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NO900661L - ISOMERE DIDEOXYNUCLEOTIDES. - Google Patents

ISOMERE DIDEOXYNUCLEOTIDES.

Info

Publication number
NO900661L
NO900661L NO90900661A NO900661A NO900661L NO 900661 L NO900661 L NO 900661L NO 90900661 A NO90900661 A NO 90900661A NO 900661 A NO900661 A NO 900661A NO 900661 L NO900661 L NO 900661L
Authority
NO
Norway
Prior art keywords
amino
isomere
dideoxynucleotides
purin
compounds
Prior art date
Application number
NO90900661A
Other languages
Norwegian (no)
Other versions
NO900661D0 (en
Inventor
Donna Mary Huryn
Steven Yik-Kai Tam
Manfred Weigele
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO900661D0 publication Critical patent/NO900661D0/en
Publication of NO900661L publication Critical patent/NO900661L/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
    • B23B—TURNING; BORING
    • B23B51/00—Tools for drilling machines
    • B23B51/08—Drills combined with tool parts or tools for performing additional working
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/22—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/08—Six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/12—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by acids having the group -X-C(=X)-X-, or halides thereof, in which each X means nitrogen, oxygen, sulfur, selenium or tellurium, e.g. carbonic acid, carbamic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Mechanical Engineering (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Furan Compounds (AREA)

Abstract

Forbindelser med formel. hvori A er 6-amino-9H-purin-9-yl eller 2-amino-6-hydroksy-9H-purin-9-yl, hvori aminogruppen kan være erstattet med NHC(0)Reller N=Cog R er OH eller OCfOJ,vorunder,,3 og Ruavhengig av hverandre kan være rettkjedet eller forgrenet C-Co-alkylC-Calkolcsyalkyl• substituert eller usubstituert fenoksy-C-C-alkyl, fenyl eller fenyl som er substituert med halogen, C-C-alkoksy, nitro, hydroksy, karboksyl eller alkyl-amino, og farmasøytisk anvendelige salter derav. Fremstilling av forbindelsene er beskrevet. De er anvendelige i midler for bekjempelse av retrovirusinfeksjoner såsom HIV.Compounds of formula. wherein A is 6-amino-9H-purin-9-yl or 2-amino-6-hydroxy-9H-purin-9-yl, wherein the amino group may be replaced by NHC (O) R or N = Cog R is OH or OCfOJ , including ,, 3 and Ru independently of one another may be straight-chain or branched C alkylamino, and pharmaceutically usable salts thereof. Preparation of the compounds is described. They are useful in agents for combating retroviral infections such as HIV.

NO90900661A 1989-02-13 1990-02-12 ISOMERE DIDEOXYNUCLEOTIDES. NO900661L (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/309,561 US5126347A (en) 1989-02-13 1989-02-13 Isomeric dideoxynuclesides

Publications (2)

Publication Number Publication Date
NO900661D0 NO900661D0 (en) 1990-02-12
NO900661L true NO900661L (en) 1990-08-14

Family

ID=23198718

Family Applications (1)

Application Number Title Priority Date Filing Date
NO90900661A NO900661L (en) 1989-02-13 1990-02-12 ISOMERE DIDEOXYNUCLEOTIDES.

Country Status (18)

Country Link
US (1) US5126347A (en)
EP (1) EP0383239A1 (en)
JP (1) JPH02235883A (en)
KR (1) KR900012944A (en)
AU (1) AU4972090A (en)
CA (1) CA2009658A1 (en)
CZ (1) CZ63990A3 (en)
FI (1) FI900677A0 (en)
HU (1) HU205367B (en)
IL (1) IL93336A0 (en)
MC (1) MC2095A1 (en)
MX (1) MX19466A (en)
NO (1) NO900661L (en)
NZ (1) NZ232452A (en)
PT (1) PT93122A (en)
RU (1) RU1809831C (en)
YU (1) YU26690A (en)
ZA (1) ZA90487B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA914894B (en) * 1990-07-02 1992-04-29 Squibb & Sons Inc Purinyl and pyrimidinyl tetrahydrofurans
US5272152A (en) * 1990-07-02 1993-12-21 E. R. Squibb & Sons, Inc. Purinyl and pyrimidinyl tetrahydrofurans

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4289884A (en) * 1979-01-08 1981-09-15 Shell Oil Company Herbicidal tetrahydrofuran derivatives
JPS5998099A (en) * 1982-11-05 1984-06-06 Fujisawa Pharmaceut Co Ltd Novel tetrahydrofurancarboxylic acid derivative, its preparation and pharmaceutical composition thereof
US4772606A (en) * 1985-08-22 1988-09-20 Warner-Lambert Company Purine derivatives
US4788181A (en) * 1986-09-29 1988-11-29 The United States Of America As Represented By The Department Of Health And Human Services 5-substituted-2',3'-dideoxycytidine compounds with anti-HTLV-III activity
EP0277599A3 (en) * 1987-01-30 1990-05-09 Asahi Glass Company Ltd. Fluorine containing cyclopentane derivatives and processes for their production
US4916224A (en) * 1988-01-20 1990-04-10 Regents Of The University Of Minnesota Dideoxycarbocyclic nucleosides

Also Published As

Publication number Publication date
NO900661D0 (en) 1990-02-12
HUT52781A (en) 1990-08-28
IL93336A0 (en) 1990-11-29
YU26690A (en) 1992-05-28
CA2009658A1 (en) 1990-08-13
KR900012944A (en) 1990-09-03
ZA90487B (en) 1990-10-31
FI900677A0 (en) 1990-02-12
HU900757D0 (en) 1990-04-28
US5126347A (en) 1992-06-30
RU1809831C (en) 1993-04-15
MX19466A (en) 1993-10-01
MC2095A1 (en) 1991-02-15
HU205367B (en) 1992-04-28
NZ232452A (en) 1992-04-28
AU4972090A (en) 1990-08-16
JPH02235883A (en) 1990-09-18
PT93122A (en) 1990-08-31
EP0383239A1 (en) 1990-08-22
CZ63990A3 (en) 1993-03-17

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