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NO952321L - Polypeptid, samt anti-HIV-preparat fremstilt fra dette - Google Patents

Polypeptid, samt anti-HIV-preparat fremstilt fra dette

Info

Publication number
NO952321L
NO952321L NO952321A NO952321A NO952321L NO 952321 L NO952321 L NO 952321L NO 952321 A NO952321 A NO 952321A NO 952321 A NO952321 A NO 952321A NO 952321 L NO952321 L NO 952321L
Authority
NO
Norway
Prior art keywords
polypeptide
pct
well
prepared therefrom
preparation prepared
Prior art date
Application number
NO952321A
Other languages
English (en)
Other versions
NO952321D0 (no
Inventor
Akiyoshi Matsumoto
Michinori Waki
Original Assignee
Seikagaku Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Seikagaku Kogyo Co Ltd filed Critical Seikagaku Kogyo Co Ltd
Publication of NO952321D0 publication Critical patent/NO952321D0/no
Publication of NO952321L publication Critical patent/NO952321L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Polypeptid representert av formel (I) , [hvor A-^ er en aminosyre eller et peptid med en eller minst to basiske aminosyrer valgt fra lysin, arginin og ornitin i det nevnte aminosyre eller peptid hvor den aminoterminale N-a gruppe kan være erstattet med en acylgruppe eller substituert tiokarbamoylgruppe; Aer tyrosin eller fenylalanin; A-j er lysin eller arginin; Aer -0H eller NH; og X er et peptid såsom D-ornityl-prolin, prolyl-D-ornitin, D-lysyl-prolin, prolyl-D-lysin, D-arginyl-prolin, prolyl-D-arginin, glysyl-ornitin, ornityl-glysin, glysyl-lysin, lysyl-glysin, glysyl-arginin og arginyl-glysin hvor hydrogenatomet av w-aminogruppen av D-lysin, L-lysin D-ornitin og L-ornitin kan være erstattet av en o-aminoacylgruppe og nevnte peptid er bundet til aminosyreresiduer ved sjette og åttende posisjoner via peptidbindinger i seg selv; Trp er tryptofan; og Cys er Cystin], samt et eksempel på slike polypeptider som er representert ifølge formel (1) er vist. Det ovennevnte polypeptid kan være anvendelig i farmasøytiske blandinger som et anti-mikrobielt eller anti-viralt middel, spesielt som et anti-HIV middel samt som en komponent av DNA-transfekterende systemer for geneterapi.
NO952321A 1993-10-14 1995-06-13 Polypeptid, samt anti-HIV-preparat fremstilt fra dette NO952321L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP28034693 1993-10-14
PCT/JP1994/001706 WO1995010534A1 (en) 1993-10-14 1994-10-12 Polypeptide and anti-hiv agent prepared therefrom

Publications (2)

Publication Number Publication Date
NO952321D0 NO952321D0 (no) 1995-06-13
NO952321L true NO952321L (no) 1995-08-09

Family

ID=17623732

Family Applications (1)

Application Number Title Priority Date Filing Date
NO952321A NO952321L (no) 1993-10-14 1995-06-13 Polypeptid, samt anti-HIV-preparat fremstilt fra dette

Country Status (17)

