NO960148L - Anvendelse av kumariner og karbostyriler som PLA2-inhibitorer, nye kumariner og karbostyriler, fremgangsmåte for fremstilling samt legemiddel inneholdende slike - Google Patents
Anvendelse av kumariner og karbostyriler som PLA2-inhibitorer, nye kumariner og karbostyriler, fremgangsmåte for fremstilling samt legemiddel inneholdende slikeInfo
- Publication number
- NO960148L NO960148L NO960148A NO960148A NO960148L NO 960148 L NO960148 L NO 960148L NO 960148 A NO960148 A NO 960148A NO 960148 A NO960148 A NO 960148A NO 960148 L NO960148 L NO 960148L
- Authority
- NO
- Norway
- Prior art keywords
- carbostyrils
- coumarins
- preparation
- drug containing
- novel
- Prior art date
Links
- ZYGHJZDHTFUPRJ-UHFFFAOYSA-N benzo-alpha-pyrone Natural products C1=CC=C2OC(=O)C=CC2=C1 ZYGHJZDHTFUPRJ-UHFFFAOYSA-N 0.000 title abstract 4
- 235000001671 coumarin Nutrition 0.000 title abstract 4
- 150000004775 coumarins Chemical class 0.000 title abstract 4
- 239000003814 drug Substances 0.000 title abstract 3
- 229940079593 drug Drugs 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 239000003358 phospholipase A2 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 102100026918 Phospholipase A2 Human genes 0.000 abstract 1
- 101710096328 Phospholipase A2 Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
- A61K31/37—Coumarins, e.g. psoralen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
- C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
- C07D311/18—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted otherwise than in position 3 or 7
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Nutrition Science (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4323409A DE4323409A1 (de) | 1993-07-13 | 1993-07-13 | Verwendung von Cumarinen und Carbostyrilen als PLA¶2¶-Inhibitoren, neue Cumarine und Carbostyrile, Verfahren zu ihrer Herstellung und Arzneimittel |
| PCT/EP1994/002251 WO1995002588A1 (de) | 1993-07-13 | 1994-07-09 | Verwendung von cumarinen und carbostyrilen als pla2-inhibitoren, neue cumarine und carbostyrile, verfahren zu ihrer herstellung und arzneimittel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO960148D0 NO960148D0 (no) | 1996-01-12 |
| NO960148L true NO960148L (no) | 1996-03-12 |
Family
ID=6492685
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO960148A NO960148L (no) | 1993-07-13 | 1996-01-12 | Anvendelse av kumariner og karbostyriler som PLA2-inhibitorer, nye kumariner og karbostyriler, fremgangsmåte for fremstilling samt legemiddel inneholdende slike |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5716983A (cs) |
| EP (1) | EP0708766B1 (cs) |
| JP (1) | JPH08512057A (cs) |
| KR (1) | KR960703887A (cs) |
| CN (1) | CN1130381A (cs) |
| AT (1) | ATE161010T1 (cs) |
| AU (1) | AU686197B2 (cs) |
| CA (1) | CA2167071A1 (cs) |
| CZ (1) | CZ6896A3 (cs) |
| DE (2) | DE4323409A1 (cs) |
| FI (1) | FI960149L (cs) |
| HU (1) | HUT73764A (cs) |
| NO (1) | NO960148L (cs) |
| NZ (1) | NZ268608A (cs) |
| RU (1) | RU2133745C1 (cs) |
| WO (1) | WO1995002588A1 (cs) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU9123198A (en) * | 1997-08-28 | 1999-03-16 | Eli Lilly And Company | Method for treatment of non-rheumatoid athritis |
| HUP0102243A2 (hu) | 1998-05-01 | 2001-10-28 | Eli Lilly And Co. | sPLA2-inhibitor vegyületek betegség kezelésére |
| US6331562B1 (en) | 1998-12-30 | 2001-12-18 | Signal Pharmaceuticals, Inc. | Compounds and methods for modulation of estrogen receptors |
| US6291456B1 (en) * | 1998-12-30 | 2001-09-18 | Signal Pharmaceuticals, Inc. | Compounds and methods for modulation of estrogen receptors |
| WO2000039120A2 (en) * | 1998-12-30 | 2000-07-06 | Signal Pharmaceuticals, Inc. | Compounds and methods for modulation of estrogen receptors |
| US7027092B2 (en) * | 2001-09-17 | 2006-04-11 | Hewlett-Packard Development Company, L.P. | Image capture and storage device |
