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NO934726D0 - (S) (+) - 2-Ethoxy-4-UN-U1- (2-piperidinophenyl) -3-methyl-1-butylamine ocarbonylmethyl¾-benzoic acid - Google Patents

(S) (+) - 2-Ethoxy-4-UN-U1- (2-piperidinophenyl) -3-methyl-1-butylamine ocarbonylmethyl¾-benzoic acid

Info

Publication number
NO934726D0
NO934726D0 NO934726A NO934726A NO934726D0 NO 934726 D0 NO934726 D0 NO 934726D0 NO 934726 A NO934726 A NO 934726A NO 934726 A NO934726 A NO 934726A NO 934726 D0 NO934726 D0 NO 934726D0
Authority
NO
Norway
Prior art keywords
piperidinophenyl
butylamine
ethoxy
methyl
benzoic acid
Prior art date
Application number
NO934726A
Other languages
Norwegian (no)
Other versions
NO934726L (en
NO303687B1 (en
Inventor
Wolfgang Grell
Andreas Greischel
Gabriele Zahn
Michael Mark
Hansjoerg Knorr
Eckhard Rupprecht
Uelrich Mueller
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36781542&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO934726(D0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of NO934726L publication Critical patent/NO934726L/en
Publication of NO934726D0 publication Critical patent/NO934726D0/en
Publication of NO303687B1 publication Critical patent/NO303687B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NO934726A 1991-06-21 1993-12-20 Analogous process for the preparation of the therapeutically active compound (S) (+) - 2-ethoxy-4- [N- [1- (2-piperidino-phenyl) -3-methyl-1-butyl] aminocarbonylmethyl] -benzoic acid NO303687B1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
PCT/EP1991/001147 WO1993000337A1 (en) 1991-06-21 1991-06-21 (s)(+)-2-ethoxy-4-[n-[1-(2-piperidinophenyl)-3-methyl-1-butyl]aminocarbonylmethyl]benzoic acid
CA002111851A CA2111851C (en) 1991-06-21 1991-06-21 (s)(+)-2-ethoxy-4-[n-{1-(2-piperidino-phenyl)-3-methyl-1-butyl]aminocarbonylmethyl]benzoic acid
SG1996002715A SG43036A1 (en) 1991-06-21 1991-06-21 (S) (+) -2-ethoxy-4-[N-[1-(2-piperidino-phenyl)-3-methyl- 1-buthyl]aminocarbony methyl] - benzoic a cid
CN91104984A CN1048722C (en) 1991-06-21 1991-07-22 (S)(+)-2-Ethoxy-4-[N-[1-(2-piperidino-phenyl)-3-methyl-1-butyl]-aminocarbonylmethyl]-benzoic acid, pharmaceutical compositions containing compound and processes for preparation thereof

Publications (3)

Publication Number Publication Date
NO934726L NO934726L (en) 1993-12-20
NO934726D0 true NO934726D0 (en) 1993-12-20
NO303687B1 NO303687B1 (en) 1998-08-17

Family

ID=36781542

Family Applications (2)

Application Number Title Priority Date Filing Date
NO934726A NO303687B1 (en) 1991-06-21 1993-12-20 Analogous process for the preparation of the therapeutically active compound (S) (+) - 2-ethoxy-4- [N- [1- (2-piperidino-phenyl) -3-methyl-1-butyl] aminocarbonylmethyl] -benzoic acid
NO1999017C NO1999017I1 (en) 1991-06-21 1999-07-20 Repaglinide

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO1999017C NO1999017I1 (en) 1991-06-21 1999-07-20 Repaglinide

Country Status (19)

