[go: up one dir, main page]

NO2024042I1 - Iptacopan or a pharmaceutically acceptable salt thereof - Google Patents

Iptacopan or a pharmaceutically acceptable salt thereof

Info

Publication number
NO2024042I1
NO2024042I1 NO2024042C NO2024042C NO2024042I1 NO 2024042 I1 NO2024042 I1 NO 2024042I1 NO 2024042 C NO2024042 C NO 2024042C NO 2024042 C NO2024042 C NO 2024042C NO 2024042 I1 NO2024042 I1 NO 2024042I1
Authority
NO
Norway
Prior art keywords
iptacopan
pharmaceutically acceptable
acceptable salt
salt
pharmaceutically
Prior art date
Application number
NO2024042C
Other languages
English (en)
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51230246&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO2024042(I1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of NO2024042I1 publication Critical patent/NO2024042I1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Child & Adolescent Psychology (AREA)
  • Psychology (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NO2024042C 2013-07-15 2024-09-30 Iptacopan or a pharmaceutically acceptable salt thereof NO2024042I1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361846355P 2013-07-15 2013-07-15
US201461977028P 2014-04-08 2014-04-08

Publications (1)

Publication Number Publication Date
NO2024042I1 true NO2024042I1 (no) 2024-09-30

Family

ID=51230246

Family Applications (1)

Application Number Title Priority Date Filing Date
NO2024042C NO2024042I1 (no) 2013-07-15 2024-09-30 Iptacopan or a pharmaceutically acceptable salt thereof

Country Status (41)

