NO327771B1 - Analysemetode for bestemmelse av transcobalamin II-(TC II) bundet cobalamin, sett samt anvendelse av holo-TC II som kalibrator. - Google Patents

Analysemetode for bestemmelse av transcobalamin II-(TC II) bundet cobalamin, sett samt anvendelse av holo-TC II som kalibrator. Download PDF

Info

Publication number: NO327771B1
Authority: NO; Norway
Prior art keywords: holo; ligand; immobilized; cobalamin; bound
Prior art date: 1998-09-18

Application number

NO20011353A

Other languages

English (en)

Norwegian (no)

Other versions

NO20011353L (no

NO20011353D0 (no

Inventor

Erling Sundrehagen

Lars Orning

Original Assignee

Axis Shield Asa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-09-18

Filing date

2001-03-16

Publication date

2009-09-21

2001-03-16 Application filed by Axis Shield Asa filed Critical Axis Shield Asa

2001-03-16 Publication of NO20011353D0 publication Critical patent/NO20011353D0/no

2001-05-11 Publication of NO20011353L publication Critical patent/NO20011353L/no

2009-09-21 Publication of NO327771B1 publication Critical patent/NO327771B1/no

Links

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JEWJRMKHSMTXPP-BYFNXCQMSA-M methylcobalamin Chemical compound C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O JEWJRMKHSMTXPP-BYFNXCQMSA-M 0.000 description 1
230000000813 microbial effect Effects 0.000 description 1
230000002906 microbiologic effect Effects 0.000 description 1
210000000653 nervous system Anatomy 0.000 description 1
230000000926 neurological effect Effects 0.000 description 1
150000003901 oxalic acid esters Chemical class 0.000 description 1
150000004893 oxazines Chemical class 0.000 description 1
230000036961 partial effect Effects 0.000 description 1
239000008188 pellet Substances 0.000 description 1
239000008363 phosphate buffer Substances 0.000 description 1
108060006184 phycobiliprotein Proteins 0.000 description 1
239000000049 pigment Substances 0.000 description 1
230000008884 pinocytosis Effects 0.000 description 1
210000002826 placenta Anatomy 0.000 description 1
230000003169 placental effect Effects 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
150000004032 porphyrins Chemical class 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
230000008569 process Effects 0.000 description 1
238000004393 prognosis Methods 0.000 description 1
125000000168 pyrrolyl group Chemical group 0.000 description 1
230000008707 rearrangement Effects 0.000 description 1
230000009467 reduction Effects 0.000 description 1
239000003488 releasing hormone Substances 0.000 description 1
PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 1
229940043267 rhodamine b Drugs 0.000 description 1
239000002336 ribonucleotide Substances 0.000 description 1
125000002652 ribonucleotide group Chemical group 0.000 description 1
210000003296 saliva Anatomy 0.000 description 1
238000002821 scintillation proximity assay Methods 0.000 description 1
229910021487 silica fume Inorganic materials 0.000 description 1
239000000741 silica gel Substances 0.000 description 1
229910002027 silica gel Inorganic materials 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
238000001179 sorption measurement Methods 0.000 description 1
210000002784 stomach Anatomy 0.000 description 1
230000004206 stomach function Effects 0.000 description 1
VNOYUJKHFWYWIR-ITIYDSSPSA-N succinyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CCC(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 VNOYUJKHFWYWIR-ITIYDSSPSA-N 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
239000000725 suspension Substances 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
150000004897 thiazines Chemical class 0.000 description 1
150000005075 thioxanthenes Chemical class 0.000 description 1
150000003918 triazines Chemical class 0.000 description 1
LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
210000004881 tumor cell Anatomy 0.000 description 1
241001148471 unidentified anaerobic bacterium Species 0.000 description 1
210000002438 upper gastrointestinal tract Anatomy 0.000 description 1
235000019156 vitamin B Nutrition 0.000 description 1
239000011720 vitamin B Substances 0.000 description 1
229940046001 vitamin b complex Drugs 0.000 description 1
239000011534 wash buffer Substances 0.000 description 1
150000003732 xanthenes Chemical class 0.000 description 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/82—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving vitamins or their receptors
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles

Landscapes

Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Chemical & Material Sciences (AREA)
Hematology (AREA)
Immunology (AREA)
Urology & Nephrology (AREA)
General Physics & Mathematics (AREA)
Biochemistry (AREA)
Cell Biology (AREA)
Food Science & Technology (AREA)
Medicinal Chemistry (AREA)
Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
Microbiology (AREA)
General Health & Medical Sciences (AREA)
Biotechnology (AREA)
Pathology (AREA)
Investigating Or Analysing Biological Materials (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Ultra Sonic Daignosis Equipment (AREA)
Lubrication Of Internal Combustion Engines (AREA)
Liquid Developers In Electrophotography (AREA)
Cable Accessories (AREA)
Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Glass Compositions (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Devices For Conveying Motion By Means Of Endless Flexible Members (AREA)
Measuring And Recording Apparatus For Diagnosis (AREA)
Mechanical Treatment Of Semiconductor (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Polyamides (AREA)
Analysing Materials By The Use Of Radiation (AREA)

NO20011353A 1998-09-18 2001-03-16 Analysemetode for bestemmelse av transcobalamin II-(TC II) bundet cobalamin, sett samt anvendelse av holo-TC II som kalibrator. NO327771B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9820473.8A GB9820473D0 (en)	1998-09-18	1998-09-18	Assay
PCT/GB1999/003127 WO2000017659A1 (en)	1998-09-18	1999-09-20	Cobalamin assay

Publications (3)

Publication Number	Publication Date
NO20011353D0 NO20011353D0 (no)	2001-03-16
NO20011353L NO20011353L (no)	2001-05-11
NO327771B1 true NO327771B1 (no)	2009-09-21

Family

ID=10839158

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
NO20011353A NO327771B1 (no)	1998-09-18	2001-03-16	Analysemetode for bestemmelse av transcobalamin II-(TC II) bundet cobalamin, sett samt anvendelse av holo-TC II som kalibrator.
NO20083610A NO331074B1 (no)	1998-09-18	2008-08-21	Analysemetode for bestemmelse av holo-Transcobalamin II i en cellefri prove i et kroppsfluid.

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
NO20083610A NO331074B1 (no)	1998-09-18	2008-08-21	Analysemetode for bestemmelse av holo-Transcobalamin II i en cellefri prove i et kroppsfluid.

Country Status (22)

Country	Link
US (1)	US7279283B1 (el)
EP (2)	EP1443328B1 (el)
JP (1)	JP4394285B2 (el)
KR (2)	KR100646305B1 (el)
CN (2)	CN1148580C (el)
AT (2)	ATE363076T1 (el)
AU (1)	AU761498B2 (el)
BR (1)	BR9913770A (el)
CA (1)	CA2344193C (el)
CY (1)	CY1106688T1 (el)
CZ (2)	CZ298310B6 (el)
DE (2)	DE69922225T2 (el)
DK (1)	DK1443328T3 (el)
ES (2)	ES2287607T3 (el)
GB (1)	GB9820473D0 (el)
HU (1)	HU228077B1 (el)
MX (1)	MXPA01002591A (el)
NO (2)	NO327771B1 (el)
NZ (1)	NZ510766A (el)
PL (2)	PL198095B1 (el)
PT (2)	PT1114323E (el)
WO (1)	WO2000017659A1 (el)

Families Citing this family (9)

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GB0016460D0 (en) *	2000-07-04	2000-08-23	Axis Shield Asa	Assay
GB0109925D0 (en) *	2001-04-23	2001-06-13	Axis Shield Asa	Method
MX2015005749A (es)	2012-11-06	2015-09-16	Hyundai Motor Co Ltd	Metodo para fabricar material amortiguador y aislantes del sonido de alta resistencia termica.
CN104198598B (zh) *	2014-07-15	2016-03-16	汤臣倍健股份有限公司	一种维生素b12的测定方法
CN106841017B (zh) *	2017-01-22	2019-05-07	耐斯检测技术服务有限公司	一种评价辐照或热处理对钴胺素-蛋白结合体影响的方法
CN106693443A (zh) *	2017-01-23	2017-05-24	北京美正生物科技有限公司	一种维生素b12适配体亲和柱及其制备方法和用途
CN118126173A (zh) *	2019-08-09	2024-06-04	美国西门子医学诊断股份有限公司	抗猪tcn1单克隆抗体及其生产和使用方法
WO2022131357A1 (ja) *	2020-12-18	2022-06-23	中外製薬株式会社	動的解析による相対ｆｕ比の測定方法
CN113189252A (zh) *	2021-04-19	2021-07-30	中国医学科学院北京协和医院	一种总钴胺素和氰钴胺的检测方法及其检测试剂盒和应用

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US4273757A (en) *	1977-06-02	1981-06-16	Yissum Research Development Company	Determination of transcobalamins
US4332785A (en) *	1980-04-09	1982-06-01	University Patents, Inc.	Immunoassay for measurement of reticulocytes, and immunoreactive reagents for use therein
EP0069450B1 (en) *	1981-06-22	1985-04-10	TECHNICON INSTRUMENTS CORPORATION (a New York corporation)	Labelled vitamin b12 derivatives, their preparation and use
US4680273A (en) *	1985-07-29	1987-07-14	Victor Herbert	Assay for vitamin B12 deficiency
US5457055A (en) *	1986-11-20	1995-10-10	The University Of Colorado Foundation	Diagnostic method for cobalamin deficiency
US5374560A (en) *	1989-04-03	1994-12-20	The University Of Colorado, Inc.	Method for screening and distinguishing between cobalamin and folic acid deficiency based on assay for cystathionine and 2-methylcitric acid
DE3900650A1 (de) *	1989-01-11	1990-07-12	Boehringer Mannheim Gmbh	Vitamin-b12-bestimmung
US5506109A (en)	1989-06-26	1996-04-09	Bayer Corporation	Vitamin B12 assay
WO1991000519A1 (en) *	1989-06-26	1991-01-10	Triton Diagnostics, Inc.	Vitamin b12 assay
US5310656A (en)	1989-06-26	1994-05-10	Tritech Partners	Vitamin B12 assay
EP0644948B1 (en) *	1992-05-08	1998-03-04	Receptagen Corporation	Anti-receptor antibodies to the vitamin b12/transcobalamin ii receptor
CA2266412A1 (en) *	1996-09-18	1998-03-26	William J. Sarill	Compositions containing cobalamin and amino acids

1998
- 1998-09-18 GB GBGB9820473.8A patent/GB9820473D0/en not_active Ceased
1999
- 1999-09-20 KR KR1020047014817A patent/KR100646305B1/ko active IP Right Grant
- 1999-09-20 DE DE69922225T patent/DE69922225T2/de not_active Expired - Lifetime
- 1999-09-20 EP EP04009702A patent/EP1443328B1/en not_active Expired - Lifetime
- 1999-09-20 PT PT99947642T patent/PT1114323E/pt unknown
- 1999-09-20 CA CA002344193A patent/CA2344193C/en not_active Expired - Lifetime
- 1999-09-20 DK DK04009702T patent/DK1443328T3/da active
- 1999-09-20 PL PL347104A patent/PL198095B1/pl unknown
- 1999-09-20 CN CNB998110396A patent/CN1148580C/zh not_active Expired - Fee Related
- 1999-09-20 MX MXPA01002591A patent/MXPA01002591A/es not_active IP Right Cessation
- 1999-09-20 PT PT04009702T patent/PT1443328E/pt unknown
- 1999-09-20 CZ CZ20010975A patent/CZ298310B6/cs not_active IP Right Cessation
- 1999-09-20 CN CNB2004100055424A patent/CN1322330C/zh not_active Expired - Fee Related
- 1999-09-20 BR BR9913770-4A patent/BR9913770A/pt not_active IP Right Cessation
- 1999-09-20 HU HU0103532A patent/HU228077B1/hu not_active IP Right Cessation
- 1999-09-20 EP EP99947642A patent/EP1114323B1/en not_active Expired - Lifetime
- 1999-09-20 NZ NZ510766A patent/NZ510766A/en not_active IP Right Cessation
- 1999-09-20 CZ CZ20023143A patent/CZ298381B6/cs not_active IP Right Cessation
- 1999-09-20 ES ES04009702T patent/ES2287607T3/es not_active Expired - Lifetime
- 1999-09-20 AU AU61026/99A patent/AU761498B2/en not_active Ceased
- 1999-09-20 KR KR1020017003485A patent/KR100781014B1/ko active IP Right Grant
- 1999-09-20 ES ES99947642T patent/ES2234299T3/es not_active Expired - Lifetime
- 1999-09-20 PL PL382436A patent/PL201360B1/pl unknown
- 1999-09-20 DE DE69936154T patent/DE69936154T2/de not_active Expired - Lifetime
- 1999-09-20 WO PCT/GB1999/003127 patent/WO2000017659A1/en active IP Right Grant
- 1999-09-20 AT AT04009702T patent/ATE363076T1/de active
- 1999-09-20 AT AT99947642T patent/ATE283490T1/de active
- 1999-09-20 JP JP2000571269A patent/JP4394285B2/ja not_active Expired - Lifetime
2000
- 2000-10-04 US US09/679,043 patent/US7279283B1/en not_active Expired - Lifetime
2001
- 2001-03-16 NO NO20011353A patent/NO327771B1/no not_active IP Right Cessation
2007
- 2007-07-02 CY CY20071100864T patent/CY1106688T1/el unknown
2008
- 2008-08-21 NO NO20083610A patent/NO331074B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
CN1530659A (zh)	2004-09-22
CN1148580C (zh)	2004-05-05
CN1324450A (zh)	2001-11-28
EP1443328A2 (en)	2004-08-04
PL201360B1 (pl)	2009-04-30
DK1443328T3 (da)	2007-09-24
CZ298310B6 (cs)	2007-08-22
PT1443328E (pt)	2007-06-11
MXPA01002591A (es)	2002-04-08
EP1443328B1 (en)	2007-05-23
DE69936154T2 (de)	2008-01-24
KR100781014B1 (ko)	2007-11-29
CA2344193C (en)	2009-04-07
HU228077B1 (en)	2012-10-29
BR9913770A (pt)	2001-06-05
AU761498B2 (en)	2003-06-05
PL347104A1 (en)	2002-03-25
NZ510766A (en)	2003-07-25
HUP0103532A3 (en)	2006-03-28
CZ298381B6 (cs)	2007-09-12
ATE283490T1 (de)	2004-12-15
EP1114323B1 (en)	2004-11-24
JP2002525607A (ja)	2002-08-13
DE69936154D1 (de)	2007-07-05
KR20010079854A (ko)	2001-08-22
GB9820473D0 (en)	1998-11-11
JP4394285B2 (ja)	2010-01-06
HUP0103532A2 (en)	2002-01-28
ATE363076T1 (de)	2007-06-15
CZ2001975A3 (cs)	2001-11-14
CN1322330C (zh)	2007-06-20
NO20011353L (no)	2001-05-11
NO20011353D0 (no)	2001-03-16
WO2000017659A1 (en)	2000-03-30
CA2344193A1 (en)	2000-03-30
EP1114323A1 (en)	2001-07-11
AU6102699A (en)	2000-04-10
US7279283B1 (en)	2007-10-09
EP1443328A3 (en)	2004-10-20
CY1106688T1 (el)	2012-05-23
NO331074B1 (no)	2011-09-26
ES2287607T3 (es)	2007-12-16
DE69922225D1 (de)	2004-12-30
PT1114323E (pt)	2005-02-28
PL198095B1 (pl)	2008-05-30
KR20040104529A (ko)	2004-12-10
NO20083610L (no)	2001-05-11
ES2234299T3 (es)	2005-06-16
DE69922225T2 (de)	2005-04-14
KR100646305B1 (ko)	2006-11-23

Publication	Publication Date	Title
EP1114323B1 (en)	2004-11-24	Cobalamin assay
JP3935437B2 (ja)	2007-06-20	トランスコバラミンｉｉ分析方法
EP1257830B1 (en)	2007-04-18	Assay for measuring holo-transcobalamin and folate
US7166473B2 (en)	2007-01-23	Transferrin assay
US7344849B2 (en)	2008-03-18	Assay
AU2003203209B2 (en)	2005-09-15	Cobalamin assay
ZA200101937B (en)	2001-09-11	Cobalamin assay.
NZ525253A (en)	2004-08-27	Cobalamin assay
EP1257831A2 (en)	2002-11-20	Diagnosis of cvd measuring folate and holo-tcii

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2019-10-07	MK1K	Patent expired