NO812427L - Antibiotisk virksomme cephalosporinforbindelser. - Google Patents

Antibiotisk virksomme cephalosporinforbindelser.

Info

Publication number: NO812427L
Authority: NO; Norway
Prior art keywords: formula; compounds; zero; group; preparation
Prior art date: 1980-07-15

Application number

NO812427A

Other languages

English (en)

Norwegian (no)

Inventor

Michele Di Schiena

Vittoria Orru

Original Assignee

Ausonia Farma Srl

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-07-15

Filing date

1981-07-14

Publication date

1982-01-18

1981-07-14 Application filed by Ausonia Farma Srl filed Critical Ausonia Farma Srl

1982-01-18 Publication of NO812427L publication Critical patent/NO812427L/no

Links

150000001875 compounds Chemical class 0.000 title claims description 54
230000003115 biocidal effect Effects 0.000 title description 3
-1 methoxy, phenyl Chemical group 0.000 claims description 22
238000000034 method Methods 0.000 claims description 17
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 12
238000002360 preparation method Methods 0.000 claims description 12
239000007858 starting material Substances 0.000 claims description 11
229910052739 hydrogen Inorganic materials 0.000 claims description 8
125000000217 alkyl group Chemical group 0.000 claims description 7
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 6
VKYKSIONXSXAKP-UHFFFAOYSA-N hexamethylene tetramine Natural products C1N(C2)CN3CN1CN2C3 VKYKSIONXSXAKP-UHFFFAOYSA-N 0.000 claims description 6
239000001257 hydrogen Substances 0.000 claims description 6
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 5
125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 5
150000008064 anhydrides Chemical class 0.000 claims description 4
125000003118 aryl group Chemical group 0.000 claims description 4
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 3
238000005917 acylation reaction Methods 0.000 claims description 3
150000001767 cationic compounds Chemical class 0.000 claims description 3
229910052736 halogen Inorganic materials 0.000 claims description 3
125000005843 halogen group Chemical group 0.000 claims description 3
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239000004312 hexamethylene tetramine Substances 0.000 claims description 3
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150000002431 hydrogen Chemical class 0.000 claims description 3
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 3
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 3
125000004433 nitrogen atom Chemical group N* 0.000 claims description 3
150000002892 organic cations Chemical class 0.000 claims description 3
125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 2
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230000002538 fungal effect Effects 0.000 description 1
210000001035 gastrointestinal tract Anatomy 0.000 description 1
229940047650 haemophilus influenzae Drugs 0.000 description 1
150000004820 halides Chemical class 0.000 description 1
229910000042 hydrogen bromide Inorganic materials 0.000 description 1
125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
125000003037 imidazol-2-yl group Chemical group [H]N1C([*])=NC([H])=C1[H] 0.000 description 1
238000011065 in-situ storage Methods 0.000 description 1
239000012442 inert solvent Substances 0.000 description 1
238000002347 injection Methods 0.000 description 1
239000007924 injection Substances 0.000 description 1
239000002198 insoluble material Substances 0.000 description 1
238000010255 intramuscular injection Methods 0.000 description 1
239000007927 intramuscular injection Substances 0.000 description 1
125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
238000002955 isolation Methods 0.000 description 1
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
239000000865 liniment Substances 0.000 description 1
239000007788 liquid Substances 0.000 description 1
239000006210 lotion Substances 0.000 description 1
231100000053 low toxicity Toxicity 0.000 description 1
239000000314 lubricant Substances 0.000 description 1
239000011777 magnesium Substances 0.000 description 1
229910052749 magnesium Inorganic materials 0.000 description 1
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