Country Link
US (2) US9682968B2 (no)
EP (2) EP3022192B1 (no)
JP (1) JP6378761B2 (no)
KR (1) KR102242742B1 (no)
CN (1) CN105579444B (no)
AP (1) AP2016008992A0 (no)
AU (1) AU2014290298B2 (no)
BR (1) BR112016000909B1 (no)
CA (1) CA2917839C (no)
CL (1) CL2016000060A1 (no)
CU (1) CU24397B1 (no)
CY (1) CY1119767T1 (no)
DK (1) DK3022192T3 (no)
EA (1) EA031030B1 (no)
ES (1) ES2655855T4 (no)
FI (1) FIC20240032I1 (no)
FR (1) FR24C1036I1 (no)
GT (1) GT201600007A (no)
HK (1) HK1221217A1 (no)
HR (1) HRP20172000T1 (no)
HU (2) HUE037510T2 (no)
IL (2) IL243540B (no)
JO (1) JO3425B1 (no)
LT (1) LT3022192T (no)
MX (1) MX351291B (no)
MY (2) MY187454A (no)
NL (1) NL301292I2 (no)
NO (1) NO2024042I1 (no)
PE (1) PE20161066A1 (no)
PH (1) PH12016500072A1 (no)
PL (1) PL3022192T3 (no)
PT (1) PT3022192T (no)
RS (1) RS56721B1 (no)
SG (1) SG11201600086PA (no)
SI (1) SI3022192T1 (no)
SV (1) SV2016005137A (no)
TN (1) TN2016000017A1 (no)
TW (1) TWI641600B (no)
UA (1) UA117371C2 (no)
UY (1) UY35663A (no)
WO (1) WO2015009616A1 (no)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO3425B1 (ar) 2013-07-15 2019-10-20 Novartis Ag مشتقات البابيريدينيل-اندول واستخدامها كعامل متمم لمثبطات b
WO2017035408A1 (en) 2015-08-26 2017-03-02 Achillion Pharmaceuticals, Inc. Compounds for treatment of immune and inflammatory disorders
AR106018A1 (es) 2015-08-26 2017-12-06 Achillion Pharmaceuticals Inc Compuestos de arilo, heteroarilo y heterocíclicos para el tratamiento de trastornos médicos
JP6994767B2 (ja) * 2016-06-21 2022-01-14 エックス４ ファーマシューティカルズ， インコーポレイテッド Ｃｘｃｒ４阻害剤およびその使用
CA3027498A1 (en) 2016-06-21 2017-12-28 X4 Pharmaceuticals, Inc. Cxcr4 inhibitors and uses thereof
KR20190036520A (ko) 2016-06-27 2019-04-04 아칠리온 파르마세우티칼스 인코포레이티드 의학적 장애를 치료하기 위한 퀴나졸린 및 인돌 화합물
CN107641121B (zh) * 2016-07-20 2021-02-19 上海高驰资产管理有限公司 一种荧光探针及其制备方法和用途
JP7133561B2 (ja) 2017-03-01 2022-09-08 アキリオン ファーマシューティカルズ，インコーポレーテッド 医学的障害の治療のためのアリール、ヘテロアリール及び複素環式医薬化合物
ES2976496T3 (es) 2017-08-24 2024-08-02 Novo Nordisk As Composiciones de GLP-1 y usos de las mismas
CN111032042A (zh) 2017-08-31 2020-04-17 诺华股份有限公司 哌啶基-吲哚衍生物的新用途
CN112513025B (zh) * 2018-07-16 2025-03-25 诺华股份有限公司 用于制备苯基哌啶基吲哚衍生物的化学方法
WO2020041301A1 (en) 2018-08-20 2020-02-27 Achillion Pharmaceuticals, Inc. Pharmaceutical compounds for the treatment of complement factor d medical disorders
MX2021003425A (es) 2018-09-25 2021-07-16 Achillion Pharmaceuticals Inc Formas morficas de los inhibidores del factor d del complemento.
WO2020144604A1 (en) 2019-01-11 2020-07-16 Novartis Ag Lta4h inhibitors for the treatment of hidradenitis suppurativa
CA3125886A1 (en) 2019-01-11 2020-07-16 Novartis Ag Anti-cd40 antibodies for use in treatment of hidradenitis suppurativa
US20230082544A1 (en) 2020-02-18 2023-03-16 Novo Nordisk A/S Pharmaceutical formulations
EP4107166A4 (en) 2020-02-20 2024-06-26 Achillion Pharmaceuticals, Inc. Heteroaryl compounds for treatment of complement factor d mediated disorders
CA3180829A1 (en) * 2020-05-18 2021-11-25 Novartis Ag Crystalline form of lnp023
JP7293513B2 (ja) 2020-07-16 2023-06-19 ノバルティス アーゲー Ｂ因子阻害剤の使用方法
AU2021323300A1 (en) * 2020-08-07 2023-04-06 Shanghai Meiyue Biotech Development Co., Ltd. Complement factor B inhibitor, and pharmaceutical composition thereof, preparation method therefor and use thereof
WO2022028507A1 (zh) 2020-08-07 2022-02-10 上海美悦生物科技发展有限公司 一种杂环类化合物、其制备方法及用途
AU2021414253B2 (en) * 2020-12-30 2024-05-16 S-Infinity Pharmaceuticals Co.,Ltd Series of piperidine-substituted benzoic acid compounds, and use thereof
JP2024504870A (ja) 2020-12-30 2024-02-01 江▲蘇▼恒瑞医▲薬▼股▲フン▼有限公司 含窒素架橋複素環化合物、その調製方法及びその医薬的応用