Country Link
US (1) US5776899A (no)
EP (1) EP0677061B1 (no)
JP (1) JPH08504837A (no)
KR (1) KR100208873B1 (no)
CN (1) CN1038841C (no)
AT (1) ATE177114T1 (no)
AU (1) AU682405B2 (no)
CA (1) CA2151283A1 (no)
CZ (1) CZ287239B6 (no)
DE (1) DE69416824T2 (no)
FI (1) FI952900A (no)
HU (1) HU217442B (no)
NO (1) NO952321L (no)
NZ (1) NZ274560A (no)
RU (1) RU2136696C1 (no)
WO (1) WO1995010534A1 (no)
ZA (1) ZA948005B (no)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5804558A (en) * 1993-07-20 1998-09-08 University Of California Protegrins
US5708145A (en) * 1993-07-20 1998-01-13 University Of California Immunglobulins reactive with protegrins
US5693486A (en) * 1993-07-20 1997-12-02 Intrabiotics DNA sequences encoding protegrins and protegrin analogs and their use in recombinant methods of producing protegrins
US6653442B1 (en) 1993-07-20 2003-11-25 Intrabiotics Pharmaceuticals, Inc. Protegrins
US6025326A (en) * 1995-07-07 2000-02-15 Intrabiotics Pharmaceuticals, Inc. Compositions and methods for the prevention and treatment of oral mucositis
US5994306A (en) * 1995-11-22 1999-11-30 Intrabiotics Pharmaceuticals, Inc. Fine-tuned protegrins
US5916872A (en) * 1996-07-24 1999-06-29 Intrabiotics Pharmaceuticals, Inc. Cyclic peptides having broad spectrum antimicrobial activity
EP1016672A4 (en) * 1996-10-15 2001-04-11 Seikagaku Kogyo Co Ltd POLYPEPTIDE TRANSITIONAL METAL SALTS AND METHOD FOR INCREASING THE ANTI-HIV EFFECTIVENESS OF POLYPEPTIDES
WO1998043995A1 (fr) * 1997-03-28 1998-10-08 Seikagaku Corporation Nouveaux complexes anti-vih et compositions medicamenteuses
EP1207897A2 (en) * 1999-08-09 2002-05-29 Tripep Ab Pharmaceutical compositions containing tripeptides
US6337317B1 (en) * 2000-06-27 2002-01-08 The University Of British Columbia Antimicrobial peptides and methods of use thereof
CA2421183C (en) 2000-09-05 2015-06-16 Seikagaku Corporation Novel polypeptide and anti-hiv agent containing the same
US8435939B2 (en) 2000-09-05 2013-05-07 Biokine Therapeutics Ltd. Polypeptide anti-HIV agent containing the same
US6593455B2 (en) * 2001-08-24 2003-07-15 Tripep Ab Tripeptide amides that block viral infectivity and methods of use thereof
WO2003024995A1 (en) * 2001-09-19 2003-03-27 Tripep Ab Molecules that block viral infectivity and methods of use thereof
KR100932520B1 (ko) * 2002-10-31 2009-12-17 박래옥 항암제 조성물
US7423007B2 (en) 2002-08-27 2008-09-09 Biokine Therapeutics Ltd. Cxcr4 antagonist and use thereof
JP4781621B2 (ja) * 2002-08-27 2011-09-28 バイオカイン セラピューティックス リミテッド Ｃｘｃｒ４拮抗薬およびその用途
AU2003274800A1 (en) * 2002-10-31 2004-05-25 Lae-Ok Park Anticancer or antiviral composition
US20040132642A1 (en) * 2002-11-12 2004-07-08 Government Of The U.S.A., Represented By The Secretary, Dept. Of Health & Human Services Methods of inhibiting metastasis or growth of a tumor cell
US20050096319A1 (en) * 2003-02-21 2005-05-05 Balzarini Jan M.R. Identification of compounds that inhibit replication of human immunodeficiency virus
PL378163A1 (pl) * 2003-02-21 2006-03-06 Tripep Ab Pochodna glicynoamidu do hamowania replikacji HIV
WO2004096839A1 (en) 2003-05-02 2004-11-11 Polyphor Ag Template-fixed beta-hairpin peptidomimetics with cxcr4 antagonizing activity
KR20080106467A (ko) 2006-03-10 2008-12-05 펩트셀 리미티드 Ｈｉｖ 조절 또는 보조 단백질의 펩타이드, 그 조성물 및 이용 방법
CN100366633C (zh) * 2006-04-18 2008-02-06 河北师范大学 棕点湍蛙抗病毒多肽及其在制药中的应用
EP2104507A4 (en) 2006-12-21 2011-05-25 Biokine Therapeutics Ltd T-140 PEPTIDE ANALOGUE WITH CXCR4 SUPERAGONIST ACTIVITY FOR CANCER THERAPY
US9789194B2 (en) 2007-11-27 2017-10-17 Rutgers, The State University Of New Jersey Graft copolymer polyelectrolyte complexes for drug delivery
US9271933B2 (en) * 2007-11-27 2016-03-01 Rutgers, The State University Of New Jersey Graft copolymer polyelectrolyte complexes for drug delivery
EP4071169A2 (en) 2008-08-25 2022-10-12 Dana Farber Cancer Institute, Inc. Conserved influenza hemagglutinin epitope and antibodies thereto
EP2442822B1 (en) 2009-06-14 2014-03-05 Biokine Therapeutics Ltd. Peptide therapy for increasing platelet levels
CA2838037C (en) 2011-06-07 2019-09-17 Polyphor Ag Beta-hairpin peptidomimetics as cxc4 antagonists
WO2013160895A1 (en) 2012-04-24 2013-10-31 Biokine Therapeutics Ltd. Peptides and use thereof in the treatment of large cell lung cancer
CN104072579B (zh) * 2014-06-11 2017-01-25 南方医科大学 具有抗菌抗病毒活性的小分子肽及其活性修饰物
EP3943098A3 (en) 2015-07-16 2022-05-11 Biokine Therapeutics Ltd. Compositions and methods for treating cancer
BR112018016924A2 (pt) 2016-02-23 2019-01-02 Biokine Therapeutics Ltd método de seleção de regime de tratamento para indivíduo que tem leucemia mieloide aguda (lma), método de maximização de resposta ao tratamento de leucemia mieloide aguda (lma), método de tratamento de lma, antagonista de cxcr4 e agente quimioterápico no tratamento de lma
RU2658781C1 (ru) * 2017-12-28 2018-06-22 Федеральное государственное бюджетное учреждение науки институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук (ИБХ РАН) Пептид, обладающий противоопухолевой активностью
CN110841607B (zh) * 2019-11-22 2020-07-24 中国科学院地质与地球物理研究所 一种超低本底金特效树脂及其制备和应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1337781C (en) * 1987-08-21 1995-12-19 Takanori Nakamura Polypeptide from horseshoe crab exhibiting affinity for lipopolysaccharide and method of preparation
JP2641744B2 (ja) * 1988-08-18 1997-08-20 マルハ株式会社 新規ペプチド及び抗菌剤
JP2641742B2 (ja) * 1988-08-18 1997-08-20 マルハ株式会社 新規ペプチド及び抗菌剤
JP2798711B2 (ja) * 1988-09-26 1998-09-17 生化学工業株式会社 ポリペプチド系抗ウィルス剤
DE69115878T2 (de) * 1990-09-11 1996-06-05 Seikagaku Kogyo Co., Ltd., Tokio/Tokyo Neue polypeptide und damit hergestellte anti-hiv medikamente
NO921715L (no) * 1991-05-02 1992-11-03 Seikagaku Kogyo Co Ltd Nye polypeptider med affinitet for lipopolysakkarider og anvendelser derav
JP3266311B2 (ja) * 1991-05-02 2002-03-18 生化学工業株式会社 新規ポリペプチドおよびこれを用いる抗ｈｉｖ剤
JP2500194B2 (ja) 1993-08-10 1996-05-29 株式会社ヴァンドームヤマダ 商品発注システム

