NO924835L - Fremgangsmaate ved fremstilling av dobbelt-inhibitorer forno-syntetase og cyklooksygenase - Google Patents

Fremgangsmaate ved fremstilling av dobbelt-inhibitorer forno-syntetase og cyklooksygenase

Info

Publication number: NO924835L
Authority: NO; Norway
Prior art keywords: forno; cycloxygenase; synthetase; procedure; preparation
Prior art date: 1992-01-04

Application number

NO92924835A

Other languages

English (en)

Other versions

NO302943B1 (no

NO924835D0 (no

Inventor

Pierre-Etienne Cha Lassauniere

Pierre Braquet

Colette Broquet

Serge Auvin

Original Assignee

Scras

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-01-04

Filing date

1992-12-14

Publication date

1993-07-05

1992-12-14 Application filed by Scras filed Critical Scras

1992-12-14 Publication of NO924835D0 publication Critical patent/NO924835D0/no

1993-07-05 Publication of NO924835L publication Critical patent/NO924835L/no

1998-05-11 Publication of NO302943B1 publication Critical patent/NO302943B1/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C211/03—Monoamines
- C07C211/04—Mono-, di- or tri-methylamine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
- C07C65/03—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring
- C07C65/05—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring o-Hydroxy carboxylic acids
- C07C65/10—Salicylic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
- C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C229/56—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in ortho-position
- C07C229/58—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in ortho-position having the nitrogen atom of at least one of the amino groups further bound to a carbon atom of a six-membered aromatic ring, e.g. N-phenyl-anthranilic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/30—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to nitro or nitroso groups
- C07C279/32—N-nitroguanidines
- C07C279/36—Substituted N-nitroguanidines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
- C07C69/12—Acetic acid esters
- C07C69/14—Acetic acid esters of monohydroxylic compounds
- C07C69/145—Acetic acid esters of monohydroxylic compounds of unsaturated alcohols
- C07C69/157—Acetic acid esters of monohydroxylic compounds of unsaturated alcohols containing six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
- C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

NO924835A 1992-01-04 1992-12-14 Forbindelser som er dobbelt-inhibitorer for NO-syntase og cyklooksygenase NO302943B1 (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB929200114A GB9200114D0 (en)	1992-01-04	1992-01-04	Dual inhibitors of no synthase and cyclooxygenase

Publications (3)

Publication Number	Publication Date
NO924835D0 NO924835D0 (no)	1992-12-14
NO924835L true NO924835L (no)	1993-07-05
NO302943B1 NO302943B1 (no)	1998-05-11

Family

ID=10708115

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO924835A NO302943B1 (no)	1992-01-04	1992-12-14	Forbindelser som er dobbelt-inhibitorer for NO-syntase og cyklooksygenase

Country Status (34)

