barr virus, and method for screening of the medicinal agent
US20090274686A1 (en) * 2008-05-02 2009-11-05 Yat Sun Or Nucleoside phosphonate derivatives
EA039123B1 (ru) * 2014-12-15 2021-12-08 Эмори Юниверсити Фосфорамидаты для лечения вируса гепатита в
CA2969372C (en) * 2014-12-15 2023-05-16 Emory University Phosphoramidates for the treatment of hepatitis b virus
AU2017281531A1 (en) 2016-06-24 2019-01-17 Emory University Phosphoramidates for the treatment of hepatitis B virus
CN109467583A (zh) * 2018-11-17 2019-03-15 扬州工业职业技术学院 一种克拉夫定的绿色合成工艺

Family Cites Families (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3116268A (en) * 1955-12-21 1963-12-31 Du Pont Polyphosphonamide polymers and copolymers
US3116266A (en) * 1960-06-17 1963-12-31 Minnesota Mining & Mfg Scorch resistant, thermally curable polymeric compositions, and their curing
US3553192A (en) * 1968-07-15 1971-01-05 Robugen Gmbh Substituted (2'-deoxyribosyl) uracil compounds, compositions containing same and process of making and using same
US4000137A (en) * 1975-06-10 1976-12-28 American Home Products Corporation Antitumor derivatives of periodate-oxidized nucleosides
JPS5668674A (en) * 1979-11-08 1981-06-09 Shionogi & Co Ltd 5-fluorouracil derivative
US4666892A (en) * 1984-03-06 1987-05-19 Sloan-Kettering Memorial Cancer Center Method and composition for hepatitis treatment with pyrimidine nucleoside compounds
FI87783C (fi) * 1985-05-15 1993-02-25 Wellcome Found Foerfarande foer framstaellning av terapeutiskt anvaendbara 2',3'-dideoxinukleosider
JPS62501712A (ja) * 1985-08-26 1987-07-09 アメリカ合衆国 ２′、３′―ジデオキシイノシン、２′，３′―ジデオキシグアノシンまたは２′，３′―ジデオキシアデノシンを含有する抗ｈｔｌｖ―３／ｌａｖ剤
US4879277A (en) * 1985-08-26 1989-11-07 The United States Of America As Represented By The Department Of Health And Human Services Antiviral compositions and methods
DK167377B1 (da) * 1985-09-17 1993-10-25 Wellcome Found 3'-azidopyrimidinnucleosider eller farmaceutisk acceptable salte eller estere deraf til anvendelse ved behandling af eller profylakse for en human retrovirusinfektion
IN164556B (no) * 1986-03-06 1989-04-08 Takeda Chemical Industries Ltd
US4916122A (en) * 1987-01-28 1990-04-10 University Of Georgia Research Foundation, Inc. 3'-Azido-2',3'-dideoxyuridine anti-retroviral composition
US5446029A (en) * 1986-07-04 1995-08-29 Medivir Ab Anti-retroviral activity of 2',3'-dideoxy-3'-fluoronucleosides
GB8617861D0 (en) * 1986-07-22 1986-08-28 Ciba Geigy Ag Flame retardant compositions
US4963533A (en) * 1986-10-24 1990-10-16 Stichting Rega Vzw (Rega) Therapeutic application of dideoxycytidinene
US5215971A (en) * 1986-12-19 1993-06-01 Medivir Ab Antiviral pharmaceutical composition comprising 5-substituted pyrimidine nucleosides
IL85778A0 (en) * 1987-03-20 1988-09-30 Bristol Myers Co Production of 2',3'-dideoxynucleosides and certain such novel compounds
ATE108183T1 (de) * 1987-03-24 1994-07-15 Nycomed Imaging As 2',3'-dideoxyribofuranoxid-derivate.
US5185437A (en) * 1987-04-09 1993-02-09 Burroughs Wellcome Co. Therapeutic nucleosides