239000011976 maleic acid Substances 0.000 description 1
125000000896 monocarboxylic acid group Chemical group 0.000 description 1
ACTNHJDHMQSOGL-UHFFFAOYSA-N n',n'-dibenzylethane-1,2-diamine Chemical compound C=1C=CC=CC=1CN(CCN)CC1=CC=CC=C1 ACTNHJDHMQSOGL-UHFFFAOYSA-N 0.000 description 1
238000002663 nebulization Methods 0.000 description 1
230000017074 necrotic cell death Effects 0.000 description 1
229910017604 nitric acid Inorganic materials 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
239000003921 oil Substances 0.000 description 1
239000002674 ointment Substances 0.000 description 1
150000007530 organic bases Chemical class 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
125000004304 oxazol-5-yl group Chemical group O1C=NC=C1* 0.000 description 1
239000003090 pesticide formulation Substances 0.000 description 1
239000003208 petroleum Substances 0.000 description 1
239000008194 pharmaceutical composition Substances 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
239000012071 phase Substances 0.000 description 1
239000008363 phosphate buffer Substances 0.000 description 1
239000006187 pill Substances 0.000 description 1
239000011591 potassium Substances 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
ZNNZYHKDIALBAK-UHFFFAOYSA-M potassium thiocyanate Chemical compound [K+].[S-]C#N ZNNZYHKDIALBAK-UHFFFAOYSA-M 0.000 description 1
229940116357 potassium thiocyanate Drugs 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
238000004321 preservation Methods 0.000 description 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
239000000047 product Substances 0.000 description 1
238000011321 prophylaxis Methods 0.000 description 1
125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 description 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
125000003373 pyrazinyl group Chemical group 0.000 description 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
239000000376 reactant Substances 0.000 description 1
239000011541 reaction mixture Substances 0.000 description 1
210000002345 respiratory system Anatomy 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
239000012047 saturated solution Substances 0.000 description 1
208000013223 septicemia Diseases 0.000 description 1
229940115939 shigella sonnei Drugs 0.000 description 1
239000005049 silicon tetrachloride Substances 0.000 description 1
229910052709 silver Inorganic materials 0.000 description 1
239000004332 silver Substances 0.000 description 1
239000002002 slurry Substances 0.000 description 1
239000000344 soap Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
235000017557 sodium bicarbonate Nutrition 0.000 description 1
229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
159000000000 sodium salts Chemical class 0.000 description 1
239000007921 spray Substances 0.000 description 1
238000001694 spray drying Methods 0.000 description 1
230000001954 sterilising effect Effects 0.000 description 1
238000004659 sterilization and disinfection Methods 0.000 description 1
125000001424 substituent group Chemical group 0.000 description 1
239000007940 sugar coated tablet Substances 0.000 description 1
239000000829 suppository Substances 0.000 description 1
238000011477 surgical intervention Methods 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
239000003826 tablet Substances 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 1
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
125000000437 thiazol-2-yl group Chemical group [H]C1=C([H])N=C(*)S1 0.000 description 1
150000003548 thiazolidines Chemical class 0.000 description 1
DZLNHFMRPBPULJ-UHFFFAOYSA-N thioproline Chemical class OC(=O)C1CSCN1 DZLNHFMRPBPULJ-UHFFFAOYSA-N 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 description 1
LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
241001148471 unidentified anaerobic bacterium Species 0.000 description 1
210000001635 urinary tract Anatomy 0.000 description 1
239000004552 water soluble powder Substances 0.000 description 1
239000011701 zinc Substances 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/57—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with a further substituent in position 7, e.g. cephamycines

