NO851423L - Benzazepinderivater, farmasoeytiske preparater inneholdende disse og fremgangsmaater for fremstilling av slike forbindelser og preparater - Google Patents

Benzazepinderivater, farmasoeytiske preparater inneholdende disse og fremgangsmaater for fremstilling av slike forbindelser og preparater

Info

Publication number: NO851423L
Authority: NO; Norway
Prior art keywords: group; benzazepine; acid; formula; tetrahydro
Prior art date: 1983-08-12

Application number

NO851423A

Other languages

English (en)

Norwegian (no)

Inventor

Joel Gilbert Berger

Wei Kong Chang

Elijah Herman Gold

Arthur John Elliott

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-08-12

Filing date

1985-04-10

Publication date

1985-04-10

1985-04-10 Application filed by Schering Corp filed Critical Schering Corp

1985-04-10 Publication of NO851423L publication Critical patent/NO851423L/no

Links

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238000002360 preparation method Methods 0.000 title claims description 17
238000000034 method Methods 0.000 title claims description 16
239000000825 pharmaceutical preparation Substances 0.000 title claims description 6
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-1 benzazePin-8-yl group Chemical group 0.000 claims description 27
125000000217 alkyl group Chemical group 0.000 claims description 26
150000003839 salts Chemical class 0.000 claims description 26
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238000006243 chemical reaction Methods 0.000 claims description 22
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230000010933 acylation Effects 0.000 claims description 12
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LVTJOONKWUXEFR-FZRMHRINSA-N protoneodioscin Natural products O(C[C@@H](CC[C@]1(O)[C@H](C)[C@@H]2[C@]3(C)[C@H]([C@H]4[C@@H]([C@]5(C)C(=CC4)C[C@@H](O[C@@H]4[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@@H](O)[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@H](CO)O4)CC5)CC3)C[C@@H]2O1)C)[C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H](CO)O1 LVTJOONKWUXEFR-FZRMHRINSA-N 0.000 description 1
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201000000980 schizophrenia Diseases 0.000 description 1
229910000029 sodium carbonate Inorganic materials 0.000 description 1
JVBXVOWTABLYPX-UHFFFAOYSA-L sodium dithionite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])=O JVBXVOWTABLYPX-UHFFFAOYSA-L 0.000 description 1
238000010561 standard procedure Methods 0.000 description 1
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YROXIXLRRCOBKF-UHFFFAOYSA-N sulfonylurea Chemical class OC(=N)N=S(=O)=O YROXIXLRRCOBKF-UHFFFAOYSA-N 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

NO851423A 1983-08-12 1985-04-10 Benzazepinderivater, farmasoeytiske preparater inneholdende disse og fremgangsmaater for fremstilling av slike forbindelser og preparater NO851423L (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US52294883A	1983-08-12	1983-08-12

Publications (1)

Publication Number	Publication Date
NO851423L true NO851423L (no)	1985-04-10

Family

ID=24083037

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO851423A NO851423L (no)	1983-08-12	1985-04-10	Benzazepinderivater, farmasoeytiske preparater inneholdende disse og fremgangsmaater for fremstilling av slike forbindelser og preparater

Country Status (11)

Country	Link
US (1)	US4996202A (da)
EP (2)	EP0135767A1 (da)
JP (1)	JPS60502007A (da)
KR (1)	KR850700030A (da)
AU (1)	AU572198B2 (da)
CA (1)	CA1234110A (da)
DK (1)	DK160885D0 (da)
FI (1)	FI76075C (da)
HU (1)	HU193711B (da)
NO (1)	NO851423L (da)
WO (1)	WO1985000808A1 (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK180485D0 (da) *	1985-04-22	1985-04-23	Novo Industri As	Nitrogenholdige forbindelser
US4707483A (en) *	1985-12-20	1987-11-17	Smithkline Beckman Corporation	1-phenyl-3-benzazepines and their use for treating gastrointestinal motility disorders
EP0244088A3 (en) *	1986-04-03	1989-03-15	Smithkline Beecham Corporation	1-phenyl-3-benzazepine compounds and medicaments containing these compounds for treating gastrointestinal motility disorders
DK67489D0 (da) *	1989-02-14	1989-02-14	Novo Industri As	Nye benzazepinderivater
DK26793D0 (da) *	1993-03-10	1993-03-10	Novo Nordisk As	Benzofuranyl- eller dihydrobenzofuranyl-substituerede tricycliske benzazepiner, der anvendelse og fremstilling
US6009909A (en) *	1997-12-09	2000-01-04	Daimlerchrysler Corporation	Method and apparatus for fluid transport

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3395150A (en) *	1965-02-26	1968-07-30	Squibb & Sons Inc	Benzothiazepine carboxamides and derivatives thereof
CA974989A (en) *	1968-03-11	1975-09-23	Wallace And Tiernan Inc.	Process for preparing 1,2,4,5-tetrahydro-3h,3-benzazepines and products obtained thereby
US4210749A (en) *	1974-11-12	1980-07-01	Pennwalt Corporation	Substituted 1,2,4,5-tetrahydro-3H,3 benzazepines
GB1600748A (en) *	1977-05-23	1981-10-21	Sandoz Ltd	Benzazepine derivatives
ZA792044B (en) *	1978-05-08	1980-05-28	Scherico Ltd	Substituted 1-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepines,process for the preparation thereof,and pharmaceutical compositions containing them
US4261890A (en) *	1979-02-26	1981-04-14	Warner-Lambert Company	Substituted tetrahydrobenzazepines and tetrahydronaphthazepines and methods for their production
US4284555A (en) *	1979-04-27	1981-08-18	Schering Corporation	7-Chloro-8(substituted amino carbonyloxy)-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
US4284556A (en) *	1980-01-31	1981-08-18	Smithkline Corporation	7,8-Amino, hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines

1984
- 1984-08-09 CA CA000460640A patent/CA1234110A/en not_active Expired
- 1984-08-10 WO PCT/EP1984/000245 patent/WO1985000808A1/en not_active Application Discontinuation
- 1984-08-10 AU AU33901/84A patent/AU572198B2/en not_active Ceased
- 1984-08-10 KR KR1019850700006A patent/KR850700030A/ko not_active Application Discontinuation
- 1984-08-10 EP EP84109567A patent/EP0135767A1/en active Pending
- 1984-08-10 HU HU844168A patent/HU193711B/hu unknown
- 1984-08-10 EP EP84903280A patent/EP0153400A1/en not_active Ceased
- 1984-08-10 JP JP59503339A patent/JPS60502007A/ja active Pending
1985
- 1985-03-27 FI FI851221A patent/FI76075C/fi not_active IP Right Cessation
- 1985-04-10 DK DK160885A patent/DK160885D0/da not_active IP Right Cessation
- 1985-04-10 NO NO851423A patent/NO851423L/no unknown
- 1985-10-17 US US06/788,274 patent/US4996202A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0135767A1 (en)	1985-04-03
FI76075B (fi)	1988-05-31
HU193711B (en)	1987-11-30
HUT37760A (en)	1986-02-28
AU3390184A (en)	1985-03-12
AU572198B2 (en)	1988-05-05
CA1234110A (en)	1988-03-15
US4996202A (en)	1991-02-26
KR850700030A (ko)	1985-10-21
FI76075C (fi)	1988-09-09
FI851221A0 (fi)	1985-03-27
EP0153400A1 (en)	1985-09-04
JPS60502007A (ja)	1985-11-21
WO1985000808A1 (en)	1985-02-28
FI851221L (fi)	1985-03-27
DK160885A (da)	1985-04-10
DK160885D0 (da)	1985-04-10

Publication	Publication Date	Title
US4748182A (en)	1988-05-31	Aromatic 2-aminoalkyl-1,2-benzoisothiazol-3(2H)one-1,1-dioxide derivatives and their use as anti-hypertensive and anxiolytic agents
CA1242193A (en)	1988-09-20	1-benzyl-aminoalkyl-pyrrolidinones and the acid addition salts thereof, processes for preparing them and pharmaceutical compositions
EP0170213B1 (en)	1990-01-10	Glutarimide antianxiety and antihypertensive agents
DK165688B (da)	1993-01-04	5,7,8-trisubstituerede 2,3,4,5-tetrahydro-1h-3-benzazepiner, farmaceutiske praeparater indeholdende forbindelserne og anvendelse af forbindelserne til fremstilling af farmaceutiske praeparater til behandling af psykoser
CA1333485C (en)	1994-12-13	Fused benzazepines
US4973586A (en)	1990-11-27	Fused benzazepines, compositions of, and medical use thereof
NO851423L (no)	1985-04-10	Benzazepinderivater, farmasoeytiske preparater inneholdende disse og fremgangsmaater for fremstilling av slike forbindelser og preparater
US4977175A (en)	1990-12-11	4,5,6,7-tetrahydrobenzimidazole derivatives as 5HT3 -antagonists
JPS5959685A (ja)	1984-04-05	新規なピペリジン誘導体
JPH0377866A (ja)	1991-04-03	新規４，４‐二置換ピペリジン誘導体、それらを含む医薬組成物およびそれらの調製方法
EP0233049A1 (en)	1987-08-19	2,3,4,8,9,9a-Hexahydro-4-aryl-1H-indeno[1,7-cd]azepines
DE3780649T2 (de)	1992-12-10	Kondensierte benzazepine.
US4789676A (en)	1988-12-06	Aromatic 2-aminoalkyl-1,2-benzoisothiazol-3(2H)one-1,1-dioxide derivatives, usefull as anxiolytic agents
Remy et al.	1977	A comparison of the antiserotonin, antihistamine, and anticholinergic activity of cyproheptadine with analogs having furan nuclei fused to the 10, 11-vinylene bridge
JPS5823667A (ja)	1983-02-12	キノリン類の製法
US4920118A (en)	1990-04-24	Aromatic 2-aminoalkyl-1,2-benzoisothiazol-3-(2H)one-1,1-dioxide and their use as anxiolytic and anti-hypertensive agents
KR100917041B1 (ko)	2009-09-10	5-ｈｔ7 수용체에 길항작용을 갖는 신규한 화합물
NO763062L (da)	1977-03-16
US4954500A (en)	1990-09-04	Aromatic 2-aminoalkyl-1,2-benzoisothiazol-3(2H)one-1,1-dioxide derivatives
US4857526A (en)	1989-08-15	Aromatic 2-aminoalkyl-1,2-benzoisothiazol-3(2H)-one-1,1-dioxide
EP0551312A1 (en)	1993-07-21	Peri-condensed benzazepines
KR790001028B1 (ko)	1979-08-21	1,3,4-트리치환-4-아릴피페리딘류의 제조방법
JPH05320157A (ja)	1993-12-03	１−置換アルキルキノキサリン誘導体およびその用途
JPH0667933B2 (ja)	1994-08-31	芳香族ω−アルキルイミノテトラヒドロ−６Ｈ−１，３−チアジン−６−オン誘導体
GB2153354A (en)	1985-08-21	Novel therapeutically active compounds of the formula