US5215970A (en) * 1987-04-16 1993-06-01 Medivir Ab Nucleosides and nucleotide analogues, pharmaceutical composition and processes for the preparation of the compounds
SE8701605D0 (sv) * 1987-04-16 1987-04-16 Astra Ab Novel medicinal compounds
US5246924A (en) * 1987-09-03 1993-09-21 Sloan-Kettering Institute For Cancer Research Method for treating hepatitis B virus infections using 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-ethyluracil
IL87646A (en) * 1987-09-03 1994-07-31 Sloan Kettering Inst Cancer Preparation for the treatment of hepatitis virus containing 1 -) 2 '- Deoxy - 2' - Fluoro - Beta - B - D - Arabino - Furanozil (- 5 - Orcil
US5270315A (en) * 1988-04-11 1993-12-14 Biochem Pharma Inc. 4-(purinyl bases)-substituted-1,3-dioxlanes
US5466806A (en) * 1989-02-08 1995-11-14 Biochem Pharma Inc. Processes for preparing substituted 1,3-oxathiolanes with antiviral properties
US5041449A (en) * 1988-04-11 1991-08-20 Iaf Biochem International, Inc. 4-(nucleoside base)-substituted-1,3-dioxolanes useful for treatment of retroviral infections
US5047407A (en) * 1989-02-08 1991-09-10 Iaf Biochem International, Inc. 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties
NZ228645A (en) * 1988-04-11 1991-09-25 Iaf Biochem Int 1,3-dioxolane derivatives substituted in the 5th position by a purine or pyrimidine radical; treatment of viral infections
US4900828A (en) * 1988-05-12 1990-02-13 Hoffmann-Laroche Inc. Intermediate compounds and an improved procedure for the synthesis of 2',3'-dideoxycytidine
GB8815265D0 (en) * 1988-06-27 1988-08-03 Wellcome Found Therapeutic nucleosides
SE8802687D0 (sv) * 1988-07-20 1988-07-20 Astra Ab Nucleoside derivatives
AU618436B2 (en) * 1988-12-19 1991-12-19 Wellcome Foundation Limited, The Antiviral cytosine and guanine derivatives
ATE237613T1 (de) * 1989-02-08 2003-05-15 Iaf Biochem Int Verfahren für die herstellung von antiviralen substituierten 1, 3-oxathiolanen
UA45942A (uk) * 1989-02-08 2002-05-15 Біокем Фарма, Інк. 1,3-оксатіолан, його похідні, спосіб (варіанти) його одержання та фармацевтична композиція
NZ233197A (en) * 1989-04-13 1991-11-26 Richard Thomas Walker Aromatically substituted nucleotide derivatives, intermediates therefor and pharmaceutical compositions
US5059690A (en) * 1990-03-01 1991-10-22 E. R. Squibb & Sons, Inc. Purinyl tetrahydrofurans
US5071983A (en) * 1989-10-06 1991-12-10 Burroughs Wellcome Co. Therapeutic nucleosides
IE904378A1 (en) * 1989-12-20 1991-07-03 Abbott Lab Analogs of oxetanyl purines and pyrimidines
US5276151A (en) * 1990-02-01 1994-01-04 Emory University Method of synthesis of 1,3-dioxolane nucleosides
US5204466A (en) * 1990-02-01 1993-04-20 Emory University Method and compositions for the synthesis of bch-189 and related compounds
US5527782A (en) * 1990-03-13 1996-06-18 Acic (Canada) Inc. 5-halo-2,3'-O-cyclocytidines
GB9009861D0 (en) * 1990-05-02 1990-06-27 Glaxo Group Ltd Chemical compounds
SE9003151D0 (sv) * 1990-10-02 1990-10-02 Medivir Ab Nucleoside derivatives
IT1246983B (it) * 1990-11-13 1994-12-12 Consiglio Nazionale Ricerche L-2'-desossiuridine e composizioni farmaceutiche che le contengono.
