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NO2010019I2 - 6-per-deoksy-6-per-(2-karboksetyl)tio-y-cyklodextrin - Google Patents

6-per-deoksy-6-per-(2-karboksetyl)tio-y-cyklodextrin

Info

Publication number
NO2010019I2
NO2010019I2 NO2010019C NO2010019C NO2010019I2 NO 2010019 I2 NO2010019 I2 NO 2010019I2 NO 2010019 C NO2010019 C NO 2010019C NO 2010019 C NO2010019 C NO 2010019C NO 2010019 I2 NO2010019 I2 NO 2010019I2
Authority
NO
Norway
Prior art keywords
per
karboksetyl
deoxy
cyclodextrin
thio
Prior art date
Application number
NO2010019C
Other languages
English (en)
Other versions
NO2010019I1 (no
Original Assignee
Msd Oss Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8241767&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO2010019(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Msd Oss Bv filed Critical Msd Oss Bv
Publication of NO2010019I1 publication Critical patent/NO2010019I1/no
Publication of NO2010019I2 publication Critical patent/NO2010019I2/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716Glucans
    • A61K31/724Cyclodextrins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02Muscle relaxants, e.g. for tetanus or cramps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
NO2010019C 1999-11-29 2010-11-10 6-per-deoksy-6-per-(2-karboksetyl)tio-y-cyklodextrin NO2010019I2 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99309558 1999-11-29
PCT/EP2000/011789 WO2001040316A1 (en) 1999-11-29 2000-11-23 6-mercapto-cyclodextrin derivatives: reversal agents for drug-induced neuromuscular block

Publications (2)

Publication Number Publication Date
NO2010019I1 NO2010019I1 (no) 2010-11-22
NO2010019I2 true NO2010019I2 (no) 2012-08-27

Family

ID=8241767

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20022522A NO328790B1 (no) 1999-11-29 2002-05-28 6-merkapto-cyklodekstrinderivater og anvendelse derav samt sett og farmasoytisk preparat
NO2010019C NO2010019I2 (no) 1999-11-29 2010-11-10 6-per-deoksy-6-per-(2-karboksetyl)tio-y-cyklodextrin

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO20022522A NO328790B1 (no) 1999-11-29 2002-05-28 6-merkapto-cyklodekstrinderivater og anvendelse derav samt sett og farmasoytisk preparat

Country Status (34)

Country Link
US (3) US6670340B1 (no)
EP (1) EP1259550B1 (no)
JP (2) JP3880041B2 (no)
KR (1) KR100716524B1 (no)
CN (1) CN1188428C (no)
AR (1) AR026605A1 (no)
AT (1) ATE288450T1 (no)
AU (1) AU776536B2 (no)
BE (1) BE2008C047I2 (no)
BR (1) BRPI0015947B8 (no)
CA (1) CA2390463C (no)
CO (1) CO5251450A1 (no)
CY (1) CY2008018I2 (no)
CZ (1) CZ298206B6 (no)
DE (2) DE60017947T2 (no)
DK (1) DK1259550T3 (no)
ES (1) ES2237496T3 (no)
FR (1) FR08C0052I2 (no)
HK (1) HK1049489A1 (no)
HU (1) HU227451B1 (no)
IL (1) IL149423A0 (no)
LU (1) LU91501I2 (no)
MX (1) MXPA02004940A (no)
NL (1) NL300356I2 (no)
NO (2) NO328790B1 (no)
NZ (1) NZ518752A (no)
PE (1) PE20010902A1 (no)
PL (1) PL203012B1 (no)
PT (1) PT1259550E (no)
RU (1) RU2260013C2 (no)
SK (1) SK286282B6 (no)
TW (1) TWI242015B (no)
WO (1) WO2001040316A1 (no)
ZA (1) ZA200203538B (no)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6744471B1 (en) * 1997-12-05 2004-06-01 Olympus Optical Co., Ltd Electronic camera that synthesizes two images taken under different exposures
TWI242015B (en) 1999-11-29 2005-10-21 Akzo Nobel Nv 6-mercapto-cyclodextrin derivatives: reversal agents for drug-induced neuromuscular block
JP2004512358A (ja) * 2000-11-02 2004-04-22 アクゾ・ノベル・エヌ・ベー 高コルチゾール血症関連の障害を治療するためのコルチゾール封鎖剤の使用
BRPI0415637A (pt) 2003-10-31 2006-12-12 Univ Kansas derivados de sulfoalquil éter-alquil éter ciclodextrina
US7851457B2 (en) 2004-01-29 2010-12-14 Innovative Biologics, Inc. β-Cyclodextrin derivatives
EP1755551A4 (en) 2004-04-23 2010-04-21 Cydex Pharmaceuticals Inc SULFOALKYL ETHERCYCLODEXTRIN CONTAINING DPI FORMULATION
CA2596026A1 (en) 2005-01-28 2006-08-10 Pinnacle Pharmaceuticals, Inc. .beta.-cyclodextrin derivatives as antibacterial agents
CN101365459B (zh) 2005-10-26 2011-11-30 锡德克斯药物公司 磺基烷基醚环糊精组合物和其制备方法
US7629331B2 (en) 2005-10-26 2009-12-08 Cydex Pharmaceuticals, Inc. Sulfoalkyl ether cyclodextrin compositions and methods of preparation thereof
US20090069412A1 (en) * 2007-09-09 2009-03-12 Protia, Llc Deuterium-enriched sugammadex
US7635773B2 (en) 2008-04-28 2009-12-22 Cydex Pharmaceuticals, Inc. Sulfoalkyl ether cyclodextrin compositions
US7938283B2 (en) * 2008-06-20 2011-05-10 Grainpro, Inc. System and method for hermetic storage of agricultural commodities during shipping
US10463677B2 (en) 2008-11-07 2019-11-05 Cydex Pharmaceuticals, Inc. Composition containing sulfoalkyl ether cyclodextrin and latanoprost
CN101591402B (zh) * 2009-05-05 2011-11-30 杭州奥默医药技术有限公司 6-脱氧砜类环糊精衍生物及其制备方法
US8492538B1 (en) 2009-06-04 2013-07-23 Jose R. Matos Cyclodextrin derivative salts
DE102010012281A1 (de) * 2010-03-22 2011-09-22 Fresenius Medical Care Deutschland Gmbh Pharmazeutische Zusammensetzungen enthaltend substituiertes 6-Deoxy-6-sulfanylcyclodextrin
CN101864003B (zh) * 2010-06-11 2012-05-02 漆又毛 一种6-脱氧硫醚氨基酸环糊精衍生物的合成方法
WO2012025937A1 (en) * 2010-08-25 2012-03-01 Ramamohan Rao Davuluri Improved process for preparation of sugammadex
CN102060941B (zh) 2010-11-26 2012-12-26 漆又毛 6-脱氧α-氨基酸衍生物环糊精及制备和应用
WO2013123254A1 (en) 2012-02-15 2013-08-22 Cydex Pharmaceuticals, Inc. Manufacturing process for cyclodextrin derivatives