Country Link
EP (1) EP0589874B1 (en)
JP (1) JP2921982B2 (en)
KR (1) KR100496720B1 (en)
CN (1) CN1048722C (en)
AU (1) AU660930B2 (en)
BG (1) BG61690B1 (en)
CA (1) CA2111851C (en)
DE (2) DE59109151D1 (en)
DK (2) DK0589874T3 (en)
FI (1) FI106027B (en)
GR (1) GR3031654T3 (en)
HK (1) HK1011968A1 (en)
NO (2) NO303687B1 (en)
PL (1) PL170210B1 (en)
RO (1) RO113462B1 (en)
SG (1) SG43036A1 (en)
SK (1) SK281246B6 (en)
UY (1) UY25923A1 (en)
WO (1) WO1993000337A1 (en)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
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DE69800806T2 (en) 1997-06-13 2001-09-13 Novo Nordisk A/S, Bagsvaerd NEW DOSAGE FOR DIABETES TYPE 2
IN192862B (en) 1999-11-16 2004-05-22 Ranbaxy Lab Ltd
PE20020617A1 (en) 2000-08-22 2002-08-05 Novartis Ag COMPOSITION INCLUDING AN AT1 RECEPTOR ANTAGONIST AND AN INSULIN SECRETION POTENTIAL OR AN INSULIN SENSITIZER
JP4625637B2 (en) 2002-02-22 2011-02-02 シャイア エルエルシー Active substance delivery system and method for protecting and administering an active substance
US20040102477A1 (en) * 2002-08-23 2004-05-27 Dr. Reddy's Laboratories Limited Polymorphic forms of (S)-Repaglinide and the processes for preparation thereof
WO2004101540A2 (en) * 2003-05-14 2004-11-25 Cilag Ag Method for the production of phenylacetic acid derivatives
AU2003237595A1 (en) * 2003-05-26 2004-12-13 Biocon Limited Process for the preparation of s(+)-2-ethoxy-4-(n-{1-(2-piperidinophelyl)-3-methyl-1- butyl} aminocarbonylmethyl)benzoic acid derivatives
EP1664008A1 (en) * 2003-08-28 2006-06-07 Ranbaxy Laboratories Limited Process for the preparation of amorphous form of repaglinide
CN1305863C (en) * 2004-12-27 2007-03-21 浙江大学 Method for synthesizing (S)-isopropyl-(2-piperidine) phenyl-methylhistamine
GT200600381A (en) 2005-08-25 2007-03-28 ORGANIC COMPOUNDS
FR2898894B1 (en) * 2006-03-24 2008-06-06 Genfit Sa SUBSTITUTED N- (PHENETHYL) BENZAMIDE DERIVATIVE COMPOUNDS, PREPARATION AND USES
US7763607B2 (en) * 2006-04-27 2010-07-27 Solvay Pharmaceuticals Gmbh Pharmaceutical compositions comprising CBx cannabinoid receptor modulators and potassium channel modulators
EP2724722B1 (en) * 2006-10-20 2016-12-07 NeurEndo Pharma, LLC Method of restoring the incretin effect
US8101769B2 (en) * 2007-02-15 2012-01-24 Actavis Group Ptc Ehf Process for preparing ethyl (S)-2-ethoxy-4-[N-[1-(2-piperidinophenyl)-3-methyl-1-butyl]aminocarbonyl methyl]benzoate and use thereof for the preparation of Repaglinide
WO2009004485A2 (en) * 2007-06-06 2009-01-08 Actavis Group Ptc Ehf Repaglinide substantially free of dimer impurity
EP2019097A1 (en) 2007-07-25 2009-01-28 Aurobindo Pharma Limited Process for preparing (alphaS)-alpha-(2-methylpropyl)-2-(1-piperidinyl)benzenemethanamine
EP2601935A1 (en) 2007-09-25 2013-06-12 Solubest Ltd. Compositions comprising lipophilic active compounds and method for their preparation
DE102008046995B4 (en) * 2008-09-12 2010-08-26 Stada Arzneimittel Ag 2-ethoxy-benzoic acid
EP2177221A1 (en) 2008-10-20 2010-04-21 Krka Tovarna Zdravil, D.D., Novo Mesto Process for the preparation of substantially optically pure Repaglinide and precursors thereof
JP5659224B2 (en) 2009-05-15 2015-01-28 ノバルティス アーゲー Arylpyridines as aldosterone synthase inhibitors
WO2010130773A2 (en) 2009-05-15 2010-11-18 Novartis Ag Benzoxazolone derivatives as aldosterone symthase inhibitors
AU2010251967B9 (en) 2009-05-28 2014-04-03 Novartis Ag Substituted aminopropionic derivatives as neprilysin inhibitors
KR20120041702A (en) 2009-05-28 2012-05-02 노파르티스 아게 Substituted aminobutyric derivatives as neprilysin inhibitors
EP2501678B1 (en) 2009-11-17 2015-09-23 Novartis AG Aryl-pyridine derivatives as aldosterone synthase inhibitors
JO2967B1 (en) 2009-11-20 2016-03-15 نوفارتس ايه جي Substituted carbamoylmethylamino acetic acid derivatives as novel NEP inhibitors
EP2507234B1 (en) 2009-11-30 2014-03-12 Novartis AG Imidazole derivatives as aldosterone synthase inhibitors
EP2364977A1 (en) 2010-01-26 2011-09-14 Reuter Chemische Apparatebau KG Process for the enantiomeric enrichment of 3-methyl-1-(2-piperidinophenyl)-1-butylamine
US8877815B2 (en) 2010-11-16 2014-11-04 Novartis Ag Substituted carbamoylcycloalkyl acetic acid derivatives as NEP
US8673974B2 (en) 2010-11-16 2014-03-18 Novartis Ag Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors
CN102267959B (en) * 2011-07-06 2013-05-01 海南锦瑞制药股份有限公司 Repaglinide crystal, preparation method thereof, and solid oral preparation containing same
CN103012319B (en) * 2011-09-20 2015-06-10 浙江九洲药业股份有限公司 Repaglinide intermediate synthesis process improvement
CN102584743A (en) * 2011-12-28 2012-07-18 中国药科大学 Dimethylaminopyridine repaglinide eutectic
UY35144A (en) 2012-11-20 2014-06-30 Novartis Ag APELINE SYNTHETIC LINEAR MIMETICS FOR THE CARDIAC INSUFFICIENCY TREATMENT
CA2900027A1 (en) 2013-02-14 2014-08-21 Novartis Ag Substituted bisphenyl butanoic phosphonic acid derivatives as nep (neutral endopeptidase) inhibitors
PE20160878A1 (en) 2013-07-25 2016-09-08 Novartis Ag CYCLIC POLYPEPTIDES FOR THE TREATMENT OF HEART FAILURE
AU2014293387B2 (en) 2013-07-25 2017-04-20 Novartis Ag Bioconjugates of synthetic apelin polypeptides
EP3215154B1 (en) 2014-11-07 2020-01-29 Regents of the University of Minnesota Salts and compositions useful for treating disease
MX2017009534A (en) 2015-01-23 2018-04-10 Novartis Ag Synthetic apelin fatty acid conjugates with improved half-life.
WO2018034627A1 (en) 2016-08-18 2018-02-22 İlko Ilaç Sanayi Ve Ticaret Anonim Şirketi Pharmaceutical composition of antidiabetic tablet
UY38072A (en) 2018-02-07 2019-10-01 Novartis Ag COMPOSITIONS DERIVED FROM BUTANOIC ESTER SUBSTITUTED WITH BISPHENYL AS INHIBITORS OF NEP, COMPOSITIONS AND COMBINATIONS OF THE SAME

