NO933772L - Substituerte (pyridinylamino)-benzisoksazoler og -benzo(b)-tiofener, en fremgangsmåte for fremstilling og deres anvendelse som medikamenter - Google Patents
Substituerte (pyridinylamino)-benzisoksazoler og -benzo(b)-tiofener, en fremgangsmåte for fremstilling og deres anvendelse som medikamenterInfo
- Publication number
- NO933772L NO933772L NO933772A NO933772A NO933772L NO 933772 L NO933772 L NO 933772L NO 933772 A NO933772 A NO 933772A NO 933772 A NO933772 A NO 933772A NO 933772 L NO933772 L NO 933772L
- Authority
- NO
- Norway
- Prior art keywords
- loweralkyl
- chem
- hydrogen
- arylloweralkyl
- substituted
- Prior art date
Links
- FCEHBMOGCRZNNI-UHFFFAOYSA-N 1-benzothiophene Chemical class C1=CC=C2SC=CC2=C1 FCEHBMOGCRZNNI-UHFFFAOYSA-N 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- QYLHPSLMFIOFLF-UHFFFAOYSA-N n-pyridin-2-yl-1,2-benzoxazol-3-amine Chemical class N=1OC2=CC=CC=C2C=1NC1=CC=CC=N1 QYLHPSLMFIOFLF-UHFFFAOYSA-N 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 150000002431 hydrogen Chemical group 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 229940005513 antidepressants Drugs 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/964,546 US5328920A (en) | 1991-04-17 | 1992-10-21 | Substituted (pyridinylamino)-indoles |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO933772D0 NO933772D0 (no) | 1993-10-20 |
| NO933772L true NO933772L (no) | 1994-04-22 |
| NO300806B1 NO300806B1 (no) | 1997-07-28 |
Family
ID=25508677
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO933772A NO300806B1 (no) | 1992-10-21 | 1993-10-20 | Substituerte (pyridinylamino)-benzisoksazoler og -benzo£b|-tiofener, og deres anvendelse som medikamenter |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5328920A (no) |
| EP (1) | EP0594000B1 (no) |
| KR (1) | KR100297651B1 (no) |
| AT (1) | ATE168689T1 (no) |
| AU (1) | AU665637B2 (no) |
| CA (1) | CA2108800A1 (no) |
| DE (1) | DE69319830T2 (no) |
| DK (1) | DK0594000T3 (no) |
| ES (1) | ES2120463T3 (no) |
| FI (1) | FI934611L (no) |
| GR (1) | GR3027574T3 (no) |
| HU (1) | HUT68875A (no) |
| IL (1) | IL107330A (no) |
| NO (1) | NO300806B1 (no) |
| NZ (1) | NZ248991A (no) |
| PL (1) | PL173540B1 (no) |
| RU (1) | RU2083575C1 (no) |
| ZA (1) | ZA937823B (no) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996039397A1 (en) * | 1995-06-06 | 1996-12-12 | Hoechst Marion Roussel, Inc. | Benzisoxazole and indazole derivatives as antipsychotic agents |
| US5668154A (en) * | 1995-06-06 | 1997-09-16 | Hoechst Marion Roussel Inc. | Pyridiniminyl-1,2-benzisoxazoles and -benzisothiazoles |
| GB2308362A (en) * | 1995-12-19 | 1997-06-25 | Lilly Industries Ltd | Pharmaceutical indole derivatives |
| CA2276203C (en) * | 1996-12-27 | 2003-07-22 | Hoechst Marion Roussel, Inc. | N-(pyridinylamino)isoindolines and related compounds |
| US5886191A (en) * | 1997-08-18 | 1999-03-23 | Dupont Pharmaceuticals Company | Amidinoindoles, amidinoazoles, and analogs thereof |
| US7091199B1 (en) | 1999-09-14 | 2006-08-15 | Aventis Pharmaceuticals Inc. | Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as d4 antagonists |
| US7125903B1 (en) | 1999-09-14 | 2006-10-24 | Aventis Pharmaceuticals Inc. | Thienoisoxazolyl-and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as D4 antagonists |
| US7253165B2 (en) * | 1999-09-14 | 2007-08-07 | Aventis Pharmaceuticals Inc. | Benzisoxazolyl-, pyridoisoxazolyl-and benzthienyl-phenoxy derivatives useful as D4 antagonists |
| US20020161002A1 (en) * | 2001-01-02 | 2002-10-31 | Mel Epstein | Use of catecholamine reuptake inhibitors to enhance memory |
| DE60313769T2 (de) * | 2002-04-23 | 2008-03-06 | Aventis Pharmaceuticals Inc. | 3-(pyridinyl-amino)-1h-indol-2-carbonsäure-verbindungen als inhibitoren der interleukin-4 genexpression |
| GB0217920D0 (en) * | 2002-04-23 | 2002-09-11 | Aventis Pharm Prod Inc | Interleukin-4 Gene Expression inhibitors |
| DE102005038947A1 (de) * | 2005-05-18 | 2006-11-30 | Grünenthal GmbH | Substituierte Benzo[d]isoxazol-3-yl-amin-Verbindungen und deren Verwendung in Arzneimitteln |