Country	Link
US (2)	US5480999A (no)
JP (1)	JP2984498B2 (no)
KR (1)	KR100287539B1 (no)
AT (1)	AT401054B (no)
AU (1)	AU664399B2 (no)
BE (1)	BE1006227A3 (no)
CA (1)	CA2085555C (no)
CH (1)	CH685629A5 (no)
DE (1)	DE4244539B4 (no)
DK (1)	DK157592A (no)
DZ (1)	DZ1657A1 (no)
ES (1)	ES2052452B1 (no)
FI (1)	FI925883A (no)
FR (2)	FR2685916B1 (no)
GB (2)	GB9200114D0 (no)
GR (1)	GR1001443B (no)
HK (1)	HK22296A (no)
HU (1)	HU220218B (no)
IE (1)	IE71675B1 (no)
IT (1)	IT1256761B (no)
LU (1)	LU88208A1 (no)
MA (1)	MA22753A1 (no)
MY (1)	MY109846A (no)
NL (1)	NL194889C (no)
NO (1)	NO302943B1 (no)
NZ (1)	NZ245499A (no)
OA (1)	OA10050A (no)
PL (1)	PL169432B1 (no)
PT (1)	PT101165B (no)
RU (1)	RU2104999C1 (no)
SE (1)	SE511568C2 (no)
TN (1)	TNSN93001A1 (no)
TW (1)	TW267152B (no)
ZA (1)	ZA9210080B (no)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH10500138A (ja) *	1994-05-07	1998-01-06	アストラ・アクチエボラーグ	酸化窒素合成酵素阻害剤としての２環アミジン誘導体
DE69534118T2 (de) *	1994-05-11	2006-02-09	Jes Olesen	Verwendung der no-faenger, inhibitoren oder antagonisten zur behandlung von migraene
CA2132690A1 (en) *	1994-09-22	1996-03-23	Dean Willis	Control and modulation of inflammatory response in humans in need of such control and modulation
US6066333A (en) *	1994-09-22	2000-05-23	William Harvey Research Limited	Pharmaceutical control of inflammation
FR2727111B1 (fr) *	1994-11-21	1997-01-17	Hoechst Lab	Nouveaux analogues soufres d'aminoacides, leur procede de preparation et leurs applications comme medicaments
DE793646T1 (de)	1994-11-23	1999-12-30	Pharmacia & Upjohn Co., Kalamazoo	Carboxylierte aminoguanidine zum behandlung von insulin-unabhängigem diabetes mellitus
JPH08333258A (ja)	1994-12-14	1996-12-17	Japan Tobacco Inc	チアジン又はチアゼピン誘導体及びそれら化合物を含有してなる一酸化窒素合成酵素阻害剤
ES2096524B1 (es) *	1994-12-22	1997-11-16	Sanchez Manuel Guerra	Uso de la ng-monometil-l-arginina, para aumentar la capacidad de hacer ejercicio fisico.
FR2730930B1 (fr)	1995-02-27	1997-04-04	Oreal	Utilisation d'inhibiteurs de no-synthase pour diminuer l'effet irritant cutane de produits utilises dans le domaine cosmetique ou pharmaceutique
GB9504350D0 (en) *	1995-03-04	1995-04-26	Sod Conseils Rech Applic	Arginine derivatives
US5703073A (en) *	1995-04-19	1997-12-30	Nitromed, Inc.	Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs
GB9514518D0 (en) *	1995-07-15	1995-09-13	Sod Conseils Rech Applic	Guanidine salt inhibitors of NO synthase and cyclooxygenase
AU2063397A (en) *	1996-03-05	1997-09-22	Children's Hospital Medical Center	Mercapto derivatives as inhibitors of cyclooxygenases
WO1997044324A1 (en)	1996-05-21	1997-11-27	Pharmacia & Upjohn Company	Aminoguanidine carboxylate lactams for the treatment of non-insulin-dependent diabetes mellitus
US5872145A (en) *	1996-08-16	1999-02-16	Pozen, Inc.	Formulation of 5-HT agonist and NSAID for treatment of migraine
US6586458B1 (en)	1996-08-16	2003-07-01	Pozen Inc.	Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs
US8022095B2 (en) *	1996-08-16	2011-09-20	Pozen, Inc.	Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs
US5789395A (en) *	1996-08-30	1998-08-04	The Research Foundation Of State University Of New York	Method of using tetracycline compounds for inhibition of endogenous nitric oxide production
IT1288123B1 (it) *	1996-09-04	1998-09-10	Nicox Sa	Uso di nitroderivati per l'incontinenza urinaria
US6066092A (en) *	1997-11-06	2000-05-23	Cady; Roger K.	Preemptive prophylaxis of migraine device and method
IT1301966B1 (it)	1998-07-30	2000-07-20	Zambon Spa	Composizioni farmaceutiche ad attivita' analgesica
US6207700B1 (en) *	1999-01-07	2001-03-27	Vanderbilt University	Amide derivatives for antiangiogenic and/or antitumorigenic use
US7345051B2 (en) *	2000-01-31	2008-03-18	Genaera Corporation	Mucin synthesis inhibitors
JP2004507444A (ja) *	2000-01-31	2004-03-11	ジェネーラ　コーポレーション	ムチン合成インヒビター
US7163958B2 (en)	2002-07-03	2007-01-16	Nitromed Inc.	Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
US7244753B2 (en) *	2002-07-29	2007-07-17	Nitromed, Inc.	Cyclooxygenase-2 selective inhibitors, compositions and methods of use
ATE546134T1 (de) *	2002-12-26	2012-03-15	Pozen Inc	Mehrschichtige dosierformen enthaltend naproxen und triptane
BRPI0410807A (pt) *	2003-06-06	2006-06-27	Glaxo Group Ltd	composição farmacêutica, e, método pata tratar um mamìfero sofrendo de ou susceptìvel a condições associadas com dor cefálica
WO2004113286A2 (en) *	2003-06-19	2004-12-29	Genaera Corporation	Mucin synthesis inhibitors
EP1638612A4 (en) *	2003-06-25	2010-09-29	Univ Vanderbilt	COX-2-MADE DISPLAY AGENTS
US7491744B2 (en) *	2004-04-26	2009-02-17	Vanderbilt University	Indoleacetic acid and indenacetic acid derivatives as therapeutic agents with reduced gastrointestinal toxicity
EP1836296A1 (en) *	2005-01-04	2007-09-26	Novartis AG	X-ray structure of human fpps and use for selecting fpps binding compounds
CA2657691A1 (en) *	2006-06-19	2007-12-27	Vanderbilt University	Methods and compositions for diagnostic and therapeutic targeting of cox-2
EP3078374B1 (en)	2011-10-17	2019-06-19	Vanderbilt University	Indomethacin analogs for the treatment of castrate-resistant prostate cancer
TWM469254U (zh)	2013-08-29	2014-01-01	J D Components Co Ltd	自行車之三件式豎管