CA3205097A1 (en) * 2021-01-14 2022-07-21 Jason Allan Wiles Macrocycle complement factor b inhibitors
EP4324828A1 (en) * 2021-04-16 2024-02-21 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Bicyclic substituted aromatic carboxylic acid compounds
JP2024517234A (ja) * 2021-05-07 2024-04-19 ノバルティス アーゲー 非典型溶血性尿毒症症候群の処置のためのイプタコパン
EP4346812A4 (en) * 2021-06-03 2025-04-09 Chinook Therapeutics Inc SUBSTITUTED INDOLE COMPOUNDS AND METHODS OF USE THEREOF
CN117500500A (zh) 2021-06-18 2024-02-02 诺华股份有限公司 治疗自身免疫性血液病的方法
EP4362933A1 (en) * 2021-06-30 2024-05-08 Apellis Pharmaceuticals, Inc. Complement inhibition
JP2024532847A (ja) 2021-08-18 2024-09-10 シーザン ハイスーク ファーマシューティカル カンパニー リミテッド ベンズアゼピン芳香環誘導体及びその医薬的な応用
US20240398779A1 (en) 2021-09-07 2024-12-05 Novartis Ag Use of factor b inhibitors for the treatment of age-related macular degeneration
AU2022376760A1 (en) * 2021-10-27 2024-05-02 Hansoh Bio Llc Piperidinyl indole derivatives, preparation methods and medicinal uses thereof
JP2025504859A (ja) 2022-01-24 2025-02-19 ノバルティス アーゲー 補体因子ｂ阻害剤としてのスピロ環式ピペリジニル誘導体及びその使用
WO2023143293A1 (zh) * 2022-01-26 2023-08-03 上海美悦生物科技发展有限公司 补体因子b抑制剂的盐型、晶型及其制备方法和应用
TW202342048A (zh) 2022-02-28 2023-11-01 瑞士商諾華公司 使用ｌｏｕ０６４治療化膿性汗腺炎之方法
CN118785906A (zh) 2022-03-04 2024-10-15 诺华股份有限公司 伊普可泮用于治疗狼疮肾炎的用途
CN119137099A (zh) 2022-04-01 2024-12-13 诺华股份有限公司 补体因子b抑制剂及其用途
CN119698414A (zh) * 2022-06-20 2025-03-25 深圳信立泰药业股份有限公司 一种吲哚-苯基哌啶化合物及其制备方法与应用
CN119546585A (zh) * 2022-06-23 2025-02-28 上海济煜医药科技有限公司 吲哚化合物的制备、应用及用途
AU2023299821A1 (en) 2022-06-30 2025-02-13 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Pharmaceutically acceptable salt and crystal form of nitrogen-containing bridge heterocyclic derivative, and method for preparing same
IL319273A (en) * 2022-08-29 2025-04-01 Cms Res & Development Pte Ltd A series of bridged nitrogen-containing heterocyclic compounds and a method for their preparation
WO2024049977A1 (en) * 2022-08-31 2024-03-07 Chinook Therapeutics, Inc. Substituted indole compounds and methods of use thereof
AU2023339335A1 (en) * 2022-09-10 2025-04-03 Hansoh Bio Llc 2-substituted piperidine derivatives, preparation methods and medicinal uses thereof
CN118026998A (zh) * 2022-11-11 2024-05-14 上海医药工业研究院有限公司 哌啶取代的苯甲酸类化合物、其药物组合物和应用
WO2024104292A1 (en) * 2022-11-14 2024-05-23 Novartis Pharma Ag Solid forms of complement factor b inhibitors
WO2024114677A1 (zh) * 2022-11-29 2024-06-06 上海济煜医药科技有限公司 苯并螺环吲哚化合物的制备、应用及用途
WO2024141011A1 (zh) * 2022-12-31 2024-07-04 深圳晶泰科技有限公司 补体因子b抑制剂及其药物组合物和应用
WO2024148274A1 (en) * 2023-01-05 2024-07-11 Apellis Pharmaceuticals, Inc. Complement inhibition
TW202434240A (zh) * 2023-02-22 2024-09-01 大陸商西藏海思科製藥有限公司 苯並氮雜芳環衍生物的藥物組合物及其在醫藥上的應用
WO2024176169A1 (en) 2023-02-23 2024-08-29 Novartis Ag Methods of using factor b inhibitors
TW202438499A (zh) * 2023-03-21 2024-10-01 大陸商上海美悦生物科技發展有限公司 螺環類化合物及其藥物組合物、製備方法和用途
WO2025008453A1 (en) 2023-07-04 2025-01-09 Sitala Bio Ltd 2-(1h-indol-4-yl)methyl)-isoindoline derivatives as factor b inhibitors
WO2025008451A1 (en) 2023-07-04 2025-01-09 Sitala Bio Ltd 2-(1h-indol-4-yl)methyl)2h-indazole derivatives as factor b inhibitors
WO2025008517A1 (en) 2023-07-06 2025-01-09 Sitala Bio Ltd Indole derivatives with factor b inhibitory activity
WO2025008516A2 (en) 2023-07-06 2025-01-09 Sitala Bio Ltd Novel compounds
WO2025021158A1 (zh) * 2023-07-26 2025-01-30 上海美悦生物科技发展有限公司 螺环烯基类或氮杂烯基类化合物及其药物组合物、制备方法和用途
WO2025046421A1 (en) 2023-08-25 2025-03-06 Novartis Ag Methods of using factor b inhibitors
WO2025068951A1 (en) 2023-09-29 2025-04-03 Novartis Ag Complement factor b inhibitors and uses thereof

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR030357A1 (es) 2000-08-18 2003-08-20 Lundbeck & Co As H Derivados 4 -, 5 -, 6 - y 7-indol
DE10217006A1 (de) 2002-04-16 2003-11-06 Merck Patent Gmbh Substituierte Indole
DE10237723A1 (de) 2002-08-17 2004-07-08 Aventis Pharma Deutschland Gmbh Verwendung von IKappaB-Kinase Inhibitoren in der Schmerztherapie
BR0317548A (pt) 2002-12-19 2005-11-22 Pfizer Compostos de indazole e composições farmacêuticas para a inibição de proteìnas-cinases e métodos para o seu uso
EP1631260A2 (en) 2003-02-28 2006-03-08 Transform Pharmaceuticals, Inc. Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen
EP1620422A2 (en) 2003-04-30 2006-02-01 The Institutes for Pharmaceutical Discovery, LLC Phenyl substituted carboxylic acids as inhibitors of protein tyrosine phosphatase-1b
AU2005307818A1 (en) 2004-11-18 2006-05-26 The Institutes For Pharmaceutical Discovery, Llc Heterocyclylbiphenyl derivates as protein Tyrosine phosphatase inhibitors
US20080004259A1 (en) * 2005-02-08 2008-01-03 Arrington Kenneth L Inhibitors of Checkpoint Kinases
EP2205085A1 (en) 2007-09-25 2010-07-14 Merck Sharp & Dohme Corp. 2-aryl or heteroaryl indole derivatives
WO2009076404A1 (en) 2007-12-10 2009-06-18 Epix Delaware, Inc. Carboxamide compounds and their use as antagonists of the chemokine ccr2 receptor
AR070398A1 (es) 2008-02-22 2010-03-31 Gruenenthal Chemie Derivados sustituidos de indol
JO3265B1 (ar) 2008-12-09 2018-09-16 Novartis Ag مثبطات بيريديلوكسى اندولات vegf-r2 واستخدامها لعلاج المرض
US8877944B2 (en) 2009-07-14 2014-11-04 Nerviano Medical Sciences S.R.L. 3-oxo-2,3-dihydro-1H-isoindole-4-carboxamides as PARP inhibitors
WO2011109059A1 (en) 2010-03-01 2011-09-09 Gtx, Inc. Compounds for treatment of cancer
WO2012068589A2 (en) 2010-11-19 2012-05-24 Constellation Pharmaceuticals Modulators of methyl modifying enzymes, compositions and uses thereof
JP5921572B2 (ja) 2011-01-04 2016-05-24 ノバルティス アーゲー 加齢性黄斑変性症（ａｍｄ）の処置に有用なインドール化合物またはそのアナログ
AU2013255470B2 (en) * 2012-05-04 2015-09-17 Novartis Ag Complement pathway modulators and uses thereof
KR20150033652A (ko) * 2012-06-20 2015-04-01 노파르티스 아게 보체 경로 조절제 및 그의 용도
JO3425B1 (ar) 2013-07-15 2019-10-20 Novartis Ag مشتقات البابيريدينيل-اندول واستخدامها كعامل متمم لمثبطات b