| MX2009001875A (es) * | 2006-08-21 | 2009-03-02 | Genentech Inc | Compuestos de aza-benzotiofenilo y metodos de uso de los mismos. |
| EP2069354B1 (en) * | 2006-08-21 | 2011-11-02 | Genentech, Inc. | Aza-benzofuranyl compounds and methods of use |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3166987D1 (en) * | 1980-09-18 | 1984-12-06 | Asahi Chemical Ind | 3-aminoindazole derivatives and process for preparation thereof |
| US4590196A (en) * | 1984-08-23 | 1986-05-20 | Bristol-Myers Company | Analgesic 1,2-benzisothiazol-3-ylpiperazine derivatives |
| IE58370B1 (en) * | 1985-04-10 | 1993-09-08 | Lundbeck & Co As H | Indole derivatives |
| US4717658A (en) * | 1985-12-03 | 1988-01-05 | Miles Inc. | Gram negative bacteria screening method with horseshoe crab amebocyte lysate (LAL) |
| DE3852335T2 (de) * | 1987-04-24 | 1995-05-11 | Hoechst Roussel Pharma | N-(Pyridinyl)-1H-indol-1-amine, Verfahren zu deren Herstellung und ihre Verwendung als Arzneimittel. |
| US4954502A (en) * | 1988-06-10 | 1990-09-04 | Bristol-Myers Squibb Company | 1-indolyalkyl-4-(substituted-pyridinyl)piperazines |
| DE69021645T2 (de) * | 1989-05-19 | 1996-02-22 | Hoechst-Roussel Pharmaceuticals Inc., Somerville, N.J. | N-(aryloxyalkyl)heteroarylpiperidine und -heteroarylpiperazine, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikamente. |
| US4954503A (en) * | 1989-09-11 | 1990-09-04 | Hoechst-Roussel Pharmaceuticals, Inc. | 3-(1-substituted-4-piperazinyl)-1H-indazoles |
| CA2030051C (en) * | 1989-11-17 | 2001-08-07 | Haruhiko Kikuchi | Indole derivatives |
| US5177088A (en) * | 1991-04-17 | 1993-01-05 | Hoechst-Roussel Pharmaceuticals Incorporated | Substituted 3-(pyridinylamino)-indoles |
-
1992
- 1992-10-21 US US07/964,546 patent/US5328920A/en not_active Expired - Lifetime
-
1993
- 1993-10-08 DE DE69319830T patent/DE69319830T2/de not_active Expired - Fee Related
- 1993-10-08 AT AT93116316T patent/ATE168689T1/de not_active IP Right Cessation
- 1993-10-08 ES ES93116316T patent/ES2120463T3/es not_active Expired - Lifetime
- 1993-10-08 EP EP93116316A patent/EP0594000B1/en not_active Expired - Lifetime
- 1993-10-08 DK DK93116316T patent/DK0594000T3/da active
- 1993-10-19 FI FI934611A patent/FI934611L/fi not_active Application Discontinuation
- 1993-10-19 NZ NZ248991A patent/NZ248991A/en unknown
- 1993-10-20 RU RU9393047920A patent/RU2083575C1/ru active
- 1993-10-20 AU AU49125/93A patent/AU665637B2/en not_active Ceased
- 1993-10-20 NO NO933772A patent/NO300806B1/no not_active IP Right Cessation
- 1993-10-20 IL IL107330A patent/IL107330A/en not_active IP Right Cessation
- 1993-10-20 CA CA002108800A patent/CA2108800A1/en not_active Abandoned
- 1993-10-21 KR KR1019930021922A patent/KR100297651B1/ko not_active Expired - Fee Related
- 1993-10-21 ZA ZA937823A patent/ZA937823B/xx unknown
- 1993-10-21 PL PL93300804A patent/PL173540B1/pl unknown
- 1993-10-21 HU HU9302979A patent/HUT68875A/hu unknown
-
1998
- 1998-08-04 GR GR980401759T patent/GR3027574T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ248991A (en) | 1996-02-27 |
| DE69319830T2 (de) | 1999-01-14 |
| PL300804A1 (en) | 1994-05-16 |
| HUT68875A (en) | 1995-08-28 |
| NO933772D0 (no) | 1993-10-20 |
| GR3027574T3 (en) | 1998-11-30 |
| KR100297651B1 (ko) | 2001-10-24 |
| FI934611L (fi) | 1994-04-22 |
| AU4912593A (en) | 1994-05-05 |
| HU9302979D0 (en) | 1994-01-28 |
| CA2108800A1 (en) | 1994-04-22 |
| KR940009182A (ko) | 1994-05-20 |
| ATE168689T1 (de) | 1998-08-15 |
| ZA937823B (en) | 1994-05-19 |
| IL107330A (en) | 1998-04-05 |
| FI934611A0 (fi) | 1993-10-19 |
| RU2083575C1 (ru) | 1997-07-10 |
| NO300806B1 (no) | 1997-07-28 |
| US5328920A (en) | 1994-07-12 |
| PL173540B1 (pl) | 1998-03-31 |
| EP0594000B1 (en) | 1998-07-22 |
| IL107330A0 (en) | 1994-01-25 |
| DE69319830D1 (de) | 1998-08-27 |
| ES2120463T3 (es) | 1998-11-01 |
| EP0594000A1 (en) | 1994-04-27 |
| DK0594000T3 (da) | 1999-04-26 |
| AU665637B2 (en) | 1996-01-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |
Free format text: LAPSED IN APRIL 2001 |