NO954764L - Psoralen-derivater, deres fremstilling og anvendelse - Google Patents
Psoralen-derivater, deres fremstilling og anvendelseInfo
- Publication number
- NO954764L NO954764L NO954764A NO954764A NO954764L NO 954764 L NO954764 L NO 954764L NO 954764 A NO954764 A NO 954764A NO 954764 A NO954764 A NO 954764A NO 954764 L NO954764 L NO 954764L
- Authority
- NO
- Norway
- Prior art keywords
- preparation
- perhalomethyl
- cyano
- nitro
- cycloalkyl
- Prior art date
Links
- ZCCUUQDIBDJBTK-UHFFFAOYSA-N psoralen Chemical class C1=C2OC(=O)C=CC2=CC2=C1OC=C2 ZCCUUQDIBDJBTK-UHFFFAOYSA-N 0.000 title abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- VXGRJERITKFWPL-UHFFFAOYSA-N 4',5'-Dihydropsoralen Natural products C1=C2OC(=O)C=CC2=CC2=C1OCC2 VXGRJERITKFWPL-UHFFFAOYSA-N 0.000 abstract 1
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- -1 diazanaphthyl Chemical group 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 150000002430 hydrocarbons Chemical class 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000009885 systemic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Immunology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Forbindelse med den generelle formel (I) l /\ o R-X N-A-O-IT (I) hvor A er hydrokarbon inneholdende 2- 6 C-atomer; R1 er (a) (a) hvor R3, R4, R5, R6 og R7 er H, halogen, alkyl, sykloalkyl, cyan, nitro eller perhalogenmetyl; eller R1 er (b) (b) hvor R8, R9, R10 og R11 er H, halogen, alkyl, sykloalkyl, cyan, nitro eller perhalogenmetyl; eller R1 er fenyl som eventuelt er substituert, eller R1 er naftyl, azanaftyl eller diazanaftyl som hver kan være substituert; B er O, S eller NH; W er N eller CH; X er CH j eller N; og R2 er et psoralen; eller farmasøytisk akseptable salter derav, kan anvendes ved behandlingen av indi- kasjoner relatert til CNS-system-, hjerte- og karsystem- eller mage- og tarmsykdommer.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK93607A DK60793D0 (da) | 1993-05-26 | 1993-05-26 | Kemiske forbindelser, deres fremstilling og anvendelse |
| PCT/DK1994/000200 WO1994027998A1 (en) | 1993-05-26 | 1994-05-25 | Psoralen®* derivatives, their preparation and use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO954764D0 NO954764D0 (no) | 1995-11-24 |
| NO954764L true NO954764L (no) | 1996-01-25 |
Family
ID=8095496
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO954764A NO954764L (no) | 1993-05-26 | 1995-11-24 | Psoralen-derivater, deres fremstilling og anvendelse |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0700398B1 (no) |
| JP (1) | JPH08510264A (no) |
| AT (1) | ATE160567T1 (no) |
| AU (1) | AU6924094A (no) |
| DE (1) | DE69407042D1 (no) |
| DK (1) | DK60793D0 (no) |
| FI (1) | FI955680L (no) |
| NO (1) | NO954764L (no) |
| WO (1) | WO1994027998A1 (no) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6133290A (en) * | 1998-07-31 | 2000-10-17 | Eli Lilly And Company | 5-HT1F agonists |
| AU7547100A (en) * | 1999-09-09 | 2001-04-10 | Egis Gyogyszergyar Rt. | Alkylpiperidi nylbenzo [d] isoxazole derivatives having psychotropic activity, pharmaceutical compositions containing the same, and a process for the preparation of the active ingredient |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1024385A (en) * | 1961-12-19 | 1966-03-30 | Chemetron Corp | Khellin derivatives |
| US5015740A (en) * | 1988-08-05 | 1991-05-14 | Janssen Pharmaceutica N.V. | Antipsychotic 3-piperazinylbenzazole derivatives |
| CA2000786C (en) * | 1988-11-07 | 1999-01-26 | Cornelus G. M. Janssen | 3-piperidinyl-1,2-benzisoxazoles |
| FR2641278B1 (fr) * | 1989-01-05 | 1991-03-22 | Lipha | Piperidines, procedes de preparation et medicaments les contenant |
| DK0402644T3 (da) * | 1989-05-19 | 1996-01-02 | Hoechst Roussel Pharma | N-(Aryloxyalkyl)-heteroarylpiperidiner og -heteroarylpiperaziner, fremgangsmåde til deres fremstilli ng samt deres anvendelse som medikamenter |
| FR2654104B1 (fr) * | 1989-11-07 | 1992-01-03 | Adir | Nouveaux derives du 1,2-benzisoxazole, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
-
1993
- 1993-05-26 DK DK93607A patent/DK60793D0/da not_active Application Discontinuation
-
1994
- 1994-05-25 EP EP94917565A patent/EP0700398B1/en not_active Expired - Lifetime
- 1994-05-25 WO PCT/DK1994/000200 patent/WO1994027998A1/en active IP Right Grant
- 1994-05-25 AU AU69240/94A patent/AU6924094A/en not_active Abandoned
- 1994-05-25 JP JP7500124A patent/JPH08510264A/ja active Pending
- 1994-05-25 DE DE69407042T patent/DE69407042D1/de not_active Expired - Lifetime
- 1994-05-25 AT AT94917565T patent/ATE160567T1/de not_active IP Right Cessation
-
1995
- 1995-11-24 NO NO954764A patent/NO954764L/no unknown
- 1995-11-24 FI FI955680A patent/FI955680L/fi not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU6924094A (en) | 1994-12-20 |
| EP0700398A1 (en) | 1996-03-13 |
| NO954764D0 (no) | 1995-11-24 |
| JPH08510264A (ja) | 1996-10-29 |
| EP0700398B1 (en) | 1997-11-26 |
| ATE160567T1 (de) | 1997-12-15 |
| DE69407042D1 (de) | 1998-01-08 |
| WO1994027998A1 (en) | 1994-12-08 |
| FI955680A0 (fi) | 1995-11-24 |
| DK60793D0 (da) | 1993-05-26 |
| FI955680L (fi) | 1995-11-24 |
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