Also Published As

Publication number Publication date
SG11201600086PA (en) 2016-02-26
BR112016000909A8 (pt) 2020-01-07
NL301292I2 (nl) 2024-10-30
CA2917839A1 (en) 2015-01-22
MY187454A (en) 2021-09-22
JO3425B1 (ar) 2019-10-20
EP3022192A1 (en) 2016-05-25
AU2014290298A1 (en) 2016-02-11
PH12016500072B1 (en) 2016-04-18
PE20161066A1 (es) 2016-10-30
EP3299365A1 (en) 2018-03-28
TW201546058A (zh) 2015-12-16
IL243540A0 (en) 2016-02-29
JP2016526576A (ja) 2016-09-05
US20180009795A1 (en) 2018-01-11
IL243540B (en) 2019-09-26
PL3022192T3 (pl) 2018-03-30
RS56721B1 (sr) 2018-03-30
US10093663B2 (en) 2018-10-09
IL268623A (en) 2019-10-31
HUE037510T2 (hu) 2018-09-28
MX351291B (es) 2017-10-09
TWI641600B (zh) 2018-11-21
EA031030B1 (ru) 2018-11-30
EA201690223A1 (ru) 2016-06-30
AP2016008992A0 (en) 2016-01-31
US20160152605A1 (en) 2016-06-02
TN2016000017A1 (en) 2017-07-05
CL2016000060A1 (es) 2016-06-10
JP6378761B2 (ja) 2018-08-22
BR112016000909B1 (pt) 2023-05-02
PH12016500072A1 (en) 2016-04-18
CU24397B1 (es) 2019-04-04
IL268623B (en) 2020-01-30
UA117371C2 (uk) 2018-07-25
HUS2400034I1 (hu) 2024-10-28
US9682968B2 (en) 2017-06-20
CN105579444B (zh) 2018-05-01
KR20160030556A (ko) 2016-03-18
BR112016000909A2 (pt) 2017-07-25
LT3022192T (lt) 2017-12-27
AU2014290298B2 (en) 2017-06-15
FIC20240032I1 (fi) 2024-10-01
EP3022192B1 (en) 2017-10-11
KR102242742B1 (ko) 2021-04-23
CN105579444A (zh) 2016-05-11
NZ715780A (en) 2021-03-26
MY196427A (en) 2023-04-10
GT201600007A (es) 2018-12-18
ES2655855T3 (es) 2018-02-21
PT3022192T (pt) 2018-01-15
UY35663A (es) 2015-02-27
CY1119767T1 (el) 2018-06-27
HK1221217A1 (zh) 2017-05-26
WO2015009616A1 (en) 2015-01-22
DK3022192T3 (en) 2018-01-22
ES2655855T4 (es) 2024-09-06
SV2016005137A (es) 2018-06-12
CA2917839C (en) 2022-05-03
FR24C1036I1 (fr) 2024-12-06
CU20160006A7 (es) 2016-08-31
HRP20172000T1 (hr) 2018-02-09
SI3022192T1 (en) 2018-01-31

Similar Documents

Publication Publication Date Title
NO2024042I1 (no) Iptacopan or a pharmaceutically acceptable salt thereof
NO2023043I1 (no) Mavacamten or a pharmaceutically acceptable salt thereof
NO2022005I1 (no) Zanubrutinib or a pharmaceutically acceptable salt thereof
NO2024001I1 (no) Ritlecitinib, or a pharmaceutically acceptable salt thereof
NO2022004I1 (no) abrocitinib, or a pharmaceutically acceptable salt thereof
NO2021034I1 (no) pemigatinib or a pharmaceutically acceptable salt thereof
NO2021041I1 (no) remimazolam or a pharmaceutically acceptable salt thereof
NO2021035I1 (no) Risdiplam or a pharmaceutically acceptable salt thereof
NL301094I2 (nl) Avapritinib en farmaceutisch aanvaardbare zouten daarvan
NO2022010I1 (no) ripretinib, or a pharmaceutically acceptable salt thereof
FIC20230028I1 (fi) Deukravasitinibi tai sen framaseuttisesti hyväksyttävä suola
FIC20240030I1 (fi) Danikopaani tai sen farmaseuttisesti hyväksyttävä suola
FIC20240012I1 (fi) Omaveloksoloni tai sen farmaseuttisesti hyväksyttävä suola
NO2020029I1 (no) Givosiran eller et farmasøytisk akseptabelt salt derav
NO2022058I1 (no) Capmatinib or a pharmaceutically acceptable salt thereof
HUE037275T2 (hu) Gyógyszer-kombináció
ZA201603624B (en) Urea derivative or pharmacologically acceptable salt thereof
DK2970389T3 (da) Farmaceutiske forbindelser
LT3077047T (lt) Aramcholio druskos
DE112014004161A5 (de) Rotationsrheometer
NO2024058I1 (no) delgocitinib or a pharmaceutically acceptable salt thereof
LT3079667T (lt) Farmacinės vaisto formos
BR302014001964S1 (pt) Configuração aplicada a travesseiro
DK3003401T3 (da) Farmaceutisk præparat
FR3010437B1 (fr) Serrure a mortaiser reglable