NO303528B1 - Anordning for pulverisering av et pulverformet inhaleringsmedikament - Google Patents
Anordning for pulverisering av et pulverformet inhaleringsmedikament Download PDFInfo
- Publication number
- NO303528B1 NO303528B1 NO914805A NO914805A NO303528B1 NO 303528 B1 NO303528 B1 NO 303528B1 NO 914805 A NO914805 A NO 914805A NO 914805 A NO914805 A NO 914805A NO 303528 B1 NO303528 B1 NO 303528B1
- Authority
- NO
- Norway
- Prior art keywords
- vortex chamber
- chamber
- air
- inhalation
- drug
- Prior art date
Links
- 239000003814 drug Substances 0.000 title claims abstract description 67
- 238000010298 pulverizing process Methods 0.000 title claims abstract description 29
- 229940079593 drug Drugs 0.000 title claims description 47
- 239000002245 particle Substances 0.000 claims abstract description 43
- 239000000843 powder Substances 0.000 claims description 28
- 239000000463 material Substances 0.000 claims description 4
- 239000002775 capsule Substances 0.000 description 37
- 238000010276 construction Methods 0.000 description 18
- 230000000694 effects Effects 0.000 description 15
- 230000033001 locomotion Effects 0.000 description 14
- 210000004072 lung Anatomy 0.000 description 9
- 230000035508 accumulation Effects 0.000 description 7
- 238000009825 accumulation Methods 0.000 description 7
- 238000002156 mixing Methods 0.000 description 7
- 230000001133 acceleration Effects 0.000 description 5
- 239000000443 aerosol Substances 0.000 description 4
- 230000035515 penetration Effects 0.000 description 4
- 210000002345 respiratory system Anatomy 0.000 description 4
- 241000509579 Draco Species 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 238000005194 fractionation Methods 0.000 description 3
- 230000005484 gravity Effects 0.000 description 3
- 238000009533 lab test Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000008177 pharmaceutical agent Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 230000000717 retained effect Effects 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 208000006673 asthma Diseases 0.000 description 2
- 230000008021 deposition Effects 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- XWTYSIMOBUGWOL-UHFFFAOYSA-N (+-)-Terbutaline Chemical compound CC(C)(C)NCC(O)C1=CC(O)=CC(O)=C1 XWTYSIMOBUGWOL-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 238000007664 blowing Methods 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 230000001427 coherent effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 229960002052 salbutamol Drugs 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 229960000195 terbutaline Drugs 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
- A61M15/0033—Details of the piercing or cutting means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2206/00—Characteristics of a physical parameter; associated device therefor
- A61M2206/10—Flow characteristics
- A61M2206/16—Rotating swirling helical flow, e.g. by tangential inflows
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Catching Or Destruction (AREA)
- Nozzles (AREA)
- Special Spraying Apparatus (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Earth Drilling (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI892956A FI84698C (fi) | 1989-06-16 | 1989-06-16 | Anordning foer finfoerdelning av agglomerat av en enkeldos av ett laekemedelpreparat i pulverform. |
| PCT/FI1990/000159 WO1990015635A1 (en) | 1989-06-16 | 1990-06-13 | Device for more effective pulverization of a powdered inhalation medicament |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO914805D0 NO914805D0 (no) | 1991-12-06 |
| NO914805L NO914805L (no) | 1992-01-30 |
| NO303528B1 true NO303528B1 (no) | 1998-07-27 |
Family
ID=8528637
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO914805A NO303528B1 (no) | 1989-06-16 | 1991-12-06 | Anordning for pulverisering av et pulverformet inhaleringsmedikament |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0477222B1 (fi) |
| JP (1) | JPH04506018A (fi) |
| KR (1) | KR940011441B1 (fi) |
| AT (1) | ATE195434T1 (fi) |
| AU (1) | AU641659B2 (fi) |
| BR (1) | BR9007440A (fi) |
| CA (1) | CA2058954C (fi) |
| DE (1) | DE69033607T2 (fi) |
