NO923616D0 - Fremgangsmaate for fremstilling av en yarrowia lipolytica-transformant som ikke produserer alkalisk protease, samt fremgangsmaate for paavisning av y. lipolytica-transformanter - Google Patents

Fremgangsmaate for fremstilling av en yarrowia lipolytica-transformant som ikke produserer alkalisk protease, samt fremgangsmaate for paavisning av y. lipolytica-transformanter

Info

Publication number: NO923616D0
Authority: NO; Norway
Prior art keywords: lipolytica; procedure; heterologous; xpr2; vectors
Prior art date: 1985-10-18

Application number

NO923616A

Other languages

English (en)

Other versions

NO178793C (no

NO178793B (no

NO923616L (no

Inventor

Lance Steven Davidow

John Robert Dezeeuw

Arthur Ernest Franke

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-10-18

Filing date

1992-09-17

Publication date

1992-09-17

1987-04-21 Publication of NO923616L publication Critical patent/NO923616L/no

1992-09-17 Application filed by Pfizer filed Critical Pfizer

1992-09-17 Priority to NO923616A priority Critical patent/NO178793C/no

1992-09-17 Publication of NO923616D0 publication Critical patent/NO923616D0/no

1996-02-26 Publication of NO178793B publication Critical patent/NO178793B/no

1996-06-05 Publication of NO178793C publication Critical patent/NO178793C/no

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6478—Aspartic endopeptidases (3.4.23)
- C12N9/6481—Pepsins (3.4.23.1; 3.4.23.2; 3.4.23.3)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/472—Complement proteins, e.g. anaphylatoxin, C3a, C5a
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
- C12N9/60—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi from yeast
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Microbiology (AREA)
Mycology (AREA)
Biophysics (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
Medicinal Chemistry (AREA)
Toxicology (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Treatment Of Sludge (AREA)
Magnetic Ceramics (AREA)
Enzymes And Modification Thereof (AREA)
Peptides Or Proteins (AREA)
Paper (AREA)
Saccharide Compounds (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Fodder In General (AREA)
Noodles (AREA)
Measurement Of Velocity Or Position Using Acoustic Or Ultrasonic Waves (AREA)
Purification Treatments By Anaerobic Or Anaerobic And Aerobic Bacteria Or Animals (AREA)

NO923616A 1985-10-18 1992-09-17 Fremgangsmåte for fremstilling av en Yarrowia lipolytica-transformant som ikke produserer alkalisk protease NO178793C (no)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
NO923616A NO178793C (no)	1985-10-18	1992-09-17	Fremgangsmåte for fremstilling av en Yarrowia lipolytica-transformant som ikke produserer alkalisk protease

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US78920685A	1985-10-18	1985-10-18
US06/841,121 US4937189A (en)	1985-10-18	1986-03-18	Expression and secretion of heterologous proteins by Yarrowia lipolytica transformants
NO864148A NO177318C (no)	1985-10-18	1986-10-17	Fremgangsmåte for fremstilling av prorennin og human-anafylatoksin C5a i Y. lipolytica, samt plasmider til fremstillingen
NO923616A NO178793C (no)	1985-10-18	1992-09-17	Fremgangsmåte for fremstilling av en Yarrowia lipolytica-transformant som ikke produserer alkalisk protease

Publications (4)

Publication Number	Publication Date
NO923616L NO923616L (no)	1987-04-21
NO923616D0 true NO923616D0 (no)	1992-09-17
NO178793B NO178793B (no)	1996-02-26
NO178793C NO178793C (no)	1996-06-05

Family

ID=27120892

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
NO864148A NO177318C (no)	1985-10-18	1986-10-17	Fremgangsmåte for fremstilling av prorennin og human-anafylatoksin C5a i Y. lipolytica, samt plasmider til fremstillingen
NO923616A NO178793C (no)	1985-10-18	1992-09-17	Fremgangsmåte for fremstilling av en Yarrowia lipolytica-transformant som ikke produserer alkalisk protease

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
NO864148A NO177318C (no)	1985-10-18	1986-10-17	Fremgangsmåte for fremstilling av prorennin og human-anafylatoksin C5a i Y. lipolytica, samt plasmider til fremstillingen