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
Pharmacology & Pharmacy (AREA)
Communicable Diseases (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Cephalosporin Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

NO812427A 1980-07-15 1981-07-14 Antibiotisk virksomme cephalosporinforbindelser. NO812427L (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT23455/80A IT1148888B (it)	1980-07-15	1980-07-15	Composti antibiotici

Publications (1)

Publication Number	Publication Date
NO812427L true NO812427L (no)	1982-01-18

Family

ID=11207252

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
NO812427A NO812427L (no)	1980-07-15	1981-07-14	Antibiotisk virksomme cephalosporinforbindelser.
NO812428A NO812428L (no)	1980-07-15	1981-07-14	Antibiotisk virksomme tiazolidinforbindelser.
NO812426A NO812426L (no)	1980-07-15	1981-07-14	Antibiotisk virksomme forbindelser.

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
NO812428A NO812428L (no)	1980-07-15	1981-07-14	Antibiotisk virksomme tiazolidinforbindelser.
NO812426A NO812426L (no)	1980-07-15	1981-07-14	Antibiotisk virksomme forbindelser.

Country Status (17)

Country	Link
US (3)	US4389407A (xx)
JP (3)	JPS5740491A (xx)
AR (3)	AR227926A1 (xx)
AU (3)	AU7256881A (xx)
BE (3)	BE889629A (xx)
CA (1)	CA1173435A (xx)
DE (3)	DE3127489A1 (xx)
DK (3)	DK314781A (xx)
ES (3)	ES8300336A1 (xx)
FR (3)	FR2486943B1 (xx)
GB (3)	GB2086883B (xx)
IT (1)	IT1148888B (xx)
NL (3)	NL8103346A (xx)
NO (3)	NO812427L (xx)
PH (2)	PH16969A (xx)
SE (3)	SE8104310L (xx)
ZA (3)	ZA814586B (xx)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3239365A1 (de) *	1982-10-23	1984-04-26	Bayer Ag, 5090 Leverkusen	Neue cephalosporine und verfahren zu ihrer herstellung

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4071529A (en) *	1971-06-02	1978-01-31	Merck & Co., Inc.	Derivatives of 6-aminopenicillanic acid
FR2100769B1 (xx) *	1971-06-16	1974-09-27	Merck & Co Inc
JPS4947385A (xx) *	1972-03-09	1974-05-08
DE2353584A1 (de) *	1973-10-25	1975-05-07	Bayer Ag	Penicilline, ein verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittal
NZ176206A (en) *	1973-12-25	1978-03-06	Takeda Chemical Industries Ltd	Cephalosporins
US3907787A (en) *	1974-02-22	1975-09-23	American Home Prod	7-(2-Thioxo-4-thiazolidinecarboxamido)cephalosporanic acids and the corresponding S-ethers
JPS5119765A (en) *	1974-08-09	1976-02-17	Takeda Chemical Industries Ltd	Aminochiazoorujudotaino seizoho
US3971776A (en) *	1975-02-19	1976-07-27	E. R. Squibb & Sons, Inc.	Thio-β-lactam penicillins
JPS5946237B2 (ja) *	1976-04-02	1984-11-10	武田薬品工業株式会社	セフアロスポリン誘導体およびその製造法
US4322347A (en) *	1978-04-03	1982-03-30	Bristol-Myers Company	2-Carbamoyloxymethyl-penicillin derivatives