| DK (1) | DK0477222T3 (fi) |
| ES (1) | ES2150412T3 (fi) |
| FI (1) | FI84698C (fi) |
| HU (1) | HU213187B (fi) |
| MX (1) | MX173780B (fi) |
| NO (1) | NO303528B1 (fi) |
| NZ (1) | NZ234031A (fi) |
| RU (1) | RU2089227C1 (fi) |
| WO (1) | WO1990015635A1 (fi) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE59107894D1 (de) * | 1991-03-21 | 1996-07-11 | Ritzau Pari Werk Gmbh Paul | Vernebler insbesondere zur Anwendung in Geräten für die Inhalationstherapie |
| CA2112674C (en) * | 1991-07-02 | 2005-10-04 | John S. Patton | Method and device for delivering aerosolized medicaments |
| US5639441A (en) * | 1992-03-06 | 1997-06-17 | Board Of Regents Of University Of Colorado | Methods for fine particle formation |
| US5301664A (en) * | 1992-03-06 | 1994-04-12 | Sievers Robert E | Methods and apparatus for drug delivery using supercritical solutions |
| US6582728B1 (en) | 1992-07-08 | 2003-06-24 | Inhale Therapeutic Systems, Inc. | Spray drying of macromolecules to produce inhaleable dry powders |
| CA2145418A1 (en) | 1992-09-29 | 1994-04-14 | John S. Patton | Pulmonary delivery of active fragments of parathyroid hormone |
| SE9302550D0 (sv) * | 1993-07-30 | 1993-07-30 | Ernst Hoerlin | Powder inhaler |
| WO1995024183A1 (en) | 1994-03-07 | 1995-09-14 | Inhale Therapeutic Systems | Methods and compositions for pulmonary delivery of insulin |
| US6051256A (en) | 1994-03-07 | 2000-04-18 | Inhale Therapeutic Systems | Dispersible macromolecule compositions and methods for their preparation and use |
| EP0682955B1 (de) * | 1994-05-19 | 2001-09-05 | PARI GmbH Spezialisten für effektive Inhalation | Vorrichtung zur Trocknung und Pufferung von Aerosolen |
| DE4440734A1 (de) * | 1994-11-15 | 1996-05-23 | Bayer Ag | Abscheidesystem für einen Pulverinhalator |
| US5900881A (en) * | 1995-03-22 | 1999-05-04 | Ikedo; Tsuneo | Computer graphics circuit |
| EP0764921A4 (en) * | 1995-03-22 | 1998-02-04 | Tsuneo Ikedo | CIRCUIT FOR COMPUTER GRAPHICS |
| US5780014A (en) * | 1995-04-14 | 1998-07-14 | Inhale Therapeutic Systems | Method and apparatus for pulmonary administration of dry powder alpha 1-antitrypsin |
| US6073629A (en) * | 1997-09-25 | 2000-06-13 | Norton Healthcare Ltd. | Inhaler spacer |
| US6309623B1 (en) | 1997-09-29 | 2001-10-30 | Inhale Therapeutic Systems, Inc. | Stabilized preparations for use in metered dose inhalers |
| US20060165606A1 (en) | 1997-09-29 | 2006-07-27 | Nektar Therapeutics | Pulmonary delivery particles comprising water insoluble or crystalline active agents |
| SE9704185D0 (sv) * | 1997-11-14 | 1997-11-14 | Astra Pharma Prod | Inhalation device |
| US6257233B1 (en) | 1998-06-04 | 2001-07-10 | Inhale Therapeutic Systems | Dry powder dispersing apparatus and methods for their use |
| GB2344533B (en) | 1998-12-11 | 2000-10-18 | Bespak Plc | Improvements in or relating to dispensing apparatus |
| JP2000217917A (ja) * | 1999-01-27 | 2000-08-08 | Unisia Jecs Corp | 吸入式投薬器 |
| GB2353222B (en) | 1999-06-23 | 2001-09-19 | Cambridge Consultants | Inhalers |
| PE20010819A1 (es) * | 2000-01-10 | 2001-09-05 | Procter & Gamble | Dispositivo para la inhalacion de polvo seco |
| US6427688B1 (en) | 2000-02-01 | 2002-08-06 | Dura Pharmaceuticals, Icn. | Dry powder inhaler |
| US7871598B1 (en) | 2000-05-10 | 2011-01-18 | Novartis Ag | Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use |
| WO2002056948A1 (en) * | 2001-01-17 | 2002-07-25 | Vectura Limited | An inhaler device |
| GB2375308A (en) * | 2001-05-10 | 2002-11-13 | Cambridge Consultants | Inhalers |
| US20040211419A1 (en) * | 2001-05-10 | 2004-10-28 | Eason Stephen William | Inhalers |
| US6681768B2 (en) | 2001-06-22 | 2004-01-27 | Sofotec Gmbh & Co. Kg | Powder formulation disintegrating system and method for dry powder inhalers |
| ATE508735T1 (de) | 2001-12-19 | 2011-05-15 | Novartis Ag | Pulmonale verabreichung von aminoglykosiden |
| US9339459B2 (en) | 2003-04-24 | 2016-05-17 | Nektar Therapeutics | Particulate materials |
| EP1658872B2 (en) | 2002-07-31 | 2019-08-21 | CHIESI FARMACEUTICI S.p.A. | Powder inhaler |
| EP1488819A1 (en) | 2003-06-16 | 2004-12-22 | Rijksuniversiteit te Groningen | Dry powder inhaler and method for pulmonary inhalation of dry powder |