Country Status (24)

Country	Link
US (1)	US4937189A (no)
EP (1)	EP0220864B1 (no)
JP (1)	JP3096297B2 (no)
KR (1)	KR900008950B1 (no)
CN (3)	CN1034428C (no)
AT (1)	ATE86302T1 (no)
AU (1)	AU586041B2 (no)
CA (1)	CA1340837C (no)
DD (7)	DD276886A5 (no)
DE (1)	DE3687878T2 (no)
DK (1)	DK496886A (no)
EG (1)	EG18142A (no)
ES (1)	ES2038966T3 (no)
FI (1)	FI90352C (no)
HU (1)	HU209150B (no)
IE (1)	IE59774B1 (no)
IL (7)	IL99893A (no)
NO (2)	NO177318C (no)
NZ (1)	NZ217985A (no)
PH (3)	PH27026A (no)
PL (2)	PL154427B1 (no)
PT (1)	PT83562B (no)
RU (2)	RU2069694C1 (no)
YU (2)	YU46412B (no)

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FR2626584B1 (fr) *	1988-01-28	1990-07-13	Agronomique Inst Nat Rech	Sequence ars efficace chez yarrowia lipolytica et procede pour sa preparation
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JPH0669365B2 (ja) *	1989-05-22	1994-09-07	株式会社ミドリ十字	アルブミン遺伝子を含むプラスミド、形質転換体、形質転換体の製造方法、アルブミンの製造方法
EP0402226A1 (en) *	1989-06-06	1990-12-12	Institut National De La Recherche Agronomique	Transformation vectors for yeast yarrowia
WO1995006739A1 (en) *	1993-09-02	1995-03-09	Pfizer Inc.	Multiple integrative vectors and yarrowia lipolytica transformants
US5837499A (en) *	1993-12-06	1998-11-17	Ciba-Geigy Corporation	DNA encoding C5A receptor antagonists having substantially no agonist activity and methods of expressing same
US5807824A (en) *	1993-12-06	1998-09-15	Ciba-Geigy Corporation	C5A receptor antagonists having substantially no agonist activity
DE19513152A1 (de) *	1995-04-07	1996-10-10	Bundesrep Deutschland	Verwendung eines "Immundefizienzvirus-supprimierenden Lymphokins (ISL)" zur Hemmung der Virusvermehrung, insbesondere von Retroviren
AU6125096A (en) *	1995-06-05	1996-12-24	Novartis Ag	C5a receptor antagonists having substantially no agonist activity and methods for preparation
EP0747484A1 (en) *	1995-06-08	1996-12-11	Institut National De La Recherche Agronomique (Inra)	Upstream activator sequences and recombinant promoter sequences functional in yarrowia and vectors containing them
EP0922109A1 (en)	1996-05-21	1999-06-16	Novo Nordisk A/S	Novel yeast promoters suitable for expression cloning in yeast and heterologous expression of proteins in yeast
FR2782733B1 (fr)	1998-09-01	2002-02-08	Agronomique Inst Nat Rech	Procede de transformation non-homologue de yarrowia lipolytica
US20110059496A1 (en) *	2003-06-25	2011-03-10	E. I. Du Pont De Nemours And Company	Glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate mutase promoters for gene expression in oleaginous yeast
US7259255B2 (en) *	2003-06-25	2007-08-21	E. I. Du Pont De Nemours And Company	Glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate mutase promoters for gene expression in oleaginous yeast
US7459546B2 (en)	2003-06-25	2008-12-02	E.I. Du Pont De Nemours And Company	Glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate mutase regulatory sequences for gene expression in oleaginous yeast
WO2005049805A2 (en) *	2003-11-14	2005-06-02	E.I. Dupont De Nemours And Company	Fructose-bisphosphate aldolase regulatory sequences for gene expression in oleaginous yeast
US7264949B2 (en) *	2004-09-15	2007-09-04	E.I. Du Pont De Nemours And Company	Glycerol-3-phosphate o-acyltransferase promoter for gene expression in oleaginous yeast
