NO892761L - PROCEDURE FOR MANUFACTURING INHIBITORS FOR 3-KETO-HMG-COA REDUCTASE. - Google Patents
PROCEDURE FOR MANUFACTURING INHIBITORS FOR 3-KETO-HMG-COA REDUCTASE.Info
- Publication number
- NO892761L NO892761L NO89892761A NO892761A NO892761L NO 892761 L NO892761 L NO 892761L NO 89892761 A NO89892761 A NO 89892761A NO 892761 A NO892761 A NO 892761A NO 892761 L NO892761 L NO 892761L
- Authority
- NO
- Norway
- Prior art keywords
- optionally substituted
- hmg
- coa reductase
- keto
- procedure
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pyrane Compounds (AREA)
Abstract
Forbindelser med formel (I) og (II):. hvor Rer eventuelt substituert c_alkyl, C_-alkoxy, C_-alkenyl, eventuelt substituert C_g-cycloalkyl, eventuelt substituert fenyl, eventuelt substituert amino, piperidinyl, pyrroli-dinyl, piperazinyl, morfolinyl, thio-morfolinyl eller RS hvor er C_-alkyl eller eventuelt substituert fenyl, Rer H, CHeller CHOH, Z er hydrogen, eventuelt substituert C-alkyl hvor substituenten er valgt fra fenyl, dimethylamino og acetylamino, eller 2,3-hydroxypropyl, og a er en enkeltbinding eller en dobbeltbinding, samt farmasøyt-isk akseptable salter av forbindelse (II) hvor Z er hydrogen. Forbindelsene er HMG-CoA-reduktaseinhibitorer.Mellomprodukter og fremstillingen av forbindelsene er beskrevet.Compounds of formula (I) and (II):. wherein R 1 is optionally substituted C 1-6 alkyl, C 1-4 alkoxy, C 1-4 alkenyl, optionally substituted C 1-8 cycloalkyl, optionally substituted phenyl, optionally substituted amino, piperidinyl, pyrrolidinyl, piperazinyl, morpholinyl, thio-morpholinyl or R 5 where is C 1-4 alkyl or optionally substituted phenyl, R 1 H, CH or CHOH, Z is hydrogen, optionally substituted C-alkyl wherein the substituent is selected from phenyl, dimethylamino and acetylamino, or 2,3-hydroxypropyl, and a is a single bond or a double bond, and is pharmaceutically acceptable salts of compound (II) wherein Z is hydrogen. The compounds are HMG-CoA reductase inhibitors. Intermediates and the preparation of the compounds are described.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/363,792 US4968693A (en) | 1988-03-02 | 1989-06-09 | 3-keto HMG-COA reductase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO892761D0 NO892761D0 (en) | 1989-07-04 |
| NO892761L true NO892761L (en) | 1990-12-10 |
Family
ID=23431752
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO89892761A NO892761L (en) | 1989-06-09 | 1989-07-04 | PROCEDURE FOR MANUFACTURING INHIBITORS FOR 3-KETO-HMG-COA REDUCTASE. |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JPH0324033A (en) |
| CN (1) | CN1047863A (en) |
| AU (1) | AU618106B2 (en) |
| CA (1) | CA1328877C (en) |
| DK (1) | DK330389A (en) |
| FI (1) | FI893272A (en) |
| HU (1) | HUT54133A (en) |
| IE (1) | IE892191L (en) |
| IL (1) | IL90847A0 (en) |
| NO (1) | NO892761L (en) |
| NZ (1) | NZ229806A (en) |
| PT (1) | PT91204B (en) |
| YU (1) | YU144589A (en) |
| ZA (1) | ZA895140B (en) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4668699A (en) * | 1985-08-05 | 1987-05-26 | Merck & Co., Inc. | Novel HMG-CoA reductase inhibitors |
| PT85109A (en) * | 1986-06-23 | 1987-07-01 | Merck & Co Inc | Process for the preparation of hydroxy-tetrahydropyranone derivatives or corresponding ring opened dihydroxy acids which are hmg-coa reductase inhibitors |
| US5073568A (en) * | 1988-11-14 | 1991-12-17 | Hoffmann-La Roche Inc. | Antipsoriatic agents |
-
1989
- 1989-07-03 IL IL90847A patent/IL90847A0/en unknown
- 1989-07-04 NZ NZ229806A patent/NZ229806A/en unknown
- 1989-07-04 NO NO89892761A patent/NO892761L/en unknown
- 1989-07-04 AU AU37838/89A patent/AU618106B2/en not_active Ceased
- 1989-07-04 DK DK330389A patent/DK330389A/en not_active Application Discontinuation
- 1989-07-04 HU HU893370A patent/HUT54133A/en unknown
- 1989-07-05 FI FI893272A patent/FI893272A/en not_active IP Right Cessation
- 1989-07-05 CA CA000604835A patent/CA1328877C/en not_active Expired - Fee Related
- 1989-07-06 ZA ZA895140A patent/ZA895140B/en unknown
- 1989-07-06 IE IE892191A patent/IE892191L/en unknown
- 1989-07-12 JP JP1178204A patent/JPH0324033A/en active Pending
- 1989-07-18 YU YU01445/89A patent/YU144589A/en unknown
- 1989-07-18 PT PT91204A patent/PT91204B/en not_active IP Right Cessation
- 1989-08-12 CN CN89106377A patent/CN1047863A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| HUT54133A (en) | 1991-01-28 |
| CN1047863A (en) | 1990-12-19 |
| JPH0324033A (en) | 1991-02-01 |
| DK330389D0 (en) | 1989-07-04 |
| FI893272A (en) | 1990-12-10 |
| FI893272A0 (en) | 1989-07-05 |
| ZA895140B (en) | 1990-03-28 |
| IL90847A0 (en) | 1990-02-09 |
| NO892761D0 (en) | 1989-07-04 |
| YU144589A (en) | 1990-12-31 |
| DK330389A (en) | 1990-12-10 |
| IE892191L (en) | 1990-12-09 |
| CA1328877C (en) | 1994-04-26 |
| AU3783889A (en) | 1990-12-13 |
| PT91204A (en) | 1991-02-08 |
| NZ229806A (en) | 1991-12-23 |
| AU618106B2 (en) | 1991-12-12 |
| PT91204B (en) | 1995-03-31 |
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