NO922603L - NEW BENZOMORPHONES AND THEIR USE AS A MEDICINE - Google Patents
NEW BENZOMORPHONES AND THEIR USE AS A MEDICINEInfo
- Publication number
- NO922603L NO922603L NO92922603A NO922603A NO922603L NO 922603 L NO922603 L NO 922603L NO 92922603 A NO92922603 A NO 92922603A NO 922603 A NO922603 A NO 922603A NO 922603 L NO922603 L NO 922603L
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- new
- benzomorphones
- medicine
- acyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/26—Benzomorphans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Benzomorphane derivs. of formula (I) are new. In (I), X = O or S; R1 = 1-8C alkyl, 3-6C alkenyl, 3-6C alkynyl or aryl; R2 = H, 1-8C alkyl, 3-6C alkenyl, 3-6C alkynyl, aryl or aralkyl; R3 = H or 1-6C alkyl; R4 and R5 = each 1-8C alkyl; R6 = 1-8C alkyl or aryl; R7 and R8 = each H, 1-8C alkyl, halogen, OH, 1-8C alkoxy, O-Acyl, CN, NO2, NH2, NH(1-8C alkyl), N(1-8C alkyl)2 (n which the alkyl gps. are opt. different), NH-acyl or N-acyl-(1-8C alkyl).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4121821A DE4121821A1 (en) | 1991-07-02 | 1991-07-02 | NEW BENZOMORPHANE AND ITS USE AS A MEDICAMENT |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| NO922603D0 NO922603D0 (en) | 1992-07-01 |
| NO922603L true NO922603L (en) | 1993-01-04 |
| NO178263B NO178263B (en) | 1995-11-13 |
| NO178263C NO178263C (en) | 1996-02-21 |
Family
ID=6435223
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO922603A NO178263C (en) | 1991-07-02 | 1992-07-01 | New benzomorphans and their use as a drug |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP0521422B1 (en) |
| JP (1) | JP3324785B2 (en) |
| KR (1) | KR100251256B1 (en) |
| AT (1) | ATE137749T1 (en) |
| AU (1) | AU657330B2 (en) |
| CA (1) | CA2072814C (en) |
| CZ (1) | CZ286949B6 (en) |
| DE (2) | DE4121821A1 (en) |
| DK (1) | DK0521422T3 (en) |
| ES (1) | ES2086585T3 (en) |
| FI (1) | FI105913B (en) |
| GR (1) | GR3020124T3 (en) |
| HK (1) | HK1003111A1 (en) |
| HU (1) | HU220873B1 (en) |
| IE (1) | IE74400B1 (en) |
| IL (1) | IL102361A (en) |
| MX (1) | MX9203845A (en) |
| NO (1) | NO178263C (en) |
| NZ (1) | NZ243388A (en) |
| PH (1) | PH31430A (en) |
| SG (1) | SG43001A1 (en) |
| SK (1) | SK280776B6 (en) |
| TW (1) | TW214547B (en) |
| ZA (1) | ZA924883B (en) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19528472A1 (en) * | 1995-08-03 | 1997-02-06 | Boehringer Ingelheim Kg | New process for the production of norbenzomorphan of an intermediate stage in the production of pharmaceutically valuable benzomorphan derivatives, in particular of (-) - (1R, 5S, S "R) -3'-hydroxy-2- (2-methoxypropyl -) - 5.9.9 -trimethyl-6.7 benzomorphan |
| DE19740110A1 (en) | 1997-09-12 | 1999-03-18 | Boehringer Ingelheim Pharma | Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-10-ols, process for their preparation and their use as medicaments |
| JPH1196519A (en) * | 1997-09-17 | 1999-04-09 | Alps Electric Co Ltd | Spin valve type thin-film element and its production |
| US6136980A (en) * | 1998-05-01 | 2000-10-24 | Boehringer Ingelheim Kg | Method of preparing norbenzomorphane as an intermediate in the preparation of pharmaceutically useful benzomorphane derivatives, in particular (-)-(1R,5S,2"R)-3'-hydroxy-2-(2-methoxypropyl)-5,9,9-trimethyl-6,7-benzo morphane |
| DE19826365A1 (en) * | 1998-06-12 | 1999-12-16 | Gruenenthal Gmbh | Use of benzomorphan derivatives as an analgesic |
| US6355652B1 (en) | 1999-11-27 | 2002-03-12 | Boehringer Ingelheim Pharma Kg | Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines and their use as pharmaceutical compositions |