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR6838M (no) *	1967-12-08	1969-03-31
ES423794A1 (es) *	1974-03-01	1976-05-01	Medicinales S A Promesa Prod	Procediemiento de obtencion de una nueva sal soluble de acido acetilsalicilico.
FR2320759A1 (fr) *	1975-08-11	1977-03-11	Union Pharma Scient Appl	Solution d'acide acetylsalicylique extemporanee injectable
IT1127274B (it) *	1979-12-04	1986-05-21	Selvi & C Spa	Sali dell'acido 5-fluoro-2-metil-1-(p-(metilsulfinil)-benzilidene)-indene-3-acetico
JPS5781409A (en) *	1980-11-10	1982-05-21	Toko Yakuhin Kogyo Kk	External plaster
CA1213888A (en) *	1983-09-28	1986-11-12	Warner-Lambert Company	L-arginine isoxicamate
US5081184A (en) *	1985-08-02	1992-01-14	General Electric Company	Solvent-resistant, compatible blends of polyphenylene ethers and linear polyesters
JPS6393718A (ja) *	1986-10-07	1988-04-25	Green Cross Corp:The	注射剤
US5059712A (en) *	1989-09-13	1991-10-22	Cornell Research Foundation, Inc.	Isolating aminoarginine and use to block nitric oxide formation in body
US5028627A (en) *	1989-09-13	1991-07-02	Cornell Research Foundation, Inc.	Method of using arginine derivatives to inhibit systemic hypotension associated with nitric oxide production or endothelial derived relaxing factor
EP0424028B1 (en) *	1989-10-17	1995-09-27	Merck & Co. Inc.	S(+)-ibuprofen-L-amino acid and S(+)-ibuprofen-D-amino acid as onset hastened enhanced analgesics
GB8929076D0 (en) *	1989-12-22	1990-02-28	Scras	Treatment of shock by blocking agents of edrf effect or formation
US5468476A (en) *	1994-03-16	1995-11-21	Ahluwalia; Gurpreet S.	Reduction of hair growth

