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NO960267L - Newly substituted benzimidazoles - Google Patents

Newly substituted benzimidazoles

Info

Publication number
NO960267L
NO960267L NO960267A NO960267A NO960267L NO 960267 L NO960267 L NO 960267L NO 960267 A NO960267 A NO 960267A NO 960267 A NO960267 A NO 960267A NO 960267 L NO960267 L NO 960267L
Authority
NO
Norway
Prior art keywords
compounds
cyclopropylmethoxy
benzimidazole
pyridinyl
fluoro
Prior art date
Application number
NO960267A
Other languages
Norwegian (no)
Other versions
NO960267D0 (en
Inventor
Per Lennart Lindberg
Gunnel Elisabeth Sunden
Per Oskar Sverker Von Unge
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/SE1995/000518 external-priority patent/WO1995032958A1/en
Application filed by Astra Ab filed Critical Astra Ab
Publication of NO960267L publication Critical patent/NO960267L/en
Publication of NO960267D0 publication Critical patent/NO960267D0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Nye optisk rene forbindelser, dvs de enantiomere enkeltforbindelsene (la, lb) (la, lb) (+)-5-fluor-2-[[(4-cyklopropylmetoksy-2-pyridinyl)metyl]sulfinyl]-lH-benzimidazol og (-)-5-fluor-2-t[(4-cyklopropylmetoksy-2-pyridinyl)metyl]sulfmyl]-lH-benzimidazol eller et terapeutisk akseptabelt salt derav, slik som Na+, Mg2+, Li+, K+, Ca^+og N+(R)4 salter, hvor R er en alkylgruppe med l -4 karbonatomer, fremgangsmåter for fremstilling derav og farmasøytiske preparater inneholdende forbindelsene som aktive bestanddeler, anvendelse av forbindelsene i farmasøytiske preparater samt mellom- produkter oppnådd ved fremstilling av forbindelsene.New optically pure compounds, i.e. the single enantiomeric compounds (Ia, 1b) (Ia, 1b) (+) - 5-fluoro-2 - [[(4-cyclopropylmethoxy-2-pyridinyl) methyl] sulfinyl] -1H-benzimidazole and ( -) - 5-Fluoro-2-t [(4-cyclopropylmethoxy-2-pyridinyl) methyl] sulfmyl] -1H-benzimidazole or a therapeutically acceptable salt thereof, such as Na +, Mg 2+, Li +, K +, Ca 2+ and N + (R) 4 salts, wherein R is an alkyl group of 1-4 carbon atoms, processes for their preparation and pharmaceutical compositions containing the compounds as active ingredients, use of the compounds in pharmaceutical preparations and intermediates obtained in the preparation of the compounds.

NO960267A 1994-05-27 1996-01-23 Newly substituted benzimidazoles NO960267D0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25616894A 1994-05-27 1994-05-27
SE9400510 1994-05-27
PCT/SE1995/000518 WO1995032958A1 (en) 1994-05-27 1995-05-11 Novel substituted benzimidazoles

Publications (2)

Publication Number Publication Date
NO960267L true NO960267L (en) 1996-01-23
NO960267D0 NO960267D0 (en) 1996-01-23

Family

ID=26661966

Family Applications (1)

Application Number Title Priority Date Filing Date
NO960267A NO960267D0 (en) 1994-05-27 1996-01-23 Newly substituted benzimidazoles

Country Status (2)

Country Link
NO (1) NO960267D0 (en)
SK (1) SK5896A3 (en)

Also Published As

Publication number Publication date
SK5896A3 (en) 1996-09-04
NO960267D0 (en) 1996-01-23

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