NO305794B1 - Ortosubstituerte benzosyrederivater, farmas°ytiske preparater som inneholder minst Ún slik forbindelse, samt anvendelse av forbindelsene til fremstilling av legemidler - Google Patents

Ortosubstituerte benzosyrederivater, farmas°ytiske preparater som inneholder minst Ún slik forbindelse, samt anvendelse av forbindelsene til fremstilling av legemidler

Info

Publication number: NO305794B1
Authority: NO; Norway
Prior art keywords: benzoic acid; ortho; pharmaceuticals; compounds; manufacture
Prior art date: 1994-08-28

Application number

NO953352A

Other languages

English (en)

Norwegian (no)

Other versions

NO953352D0 (no

NO953352L (no

Inventor

Rolf Gericke

Dieter Dorsch

Manfred Baumgarth

Klaus-Otto Minck

Norbert Beier

Original Assignee

Merck Patent Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-08-28

Filing date

1995-08-25

Publication date

1999-07-26

1995-08-25 Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh

1995-08-25 Publication of NO953352D0 publication Critical patent/NO953352D0/no

1996-02-29 Publication of NO953352L publication Critical patent/NO953352L/no

1999-07-26 Publication of NO305794B1 publication Critical patent/NO305794B1/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C317/50—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/17—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- C07C317/46—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Oncology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

NO953352A 1994-08-28 1995-08-25 Ortosubstituerte benzosyrederivater, farmas°ytiske preparater som inneholder minst Ún slik forbindelse, samt anvendelse av forbindelsene til fremstilling av legemidler NO305794B1 (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE4430212A DE4430212A1 (de)	1994-08-28	1994-08-28	Ortho-substituierte Benzoesäure-Derivate

Publications (3)

Publication Number	Publication Date
NO953352D0 NO953352D0 (no)	1995-08-25
NO953352L NO953352L (no)	1996-02-29
NO305794B1 true NO305794B1 (no)	1999-07-26

Family

ID=6526569

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO953352A NO305794B1 (no)	1994-08-28	1995-08-25	Ortosubstituerte benzosyrederivater, farmas°ytiske preparater som inneholder minst Ún slik forbindelse, samt anvendelse av forbindelsene til fremstilling av legemidler

Country Status (23)

Country	Link
US (1)	US5849796A (cs)
EP (1)	EP0704431B1 (cs)
JP (1)	JPH0859602A (cs)
KR (1)	KR100406686B1 (cs)
CN (1)	CN1068587C (cs)
AT (1)	ATE193282T1 (cs)
AU (1)	AU703633B2 (cs)
BR (1)	BR9503817A (cs)
CA (1)	CA2156959A1 (cs)
CZ (1)	CZ289492B6 (cs)
DE (2)	DE4430212A1 (cs)
DK (1)	DK0704431T3 (cs)
ES (1)	ES2147810T3 (cs)
GR (1)	GR3033989T3 (cs)
HU (1)	HUT74946A (cs)
NO (1)	NO305794B1 (cs)
PL (1)	PL181183B1 (cs)
PT (1)	PT704431E (cs)
RU (1)	RU2125981C1 (cs)
SK (1)	SK282202B6 (cs)
TW (1)	TW406067B (cs)
UA (1)	UA44238C2 (cs)
ZA (1)	ZA957161B (cs)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19713427A1 (de) *	1997-04-01	1998-10-08	Hoechst Ag	Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19919349A1 (de) *	1999-04-28	2000-11-02	Merck Patent Gmbh	Verfahren zur Herstellung eines Benzoylguanidinderivates
AU2001293555A1 (en) *	2000-09-21	2002-04-02	Novation Pharmaceuticals Inc.	Benzoic acid derivatives and uses thereof
NZ531153A (en) *	2001-08-09	2005-10-28	Ono Pharmaceutical Co	Carboxylic acid derivative compounds and drugs comprising these compounds as the active ingredient
US8980952B2 (en) *	2002-03-20	2015-03-17	University Of Maryland, Baltimore	Methods for treating brain swelling with a compound that blocks a non-selective cation channel
EP1529058B1 (en) *	2002-03-20	2013-11-06	University of Maryland Baltimore	A non-selective cation channel in neural cells and sur1 antagonists for treating brain swelling
EP1799227B1 (en) *	2004-09-18	2010-11-10	University of Maryland, Baltimore	Therapeutic agents targeting the nc ca-atp channel and methods of use thereof
CA2583397C (en) *	2004-09-18	2013-05-21	University Of Maryland, Baltimore	Therapeutic agents targeting the ncca-atp channel and methods of use thereof
HUE027370T2 (en) *	2005-06-22	2016-10-28	Plexxikon Inc	Pyrrolo [2,3-b] pyridine derivatives as protein kinase inhibitors
US9511075B2 (en)	2007-01-12	2016-12-06	The University Of Maryland, Baltimore	Targeting NCCA-ATP channel for organ protection following ischemic episode
EP2114160B1 (en) *	2007-02-09	2016-11-16	University of Maryland, Baltimore	Antagonists of a non-selective cation channel in neural cells
WO2009002832A2 (en)	2007-06-22	2008-12-31	University Of Maryland, Baltimore	Inhibitors of ncca-atp channels for therapy
LT6401B (lt) *	2015-07-28	2017-06-12	Vilniaus Universitetas	Karboanhidrazės selektyvūs inhibitoriai
CN105732357A (zh) *	2016-03-23	2016-07-06	叶芳	2-氯-4氟苯甲酸及其制备方法
CN106892852B (zh) *	2017-03-21	2019-07-09	重庆医科大学	具有抗流感病毒活性的胍基类似物及其制备方法
CN111116395B (zh) *	2019-12-27	2023-04-07	湖北工业大学	多碘代芳香酸类化合物及其在抗腺病毒7型中的应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3929582A1 (de) *	1989-09-06	1991-03-07	Hoechst Ag	Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament
ES2089600T3 (es) *	1992-02-15	1996-10-01	Hoechst Ag	Benzoilguanidina sustituida en 3,5, con efecto antiarritmico y efecto inhibidor de la proliferacion de celulas.
ES2108144T3 (es) *	1992-02-15	1997-12-16	Hoechst Ag	Benzoilguanidinas sustituidas en orto, procedimiento para su preparacion, su utilizacion como medicamento o agente de diagnostico, asi como medicamento que las contiene.
DE59304166D1 (de) *	1992-07-01	1996-11-21	Hoechst Ag	3,4,5-Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DK0589336T3 (da) *	1992-09-22	1997-06-16	Hoechst Ag	Benzylguanidiner, fremgangsmåde til deres fremstilling samt deres anvendelse som antiarytmetika
TW250479B (cs) *	1992-12-15	1995-07-01	Hoechst Ag
DE4404183A1 (de) *	1994-02-10	1995-08-17	Merck Patent Gmbh	4-Amino-1-piperidylbenzoylguanidine
DE4422685A1 (de) *	1994-06-29	1996-01-04	Hoechst Ag	Ortho-amino-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