US20060094102A1 (en) *	2004-11-04	2006-05-04	Zhixiong Xue	Ammonium transporter promoter for gene expression in oleaginous yeast
BRPI0609040B1 (pt)	2005-03-18	2018-07-31	Microbia, Inc.	Fungo recombinante do gênero yarrowia, método de produção de um carotenóide e método de preparo de um aditivo alimentício ou ração contendo um carotenóide
EP2078092A2 (en)	2006-09-28	2009-07-15	Microbia, Inc.	Production of carotenoids in oleaginous yeast and fungi
FR2927089B1 (fr) *	2008-02-05	2011-03-25	Inst Nat De La Rech Agronomique Inra	Procede d'integration ciblee de multicopies d'un gene d'interet dans une souche de yarrowia
DK2310517T3 (en) *	2008-07-11	2016-06-06	Inst Nat De La Rech Agronomique (Inra)	Novel mutant yeast strains having a capability to accumulate a large amount of lipids
FR2962133B1 (fr)	2010-07-01	2014-09-12	Agronomique Inst Nat Rech	Optimisation de la synthese et de l'accumulation de lipides
US8735137B2 (en)	2010-12-30	2014-05-27	E I Du Pont De Nemours And Company	Use of Saccharomyces cerevisiae SUC2 gene in Yarrowia lipolytica for sucrose utilization
EP2691518A1 (en)	2011-03-31	2014-02-05	E.I. Du Pont De Nemours And Company	Yarrowia diacylglycerol acyltransferase promoter regions for gene expression in yeast
EP2694657A1 (en)	2011-04-05	2014-02-12	E. I. Du Pont de Nemours and Company	Yarrowia n-alkane-hydroxylating cytochrome p450 promoter regions for gene expression in yeast
US8609369B2 (en)	2011-04-07	2013-12-17	E I Du Pont De Nemours And Company	Yarrowia peroxisomal 2,4-dienoyl-CoA reductase promoter regions for gene expression in yeast
GB201106188D0 (en)	2011-04-12	2011-05-25	Csir	Production of extracellular polypeptides
FR3002774A1 (fr)	2013-03-04	2014-09-05	Agronomique Inst Nat Rech	Levures mutantes ayant une production accrue de lipides et d'acide citrique
FR3005317B1 (fr)	2013-05-02	2016-03-18	Agronomique Inst Nat Rech	Levures mutantes capables de produire un acide gras inhabituel
EP3102683B1 (en)	2014-01-31	2019-10-23	DSM IP Assets B.V.	Promoters suitable for heterologous gene expression in yeast
EP3155094A1 (en)	2014-06-11	2017-04-19	Institut National De La Recherche Agronomique (INRA)	Improved lipid accumulation in yarrowia lipolytica strains by overexpression of hexokinase and new strains thereof
FR3028527A1 (fr)	2014-11-13	2016-05-20	Pivert	Identification de facteurs de transcription de yarrowia lipolytica
WO2016075314A1 (fr)	2014-11-13	2016-05-19	Institut National De La Recherche Agronomique	Identification de facteurs de transcription de yarrowia lipolytica affectant la production de proteines
EP3387134B1 (en)	2015-12-11	2020-10-14	Danisco US Inc.	Methods and compositions for enhanced nuclease-mediated genome modification and reduced off-target site effects
EP3708665A1 (en)	2015-12-18	2020-09-16	Danisco US Inc.	Methods and compositions for t-rna based guide rna expression
US20190136278A1 (en)	2016-05-10	2019-05-09	Institut National De La Recherche Agronomique	Mutant yeast strains with enhanced production of erythritol or erythrulose
EP3348647A1 (en)	2017-01-13	2018-07-18	Institut National De La Recherche Agronomique	Mutant yeast strain capable of producing medium chain fatty acids

