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NO930505L - Nye azaindoler, fremgangsmaate for deres fremstilling og farmasoeytiske preparater derav - Google Patents

Nye azaindoler, fremgangsmaate for deres fremstilling og farmasoeytiske preparater derav

Info

Publication number
NO930505L
NO930505L NO93930505A NO930505A NO930505L NO 930505 L NO930505 L NO 930505L NO 93930505 A NO93930505 A NO 93930505A NO 930505 A NO930505 A NO 930505A NO 930505 L NO930505 L NO 930505L
Authority
NO
Norway
Prior art keywords
cycloalkyl
alkyl
optionally substituted
preparation
phenyl
Prior art date
Application number
NO93930505A
Other languages
English (en)
Other versions
NO930505D0 (no
Inventor
Didier Festal
Denis Descours
Jacques Decerprit
Original Assignee
Lipha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lipha filed Critical Lipha
Publication of NO930505D0 publication Critical patent/NO930505D0/no
Publication of NO930505L publication Critical patent/NO930505L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)

Abstract

Nye forbindelser som har den generelle formel: hvor en av gruppene X1 til X4 er nitrogen og de andre er et CH-radikal, R1 og R2 er H, halogen, alkyl, hydroksymetyl, alkyloksymetyl, dialkylaminoalkyl, dialkylaminoalkyloksymetyl, karboksyl, metylkarboksylat, piperidin, alkenyl, cykloalkyl, cykloalkenyl, alkyltio, benzyl, fenyl, tiofen eller pyridin som eventuelt er substituerte, R2 og R4 er H, halogen, alkyl, cykloalkyl, alkoksy eller alkyltio, R5 og R6 er K, alkyl, alkenyl, cykloalkyl, cykloalkenyl, alkoksyalkyl eller alkyltioalkyl, eller danner sammen alkylen- eller alkylenoksyalkylenkjeder, R, er H, alkyl eller cykloalkyl, et av radikalene R5 - R7 kan også være eventuelt substituert fenyl eller benzyl, Reer H, alkyl, cykloalkyl eller eventuelt substituert fenyl eller benzyl, R, er eventuelt substituert fenyl, naftyl eller en heterosyklisk forbindelse, så vel som deres tautomere former. Fremgangsmåter for deres fremstilling er også beskrevet. Forbindelsene har terapeutisk anvendelse.
NO93930505A 1992-02-14 1993-02-12 Nye azaindoler, fremgangsmaate for deres fremstilling og farmasoeytiske preparater derav NO930505L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9201701A FR2687402B1 (fr) 1992-02-14 1992-02-14 Nouveaux azaindoles, procedes de preparation et medicaments les contenant.

Publications (2)

Publication Number Publication Date
NO930505D0 NO930505D0 (no) 1993-02-12
NO930505L true NO930505L (no) 1993-08-16

Family

ID=9426663

Family Applications (1)

Application Number Title Priority Date Filing Date
NO93930505A NO930505L (no) 1992-02-14 1993-02-12 Nye azaindoler, fremgangsmaate for deres fremstilling og farmasoeytiske preparater derav

Country Status (27)

Country Link
US (1) US5338849A (no)
EP (1) EP0557171B1 (no)
JP (1) JPH061788A (no)
KR (1) KR930017905A (no)
AT (1) ATE125257T1 (no)
AU (1) AU658475B2 (no)
CA (1) CA2089470A1 (no)
CZ (1) CZ16893A3 (no)
DE (1) DE69300268T2 (no)
DK (1) DK0557171T3 (no)
ES (1) ES2076827T3 (no)
FR (1) FR2687402B1 (no)
GR (1) GR3017614T3 (no)
HR (1) HRP930180A2 (no)
HU (1) HUT64067A (no)
IL (1) IL104573A0 (no)
LT (1) LT3065B (no)
LV (1) LV10453B (no)
MA (1) MA22797A1 (no)
MX (1) MX9300745A (no)
NO (1) NO930505L (no)
NZ (1) NZ245869A (no)
OA (1) OA09775A (no)
SI (1) SI9300076A (no)
SK (1) SK9093A3 (no)
TN (1) TNSN93016A1 (no)
ZA (1) ZA93844B (no)