1992
- 1992-01-04 GB GB929200114A patent/GB9200114D0/en active Pending
- 1992-12-14 NO NO924835A patent/NO302943B1/no unknown
- 1992-12-16 CA CA002085555A patent/CA2085555C/en not_active Expired - Fee Related
- 1992-12-17 NZ NZ245499A patent/NZ245499A/en unknown
- 1992-12-18 GR GR920100563A patent/GR1001443B/el not_active IP Right Cessation
- 1992-12-18 MY MYPI92002343A patent/MY109846A/en unknown
- 1992-12-18 TW TW081110175A patent/TW267152B/zh active
- 1992-12-18 SE SE9203825A patent/SE511568C2/sv not_active IP Right Cessation
- 1992-12-18 CH CH3890/92A patent/CH685629A5/fr not_active IP Right Cessation
- 1992-12-22 FR FR9215448A patent/FR2685916B1/fr not_active Expired - Fee Related
- 1992-12-22 FR FR9215447A patent/FR2685869B1/fr not_active Expired - Fee Related
- 1992-12-22 BE BE9201127A patent/BE1006227A3/fr not_active IP Right Cessation
- 1992-12-23 IT ITMI922953A patent/IT1256761B/it active IP Right Grant
- 1992-12-23 AT AT0256092A patent/AT401054B/de not_active IP Right Cessation
- 1992-12-23 US US07/995,792 patent/US5480999A/en not_active Expired - Lifetime
- 1992-12-24 GB GB9227026A patent/GB2263111B/en not_active Expired - Lifetime
- 1992-12-25 MA MA23045A patent/MA22753A1/fr unknown
- 1992-12-28 FI FI925883A patent/FI925883A/fi not_active Application Discontinuation
- 1992-12-29 ES ES09202635A patent/ES2052452B1/es not_active Expired - Fee Related
- 1992-12-29 LU LU88208A patent/LU88208A1/fr unknown
- 1992-12-29 ZA ZA9210080A patent/ZA9210080B/xx unknown
- 1992-12-29 DZ DZ920171A patent/DZ1657A1/fr active
- 1992-12-30 PT PT101165A patent/PT101165B/pt not_active IP Right Cessation
- 1992-12-30 DE DE4244539A patent/DE4244539B4/de not_active Expired - Fee Related
- 1992-12-30 PL PL92297247A patent/PL169432B1/pl not_active IP Right Cessation
- 1992-12-30 HU HU9204173A patent/HU220218B/hu not_active IP Right Cessation
- 1992-12-30 KR KR1019920026433A patent/KR100287539B1/ko not_active IP Right Cessation
- 1992-12-30 DK DK157592A patent/DK157592A/da not_active Application Discontinuation
- 1992-12-31 OA OA60325A patent/OA10050A/fr unknown
- 1992-12-31 AU AU30498/92A patent/AU664399B2/en not_active Ceased
- 1992-12-31 IE IE922954A patent/IE71675B1/en not_active IP Right Cessation
- 1992-12-31 RU RU92016217A patent/RU2104999C1/ru not_active IP Right Cessation
1993
- 1993-01-04 NL NL9300001A patent/NL194889C/nl not_active IP Right Cessation
- 1993-01-04 JP JP5000091A patent/JP2984498B2/ja not_active Expired - Fee Related
- 1993-01-04 TN TNTNSN93001A patent/TNSN93001A1/fr unknown
- 1993-09-29 US US08/128,908 patent/US5360925A/en not_active Expired - Lifetime
1996
- 1996-02-08 HK HK22296A patent/HK22296A/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
ES2052452B1 (es)	1995-02-01
SE9203825D0 (sv)	1992-12-18
RU2104999C1 (ru)	1998-02-20
SE511568C2 (sv)	1999-10-18
NO302943B1 (no)	1998-05-11
IE71675B1 (en)	1997-02-26
NL194889B (nl)	2003-02-03
US5360925A (en)	1994-11-01
DK157592D0 (da)	1992-12-30
DE4244539A1 (no)	1993-07-08
DE4244539B4 (de)	2006-10-26
LU88208A1 (fr)	1993-04-15
FR2685869A1 (fr)	1993-07-09
DK157592A (da)	1993-07-05
GB2263111B (en)	1995-08-16
CA2085555A1 (en)	1993-07-05
ATA256092A (de)	1995-10-15
AU3049892A (en)	1993-07-08
PT101165B (pt)	1999-09-30
PT101165A (pt)	1994-02-28
CA2085555C (en)	2004-07-20
MY109846A (en)	1997-08-30
IE922954A1 (en)	1993-07-14
GB2263111A (en)	1993-07-14
GR1001443B (el)	1993-12-30
ITMI922953A1 (it)	1994-06-23
NL194889C (nl)	2003-06-04
HK22296A (en)	1996-02-16
GB9227026D0 (en)	1993-02-17
OA10050A (fr)	1996-10-14
FR2685869B1 (fr)	1995-06-09
MA22753A1 (fr)	1993-07-01
KR930016389A (ko)	1993-08-26
TW267152B (no)	1996-01-01
ZA9210080B (en)	1993-08-02
FI925883A0 (fi)	1992-12-28
NL9300001A (nl)	1993-08-02
CH685629A5 (fr)	1995-08-31
HU220218B (hu)	2001-11-28
PL297247A1 (en)	1993-09-06
TNSN93001A1 (fr)	1994-03-17
BE1006227A3 (fr)	1994-06-14
IT1256761B (it)	1995-12-15
SE9203825L (sv)	1993-07-05
ES2052452A1 (es)	1994-07-01
DZ1657A1 (fr)	2002-02-17
JP2984498B2 (ja)	1999-11-29
JPH05286916A (ja)	1993-11-02
AT401054B (de)	1996-06-25
FR2685916A1 (fr)	1993-07-09
FI925883A (fi)	1993-07-05
HUT64047A (en)	1993-11-29
GB9200114D0 (en)	1992-02-26
PL169432B1 (pl)	1996-07-31
NO924835D0 (no)	1992-12-14
US5480999A (en)	1996-01-02
AU664399B2 (en)	1995-11-16
FR2685916B1 (fr)	2001-09-28
KR100287539B1 (ko)	2001-04-16
HU9204173D0 (en)	1993-04-28
NZ245499A (en)	1995-07-26