1980
- 1980-07-15 IT IT23455/80A patent/IT1148888B/it active
1981
- 1981-07-01 US US06/279,425 patent/US4389407A/en not_active Expired - Fee Related
- 1981-07-01 US US06/279,456 patent/US4387096A/en not_active Expired - Fee Related
- 1981-07-01 US US06/279,454 patent/US4405618A/en not_active Expired - Fee Related
- 1981-07-02 PH PH25858A patent/PH16969A/en unknown
- 1981-07-02 PH PH25857A patent/PH16897A/en unknown
- 1981-07-03 GB GB8120693A patent/GB2086883B/en not_active Expired
- 1981-07-03 GB GB8120695A patent/GB2086375B/en not_active Expired
- 1981-07-03 AU AU72568/81A patent/AU7256881A/en not_active Abandoned
- 1981-07-03 AU AU72567/81A patent/AU7256781A/en not_active Abandoned
- 1981-07-03 AU AU72569/81A patent/AU7256981A/en not_active Abandoned
- 1981-07-03 GB GB8120694A patent/GB2086374B/en not_active Expired
- 1981-07-07 ZA ZA814586A patent/ZA814586B/xx unknown
- 1981-07-07 ZA ZA814582A patent/ZA814582B/xx unknown
- 1981-07-07 ZA ZA814584A patent/ZA814584B/xx unknown
- 1981-07-09 CA CA000381453A patent/CA1173435A/en not_active Expired
- 1981-07-10 AR AR286036A patent/AR227926A1/es active
- 1981-07-10 AR AR286034A patent/AR229589A1/es active
- 1981-07-10 SE SE8104310A patent/SE8104310L/xx not_active Application Discontinuation
- 1981-07-10 SE SE8104308A patent/SE8104308L/xx not_active Application Discontinuation
- 1981-07-10 FR FR8113695A patent/FR2486943B1/fr not_active Expired
- 1981-07-10 FR FR8113697A patent/FR2486945A1/fr active Granted
- 1981-07-10 AR AR286035A patent/AR230641A1/es active
- 1981-07-10 FR FR8113696A patent/FR2486944A1/fr active Granted
- 1981-07-10 SE SE8104309A patent/SE8104309L/xx not_active Application Discontinuation
- 1981-07-11 DE DE19813127489 patent/DE3127489A1/de not_active Withdrawn
- 1981-07-11 DE DE19813127555 patent/DE3127555A1/de not_active Withdrawn
- 1981-07-11 DE DE19813127488 patent/DE3127488A1/de not_active Withdrawn
- 1981-07-13 JP JP56109910A patent/JPS5740491A/ja active Pending
- 1981-07-13 JP JP56109908A patent/JPS5740489A/ja active Pending
- 1981-07-13 JP JP56109909A patent/JPS5740490A/ja active Pending
- 1981-07-14 ES ES503933A patent/ES8300336A1/es not_active Expired
- 1981-07-14 ES ES503931A patent/ES8203905A1/es not_active Expired
- 1981-07-14 NO NO812427A patent/NO812427L/no unknown
- 1981-07-14 NL NL8103346A patent/NL8103346A/nl not_active Application Discontinuation
- 1981-07-14 NL NL8103345A patent/NL8103345A/nl not_active Application Discontinuation
- 1981-07-14 ES ES503932A patent/ES503932A0/es active Granted
- 1981-07-14 NL NL8103350A patent/NL8103350A/nl not_active Application Discontinuation
- 1981-07-14 NO NO812428A patent/NO812428L/no unknown
- 1981-07-14 NO NO812426A patent/NO812426L/no unknown
- 1981-07-15 DK DK314781A patent/DK314781A/da not_active Application Discontinuation
- 1981-07-15 BE BE2/59262A patent/BE889629A/nl not_active IP Right Cessation
- 1981-07-15 BE BE2/59263A patent/BE889630A/nl not_active IP Right Cessation
- 1981-07-15 DK DK314981A patent/DK314981A/da not_active Application Discontinuation
- 1981-07-15 BE BE2/59261A patent/BE889628A/nl not_active IP Right Cessation
- 1981-07-15 DK DK314881A patent/DK314881A/da not_active Application Discontinuation

Also Published As

Publication number	Publication date
BE889629A (nl)	1981-11-03
BE889630A (nl)	1981-11-03
DE3127489A1 (de)	1982-04-29
DE3127555A1 (de)	1982-06-03
FR2486944B1 (xx)	1984-03-23
GB2086375A (en)	1982-05-12
NO812428L (no)	1982-01-18
SE8104309L (sv)	1982-01-16
ES503933A0 (es)	1982-11-01
DK314881A (da)	1982-01-16
AU7256781A (en)	1982-01-21
AU7256881A (en)	1982-01-21
ES8300336A1 (es)	1982-11-01
GB2086883B (en)	1983-11-23
FR2486943B1 (xx)	1983-12-02
ZA814584B (en)	1982-07-28
PH16897A (en)	1984-04-05
DK314781A (da)	1982-01-16
NO812426L (no)	1982-01-18
PH16969A (en)	1984-04-27
AR227926A1 (es)	1982-12-30
US4405618A (en)	1983-09-20
AR229589A1 (es)	1983-09-30
DE3127488A1 (de)	1982-05-19
GB2086374A (en)	1982-05-12
NL8103345A (nl)	1982-02-01
CA1173435A (en)	1984-08-28
ES503931A0 (es)	1982-04-16
FR2486945A1 (fr)	1982-01-22
IT8023455A0 (it)	1980-07-15
FR2486944A1 (fr)	1982-01-22
ZA814586B (en)	1982-07-28
JPS5740491A (en)	1982-03-06
SE8104308L (sv)	1982-01-16
IT1148888B (it)	1986-12-03
JPS5740490A (en)	1982-03-06
AU7256981A (en)	1982-01-21
FR2486945B1 (xx)	1984-04-27
FR2486943A1 (xx)	1982-01-22
GB2086883A (en)	1982-05-19
NL8103346A (nl)	1982-02-01
ES8203905A1 (es)	1982-04-16
AR230641A1 (es)	1984-05-31
GB2086375B (en)	1984-03-07
ES8203904A1 (es)	1982-04-16
ZA814582B (en)	1982-07-28
US4389407A (en)	1983-06-21
ES503932A0 (es)	1982-04-16
US4387096A (en)	1983-06-07
JPS5740489A (en)	1982-03-06
SE8104310L (sv)	1982-01-16
NL8103350A (nl)	1982-02-01
GB2086374B (en)	1983-11-23
BE889628A (nl)	1981-11-03
DK314981A (da)	1982-01-16