| WO2003090672A2 (en) * | 2002-04-26 | 2003-11-06 | Ortho-Mcneil Pharmaceutical, Inc. | 2-(quinolonyl)-fused heterocycles as androgen receptor modulators |
| KR20040001144A (ko) * | 2002-06-27 | 2004-01-07 | 김대경 | 신규한 적혈구 세포질형 포스포리파아제 에이 투 효소,그에 대한 항체, 이들의 용도 및 제조 방법 |
| US7538233B2 (en) * | 2003-09-05 | 2009-05-26 | Aventis Pharmaceuticals Inc. | Coumarins as iNOS inhibitors |
| CN102532015B (zh) * | 2012-01-18 | 2013-10-23 | 云南大学 | 香豆素及其类似物的固相合成方法 |
| CN105687184A (zh) * | 2016-04-06 | 2016-06-22 | 梁海月 | 蛇床子素在制备治疗溃疡性结肠炎的药物方面的应用 |
| CN111423450B (zh) * | 2020-04-29 | 2021-10-26 | 上海天马有机发光显示技术有限公司 | 化合物、显示面板以及显示装置 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2035M (fr) * | 1962-06-29 | 1963-09-23 | Dausse Lab | Médicament a base de dérivé du méthyl-4 esculétol. |
| BE734121A (cs) * | 1968-06-14 | 1969-11-17 | ||
| FR2276819A1 (fr) * | 1974-07-05 | 1976-01-30 | Fabre Sa Pierre | Facteurs p lipophile a action anti-inflammatoire locale utilisables dans le traitement de syndromes dermatologiques |
| JPS6056985A (ja) * | 1983-09-08 | 1985-04-02 | Sankyo Co Ltd | クマリン誘導体 |
| EP0165897B1 (de) * | 1984-05-24 | 1989-03-15 | Ciba-Geigy Ag | Neue Resorcinäther |
| IT1196133B (it) * | 1984-06-06 | 1988-11-10 | Ausonia Farma Srl | Derivati furanici con attivita' antiulcera |
| US5124334A (en) * | 1987-11-30 | 1992-06-23 | Du Pont Merck Pharmaceutical Company | Benzylalcohol phospholipase A2 inhibitors |
| FR2677023B1 (fr) * | 1991-05-30 | 1994-02-25 | Eurobio Laboratoires | Derives de coumarine hydrosolubles, leur preparation et leur utilisation comme substrat d'enzyme. |
| JPH06312925A (ja) * | 1993-03-02 | 1994-11-08 | Kureha Chem Ind Co Ltd | 軟骨保護剤及び新規エスクレチン誘導体 |
| CA2133115A1 (en) * | 1993-10-01 | 1995-04-02 | Yozo Hori | Carboxylate derivatives exhibiting phospholipase a2 inhibitory activity |
-
1993
- 1993-07-13 DE DE4323409A patent/DE4323409A1/de not_active Withdrawn
-
1994
- 1994-07-09 CA CA002167071A patent/CA2167071A1/en not_active Abandoned
- 1994-07-09 NZ NZ268608A patent/NZ268608A/en unknown
- 1994-07-09 JP JP7503693A patent/JPH08512057A/ja active Pending
- 1994-07-09 KR KR1019960700230A patent/KR960703887A/ko not_active Ceased
- 1994-07-09 AU AU71880/94A patent/AU686197B2/en not_active Ceased
- 1994-07-09 US US08/569,197 patent/US5716983A/en not_active Expired - Fee Related
- 1994-07-09 RU RU96102842A patent/RU2133745C1/ru active
- 1994-07-09 WO PCT/EP1994/002251 patent/WO1995002588A1/de not_active Application Discontinuation
- 1994-07-09 DE DE59404786T patent/DE59404786D1/de not_active Expired - Fee Related
- 1994-07-09 CZ CZ9668A patent/CZ6896A3/cs unknown
- 1994-07-09 AT AT94920981T patent/ATE161010T1/de not_active IP Right Cessation
- 1994-07-09 EP EP94920981A patent/EP0708766B1/de not_active Expired - Lifetime
- 1994-07-09 CN CN94193250A patent/CN1130381A/zh active Pending
- 1994-07-09 HU HU9503973A patent/HUT73764A/hu unknown
-
1996
- 1996-01-12 NO NO960148A patent/NO960148L/no not_active Application Discontinuation
- 1996-01-12 FI FI960149A patent/FI960149L/fi unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR960703887A (ko) | 1996-08-31 |
| HUT73764A (en) | 1996-09-30 |
| CZ6896A3 (en) | 1996-04-17 |
| DE4323409A1 (de) | 1995-01-19 |
| HU9503973D0 (en) | 1996-03-28 |
| FI960149A0 (fi) | 1996-01-12 |
| CA2167071A1 (en) | 1995-01-26 |
| RU2133745C1 (ru) | 1999-07-27 |
| ATE161010T1 (de) | 1997-12-15 |
| FI960149L (fi) | 1996-01-12 |
| NZ268608A (en) | 1997-09-22 |
| NO960148D0 (no) | 1996-01-12 |
| EP0708766A1 (de) | 1996-05-01 |
| US5716983A (en) | 1998-02-10 |
| WO1995002588A1 (de) | 1995-01-26 |
| JPH08512057A (ja) | 1996-12-17 |
| EP0708766B1 (de) | 1997-12-10 |
| DE59404786D1 (de) | 1998-01-22 |
| CN1130381A (zh) | 1996-09-04 |
| AU686197B2 (en) | 1998-02-05 |
| AU7188094A (en) | 1995-02-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |