NO882454D0 - Plasminogen-aktivator. - Google Patents

Plasminogen-aktivator.

Info

Publication number: NO882454D0
Authority: NO; Norway
Prior art keywords: analogs; plasminogen activator; domain; native; diluent
Prior art date: 1987-06-04

Application number

NO882454A

Other languages

English (en)

Other versions

NO179874B (no

NO179874C (no

NO882454L (no

Inventor

Eileen R Mulvihill

Patrick J O'hara

Bjoern A Nexoe

Shinji Yoshitake

Yasunori Ikeda

Suguru Suzuki

Akira Hashimoto

Teruaki Yuzuriha

Original Assignee

Zymogenetics Inc

Novo Industri As

Eisai Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-06-04

Filing date

1988-06-03

Publication date

1988-06-03

1988-06-03 Application filed by Zymogenetics Inc, Novo Industri As, Eisai Co Ltd filed Critical Zymogenetics Inc

1988-06-03 Publication of NO882454D0 publication Critical patent/NO882454D0/no

1988-12-05 Publication of NO882454L publication Critical patent/NO882454L/no

1996-09-23 Publication of NO179874B publication Critical patent/NO179874B/no

1997-01-02 Publication of NO179874C publication Critical patent/NO179874C/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
General Health & Medical Sciences (AREA)
General Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biomedical Technology (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Biophysics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Hematology (AREA)
Toxicology (AREA)
Gastroenterology & Hepatology (AREA)
Diabetes (AREA)
Veterinary Medicine (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Enzymes And Modification Thereof (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Semiconductor Integrated Circuits (AREA)

NO882454A 1987-06-04 1988-06-03 Fremgangsmåte for fremstilling av en t-PA-analog, DNA-sekvens som koder for t-PA-analogen, samt ekspresjonsvektor omfattende DNA-sekvensen og vertcelle omfattende denne NO179874C (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US5806187A	1987-06-04	1987-06-04
US16284788A	1988-03-02	1988-03-02

Publications (4)

Publication Number	Publication Date
NO882454D0 true NO882454D0 (no)	1988-06-03
NO882454L NO882454L (no)	1988-12-05
NO179874B NO179874B (no)	1996-09-23
NO179874C NO179874C (no)	1997-01-02

Family

ID=26737188

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO882454A NO179874C (no)	1987-06-04	1988-06-03	Fremgangsmåte for fremstilling av en t-PA-analog, DNA-sekvens som koder for t-PA-analogen, samt ekspresjonsvektor omfattende DNA-sekvensen og vertcelle omfattende denne

Country Status (14)

Country	Link
US (1)	US5403734A (no)
EP (1)	EP0293936B1 (no)
JP (1)	JPS6485079A (no)
KR (1)	KR0135427B1 (no)
AT (1)	ATE118815T1 (no)
AU (1)	AU625752B2 (no)
CA (1)	CA1341446C (no)
DE (1)	DE3853100T2 (no)
DK (1)	DK302388A (no)
ES (1)	ES2069536T3 (no)
FI (1)	FI101306B (no)
IE (1)	IE67036B1 (no)
NO (1)	NO179874C (no)
NZ (1)	NZ224914A (no)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5714372A (en) *	1985-04-22	1998-02-03	Genentech, Inc.	Tissue plasminogen activator variants
US5756093A (en) *	1985-04-22	1998-05-26	Genentech, Inc.	Tissue plasminogen activator variants
US5736134A (en) *	1985-04-22	1998-04-07	Genentech, In.C	Tissue plasminogen activator variants
IE64782B1 (en) *	1987-06-04	1995-09-06	Eisai Co Ltd	Mutant t-PA with kringle replacement
GB8815135D0 (en) *	1988-06-24	1988-08-03	British Bio Technology	Proteins & nucleic acids
US5262170A (en) *	1988-09-02	1993-11-16	Genentech, Inc.	Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells
US5108901A (en) *	1988-09-02	1992-04-28	Genentech, Inc.	Tissue plasminogen activator having zymogenic or fibrin specific properties
US5714145A (en) *	1988-09-02	1998-02-03	Genentech, Inc.	Tissue plasminogen activator having zymogenic or fibrin specific properties
US5258180A (en) *	1988-09-02	1993-11-02	Genetech, Inc.	Tissue plasminogen activator having fibrin specific properties and deletion of amino acids 466-970, compositions and methods of treatment
US5087572A (en) *	1989-12-01	1992-02-11	Genentech, Inc.	Dna encoding human plasminogen modified at the cleavage site
US5190756A (en) *	1989-12-01	1993-03-02	Genentech, Inc.	Methods and materials for expression of human plasminogen variant
JPH0595786A (ja) *	1991-10-07	1993-04-20	Green Cross Corp:The	変異ヒトプロウロキナーゼ
EP0643772B1 (en) *	1992-06-03	1997-07-23	Genentech, Inc.	Tissue plasminogen activator glycosylation variants with improved therapeutic properties
US6706504B1 (en)	1996-11-12	2004-03-16	The Scripps Research Institute	Tissue type plasminogen activator (t-PA) variants: compositions and methods of use
CA2807749C (en) *	2010-08-05	2023-02-28	Council Of Scientific & Industrial Research	Protein fusion constructs possessing thrombolytic and anticoagulant properties

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GR79202B (no) *	1982-05-05	1984-10-22	Genentech Inc
WO1984001786A1 (en) *	1982-10-28	1984-05-10	Beecham Group Plc	Enzyme derivatives and their use in the treatment of thrombosis
NZ215660A (en) *	1985-04-04	1990-03-27	Beecham Group Plc	Tissue plasminogen activator modified in the growth factor domain
ATE68825T1 (de) *	1985-04-22	1991-11-15	Genentech Inc	Plasminogenaktivator-mutante des menschlichen gewebes, verfahren und zwischenprodukte dafuer und diese mutante verwendende zusammensetzungen.
US4916071A (en) *	1985-08-14	1990-04-10	American Home Products Corporation	Poly-kringle plasminogen activator
DE3789664T3 (de) *	1986-01-31	2004-09-16	Genetics Institute, LLC, Cambridge	Neue thrombolytische proteine.
GB2200640B (en) *	1987-01-30	1991-07-10	American Home Prod	Des-epidermal growth factor plasminogen activators

1988
- 1988-06-03 AT AT88108951T patent/ATE118815T1/de not_active IP Right Cessation
- 1988-06-03 IE IE168088A patent/IE67036B1/en not_active IP Right Cessation
- 1988-06-03 DK DK302388A patent/DK302388A/da not_active Application Discontinuation
- 1988-06-03 FI FI882627A patent/FI101306B/fi active IP Right Grant
- 1988-06-03 DE DE3853100T patent/DE3853100T2/de not_active Expired - Fee Related
- 1988-06-03 NO NO882454A patent/NO179874C/no not_active IP Right Cessation
- 1988-06-03 ES ES88108951T patent/ES2069536T3/es not_active Expired - Lifetime
- 1988-06-03 EP EP88108951A patent/EP0293936B1/en not_active Expired - Lifetime
- 1988-06-04 JP JP63138233A patent/JPS6485079A/ja active Granted
- 1988-06-04 KR KR1019880006717A patent/KR0135427B1/ko not_active IP Right Cessation
- 1988-06-06 CA CA000568718A patent/CA1341446C/en not_active Expired - Fee Related
- 1988-06-06 AU AU17430/88A patent/AU625752B2/en not_active Ceased
- 1988-06-07 NZ NZ224914A patent/NZ224914A/xx unknown
1991
- 1991-10-15 US US07/776,854 patent/US5403734A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
FI882627L (fi)	1988-12-05
NO179874B (no)	1996-09-23
EP0293936A3 (en)	1989-09-20
JPH0448434B2 (no)	1992-08-06
CA1341446C (en)	2003-11-18
ATE118815T1 (de)	1995-03-15
IE67036B1 (en)	1996-05-15
NO179874C (no)	1997-01-02
AU1743088A (en)	1988-12-08
EP0293936A2 (en)	1988-12-07
DE3853100T2 (de)	1995-08-03
DE3853100D1 (de)	1995-03-30
NZ224914A (en)	1991-02-26
KR890000521A (ko)	1989-03-15
US5403734A (en)	1995-04-04
AU625752B2 (en)	1992-07-16
KR0135427B1 (ko)	1998-04-23
ES2069536T3 (es)	1995-05-16
EP0293936B1 (en)	1995-02-22
FI101306B1 (fi)	1998-05-29
JPS6485079A (en)	1989-03-30
FI882627A0 (fi)	1988-06-03
DK302388A (da)	1989-02-03
FI101306B (fi)	1998-05-29
IE881680L (en)	1988-12-04
DK302388D0 (da)	1988-06-03
NO882454L (no)	1988-12-05

Publication	Publication Date	Title
NO882454D0 (no)	1988-06-03	Plasminogen-aktivator.
FR2591485B1 (fr)	1989-07-28	Compositions stabilisees contenant l'activateur du plasminogene du tissu humain.
GB8922026D0 (en)	1989-11-15	Novel anti-viral and cytotoxic agent
FI882628A0 (fi)	1988-06-03	T-pa mutaterad genom remplacering av en region bestaoende av tre disulfidbindningar (kringle).
NZ223293A (en)	1990-02-26	Beta-alkyl melatonins and pharmaceutical compositions
DE59005128D1 (de)	1994-04-28	t-PA pro STABILISIERUNG.
IT1231255B (it)	1991-11-28	Peptidi anoressizzanti e ipotensivi.

Legal Events

Date	Code	Title	Description
2008-06-23	MK1K	Patent expired