1994
- 1994-08-28 DE DE4430212A patent/DE4430212A1/de not_active Withdrawn
1995
- 1995-07-25 TW TW084107705A patent/TW406067B/zh not_active IP Right Cessation
- 1995-08-18 DE DE59508383T patent/DE59508383D1/de not_active Expired - Fee Related
- 1995-08-18 AT AT95112998T patent/ATE193282T1/de not_active IP Right Cessation
- 1995-08-18 DK DK95112998T patent/DK0704431T3/da active
- 1995-08-18 PT PT95112998T patent/PT704431E/pt unknown
- 1995-08-18 EP EP95112998A patent/EP0704431B1/de not_active Expired - Lifetime
- 1995-08-18 ES ES95112998T patent/ES2147810T3/es not_active Expired - Lifetime
- 1995-08-21 AU AU30145/95A patent/AU703633B2/en not_active Ceased
- 1995-08-23 UA UA95083919A patent/UA44238C2/uk unknown
- 1995-08-25 PL PL95310192A patent/PL181183B1/pl not_active IP Right Cessation
- 1995-08-25 HU HU9502500A patent/HUT74946A/hu unknown
- 1995-08-25 NO NO953352A patent/NO305794B1/no not_active IP Right Cessation
- 1995-08-25 ZA ZA957161A patent/ZA957161B/xx unknown
- 1995-08-25 CA CA002156959A patent/CA2156959A1/en not_active Abandoned
- 1995-08-25 SK SK1054-95A patent/SK282202B6/sk unknown
- 1995-08-25 RU RU95114389/04A patent/RU2125981C1/ru not_active IP Right Cessation
- 1995-08-25 CZ CZ19952181A patent/CZ289492B6/cs not_active IP Right Cessation
- 1995-08-25 CN CN95116623A patent/CN1068587C/zh not_active Expired - Fee Related
- 1995-08-28 JP JP7240500A patent/JPH0859602A/ja active Pending
- 1995-08-28 KR KR1019950026798A patent/KR100406686B1/ko not_active IP Right Cessation
- 1995-08-28 BR BR9503817A patent/BR9503817A/pt not_active IP Right Cessation
- 1995-08-28 US US08/520,340 patent/US5849796A/en not_active Expired - Fee Related
2000
- 2000-07-21 GR GR20000401675T patent/GR3033989T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
ZA957161B (en)	1996-04-17
KR100406686B1 (ko)	2004-07-19
CZ289492B6 (cs)	2002-02-13
BR9503817A (pt)	1996-04-16
NO953352D0 (no)	1995-08-25
CN1068587C (zh)	2001-07-18
US5849796A (en)	1998-12-15
SK105495A3 (en)	1996-03-06
TW406067B (en)	2000-09-21
AU3014595A (en)	1996-03-14
EP0704431A3 (de)	1997-01-29
DE4430212A1 (de)	1996-02-29
ATE193282T1 (de)	2000-06-15
CZ218195A3 (en)	1996-03-13
UA44238C2 (uk)	2002-02-15
ES2147810T3 (es)	2000-10-01
CN1125722A (zh)	1996-07-03
HU9502500D0 (en)	1995-10-30
DK0704431T3 (da)	2000-09-11
HUT74946A (en)	1997-03-28
EP0704431B1 (de)	2000-05-24
DE59508383D1 (de)	2000-06-29
GR3033989T3 (en)	2000-11-30
RU2125981C1 (ru)	1999-02-10
PT704431E (pt)	2000-10-31
KR960007539A (ko)	1996-03-22
NO953352L (no)	1996-02-29
PL310192A1 (en)	1996-03-04
JPH0859602A (ja)	1996-03-05
EP0704431A2 (de)	1996-04-03
CA2156959A1 (en)	1996-03-01
PL181183B1 (pl)	2001-06-29
SK282202B6 (sk)	2001-12-03
AU703633B2 (en)	1999-03-25

