NO942549L - Kunitz type human protease inhibitor variant - Google Patents
Kunitz type human protease inhibitor variantInfo
- Publication number
- NO942549L NO942549L NO942549A NO942549A NO942549L NO 942549 L NO942549 L NO 942549L NO 942549 A NO942549 A NO 942549A NO 942549 A NO942549 A NO 942549A NO 942549 L NO942549 L NO 942549L
- Authority
- NO
- Norway
- Prior art keywords
- cys
- amino acid
- phe
- naturally occurring
- variant
- Prior art date
Links
- 229940124158 Protease/peptidase inhibitor Drugs 0.000 title abstract 2
- 239000000137 peptide hydrolase inhibitor Substances 0.000 title abstract 2
- 125000000539 amino acid group Chemical group 0.000 abstract 5
- 102100030951 Tissue factor pathway inhibitor Human genes 0.000 abstract 2
- 108010013555 lipoprotein-associated coagulation inhibitor Proteins 0.000 abstract 2
- HUZGPXBILPMCHM-IHRRRGAJSA-N Asn-Arg-Phe Chemical compound [H]N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O HUZGPXBILPMCHM-IHRRRGAJSA-N 0.000 abstract 1
- XLZCLJRGGMBKLR-PCBIJLKTSA-N Asn-Ile-Phe Chemical compound NC(=O)C[C@H](N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H](C(O)=O)CC1=CC=CC=C1 XLZCLJRGGMBKLR-PCBIJLKTSA-N 0.000 abstract 1
- ZOLXQKZHYOHHMD-DLOVCJGASA-N Cys-Ala-Phe Chemical compound C[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)O)NC(=O)[C@H](CS)N ZOLXQKZHYOHHMD-DLOVCJGASA-N 0.000 abstract 1
- XMBSYZWANAQXEV-QWRGUYRKSA-N Glu-Phe Chemical compound OC(=O)CC[C@H](N)C(=O)N[C@H](C(O)=O)CC1=CC=CC=C1 XMBSYZWANAQXEV-QWRGUYRKSA-N 0.000 abstract 1
- FADYJNXDPBKVCA-UHFFFAOYSA-N L-Phenylalanyl-L-lysin Natural products NCCCCC(C(O)=O)NC(=O)C(N)CC1=CC=CC=C1 FADYJNXDPBKVCA-UHFFFAOYSA-N 0.000 abstract 1
- MPGHETGWWWUHPY-CIUDSAMLSA-N Lys-Ala-Asp Chemical compound OC(=O)C[C@@H](C(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CCCCN MPGHETGWWWUHPY-CIUDSAMLSA-N 0.000 abstract 1
- CEGVMWAVGBRVFS-XGEHTFHBSA-N Met-Cys-Thr Chemical compound CSCC[C@H](N)C(=O)N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)O)C(O)=O CEGVMWAVGBRVFS-XGEHTFHBSA-N 0.000 abstract 1
- XMBSYZWANAQXEV-UHFFFAOYSA-N N-alpha-L-glutamyl-L-phenylalanine Natural products OC(=O)CCC(N)C(=O)NC(C(O)=O)CC1=CC=CC=C1 XMBSYZWANAQXEV-UHFFFAOYSA-N 0.000 abstract 1
- CBENHWCORLVGEQ-HJOGWXRNSA-N Phe-Phe-Phe Chemical compound C([C@H](N)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CBENHWCORLVGEQ-HJOGWXRNSA-N 0.000 abstract 1
- ZIFYDQAFEMIZII-GUBZILKMSA-N Ser-Leu-Glu Chemical compound [H]N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(O)=O ZIFYDQAFEMIZII-GUBZILKMSA-N 0.000 abstract 1
- HIINQLBHPIQYHN-JTQLQIEISA-N Tyr-Gly-Gly Chemical compound OC(=O)CNC(=O)CNC(=O)[C@@H](N)CC1=CC=C(O)C=C1 HIINQLBHPIQYHN-JTQLQIEISA-N 0.000 abstract 1
- KOSRFJWDECSPRO-UHFFFAOYSA-N alpha-L-glutamyl-L-glutamic acid Natural products OC(=O)CCC(N)C(=O)NC(CCC(O)=O)C(O)=O KOSRFJWDECSPRO-UHFFFAOYSA-N 0.000 abstract 1
- 150000001413 amino acids Chemical group 0.000 abstract 1
- 108010055341 glutamyl-glutamic acid Proteins 0.000 abstract 1
- 108010065135 phenylalanyl-phenylalanyl-phenylalanine Proteins 0.000 abstract 1
