NO302525B1 - 17-spirofuran-3'-yliden-steroider - Google Patents

17-spirofuran-3'-yliden-steroider Download PDF

Info

Publication number: NO302525B1
Authority: NO; Norway
Prior art keywords: hydrogen; lower alkyl; spirofuran; ylidene; mixture
Prior art date: 1991-12-20

Application number

NO924857A

Other languages

English (en)

Norwegian (no)

Other versions

NO924857D0 (no

NO924857L (no

Inventor

Johannes Antonius Mar Hamersma

Everardus Otto Maria Orlemans

Johannes Bernardus Ma Rewinkel

Original Assignee

Akzo Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-12-20

Filing date

1992-12-15

Publication date

1998-03-16

1992-12-15 Application filed by Akzo Nv filed Critical Akzo Nv

1992-12-15 Publication of NO924857D0 publication Critical patent/NO924857D0/no

1993-06-21 Publication of NO924857L publication Critical patent/NO924857L/no

1998-03-16 Publication of NO302525B1 publication Critical patent/NO302525B1/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/36—Antigestagens
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
- C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

NO924857A 1991-12-20 1992-12-15 17-spirofuran-3'-yliden-steroider NO302525B1 (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP91203366		1991-12-20

Publications (3)

Publication Number	Publication Date
NO924857D0 NO924857D0 (no)	1992-12-15
NO924857L NO924857L (no)	1993-06-21
NO302525B1 true NO302525B1 (no)	1998-03-16

Family

ID=8208088

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO924857A NO302525B1 (no)	1991-12-20	1992-12-15	17-spirofuran-3'-yliden-steroider

Country Status (17)

Country	Link
US (1)	US5292878A (fi)
EP (1)	EP0549041B1 (fi)
JP (1)	JP3462515B2 (fi)
KR (1)	KR100287513B1 (fi)
AT (1)	ATE128983T1 (fi)
AU (1)	AU655858B2 (fi)
CA (1)	CA2084431C (fi)
DE (1)	DE69205405T2 (fi)
DK (1)	DK0549041T3 (fi)
ES (1)	ES2081040T3 (fi)
FI (1)	FI104178B1 (fi)
GR (1)	GR3018630T3 (fi)
HK (1)	HK1002033A1 (fi)
MX (1)	MX9207394A (fi)
NO (1)	NO302525B1 (fi)
NZ (1)	NZ245520A (fi)
ZA (1)	ZA929315B (fi)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2100514C (en) *	1992-07-29	2005-03-29	Johannes A. M. Hamersma	17-spiromethylene steroids
RU2215540C2 (ru)	1997-11-14	2003-11-10	Акцо Нобель Н.В.	Схемы приема гестаген-антигестагена
US6020328A (en) *	1998-03-06	2000-02-01	Research Triangle Institute	20-keto-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
EP1079859B1 (en)	1998-05-22	2010-07-14	The Board Of Trustees Of The Leland Stanford Junior University	Bifunctional molecules and therapies based thereon
US6262042B1 (en)	1998-05-29	2001-07-17	Research Triangle Institute	17β-amino and hydroxylamino-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
US5962444A (en) *	1998-05-29	1999-10-05	Research Triangle Institute	17β-nitro-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
RU2234321C2 (ru) *	1999-04-29	2004-08-20	Акцо Нобель Н.В.	Применение антипрогестагенов в комбинированной терапии
US6043235A (en) *	1999-07-21	2000-03-28	Research Triangle Institute	11β-aryl-17, 17-spirothiolane-substituted steroids
US7426602B2 (en) *	2004-01-08	2008-09-16	Topside Research, Llc	Switch for bus optimization
TW200531977A (en)	2004-03-25	2005-10-01	Akzo Nobel Nv	Progesterone receptor modulators
CN103259027A (zh)	2005-04-28	2013-08-21	普罗透斯数字保健公司	药物信息系统
US9062126B2 (en)	2005-09-16	2015-06-23	Raptor Pharmaceuticals Inc.	Compositions comprising receptor-associated protein (RAP) variants specific for CR-containing proteins and uses thereof
JP5230449B2 (ja) *	2006-02-17	2013-07-10	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	プロゲステロン受容体モジュレーターとして有用な１１−燐ステロイド誘導体
US7671045B2 (en) *	2006-02-17	2010-03-02	Janssen Pharmaceutica N.V.	17-phosphorous steroid derivatives useful as progesterone receptor modulators
BRPI0717747A2 (pt)	2006-10-24	2013-10-22	Repros Therapeutics Inc	Composições e métodos de supressão da proliferação endometrial
TWI539953B (zh)	2008-04-28	2016-07-01	瑞波若斯治療學公司	用於治療乳癌之組成物和方法
CN102316902B (zh)	2009-02-20	2014-09-24	to-BBB控股股份有限公司	基于谷胱甘肽的药物递送系统
US8673968B2 (en) *	2009-04-06	2014-03-18	Evestra, Inc.	Progesterone antagonists
CN110075069A (zh)	2009-05-06	2019-08-02	实验室护肤股份有限公司	包含活性剂-磷酸钙颗粒复合物的皮肤递送组合物及其应用
CN101926806A (zh) *	2009-06-24	2010-12-29	天津金耀集团有限公司	一种17磷类雌甾化合物在制备紧急避孕药物中的应用
MX2012010327A (es)	2010-03-22	2012-11-16	Repros Therapeutics Inc	Composiciones y metodos para la administracion no toxica de antiprogestinas.
WO2011157443A1 (en)	2010-06-17	2011-12-22	N.V. Organon	(11b,17a)-11-(4-(2-11c-acetyl)phenyl)-17,23-epoxy-19,24-dinorchola-4,9,20-trien-3-one
US9096641B2 (en)	2013-06-05	2015-08-04	Evestra, Inc.	Imidazolyl progesterone antagonists

