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NO954654L - Benzimiddazolyl-diazacyklo-oktanforbindelse - Google Patents

Benzimiddazolyl-diazacyklo-oktanforbindelse

Info

Publication number
NO954654L
NO954654L NO954654A NO954654A NO954654L NO 954654 L NO954654 L NO 954654L NO 954654 A NO954654 A NO 954654A NO 954654 A NO954654 A NO 954654A NO 954654 L NO954654 L NO 954654L
Authority
NO
Norway
Prior art keywords
carbon atoms
straight chain
hydrogen atom
diazacyklo
benzimiddazolyl
Prior art date
Application number
NO954654A
Other languages
English (en)
Other versions
NO954654D0 (no
Inventor
Den-Ichi Momose
Masaaki Satoh
Yoshinori Nonaka
Hidetoshi Isawa
Nobuko Yanagi
Yasuo Takehana
Original Assignee
Kissei Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kissei Pharmaceutical filed Critical Kissei Pharmaceutical
Publication of NO954654D0 publication Critical patent/NO954654D0/no
Publication of NO954654L publication Critical patent/NO954654L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

l- (2-Benzimidazolyl)-l,5-diazacyklooktanforbin- ! deiser representert ved formel: ¿Y¿COOR hvor X representerer et hydrogenatom eller et halo- genatom; Y representerer en kovalent binding, en rettkjedet eller forgrenet alkylengruppe med l til 6 karbonatomer, eller en rettkjedet eller forgrenet alkenylengruppe med 2 til 6 karbonatomer; R repre- senterer et hydrogenatom eller en rettkjedet eller forgrenet alkylgruppe med l til 6 karbonatomer; og farmasøytisk akseptable salter derav. Forbindelsene representert ovenfor er nye kraftige og langvarige histamin Hi-reseptorantagonister med mindre topisk irritasjon, og de kan anvendes for topisk admini- I strasjon ved inhalering for behandling av bronkial astma.
NO954654A 1993-05-20 1995-11-17 Benzimiddazolyl-diazacyklo-oktanforbindelse NO954654L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP15599593 1993-05-20
PCT/JP1994/000787 WO1994027973A1 (fr) 1993-05-20 1994-05-16 Derive 1-(2-benzimidazolyl)-1,5-diazacyclooctane

Publications (2)

Publication Number Publication Date
NO954654D0 NO954654D0 (no) 1995-11-17
NO954654L true NO954654L (no) 1996-01-22

Family

ID=15618048

Family Applications (1)

Application Number Title Priority Date Filing Date
NO954654A NO954654L (no) 1993-05-20 1995-11-17 Benzimiddazolyl-diazacyklo-oktanforbindelse

Country Status (7)

Country Link
US (1) US5624948A (no)
EP (1) EP0699668A4 (no)
KR (1) KR960702445A (no)
CA (1) CA2161876A1 (no)
FI (1) FI955523A0 (no)
NO (1) NO954654L (no)
WO (1) WO1994027973A1 (no)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6194406B1 (en) 1995-12-20 2001-02-27 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease
IL125002A0 (en) * 1995-12-20 1999-01-26 Hoechst Marion Roussel Inc Novel substituted 4-(1H-benzimidazol-2-yl) [1,4] diazepanes useful for the treatment of allergic diseases
US6423704B2 (en) 1995-12-20 2002-07-23 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1140119A (en) * 1978-04-03 1983-01-25 Joseph Torremans N-heterocyclyl-4-piperidinamines
JPS5879983A (ja) * 1981-11-06 1983-05-13 Kanebo Ltd 新規なベンズイミダゾ−ル誘導体、その製造法およびその医薬組成物
US4588722A (en) * 1984-01-09 1986-05-13 Janssen Pharmaceutica N.V. N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives
EP0232937B1 (en) * 1986-02-03 1992-08-19 Janssen Pharmaceutica N.V. Anti-histaminic compositions containing n-heterocyclyl-4-piperidinamines
US4835161A (en) * 1986-02-03 1989-05-30 Janssen Pharmaceutica N.V. Anti-histaminic compositions containing n-heterocyclyl-4-piperidinamines
US4943580A (en) * 1987-03-09 1990-07-24 Janssen Pharmaceutica N.V. Anti-histaminic benzimidazole, imidazopyridine and purine derivatives
US4988689A (en) * 1987-07-01 1991-01-29 Janssen Pharmaceutica N.V. ((Pharmacologically active bicyclic heterocyclic)methyl and -heteroatom) substituted hexahydro-1H-azepines and pyrrolidines
FR2668150B1 (fr) * 1990-10-17 1994-11-18 Theramex Nouveaux derives du terbutylphenyl 1-amino 4-hydroxybutane, leurs procedes de preparation et les compositions pharmaceutiques en renfermant.

Also Published As

Publication number Publication date
FI955523A (fi) 1995-11-16
US5624948A (en) 1997-04-29
NO954654D0 (no) 1995-11-17
WO1994027973A1 (fr) 1994-12-08
CA2161876A1 (en) 1994-12-08
FI955523A0 (fi) 1995-11-16
EP0699668A4 (en) 1996-09-18
EP0699668A1 (en) 1996-03-06
KR960702445A (ko) 1996-04-27

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