- 108010017949 tyrosyl-glycyl-glycine Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Rheumatology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pain & Pain Management (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Variant av humanprotease- inhibitorområde I av Kunitz-type fra vevsfaktorreaksjonsveiinhibitor (TFPI), hvor varianten omfatter den følgende aminosyresekvens X1 Cys Ala Phe Lys Ala Asp X2 Gly X3 Cys X4 X5 X6 X7 X8 X9 Phe Phe Phe Asn Ile Phe Thr Arg Gin Cys Glu Glu Phe X10 Tyr Gly Gly Cys X11 X12 X13 Gin Asn Arg Phe X14 Ser Leu Glu Glu Cys X15 X16 Met Cys Thr Arg X17 (sekvens- identitet nr. 1), hvor X1 er H eller 1-7 naturlig forekommende aminosyre- rester bortsett fra Cys, X2-x" hver uavhengig av hverandre er en naturlig forekommende aminosyrerest, og X17 er OH eller 1-5 naturlig forekommende amino- syrerester bortsett fra Cys, med det forbehold at minst en av aminosyreres- tene X^X17 er forskjellig fra den til- svarende aminosyrerest i den naturlig forekommende sekvens.Kunitz-type human protease inhibitor region I variant from tissue factor pathway inhibitor (TFPI), the variant comprising the following amino acid sequence X1 Cys Ala Phe Lys Ala Asp X2 Gly X3 Cys X4 X5 X6 X7 X8 X9 Phe Phe Phe Asn Ile Phe Thr Arg Gin Glu Phe X10 Tyr Gly Gly Cys X11 X12 X13 Gin Asn Arg Phe X14 Ser Leu Glu Glu Cys X15 X16 Met Cys Thr Arg X17 (Sequence Identity # 1), where X1 is H or 1-7 naturally occurring amino acid residues except from Cys, X2-x "each independently is a naturally occurring amino acid residue, and X17 is OH or 1-5 naturally occurring amino acid residues except Cys, with the proviso that at least one of the amino acid residues X the corresponding amino acid residue in the naturally occurring sequence.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK9200002 | 1992-01-07 | ||
| DK9200340 | 1992-11-16 | ||
| PCT/DK1993/000005 WO1993014122A1 (en) | 1992-01-07 | 1993-01-07 | A human kunitz-type protease inhibitor variant |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO942549D0 NO942549D0 (en) | 1994-07-06 |
| NO942549L true NO942549L (en) | 1994-09-07 |
Family
ID=26068350
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO942549A NO942549L (en) | 1992-01-07 | 1994-07-06 | Kunitz type human protease inhibitor variant |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0621872A1 (en) |
| JP (1) | JPH07504891A (en) |
| AU (1) | AU675926B2 (en) |
| CA (1) | CA2127246A1 (en) |
| CZ (1) | CZ164494A3 (en) |
| FI (1) | FI943234L (en) |
| HU (1) | HUT70293A (en) |
| IL (1) | IL104324A0 (en) |
| NO (1) | NO942549L (en) |
| NZ (1) | NZ246570A (en) |
| RU (1) | RU94036773A (en) |
| WO (1) | WO1993014122A1 (en) |
| ZA (1) | ZA9396B (en) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5455338A (en) * | 1993-11-05 | 1995-10-03 | Zymogenetics, Inc. | DNA encoding novel human kunitz-type inhibitors and methods relating thereto |
| JP3805785B2 (en) * | 1994-01-11 | 2006-08-09 | ダイアックス コープ． | Kallikrein-inhibiting Kunitz domain protein and its homologues |
| US6010880A (en) | 1994-01-11 | 2000-01-04 | Dyax Corp. | Inhibitors of human plasmin derived from the kunitz domains |
| US6057287A (en) * | 1994-01-11 | 2000-05-02 | Dyax Corp. | Kallikrein-binding "Kunitz domain" proteins and analogues thereof |
| US5795954A (en) * | 1994-03-04 | 1998-08-18 | Genentech, Inc. | Factor VIIa inhibitors from Kunitz domain proteins |
| JP3779728B2 (en) * | 1994-08-05 | 2006-05-31 | カイロン コーポレイション | Production of tissue factor activity inhibitors |
| US5589359A (en) * | 1994-08-05 | 1996-12-31 | Chiron Corporation | Chimeric proteins |
| US5780265A (en) * | 1995-06-05 | 1998-07-14 | Genentech, Inc. | Kunitz type plasma kallikrein inhibitors |
| US5786328A (en) * | 1995-06-05 | 1998-07-28 | Genentech, Inc. | Use of kunitz type plasma kallikrein inhibitors |
| US6242414B1 (en) | 1995-06-07 | 2001-06-05 | Chiron Corporation | Regulation of cytokine synthesis and release |
| JPH11507060A (en) * | 1995-06-07 | 1999-06-22 | カイロン コーポレイション | Regulation of cytokine synthesis and release |