Also Published As

Publication number Publication date
JPH08504837A (ja) 1996-05-28
AU7862894A (en) 1995-05-04
EP0677061B1 (en) 1999-03-03
RU2136696C1 (ru) 1999-09-10
FI952900A0 (fi) 1995-06-13
EP0677061A1 (en) 1995-10-18
US5776899A (en) 1998-07-07
ATE177114T1 (de) 1999-03-15
DE69416824D1 (de) 1999-04-08
CZ287239B6 (en) 2000-10-11
ZA948005B (en) 1996-02-06
HUT72974A (en) 1996-06-28
WO1995010534A1 (en) 1995-04-20
CA2151283A1 (en) 1995-04-20
NZ274560A (en) 1998-03-25
KR100208873B1 (ko) 1999-07-15
FI952900A (fi) 1995-06-13
CN1116427A (zh) 1996-02-07
RU95112539A (ru) 1997-06-27
HU9501719D0 (en) 1995-08-28
DE69416824T2 (de) 1999-07-08
AU682405B2 (en) 1997-10-02
HU217442B (hu) 2000-01-28
CN1038841C (zh) 1998-06-24
NO952321D0 (no) 1995-06-13
CZ153395A3 (en) 1995-12-13

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Legal Events

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FC2A Withdrawal, rejection or dismissal of laid open patent application