NO821086L - Fremgangsmaate for fremstilling av 8-(4-(4-(2-pyrimidinyl)-1-piperazinyl)-butyl)-8-azaspiro(4,5) dekan-7,9-dion - Google Patents

Fremgangsmaate for fremstilling av 8-(4-(4-(2-pyrimidinyl)-1-piperazinyl)-butyl)-8-azaspiro(4,5) dekan-7,9-dion

Info

Publication number: NO821086L
Authority: NO; Norway
Prior art keywords: compound; formula; azaspiro; butyl; pyrimidinyl
Prior art date: 1981-04-09

Application number

NO821086A

Other languages

English (en)

Norwegian (no)

Inventor

Pekka Juhani Kairisalo

Erkki Juhani Honkanen

Original Assignee

Orion Yhtymae Oy

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-04-09

Filing date

1982-03-31

Publication date

1982-10-11

1982-03-31 Application filed by Orion Yhtymae Oy filed Critical Orion Yhtymae Oy

1982-10-11 Publication of NO821086L publication Critical patent/NO821086L/no

Links

238000000034 method Methods 0.000 title claims description 9
QWCRAEMEVRGPNT-UHFFFAOYSA-N buspirone Chemical compound C1C(=O)N(CCCCN2CCN(CC2)C=2N=CC=CN=2)C(=O)CC21CCCC2 QWCRAEMEVRGPNT-UHFFFAOYSA-N 0.000 title claims description 6
ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 12
150000001875 compounds Chemical class 0.000 claims description 11
LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims description 6
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 3
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 3
FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 claims description 3
229910052783 alkali metal Inorganic materials 0.000 claims description 3
125000003118 aryl group Chemical group 0.000 claims description 3
229910052801 chlorine Inorganic materials 0.000 claims description 3
239000000460 chlorine Substances 0.000 claims description 3
238000002360 preparation method Methods 0.000 claims description 3
229910052708 sodium Inorganic materials 0.000 claims description 3
239000011734 sodium Substances 0.000 claims description 3
150000001340 alkali metals Chemical class 0.000 claims description 2
125000000217 alkyl group Chemical group 0.000 claims description 2
239000000010 aprotic solvent Substances 0.000 claims description 2
125000005843 halogen group Chemical group 0.000 claims description 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 claims description 2
-1 sodium Chemical class 0.000 claims description 2
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 6
BCNBRBQCDHLCBD-UHFFFAOYSA-N 8-(4-chlorobutyl)-8-azaspiro[4.5]decane-7,9-dione Chemical compound C1C(=O)N(CCCCCl)C(=O)CC11CCCC1 BCNBRBQCDHLCBD-UHFFFAOYSA-N 0.000 description 3
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
239000000203 mixture Substances 0.000 description 3
239000002904 solvent Substances 0.000 description 3
MRBFGEHILMYPTF-UHFFFAOYSA-N 1-(2-Pyrimidyl)piperazine Chemical compound C1CNCCN1C1=NC=CC=N1 MRBFGEHILMYPTF-UHFFFAOYSA-N 0.000 description 2
XBVZKHPTGUWNEH-UHFFFAOYSA-N 2-[4-(4-chlorobutyl)piperazin-1-yl]pyrimidine Chemical compound C1CN(CCCCCl)CCN1C1=NC=CC=N1 XBVZKHPTGUWNEH-UHFFFAOYSA-N 0.000 description 2
BLFRQYKZFKYQLO-UHFFFAOYSA-N 4-aminobutan-1-ol Chemical compound NCCCCO BLFRQYKZFKYQLO-UHFFFAOYSA-N 0.000 description 2
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
229960002495 buspirone Drugs 0.000 description 2
239000007788 liquid Substances 0.000 description 2
LRHPLDYGYMQRHN-UHFFFAOYSA-N 1-butanol Substances CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 1
238000005160 1H NMR spectroscopy Methods 0.000 description 1
FWPVKDFOUXHOKQ-UHFFFAOYSA-N 2-[1-(carboxymethyl)cyclopentyl]acetic acid Chemical compound OC(=O)CC1(CC(O)=O)CCCC1 FWPVKDFOUXHOKQ-UHFFFAOYSA-N 0.000 description 1
WBRXGQPUYZLAFA-UHFFFAOYSA-N 4-chlorobutyl 4-methylbenzenesulfonate Chemical compound CC1=CC=C(S(=O)(=O)OCCCCCl)C=C1 WBRXGQPUYZLAFA-UHFFFAOYSA-N 0.000 description 1
HUNFFPQEYDANPE-UHFFFAOYSA-N 4-chlorobutyl methanesulfonate Chemical compound CS(=O)(=O)OCCCCCl HUNFFPQEYDANPE-UHFFFAOYSA-N 0.000 description 1
GFWLMILMVMCJDI-UHFFFAOYSA-N 8-oxaspiro[4.5]decane-7,9-dione Chemical compound C1C(=O)OC(=O)CC11CCCC1 GFWLMILMVMCJDI-UHFFFAOYSA-N 0.000 description 1
AFVFQIVMOAPDHO-UHFFFAOYSA-M Methanesulfonate Chemical compound CS([O-])(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-M 0.000 description 1
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
239000003513 alkali Substances 0.000 description 1
JXLHNMVSKXFWAO-UHFFFAOYSA-N azane;7-fluoro-2,1,3-benzoxadiazole-4-sulfonic acid Chemical compound N.OS(=O)(=O)C1=CC=C(F)C2=NON=C12 JXLHNMVSKXFWAO-UHFFFAOYSA-N 0.000 description 1
239000004202 carbamide Substances 0.000 description 1
239000013078 crystal Substances 0.000 description 1
238000004821 distillation Methods 0.000 description 1
229940079593 drug Drugs 0.000 description 1
239000003814 drug Substances 0.000 description 1
229910052736 halogen Inorganic materials 0.000 description 1
150000002367 halogens Chemical class 0.000 description 1
150000003949 imides Chemical class 0.000 description 1
238000009776 industrial production Methods 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
229910052751 metal Inorganic materials 0.000 description 1
239000002184 metal Substances 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
229910000029 sodium carbonate Inorganic materials 0.000 description 1
239000007858 starting material Substances 0.000 description 1
238000003756 stirring Methods 0.000 description 1
125000001273 sulfonato group Chemical group [O-]S(*)(=O)=O 0.000 description 1
150000003512 tertiary amines Chemical class 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