| US6521410B1 (en) * | 1998-08-25 | 2003-02-18 | Knut Kleesiek | Mutant of tissue factor pathway inhibitor, DNA sequence and use for detecting thrombotic disorders |
| CN1325889A (en) * | 2000-05-26 | 2001-12-12 | 上海博德基因开发有限公司 | Polypeptide-human kazal-type inhibitor 11 and polynucleotide for coding it |
| ES2372978T3 (en) | 2002-06-07 | 2012-01-30 | Dyax Corp. | POLYPEPTIDE WITH MODIFIED KUNITZ DOMAIN. |
| US7153829B2 (en) | 2002-06-07 | 2006-12-26 | Dyax Corp. | Kallikrein-inhibitor therapies |
| ES2395014T3 (en) * | 2002-08-28 | 2013-02-07 | Dyax Corp. | Methods to preserve organs and tissues |
| US6989369B2 (en) | 2003-02-07 | 2006-01-24 | Dyax Corp. | Kunitz domain peptides |
| DK1663281T3 (en) | 2003-08-29 | 2014-03-17 | Dyax Corp | POLY-PEGYLED PROTEASE INHIBITORS |
| US7235530B2 (en) | 2004-09-27 | 2007-06-26 | Dyax Corporation | Kallikrein inhibitors and anti-thrombolytic agents and uses thereof |
| US7276480B1 (en) | 2005-12-30 | 2007-10-02 | Dyax Corp. | Prevention and reduction of blood loss |
| NZ593815A (en) | 2008-12-19 | 2013-05-31 | Tissue factor pathway inhibitor (tfpi) inhibitors and methods of use | |
| WO2010080833A1 (en) | 2009-01-06 | 2010-07-15 | Dyax Corp. | Treatment of mucositis with kallikrein inhibitors |
| AU2011204349C1 (en) | 2010-01-06 | 2017-02-16 | Takeda Pharmaceutical Company Limited | Plasma kallikrein binding proteins |
| BR112012023559A2 (en) | 2010-03-19 | 2017-10-17 | Baxter Healthcare Sa | tfpi inhibitors and methods of use |
| KR102011156B1 (en) | 2011-01-06 | 2019-08-16 | 다이액스 코포레이션 | Plasma kallikrein binding proteins |
| BR112014022435B1 (en) | 2012-03-21 | 2023-02-14 | Takeda Pharmaceutical Company Limited | TFPI INHIBITORS AND METHODS OF USE |
| CO2018007151A2 (en) | 2015-12-11 | 2018-09-20 | Dyax Corp | Plasma kallikrein inhibitors and their uses to treat hereditary angioedema attack |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5106833A (en) * | 1987-07-23 | 1992-04-21 | Washington University | Coagulation inhibitors |
| DK408089D0 (en) * | 1989-08-18 | 1989-08-18 | Novo Nordisk As | PROTEINS |
-
1993
- 1993-01-06 IL IL104324A patent/IL104324A0/en unknown
- 1993-01-07 NZ NZ246570A patent/NZ246570A/en unknown
- 1993-01-07 EP EP93902106A patent/EP0621872A1/en not_active Withdrawn
- 1993-01-07 HU HU9401990A patent/HUT70293A/en unknown
- 1993-01-07 AU AU33460/93A patent/AU675926B2/en not_active Ceased
- 1993-01-07 ZA ZA9396A patent/ZA9396B/en unknown
- 1993-01-07 JP JP5511993A patent/JPH07504891A/en active Pending
- 1993-01-07 CA CA002127246A patent/CA2127246A1/en not_active Abandoned
- 1993-01-07 RU RU94036773/13A patent/RU94036773A/en unknown
- 1993-01-07 CZ CZ941644A patent/CZ164494A3/en unknown
- 1993-01-07 WO PCT/DK1993/000005 patent/WO1993014122A1/en not_active Application Discontinuation
-
1994
- 1994-07-06 NO NO942549A patent/NO942549L/en unknown
- 1994-07-06 FI FI943234A patent/FI943234L/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU94036773A (en) | 1996-09-27 |
| JPH07504891A (en) | 1995-06-01 |
| HU9401990D0 (en) | 1994-09-28 |
| FI943234A0 (en) | 1994-07-06 |
| FI943234L (en) | 1994-07-06 |
| WO1993014122A1 (en) | 1993-07-22 |
| NZ246570A (en) | 1996-09-25 |
| CA2127246A1 (en) | 1993-07-22 |
| HUT70293A (en) | 1995-09-28 |
| CZ164494A3 (en) | 1994-12-15 |
| NO942549D0 (en) | 1994-07-06 |
| AU675926B2 (en) | 1997-02-27 |
| AU3346093A (en) | 1993-08-03 |
| EP0621872A1 (en) | 1994-11-02 |
| ZA9396B (en) | 1993-08-10 |
| IL104324A0 (en) | 1993-05-13 |
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