| US7862552B2 (en) | 2005-05-09 | 2011-01-04 | Boston Scientific Scimed, Inc. | Medical devices for treating urological and uterine conditions |
| EP2534958A1 (en) | 2007-12-14 | 2012-12-19 | AeroDesigns, Inc | Delivering aerosolizable food products |
| SI2082769T1 (sl) | 2008-01-24 | 2015-10-30 | Vectura Delivery Devices Limited | Inhalator |
| GB0818476D0 (en) | 2008-10-09 | 2008-11-12 | Vectura Delivery Device Ltd | Inhaler |
| FR2979058B1 (fr) * | 2011-08-19 | 2013-08-30 | Valois Sas | Dispositif d'inhalation de poudre. |
| WO2015012758A1 (en) * | 2013-07-22 | 2015-01-29 | Inhalation Sciences Sweden Ab | Apparatus and method for generating an aerosol |
| RU209001U1 (ru) * | 2021-10-19 | 2022-01-26 | Анатолий Анатольевич Кутьев | Портативный небулайзер |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1445520A (fr) * | 1965-04-05 | 1966-07-15 | Procédé et appareil pour mélanger un gaz à des particules solides | |
| US3809084A (en) * | 1970-02-16 | 1974-05-07 | American Cyanamid Co | Pressurized portable dispenser |
| IT1016489B (it) * | 1974-03-18 | 1977-05-30 | Isf Spa | Inalatore |
| FR2352556A1 (fr) * | 1976-05-26 | 1977-12-23 | Pasteur Institut | Inhalateur de poudre |
| EP0005585B1 (en) * | 1978-05-03 | 1981-08-12 | FISONS plc | Inhalation device |
| DE3167567D1 (en) * | 1980-06-06 | 1985-01-17 | Fisons Plc | Inhalation device for powdered medicaments |
| US4702415A (en) * | 1983-11-28 | 1987-10-27 | Vortran Corporation | Aerosol producing device |
| AT384552B (de) * | 1985-08-01 | 1987-12-10 | Hurka Wilhelm | Inhalationsgeraet zur dosierung und verteilung von festkoerpern in die atemluft |
| SE453566B (sv) * | 1986-03-07 | 1988-02-15 | Draco Ab | Anordning vid pulverinhalatorer |
| ES2060040T5 (es) * | 1989-05-31 | 1999-09-16 | Fisons Plc | Dispositivo y formulacion de inhalacion de medicamento. |
-
1989
- 1989-06-16 FI FI892956A patent/FI84698C/fi active IP Right Grant
-
1990
- 1990-06-12 NZ NZ234031A patent/NZ234031A/en unknown
- 1990-06-13 EP EP90908952A patent/EP0477222B1/en not_active Expired - Lifetime
- 1990-06-13 ES ES90908952T patent/ES2150412T3/es not_active Expired - Lifetime
- 1990-06-13 DE DE69033607T patent/DE69033607T2/de not_active Expired - Lifetime
- 1990-06-13 JP JP2508385A patent/JPH04506018A/ja active Pending
- 1990-06-13 AU AU57469/90A patent/AU641659B2/en not_active Ceased
- 1990-06-13 RU SU905010728A patent/RU2089227C1/ru not_active IP Right Cessation
- 1990-06-13 CA CA002058954A patent/CA2058954C/en not_active Expired - Lifetime
- 1990-06-13 KR KR1019910701862A patent/KR940011441B1/ko not_active Expired - Fee Related
- 1990-06-13 HU HU904762A patent/HU213187B/hu not_active IP Right Cessation
- 1990-06-13 DK DK90908952T patent/DK0477222T3/da active
- 1990-06-13 BR BR909007440A patent/BR9007440A/pt not_active Application Discontinuation
- 1990-06-13 WO PCT/FI1990/000159 patent/WO1990015635A1/en not_active Ceased
- 1990-06-13 AT AT90908952T patent/ATE195434T1/de not_active IP Right Cessation
- 1990-06-15 MX MX021181A patent/MX173780B/es unknown
-
1991
- 1991-12-06 NO NO914805A patent/NO303528B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0477222A1 (en) | 1992-04-01 |
| AU5746990A (en) | 1991-01-08 |
| DK0477222T3 (da) | 2000-12-18 |
| WO1990015635A1 (en) | 1990-12-27 |
| JPH04506018A (ja) | 1992-10-22 |
| HU904762D0 (en) | 1992-04-28 |
| DE69033607T2 (de) | 2000-12-28 |
| FI892956L (fi) | 1990-12-17 |
| FI892956A0 (fi) | 1989-06-16 |
| AU641659B2 (en) | 1993-09-30 |
| NO914805L (no) | 1992-01-30 |
| FI84698C (fi) | 1992-01-10 |
| BR9007440A (pt) | 1992-04-28 |
| ES2150412T3 (es) | 2000-12-01 |
| NZ234031A (en) | 1993-10-26 |
| HU213187B (en) | 1997-03-28 |
| EP0477222B1 (en) | 2000-08-16 |
| ATE195434T1 (de) | 2000-09-15 |
| HK1011298A1 (en) | 1999-07-09 |
| KR920702629A (ko) | 1992-10-06 |
| DE69033607D1 (de) | 2000-09-21 |
| KR940011441B1 (ko) | 1994-12-15 |
| FI84698B (fi) | 1991-09-30 |
| NO914805D0 (no) | 1991-12-06 |
| CA2058954A1 (en) | 1991-12-14 |
| MX173780B (es) | 1994-03-25 |
| RU2089227C1 (ru) | 1997-09-10 |
| CA2058954C (en) | 1999-02-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |