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NO310075B1 - AZA spiroforbindelser som virker på det cholinergiske system med muscarinisk agonistaktivitet, anvendelse av samme for fremstilling av medikament, farmasöytisk sammensetning omfattende samme samt kjemisk forbindelse til bruk som medikament - Google Patents

AZA spiroforbindelser som virker på det cholinergiske system med muscarinisk agonistaktivitet, anvendelse av samme for fremstilling av medikament, farmasöytisk sammensetning omfattende samme samt kjemisk forbindelse til bruk som medikament Download PDF

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Publication number
NO310075B1
NO310075B1 NO960225A NO960225A NO310075B1 NO 310075 B1 NO310075 B1 NO 310075B1 NO 960225 A NO960225 A NO 960225A NO 960225 A NO960225 A NO 960225A NO 310075 B1 NO310075 B1 NO 310075B1
Authority
NO
Norway
Prior art keywords
spiro
methyl
methylpiperidine
ethyl
methylpiperidin
Prior art date
Application number
NO960225A
Other languages
English (en)
Norwegian (no)
Other versions
NO960225L (no
NO960225D0 (no
Inventor
Abraham Fisher
Yishai Karton
Daniele Marciano
Dov Barak
Haim Meshulam
Original Assignee
Israel State
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Israel State filed Critical Israel State
Publication of NO960225D0 publication Critical patent/NO960225D0/no
Publication of NO960225L publication Critical patent/NO960225L/no
Publication of NO310075B1 publication Critical patent/NO310075B1/no

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D497/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/10—Spiro-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NO960225A 1993-07-20 1996-01-18 AZA spiroforbindelser som virker på det cholinergiske system med muscarinisk agonistaktivitet, anvendelse av samme for fremstilling av medikament, farmasöytisk sammensetning omfattende samme samt kjemisk forbindelse til bruk som medikament NO310075B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/094,855 US5534520A (en) 1990-04-10 1993-07-20 Spiro compounds containing five-membered rings
PCT/GB1994/001543 WO1995003303A2 (en) 1993-07-20 1994-07-15 Aza spiro compounds acting on the cholinergic system with muscarinic agonist activity

Publications (3)

Publication Number Publication Date
NO960225D0 NO960225D0 (no) 1996-01-18
NO960225L NO960225L (no) 1996-03-12
NO310075B1 true NO310075B1 (no) 2001-05-14

Family

ID=22247578

Family Applications (1)

Application Number Title Priority Date Filing Date
NO960225A NO310075B1 (no) 1993-07-20 1996-01-18 AZA spiroforbindelser som virker på det cholinergiske system med muscarinisk agonistaktivitet, anvendelse av samme for fremstilling av medikament, farmasöytisk sammensetning omfattende samme samt kjemisk forbindelse til bruk som medikament

Country Status (25)

Country Link
US (1) US5534520A (zh)
EP (1) EP0711292B1 (zh)
JP (1) JP3802050B2 (zh)
KR (1) KR100341683B1 (zh)
CN (1) CN1129942B (zh)
AT (1) ATE212347T1 (zh)
AU (1) AU696530B2 (zh)
BG (1) BG62774B1 (zh)
BR (1) BR9407088A (zh)
CA (1) CA2167584C (zh)
CZ (1) CZ295929B6 (zh)
DE (1) DE69429724T2 (zh)
DK (1) DK0711292T3 (zh)
ES (1) ES2171458T3 (zh)
FI (1) FI113777B (zh)
HU (1) HU224638B1 (zh)
IL (1) IL110340A (zh)
NO (1) NO310075B1 (zh)
NZ (1) NZ268637A (zh)
PL (1) PL178931B1 (zh)
PT (1) PT711292E (zh)
RO (1) RO117851B1 (zh)
RU (1) RU2129555C1 (zh)
WO (1) WO1995003303A2 (zh)
ZA (1) ZA945284B (zh)

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Also Published As

Publication number Publication date
BG100370A (bg) 1996-11-29
CN1129942A (zh) 1996-08-28
FI960238A (fi) 1996-03-18
RO117851B1 (ro) 2002-08-30
JPH09503491A (ja) 1997-04-08
ES2171458T3 (es) 2002-09-16
DE69429724T2 (de) 2002-08-29
RU2129555C1 (ru) 1999-04-27
NO960225L (no) 1996-03-12
HU9600126D0 (en) 1996-03-28
JP3802050B2 (ja) 2006-07-26
FI113777B (fi) 2004-06-15
KR960703914A (ko) 1996-08-31
AU696530B2 (en) 1998-09-10
FI960238A0 (fi) 1996-01-17
IL110340A (en) 1999-06-20
DE69429724D1 (de) 2002-03-14
NO960225D0 (no) 1996-01-18
DK0711292T3 (da) 2002-05-06
HUT74588A (en) 1997-01-28
CN1129942B (zh) 2011-08-10
BR9407088A (pt) 1996-08-13
NZ268637A (en) 1998-01-26
ATE212347T1 (de) 2002-02-15
WO1995003303A3 (en) 1995-03-02
CZ295929B6 (cs) 2005-12-14
PT711292E (pt) 2002-07-31
HU224638B1 (hu) 2005-12-28
EP0711292A1 (en) 1996-05-15
PL312684A1 (en) 1996-05-13
CA2167584C (en) 2006-10-24
AU7191594A (en) 1995-02-20
IL110340A0 (en) 1994-10-21
PL178931B1 (pl) 2000-06-30
BG62774B1 (bg) 2000-07-31
KR100341683B1 (ko) 2002-11-30
CA2167584A1 (en) 1995-02-02
US5534520A (en) 1996-07-09
EP0711292B1 (en) 2002-01-23
WO1995003303A2 (en) 1995-02-02
ZA945284B (en) 1995-10-12
CZ18296A3 (en) 1996-07-17

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