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3461090D1 (en) *	1983-02-18	1986-12-04	Schering Ag	11-beta-aryl-estradienes, process for their preparation and pharmaceutical compositions containing them
FR2596395B1 (fr) *	1986-03-26	1989-05-26	Roussel Uclaf	Nouveaux steroides comportant un cycle spirannique en position 17, leur procede de preparation, leur application comme medicaments et les compositions les renfermant
DE3761308D1 (de) *	1986-07-23	1990-02-08	Akzo Nv	18-phenylestrane-derivate.
IE60780B1 (en) *	1987-01-23	1994-08-10	Akzo Nv	New 11-aryl steroid derivatives
EP0289073B1 (en) *	1987-04-24	1991-11-27	Akzo N.V.	Novel 11-aryloestrane and 11-arylpregnane derivatives
DE3878198T2 (de) *	1987-12-12	1993-06-24	Akzo Nv	11-arylsteroid-derivate.

1992
- 1992-12-01 ZA ZA929315A patent/ZA929315B/xx unknown
- 1992-12-03 CA CA002084431A patent/CA2084431C/en not_active Expired - Fee Related
- 1992-12-11 AU AU30093/92A patent/AU655858B2/en not_active Ceased
- 1992-12-15 DE DE69205405T patent/DE69205405T2/de not_active Expired - Fee Related
- 1992-12-15 AT AT92203923T patent/ATE128983T1/de not_active IP Right Cessation
- 1992-12-15 NO NO924857A patent/NO302525B1/no unknown
- 1992-12-15 ES ES92203923T patent/ES2081040T3/es not_active Expired - Lifetime
- 1992-12-15 EP EP92203923A patent/EP0549041B1/en not_active Expired - Lifetime
- 1992-12-15 DK DK92203923.5T patent/DK0549041T3/da active
- 1992-12-17 KR KR1019920024581A patent/KR100287513B1/ko not_active Expired - Fee Related
- 1992-12-17 MX MX9207394A patent/MX9207394A/es not_active IP Right Cessation
- 1992-12-18 FI FI925790A patent/FI104178B1/fi active
- 1992-12-18 JP JP33883092A patent/JP3462515B2/ja not_active Expired - Fee Related
- 1992-12-18 NZ NZ245520A patent/NZ245520A/en unknown
- 1992-12-21 US US07/994,039 patent/US5292878A/en not_active Expired - Lifetime
1996
- 1996-01-10 GR GR960400050T patent/GR3018630T3/el unknown
1998
- 1998-02-11 HK HK98101028A patent/HK1002033A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE69205405D1 (de)	1995-11-16
ZA929315B (en)	1993-05-24
DE69205405T2 (de)	1996-05-09
JP3462515B2 (ja)	2003-11-05
ATE128983T1 (de)	1995-10-15
KR100287513B1 (ko)	2001-05-02
EP0549041B1 (en)	1995-10-11
CA2084431A1 (en)	1993-06-21
ES2081040T3 (es)	1996-02-16
FI925790A0 (fi)	1992-12-18
EP0549041A1 (en)	1993-06-30
NO924857D0 (no)	1992-12-15
NO924857L (no)	1993-06-21
FI104178B (fi)	1999-11-30
AU655858B2 (en)	1995-01-12
JPH05255380A (ja)	1993-10-05
US5292878A (en)	1994-03-08
HK1002033A1 (en)	1998-07-24
AU3009392A (en)	1993-06-24
DK0549041T3 (da)	1996-01-29
GR3018630T3 (en)	1996-04-30
FI104178B1 (fi)	1999-11-30
CA2084431C (en)	2003-04-08
MX9207394A (es)	1993-07-30
FI925790L (fi)	1993-06-21
NZ245520A (en)	1995-02-24

Publication	Publication Date	Title
NO302525B1 (no)	1998-03-16	17-spirofuran-3'-yliden-steroider
FI81588C (fi)	1990-11-12	Foerfarande foer framstaellning av terapeutiskt anvaendbara 11 -fenyl-17-hydroxi-4,9(10)-estradien-3-oner.
US5693628A (en)	1997-12-02	11-benzaldoxime-estra-diene derivatives, methods for their production and pharmaceuticals containing these compounds
FI85377B (fi)	1991-12-31	Foerfarande foer framstaellning av terapeutiskt aktiva 13-alkyl-11 -fenylgonaner.
KR100445376B1 (ko)	2004-11-08	11-(치환된페닐)-에스트라-4,9-디엔유도체
FI89054C (fi)	1993-08-10	Nya 11-arylsteroidderivat
JP2652007B2 (ja)	1997-09-10	位置１７にスピロ環を有する新規なステロイドの製造用中間体
KR100341169B1 (ko)	2002-10-25	17-스피로메틸렌스테로이드
US5728689A (en)	1998-03-17	11β-aryl-4-estrenes, process for their production as well as their use as pharmaceutical agents
RU2152952C2 (ru)	2000-07-20	Производные 11,21-бисфенил-19-норпрегнана, способ их получения, фармацевтическая композиция и способ ее получения
HU196224B (en)	1988-10-28	Process for production of 19-nor or 19-nor-d-homo stereoids substituated in position 11-beta by alkinylphenil group and medical preparatives containing them as active substance
IE892141L (en)	1990-01-01	13-alkyl-11ß-phenylgonanes
RU2187510C2 (ru)	2002-08-20	Производные 16-гидрокси-11-(замещенный фенил)-эстра-4,9-диена, соединение, фармацевтическая композиция
US5739125A (en)	1998-04-14	11 Beta-aryl-gona-4, 9-dien-3-ones
JP5731498B2 (ja)	2015-06-10	１７−ヒドロキシ−１７−ペンタフルオロエチルエステル−４，９（１０）−ジエン１１−エチニルフェニル誘導体、その製造方法、及び疾病の治療のためのその使用
US5232915A (en)	1993-08-03	9α-hydroxy-19,11β-bridged steroids, their production and pharmaceutical preparations containing these steroids
JP3181589B2 (ja)	2001-07-03	６、７−変性１１β−アリール−４−エステレン
Faraj et al.	1990	Synthesis of new steroidal 11β-substituted spirolactones
JPH08502276A (ja)	1996-03-12	ゲスターゲン作用を有する１９，１１−架橋した４−エストレン
HU201091B (en)	1990-09-28	Process for producing gonatriene derivatives and pharmaceutical compositions comprising same
MXPA96003476A (es)	1997-12-01	Derivados de 11-(fenilo sustituido)-estra-4,9-dieno