Publication	Publication Date	Title
NO305794B1 (no)	1999-07-26	Ortosubstituerte benzosyrederivater, farmas°ytiske preparater som inneholder minst Ún slik forbindelse, samt anvendelse av forbindelsene til fremstilling av legemidler
NO305798B1 (no)	1999-07-26	Heterosyklylbenzoylguanidiner, farmas°ytiske preparater som inneholder minst Ún slik forbindelse, samt anvendelse av forbindelsene til fremstilling av legemidler
FI955024A0 (fi)	1995-10-20	Uudet piperidiiniyhdisteet, menetelmä niiden valmistamiseksi ja niitä sisältävät farmaseuttiset koostumukset
NO305246B1 (no)	1999-04-26	Oksazolidinonforbindelser, farmas°ytiske preparater som inneholder minst Ún slik forbindelse, og anvendelse av forbindelsene til fremstilling av legemidler
NO305242B1 (no)	1999-04-26	Arylbenzoylguanidiner, farmas°ytiske preparater som inneholder minst Ún slik forbindelse, samt anvendelse av forbindelsene til fremstilling av legemidler
NO304988B1 (no)	1999-03-15	11-benzaldoksim-17<beta>-metoksy-17<alfa>-metoksymetyl-°stradienderivater samt farmas°ytisk preparat inneholdende slike
TR199903120T2 (xx)	2000-05-22	Yeni sistein türevleri, bunların üretimi için işlemler ve bunları ihtiva eden farmasötik maddeler.
BR9202804A (pt)	1994-01-25	Complexo e processo para sua preparacao,formulacao farmaceuticha e processo para sua preparacao
NO306858B1 (no)	2000-01-03	Sulfonyl- eller sulfinylbenzoylguanidinderivater, farmasöytiske preparater som inneholder slike, samt anvendelse av dem til fremstilling av legemidler
NO305901B1 (no)	1999-08-16	Alkylbenzoylguanidiner, farmasöytiske preparater som inneholder minst en slik forbindelse, samt anvendelse av forbindelsene til fremstilling av legemidler
DK162646C (da)	1992-04-13	3-(4-benzyl-piperazin-1-yl)-rifamycin sv- og s-forbindelser samt salte deraf, fremgangsmaade til fremstilling deraf og farmaceutiske sammensaetninger indeholdende disse forbindelser
NO306157B1 (no)	1999-09-27	Fluorholdige benzoylguanidiner, farmasöytiske preparater som inneholder minst én slik forbindelse, samt anvendelse av forbindelsene til fremstilling av et legemiddel
NO305243B1 (no)	1999-04-26	Benzoylguanidinderivater, farmas°ytiske preparater som inneholder minst Ún slik forbindelse, samt anvendelse av forbindelsene til fremstilling av et legemiddel
NO306991B1 (no)	2000-01-24	Alkenylbenzoylguanidinderivater, farmasoeytiske preparater som inneholder slike, samt anvendelse av forbindelsene til fremstilling av legemidler
NO305597B1 (no)	1999-06-28	Heterosyklyloksybenzoylguanidiner, farmas°ytiske preparater som inneholder minst Ún slik forbindelse, samt anvendelse av forbindelsene til fremstilling av legemidler
FR2694005B1 (fr)	1994-08-26	Nouvelles aminoalkylchromones, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent.
NO306300B1 (no)	1999-10-18	3-alkoksykarbonyltiadiazinoner, farmasöytiske preparater som inneholder minst èn slik forbindelse, og anvendelse av forbindelsene til fremstilling av legemidler

Legal Events

Date	Code	Title	Description
2005-05-02	MM1K	Lapsed by not paying the annual fees