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3347565A1 (en) * 1983-12-30 1985-07-11 Thomae Gmbh Dr K NEW PHENYL ACETIC DERIVATIVES, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF

Also Published As

Publication number Publication date
DE10075006I1 (en) 2000-04-20
NO934726L (en) 1993-12-20
BG61690B1 (en) 1998-03-31
HK1011968A1 (en) 1999-07-23
DE59109151D1 (en) 1999-10-14
CN1048722C (en) 2000-01-26
CA2111851A1 (en) 1993-01-07
GR3031654T3 (en) 2000-02-29
KR100496720B1 (en) 2006-01-27
NO303687B1 (en) 1998-08-17
BG98300A (en) 1994-09-30
SK128093A3 (en) 1994-11-09
NO1999017I1 (en) 1999-07-20
JPH06508816A (en) 1994-10-06
FI935724A0 (en) 1993-12-20
AU8078191A (en) 1993-01-25
WO1993000337A1 (en) 1993-01-07
CA2111851C (en) 2002-02-26
AU660930B2 (en) 1995-07-13
EP0589874A1 (en) 1994-04-06
FI106027B (en) 2000-11-15
DE10075006I2 (en) 2004-01-08
UY25923A1 (en) 2001-08-27
JP2921982B2 (en) 1999-07-19
FI935724A (en) 1993-12-20
SK281246B6 (en) 2001-01-18
CN1068820A (en) 1993-02-10
SG43036A1 (en) 1997-10-17
RO113462B1 (en) 1998-07-30
DK0965591T3 (en) 2002-11-18
PL170210B1 (en) 1996-11-29
EP0589874B1 (en) 1999-09-08
DK0589874T3 (en) 2000-04-03

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Legal Events

Date Code Title Description
SPCG Granted supplementary protection certificate

Free format text: PRODUCT NAME: REPAGLINID; NAT. REG. NO/DATE: NO , 97-2543 , NO , 97-2544 , NO , 97-2545 19990301; FIRST REG. NO/DATE: EP , 1/98/076/- 19980817

Spc suppl protection certif: 1999017

Filing date: 19990720

Extension date: 20130817

MK1K Patent expired
SPCX Expiry of an spc

Spc suppl protection certif: 1999017

Effective date: 20130817