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1986
- 1986-03-18 US US06/841,121 patent/US4937189A/en not_active Expired - Lifetime
- 1986-10-10 DE DE8686307839T patent/DE3687878T2/de not_active Expired - Lifetime
- 1986-10-10 AT AT86307839T patent/ATE86302T1/de not_active IP Right Cessation
- 1986-10-10 ES ES198686307839T patent/ES2038966T3/es not_active Expired - Lifetime
- 1986-10-10 EP EP86307839A patent/EP0220864B1/en not_active Expired - Lifetime
- 1986-10-14 IL IL99893A patent/IL99893A/xx not_active IP Right Cessation
- 1986-10-14 IL IL80297A patent/IL80297A/xx not_active IP Right Cessation
- 1986-10-14 IL IL99892A patent/IL99892A/xx not_active IP Right Cessation
- 1986-10-14 IL IL99894A patent/IL99894A/xx not_active IP Right Cessation
- 1986-10-16 PT PT83562A patent/PT83562B/pt unknown
- 1986-10-16 CA CA000520577A patent/CA1340837C/en not_active Expired - Lifetime
- 1986-10-16 EG EG652/86A patent/EG18142A/xx active
- 1986-10-17 CN CN86106522A patent/CN1034428C/zh not_active Expired - Lifetime
- 1986-10-17 KR KR1019860008726A patent/KR900008950B1/ko not_active IP Right Cessation
- 1986-10-17 IE IE275486A patent/IE59774B1/en not_active IP Right Cessation
- 1986-10-17 HU HU864332A patent/HU209150B/hu unknown
- 1986-10-17 DD DD29535886A patent/DD276886A5/de not_active IP Right Cessation
- 1986-10-17 NZ NZ217985A patent/NZ217985A/en unknown
- 1986-10-17 DD DD31347586A patent/DD267998A5/de unknown
- 1986-10-17 PL PL1986261912A patent/PL154427B1/pl unknown
- 1986-10-17 RU SU864028319A patent/RU2069694C1/ru active
- 1986-10-17 FI FI864206A patent/FI90352C/fi not_active IP Right Cessation
- 1986-10-17 DD DD31347486A patent/DD267997A5/de unknown
- 1986-10-17 RU SU5010596/13A patent/RU2157845C2/ru active
- 1986-10-17 NO NO864148A patent/NO177318C/no unknown
- 1986-10-17 YU YU177386A patent/YU46412B/sh unknown
- 1986-10-17 PL PL1986288208A patent/PL155850B1/pl unknown
- 1986-10-17 DK DK496886A patent/DK496886A/da not_active Application Discontinuation
- 1986-10-17 PH PH34383A patent/PH27026A/en unknown
- 1986-10-17 DD DD31347286A patent/DD269397A5/de unknown
- 1986-10-17 DD DD31347386A patent/DD267996A5/de unknown
- 1986-10-17 DD DD31347186A patent/DD269396A5/de unknown
- 1986-10-17 AU AU64161/86A patent/AU586041B2/en not_active Expired
- 1986-10-17 DD DD31347086A patent/DD267995A5/de unknown
- 1986-10-18 JP JP61248263A patent/JP3096297B2/ja not_active Expired - Lifetime
1988
- 1988-05-06 PH PH36896A patent/PH27171A/en unknown
- 1988-05-06 PH PH36903A patent/PH27198A/en unknown
- 1988-06-27 YU YU124588A patent/YU46571B/sh unknown
1991
- 1991-10-29 IL IL99894A patent/IL99894A0/xx unknown
- 1991-10-29 IL IL99892A patent/IL99892A0/xx unknown
- 1991-10-29 IL IL99893A patent/IL99893A0/xx unknown
1992
- 1992-09-17 NO NO923616A patent/NO178793C/no unknown
1996
- 1996-01-15 CN CN96100922A patent/CN1141339A/zh active Pending
- 1996-01-15 CN CN96101527A patent/CN1069346C/zh not_active Expired - Lifetime

Also Published As

Publication number	Publication date
HUT43632A (en)	1987-11-30
EP0220864A1 (en)	1987-05-06
FI864206A (fi)	1987-04-19
NO177318B (no)	1995-05-15
JPS63164889A (ja)	1988-07-08
DE3687878D1 (de)	1993-04-08
ATE86302T1 (de)	1993-03-15
DD276886A5 (de)	1990-03-14
PH27026A (en)	1993-02-01
YU177386A (en)	1989-04-30
JP3096297B2 (ja)	2000-10-10
PL155850B1 (en)	1992-01-31
YU124588A (en)	1989-08-31
YU46412B (sh)	1993-10-20
DK496886D0 (da)	1986-10-17
IL99892A0 (en)	1992-08-18
ES2038966T3 (es)	1993-08-16
FI90352C (fi)	1994-01-25
DD267998A5 (de)	1989-05-17
NZ217985A (en)	1991-06-25
DD269396A5 (de)	1989-06-28
PT83562B (pt)	1989-05-31
NO864148L (no)	1987-04-21
NO178793C (no)	1996-06-05
EG18142A (en)	1992-08-30
IL99892A (en)	1993-02-21
IL99893A (en)	1993-02-21
PH27198A (en)	1993-04-16
DD267995A5 (de)	1989-05-17
FI90352B (fi)	1993-10-15
DD267996A5 (de)	1989-05-17
CN1141339A (zh)	1997-01-29
IL99893A0 (en)	1992-08-18
RU2157845C2 (ru)	2000-10-20
IL99894A (en)	1993-02-21
DD267997A5 (de)	1989-05-17
IL99894A0 (en)	1992-08-18
NO178793B (no)	1996-02-26
CN1138632A (zh)	1996-12-25
IL80297A (en)	1993-02-21
NO923616L (no)	1987-04-21
RU2069694C1 (ru)	1996-11-27
HU209150B (en)	1994-03-28
DE3687878T2 (de)	1993-07-15
CN1034428C (zh)	1997-04-02
AU586041B2 (en)	1989-06-29
IE862754L (en)	1987-04-18
US4937189A (en)	1990-06-26
KR870004138A (ko)	1987-05-07
IL80297A0 (en)	1987-01-30
EP0220864B1 (en)	1993-03-03
CN1069346C (zh)	2001-08-08
PL261912A1 (en)	1987-10-19
PT83562A (en)	1986-11-01
NO177318C (no)	1995-08-23
AU6416186A (en)	1987-05-14
PL154427B1 (en)	1991-08-30
DD269397A5 (de)	1989-06-28
CN86106522A (zh)	1987-09-16
IE59774B1 (en)	1994-04-06
KR900008950B1 (ko)	1990-12-15
FI864206A0 (fi)	1986-10-17
YU46571B (sh)	1993-11-16
NO864148D0 (no)	1986-10-17
CA1340837C (en)	1999-12-07
DK496886A (da)	1987-06-11
PH27171A (en)	1993-04-02

Publication	Publication Date	Title
NO923616D0 (no)	1992-09-17	Fremgangsmaate for fremstilling av en yarrowia lipolytica-transformant som ikke produserer alkalisk protease, samt fremgangsmaate for paavisning av y. lipolytica-transformanter
EP0196864A3 (en)	1988-03-23	Alkaline phosphatase-mediated processing and secretion of recombinant proteins, dna sequences for use therein and cells transformed using such sequences
DE3072070D1 (en)	1988-02-25	Plasmid vectors, plasmids containing genes for alkaline phosphatases and bacteria containing the latter, their preparation and use
FR2724183B1 (fr)	1997-04-11	Vecteurs de criblage et/ou d'expression fonctionnels chez les mycobacteries - utilisation pour l'identification et l'expression de polypeptides exportes
IL94422A0 (en)	1991-03-10	Saf polypeptide,gene coding therefor,saf promoter and expression methods for expressing foreign dna sequences in streptomyces
ES8800721A1 (es)	1987-11-16	Un metodo para producir un granulo intracelular de la hormona bovina del crecimiento, altamente homogeneo.
EP0266057A3 (en)	1989-11-08	Plasmid containing an eucaryotic secretory signal sequence and process for secreting encoded proteins
IE873300L (en)	1988-06-05	Expression vectors
LTIP237A (en)	1994-07-15	Po438, a new calcium-regulated promotor
RU92004585A (ru)	1996-09-20	Промотор, днк-последовательность, вектор, клетки, способ экспрессии днк
ES8705040A1 (es)	1987-04-16	Un procedimiento para la preparacion de un vector de expre- sion de una recombinante
HUT36498A (en)	1985-09-30	Gene of modeified antibiotic resistency