US5444063A (en) * 1990-12-05 1995-08-22 Emory University Enantiomerically pure β-D-dioxolane nucleosides with selective anti-Hepatitis B virus activity
AU9125991A (en) * 1990-12-05 1992-07-08 University Of Georgia Research Foundation, Inc., The Enantiomerically pure beta -l-(-)-1,3-oxathiolane nucleosides
US5179104A (en) * 1990-12-05 1993-01-12 University Of Georgia Research Foundation, Inc. Process for the preparation of enantiomerically pure β-D-(-)-dioxolane-nucleosides
US5248776A (en) * 1990-12-05 1993-09-28 University Of Georgia Research Foundation, Inc. Process for enantiomerically pure β-L-1,3-oxathiolane nucleosides
IL100502A (en) * 1991-01-03 1995-12-08 Iaf Biochem Int PHARMACEUTICAL PREPARATIONS CONTAINING CIS-4-AMINO-1-) 2-HYDROXIMETHIL-1,3-OXETYOLEN-5-IL (-
NZ250842A (en) * 1991-02-22 1996-03-26 Univ Emory Resolution of a racemic mixture of nucleoside enantiomers such as 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane (ftc)
IL101144A (en) * 1991-03-06 1996-09-12 Wellcome Found Pharmaceutical compositions containing 1-(2-hydroxymethyl)-1,3-oxathiolan-5-fluorocytosine and derivatives thereof for the treatment of hepatitis b virus infections
GB9104740D0 (en) * 1991-03-06 1991-04-17 Wellcome Found Antiviral nucleoside combination
WO1992018517A1 (en) * 1991-04-17 1992-10-29 Yale University Method of treating or preventing hepatitis b virus
GB9110874D0 (en) * 1991-05-20 1991-07-10 Iaf Biochem Int Medicaments
ZA923640B (en) * 1991-05-21 1993-02-24 Iaf Biochem Int Processes for the diastereoselective synthesis of nucleosides
EP0586560A1 (en) * 1991-05-23 1994-03-16 Schering Corporation Novel benzopyrido piperidylidene compounds, compositions, methods of manufacture and methods of use
GB9111902D0 (en) * 1991-06-03 1991-07-24 Glaxo Group Ltd Chemical compounds
GB9116601D0 (en) * 1991-08-01 1991-09-18 Iaf Biochem Int 1,3-oxathiolane nucleoside analogues
US5432165A (en) * 1992-04-06 1995-07-11 Oclassen Pharmaceuticals, Inc. Methods for the treatment of infection caused by Hepatitis B virus (HBV)
FR2698325B1 (fr) * 1992-11-20 1995-01-13 Renault Dispositif de commande de débrayage à l'arrêt de transmission automatique.
GB9226927D0 (en) * 1992-12-24 1993-02-17 Iaf Biochem Int Dideoxy nucleoside analogues
US5627160A (en) * 1993-05-25 1997-05-06 Yale University L-2',3'-dideoxy nucleoside analogs as anti-hepatitis B (HBV) and anti-HIV agents
US5439893A (en) * 1993-05-26 1995-08-08 University Of Montana Methods for the treatment and prevention of diarrhea
AU7954694A (en) * 1993-09-10 1995-03-27 Centre National De La Recherche Scientifique (Cnrs) Nucleosides with anti-hepatitis b virus activity
FR2709754B1 (fr) * 1993-09-10 1995-12-01 Centre Nat Rech Scient Composés 2' ou 3'-déoxy- et 2', 3'-didéoxy-beta-L-pentofuranonucléosides, procédé de préparation et application thérapeutique, notamment anti-virale.
AU1596495A (en) * 1993-12-30 1995-07-17 Genta Incorporated Improved process for the purification of oligomers
US5587362A (en) * 1994-01-28 1996-12-24 Univ. Of Ga Research Foundation L-nucleosides