Publication	Publication Date	Title
NO924835L (no)	1993-07-05	Fremgangsmaate ved fremstilling av dobbelt-inhibitorer forno-syntetase og cyklooksygenase
NO963253D0 (no)	1996-08-02	Inhibitorer for poly(ADP-ribose)syntetase og anvendelse derav til forhindring av NMDA-nevrotoksisitet
EP0794789A4 (en)	1999-05-26	PRENYL TRANSFERASE INHIBITORS
AU6178894A (en)	1994-09-26	Alkanesulfonamido-1-indanone derivatives as inhibitors of cyclooxygenase
AU4267293A (en)	1993-11-29	Use of MMP inhibitors
NO940825D0 (no)	1994-03-09	2-Debenzoyl-2-acyltaxolderivater og fremgangsmåter ved fremstilling derav
DK0832065T3 (da)	2001-11-19	Substituerede N-(indol-2-carbonyl)glycinamider og derivater som glycogenphosphorylaseinhibitorer
NO955074D0 (no)	1995-12-14	1-substituerte istain- og oksindolderivater som inhibitorer til acetylkolinesterase
NO995077L (no)	1999-12-17	Fremgangsmåte ved anvendelse av cyklooksygenase-2 inhibitorer
PL331047A1 (en)	1999-06-21	Novel amidinic derivatives and their application as inhibitors of thrombosin
NO943353D0 (no)	1994-09-09	Kombinasjoner av ACE-inhibitorer og diuretiske midler
NO20012963D0 (no)	2001-06-15	Fremgangsmåte for fremstilling av 3-alkanoylindoler og 3- alkylindoler
EP0666849A4 (en)	1995-12-13	ARYL AND HETEROARYL METHOXYPHENYL INHIBITORS OF LEUKOTRIA BIOSYNTHESIS.
NO944872D0 (no)	1994-12-15	Partikulært sprengstoff, fremgangsmåte ved dets fremstilling og anvendelse av sprengstoffet
DK0623614T3 (da)	1998-09-28	4-aryl-4-hydroxy-tetrahydropyraner og 3-aryl-3-hydroxy-tetrahydrofuraner som inhibitorer for 5-lipoxygenase
NO931400D0 (no)	1993-04-16	Derivater av adipogeneseinhiberende faktor, samt fremstilling og anvendelse derav
NO975634D0 (no)	1997-12-04	Stabile farmasöytiske preparater inneholdende tiludronathydrater og fremgangsmåte for fremstilling av farmasöytiske preparater
NO20001758D0 (no)	2000-04-05	Fremgangsmåter og blandinger for behandling av leddgikt
ZA948337B (en)	1995-07-25	Pyrrolidine derivatives inhibitors of leukotriene biosynthesis
NO933285D0 (no)	1993-09-15	Fremgangsmaate og anordning ved funksjonsdefinering av en ovn
NO307547B1 (no)	2000-04-25	Anvendelse av en eosinofil kjemotaksishemmende forbindelse
AU673961B2 (en)	1996-11-28	Methods of inhibiting the effects of amyloidogenic proteins
NO924390D0 (no)	1992-11-13	Fremgangsmaate og system for fremskaffelse av volumgjengivelse
NO930795D0 (no)	1993-03-04	Fremgangsmaate og elementsett til bruk ved ettertrekking av eternittak
NO950033D0 (no)	1995-01-05	Integrering av telemetri og sonarteknologi