NO821086A 1981-04-09 1982-03-31 Fremgangsmaate for fremstilling av 8-(4-(4-(2-pyrimidinyl)-1-piperazinyl)-butyl)-8-azaspiro(4,5) dekan-7,9-dion NO821086L (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FI811108		1981-04-09

Publications (1)

Publication Number	Publication Date
NO821086L true NO821086L (no)	1982-10-11

Family

ID=8514296

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO821086A NO821086L (no)	1981-04-09	1982-03-31	Fremgangsmaate for fremstilling av 8-(4-(4-(2-pyrimidinyl)-1-piperazinyl)-butyl)-8-azaspiro(4,5) dekan-7,9-dion

Country Status (3)

Country	Link
DK (1)	DK152730C (da)
NO (1)	NO821086L (da)
SE (1)	SE449224B (da)

1982
- 1982-03-31 NO NO821086A patent/NO821086L/no unknown
- 1982-04-02 SE SE8202132A patent/SE449224B/sv not_active IP Right Cessation
- 1982-04-07 DK DK160082A patent/DK152730C/da not_active IP Right Cessation

Also Published As

Publication number	Publication date
SE8202132L (sv)	1982-10-10
DK160082A (da)	1982-10-10
DK152730C (da)	1988-10-03
SE449224B (sv)	1987-04-13
DK152730B (da)	1988-05-02

Publication	Publication Date	Title
CA1138454A (en)	1982-12-28	Substituted 5-(2-imidazoline-2-yl)- aminopyrimidines and method for their production
KR820002136B1 (ko)	1982-11-15	2-아미노 피리미돈 화합물의 제조방법
EP0653421B1 (en)	1997-01-15	Process for preparing 2-cyanoimidazole compounds
KR20020000167A (ko)	2002-01-04	치환된 피리미딘의 제조방법
NO821086L (no)	1982-10-11	Fremgangsmaate for fremstilling av 8-(4-(4-(2-pyrimidinyl)-1-piperazinyl)-butyl)-8-azaspiro(4,5) dekan-7,9-dion
JP2762430B2 (ja)	1998-06-04	アラルキルアミノピリミジン類の製法
US5266697A (en)	1993-11-30	Process for the production of 2-substituted 4,6-dialkoxypyrimidines
KR970009726B1 (ko)	1997-06-17	4,6-비스(디플루오로메톡시)피리미딘의 제조방법
US20020004600A1 (en)	2002-01-10	Process for the preparation of substituted pyrimidines
CA1208213A (en)	1986-07-22	Process for producing heterocyclic compound having nitromethylene group as the side chain group
US4292431A (en)	1981-09-29	Process for the production of hydroxymethylimidazoles
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US6673925B2 (en)	2004-01-06	Method of producing thiobarbituric acid derivatives
FI72975B (fi)	1987-04-30	Foerfarande foer framstaellning av 8-(4- (4-(2-pyrimidinyl)-1-piperazinyl)butyl)-8-azaspiro(4,5)dekan-7,9-dion.
EP0293742A1 (de)	1988-12-07	Verfahren zur Herstellung von 4-Nitro-5-imidazolylethern und -thioethern
KR19990013838A (ko)	1999-02-25	피리딜메틸 이소티오시아네이트의 제조방법
US5208337A (en)	1993-05-04	Process for the preparation of aminopyrimidines
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US4526974A (en)	1985-07-02	Synthesis of 2-pyridylalkylamines
NO781587L (no)	1978-11-07	Benzylpyrimidiner og fremgangsmaate til fremstilling av disse
JPH0655711B2 (ja)	1994-07-27	シアノグアニジン誘導体の製造方法
SK142195A3 (en)	1996-04-03	Preparation of symetrical or unsymetrical disubstituted n-cyanoditioimino-carbonates