Also Published As

Publication number Publication date
FI121846B (fi) 2011-05-13
FI20051033A (fi) 2005-10-13
PT1283211E (pt) 2006-09-29
DE69535047T2 (de) 2006-12-07
HU228135B1 (en) 2012-12-28
BR9506596B1 (pt) 2010-10-05
CA2182273A1 (en) 1995-08-03
DK1283211T3 (da) 2006-10-09
BG100792A (bg) 1997-03-31
NZ330137A (en) 2000-08-25
SK285191B6 (sk) 2006-08-03
DE69530192D1 (de) 2003-05-08
US5587362A (en) 1996-12-24
CN1143966A (zh) 1997-02-26
FI117475B (fi) 2006-10-31
PT748330E (pt) 2003-08-29
HU9601774D0 (en) 1996-09-30
EP1283211A3 (en) 2003-02-19
RO116623B1 (ro) 2001-04-30
FI962986A0 (fi) 1996-07-26
EP0748330B1 (en) 2003-04-02
NO306408B1 (no) 1999-11-01
ES2266402T3 (es) 2007-03-01
US5565438A (en) 1996-10-15
SK92696A3 (en) 1997-08-06
EP0748330A4 (en) 1997-03-19
EP0748330A1 (en) 1996-12-18
KR100321209B1 (ko) 2002-10-04
NZ281058A (en) 1998-06-26
ES2194902T3 (es) 2003-12-01
DK0748330T3 (da) 2003-07-28
BR9506596A (pt) 1997-09-09
BG62571B1 (bg) 2000-02-29
US5567688A (en) 1996-10-22
HUT75514A (en) 1997-05-28
AU1737695A (en) 1995-08-15
JPH09508394A (ja) 1997-08-26
FI20080432A (fi) 2008-07-08
AU710262B2 (en) 1999-09-16
DE69530192T2 (de) 2004-01-08
FI118954B (fi) 2008-05-30
FI119416B (fi) 2008-11-14
CA2182273C (en) 2006-07-11
CZ292574B6 (cs) 2003-10-15
NO963138D0 (no) 1996-07-26
ATE236186T1 (de) 2003-04-15
FI962986A (fi) 1996-07-26
FI20070005A (fi) 2007-01-03
BRPI9506596B8 (pt) 2016-05-24
EP1283211A2 (en) 2003-02-12
CZ211496A3 (cs) 1998-09-16
JP3899440B2 (ja) 2007-03-28
ATE328889T1 (de) 2006-06-15
EP1283211B1 (en) 2006-06-07
DE69535047D1 (de) 2006-07-20
CN1043769C (zh) 1999-06-23
WO1995020595A1 (en) 1995-08-03
HK1014716A1 (en) 1999-09-30

Similar Documents

Publication Publication Date Title
NO963138D0 (no) L-Nukleosider for behandling av hepatit-B-virus og Epstein-bar-virus
ATE165004T1 (de) Ematiomerenreine beta-d-dioxolane nucleoside mit selektiver antihepatitis b-virus wirkung
ATE314077T1 (de) 5-fluoro-2',3'-ungesättigte pyrimidinnucleoside
FI20001231A (fi) 2-Deoksi-2,3-didehydro-N-asetyylineuramiinihapon johdannaisia ja niiden analogeja ja niiden käyttö antiviraalisina aineina
DE69330274D1 (de) Enantiomerisch reine beta-d-dioxolan-nukleoside
AU644095B2 (en) Antiviral compounds
CA2063417A1 (en) Antiviral composition
DK615788A (da) Nucleosidforbindelser til anvendelse mod virale infektioner
MX9603029A (es) Nucleosidos-l para el tratamiento del virus-b de hepatitis y el virus de epstein-barr.
ES2078380T3 (es) Oligofosfatos de accion antiviral.
RU96117323A (ru) L-нуклеозиды для лечения заболеваний, вызванных вирусом гепатита b и вирусом эпштейна - барра
JPS6426594A (en) Nucleotides and antitumor agent
RU98103770A (ru) 2-амино-9-(3-гидроксиметил-4-алкоксикарбонилоксибут-1-ил)пурина и фармацевтическая композиция, содержащая его

Legal Events

Date Code Title Description
MK1K Patent expired