| DE19957156A1 (en) * | 1999-11-27 | 2001-05-31 | Boehringer Ingelheim Pharma | New amino and fluoro substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocine derivatives useful in treatment of e.g. arrythmias, spasms, ischaemia, pain and neurodegenerative disorders |
| DE10204276A1 (en) * | 2002-02-02 | 2003-08-07 | Boehringer Ingelheim Pharma | N-Allyloxyethyl-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines and their use as pharmaceuticals |
| US7923454B2 (en) | 2002-05-17 | 2011-04-12 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| EP1506174B1 (en) | 2002-05-17 | 2015-09-30 | Taiwanj Pharmaceuticals Co., Ltd. | Use of naltrexone for treating kidney and liver damage |
| US7501433B2 (en) | 2002-05-17 | 2009-03-10 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| US8017622B2 (en) | 2003-05-16 | 2011-09-13 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| US8859580B2 (en) * | 2007-11-16 | 2014-10-14 | Boehringer Ingelheim International Gmbh | Aryl- and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use |
| US9862726B2 (en) | 2013-12-26 | 2018-01-09 | Purdue Pharma L.P. | Opioid receptor modulating oxabicyclo[2.2.2]octane morphinans |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL7804509A (en) * | 1978-04-26 | 1979-10-30 | Acf Chemiefarma Nv | Novel 6,7-benzomorphan derivatives and their acid addition salts. |
| DE2828039A1 (en) * | 1978-06-26 | 1980-01-10 | Boehringer Sohn Ingelheim | 2- (2-ALKOXYETHYL) -2'-HYDROXY-6,7-BENZOMORPHANES THEIR ACID ADDITION SALTS, THESE MEDICINAL PRODUCTS, AND METHOD FOR THE PRODUCTION THEREOF |
| NL7907800A (en) * | 1979-10-23 | 1981-04-27 | Acf Chemiefarma Nv | Novel 6,7-benzomorphan derivatives and their acid addition salts, pharmaceutical compositions containing such a compound, and process for the preparation of these compounds and their pharmaceutical compositions. |
-
1991
- 1991-07-02 DE DE4121821A patent/DE4121821A1/en not_active Withdrawn
-
1992
- 1992-06-03 TW TW081104377A patent/TW214547B/zh not_active IP Right Cessation
- 1992-06-27 AT AT92110923T patent/ATE137749T1/en active
- 1992-06-27 DE DE59206212T patent/DE59206212D1/en not_active Expired - Lifetime
- 1992-06-27 ES ES92110923T patent/ES2086585T3/en not_active Expired - Lifetime
- 1992-06-27 SG SG1996002082A patent/SG43001A1/en unknown
- 1992-06-27 EP EP92110923A patent/EP0521422B1/en not_active Expired - Lifetime
- 1992-06-27 DK DK92110923.7T patent/DK0521422T3/en active
- 1992-06-30 AU AU18686/92A patent/AU657330B2/en not_active Expired
- 1992-06-30 MX MX9203845A patent/MX9203845A/en unknown
- 1992-06-30 CA CA002072814A patent/CA2072814C/en not_active Expired - Lifetime
- 1992-06-30 NZ NZ243388A patent/NZ243388A/en not_active IP Right Cessation
- 1992-06-30 IL IL10236192A patent/IL102361A/en not_active IP Right Cessation
- 1992-07-01 NO NO922603A patent/NO178263C/en not_active IP Right Cessation
- 1992-07-01 FI FI923050A patent/FI105913B/en not_active IP Right Cessation
- 1992-07-01 IE IE922144A patent/IE74400B1/en not_active IP Right Cessation
- 1992-07-01 ZA ZA924883A patent/ZA924883B/en unknown
- 1992-07-01 JP JP17447992A patent/JP3324785B2/en not_active Expired - Lifetime
- 1992-07-01 KR KR1019920011664A patent/KR100251256B1/en not_active IP Right Cessation
- 1992-07-01 HU HU9202199A patent/HU220873B1/en unknown
- 1992-07-02 PH PH44606A patent/PH31430A/en unknown
- 1992-07-02 SK SK2075-92A patent/SK280776B6/en not_active IP Right Cessation
- 1992-07-02 CZ CS19922075A patent/CZ286949B6/en not_active IP Right Cessation
-
1996
- 1996-05-31 GR GR960401503T patent/GR3020124T3/en unknown
-
1998
- 1998-03-16 HK HK98102148A patent/HK1003111A1/en not_active IP Right Cessation
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK1K | Patent expired |