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EP1787991B2 (en) * 2004-07-28 2020-06-24 Takeda Pharmaceutical Company Limited PYRROLO[2,3-c]PYRIDINE COMPOUND, PROCESS FOR PRODUCING THE SAME, AND USE
US20060183758A1 (en) * 2005-02-17 2006-08-17 Cb Research And Development, Inc. Method for synthesis of AZA-annelated pyrroles, thiophenes, and furans
US7846941B2 (en) * 2005-05-17 2010-12-07 Plexxikon, Inc. Compounds modulating c-kit and c-fms activity and uses therefor
CN102603581B (zh) * 2005-06-22 2015-06-24 普莱希科公司 作为蛋白质激酶抑制剂的吡咯并[2,3-b]吡啶衍生物
UA95940C2 (uk) 2006-01-17 2011-09-26 Вертекс Фармасьютикалс Інкорпорейтед Азаіндоли як інгібітори кіназ януса
WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
WO2008079909A1 (en) * 2006-12-21 2008-07-03 Plexxikon, Inc. Pyrrolo [2,3-b] pyridines as kinase modulators
CA2673472A1 (en) 2006-12-21 2008-07-03 Vertex Pharmaceuticals Incorporated 5-cyan0-4- (pyrrolo) [2, 3b] pyridine-3-yl) -pyrimidine derivatives useful as protein kinase inhibitors
AU2007336811A1 (en) 2006-12-21 2008-07-03 Plexxikon, Inc. Compounds and methods for kinase modulation, and indications therefor
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US8962830B2 (en) * 2010-07-09 2015-02-24 The Walter And Eliza Hall Institute Of Medical Research Protein kinase inhibitors and methods of treatment
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UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
ES2741444T3 (es) 2013-11-13 2020-02-11 Vertex Pharma Inhibidores de la replicación de virus de la gripe
RS57541B1 (sr) 2013-11-13 2018-10-31 Vertex Pharma Postupci za pripremu inhibitora replikacije virusa gripa
JP6857617B2 (ja) 2015-05-13 2021-04-14 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ インフルエンザウイルスの複製の阻害剤
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Also Published As

Publication number Publication date
HUT64067A (en) 1993-11-29
CZ16893A3 (en) 1993-12-15
SI9300076A (en) 1993-09-30
GR3017614T3 (en) 1996-01-31
JPH061788A (ja) 1994-01-11
ZA93844B (en) 1994-08-08
MX9300745A (es) 1993-09-01
LT3065B (en) 1994-10-25
ATE125257T1 (de) 1995-08-15
SK9093A3 (en) 1993-09-09
EP0557171B1 (fr) 1995-07-19
CA2089470A1 (en) 1993-08-15
OA09775A (fr) 1993-11-30
EP0557171A1 (fr) 1993-08-25
DE69300268D1 (de) 1995-08-24
ES2076827T3 (es) 1995-11-01
HRP930180A2 (en) 1995-10-31
MA22797A1 (fr) 1993-10-01
FR2687402B1 (fr) 1995-06-30
LTIP339A (en) 1994-06-15
AU658475B2 (en) 1995-04-13
IL104573A0 (en) 1993-06-10
AU3300593A (en) 1993-08-19
US5338849A (en) 1994-08-16
FR2687402A1 (fr) 1993-08-20
DK0557171T3 (da) 1995-12-04
LV10453A (lv) 1995-02-20
NO930505D0 (no) 1993-02-12
KR930017905A (ko) 1993-09-20
DE69300268T2 (de) 1996-04-04
LV10453B (en) 1995-10-20
NZ245869A (en) 1995-05-26
HU9300372D0 (en) 1993-04-28
TNSN93016A1 (fr) 1994-03-17

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