Publication	Publication Date	Title
US4517361A (en)	1985-05-14	Cephalosporin derivatives
DE2727753C2 (xx)	1987-11-05
JPS62149682A (ja)	1987-07-03	抗菌性化合物
US4254119A (en)	1981-03-03	3-Unsubstituted-3-cephem compounds
CA1283096C (en)	1991-04-16	Antibacterial compounds
HU195512B (en)	1988-05-30	Process for production of derivatives of cef-3-em-4-carbonic acid substituated in 3 positions by dicyclic piridium-methil group
US4012379A (en)	1977-03-15	7-Acetoacetamidocephem compounds
US4226864A (en)	1980-10-07	7-Substituted aminoacetamido oxadethiacephalosporins
SU1418329A1 (ru)	1988-08-23	7-Ациламидоцефалоспорины,про вл ющие антибактериальные свойства
US4921851A (en)	1990-05-01	Cephem compounds, their production and use
DE3686749T2 (de)	1993-04-22	Cephalosporinverbindungen und sie enthaltende bakterizide.
NO812427L (no)	1982-01-18	Antibiotisk virksomme cephalosporinforbindelser.
BE823861A (fr)	1975-06-24	Derives de cephalosporine
US4683227A (en)	1987-07-28	Antibiotic derivatives of 7β-[2-(thiazol-4-yl)acetamide]-3-chloro-3-cephem-4-carboxylic acids and compositions and method of use thereof
Numata et al.	1978	NEW CEPHALOSPORINS WITH 7-ACYL GROUPS DERIVED FROM β-KETOACIDS II. FURTHER MODIFICATIONS OF 7-(3-OXOBUTYRYLAMINO)-CEPHALOSPORINS
US4342758A (en)	1982-08-03	Allylsulfoxide enzyme inhibitors
US4179502A (en)	1979-12-18	7[2-Hydroxyiminoacetamido]cephalosporins
EP0249170A2 (en)	1987-12-16	Cephem compounds, their production and use
US3813391A (en)	1974-05-28	7-(beta-(o-aminomethylphenyl)propion-amido)-3-(tetrazolo(4,5-b)pyridazin-6-ylthiomethyl)-3-cephem-4-carboxylic acid
US3929782A (en)	1975-12-30	1,2,4-Oxadiazolonylacetyl cephalosporins
Essery et al.	1974	3-Acylthiomethyl cephalosporins
US4379924A (en)	1983-04-12	Cephalosporin derivatives
EP0006011B1 (en)	1983-04-06	Cephalosporins and pharmaceutical compositions containing them
US3687948A (en)	1972-08-29	7-{8 D-(a-AMINO-a-PHENYLACETAMIDO){9 -3-(4-METHYL-1,3-OXAZOL-2-YLTHIOMETHYL-3-CEPHEM-4-CARBOXYLIC ACID AND SALTS THEREOF
US3823141A (en)	1974-07-09	7-(o-aminomethyl-p-hydroxy-phenylacetamido)-3-(3-hydroxy-pyridazin-6-ylthiomethyl)-3-cephem-4-carboxylic acid