CN104704007A (zh) 2012-02-28 2015-06-10 锡德克斯药物公司 烷基化环糊精组合物及其制备和使用方法
JP5892847B2 (ja) * 2012-04-27 2016-03-23 Dowaホールディングス株式会社 シクロデキストリンとシリカ含有物質との複合材料、及びその製造方法、並びにガス吸着剤
GB201211153D0 (en) * 2012-06-22 2012-08-08 Farmhispania Pharmaceutical compositions
US10040872B2 (en) 2012-10-22 2018-08-07 Cydex Pharmaceuticals, Inc. Alkylated cyclodextrin compositions and processes for preparing and using the same
WO2014125501A1 (en) 2013-02-14 2014-08-21 Neuland Laboratories Limited An improved process for preparation of sugammadex sodium
WO2015179963A1 (en) 2014-05-29 2015-12-03 Uti Limited Partnership Cyclodextrin-based polyanionic and non-ionic dendrimers
PH12016502418B1 (en) 2014-06-26 2024-02-21 Maruishi Pharma Rocuronium preparation with improved stability
WO2016029179A1 (en) 2014-08-22 2016-02-25 Cydex Pharmaceuticals, Inc. Fractionated alkylated cyclodextrin compositions and processes for preparing and using the same
CN105348412B (zh) * 2014-08-22 2018-06-05 江苏恩华药业股份有限公司 一种舒更葡糖钠的纯化方法
EP3939582A1 (en) 2015-03-19 2022-01-19 Cydex Pharmaceuticals, Inc. Compositions containing silymarin and sulfoalkyl ether cyclodextrin and methods of using the same
CN104844732B (zh) * 2015-03-27 2017-05-03 山东滨州智源生物科技有限公司 一种舒更葡糖钠的制备方法
JP2018510912A (ja) * 2015-04-08 2018-04-19 リン,チャン−チュン ポリアニオン性および非イオン性のシクロデキストリン系デンドリマーの医薬組成物およびその使用
CN107849157A (zh) * 2015-05-29 2018-03-27 拉克什米·普拉萨德·阿拉帕斯 制备舒更葡糖及其中间体的方法
CN104922693A (zh) * 2015-06-19 2015-09-23 南开大学 一种阴离子型环糊精与抗癌药物包合物及制备方法
AU2016334062A1 (en) * 2015-10-07 2018-05-10 Uti Limited Partnership Multifunctional polyanionic cyclodextrin dendrimers
SI3380554T2 (sl) 2015-11-25 2024-01-31 Fresenius Kabi Ipsum S.R.L. Kristalne oblike per-kloro-gama-ciklodekstrinov
SI3380530T1 (sl) 2015-11-25 2021-02-26 Fresenius Kabi Ipsum S.R.L. Izboljšan postopek za pripravo sugamadeksa in njegovih intermediatov
JP6829304B2 (ja) * 2016-03-22 2021-02-10 フレゼニウス カビ イプスム エス.アール.エルFresenius Kabi Ipsum S.R.L. スガマデクスの調製のための改善されたプロセス
ES2794796T3 (es) * 2016-04-29 2020-11-19 Alveron Pharma B V Ciclodextrinas como procoagulantes
WO2017144734A2 (en) 2016-06-23 2017-08-31 Synthon B.V. Process for making sugammadex
US20180016359A1 (en) 2016-06-29 2018-01-18 Beijing Creatron Institute Of Pharmaceutical Research Co., Ltd. Sugammadex preparation and purification method
US10526422B2 (en) 2016-06-29 2020-01-07 Beijing Creatron Institute Of Pharmaceutical Research Co., Ltd. Process for preparation and purification of Sugammades sodium
CN107778383B (zh) * 2016-08-24 2020-03-10 王炳永 一种舒更葡糖钠的精制方法
US10385142B2 (en) 2017-01-23 2019-08-20 Scinopharm Taiwan, Ltd. Method for preparing sugammadex sodium
JP7204670B2 (ja) 2017-05-03 2023-01-16 サイデックス・ファーマシューティカルズ・インコーポレイテッド シクロデキストリン及びブスルファンを含有する組成物
CN109021148B (zh) * 2017-06-08 2020-11-10 天津科伦药物研究有限公司 一种制备舒更葡糖钠的方法
US10442871B2 (en) * 2017-06-22 2019-10-15 Lawrence Livermore National Security, Llc Modified cyclodextrins for the selective sequestration of fentanyl related compounds and uses thereof
ES2761899T3 (es) 2017-06-30 2020-05-21 Synthon Bv Proceso para preparar Sugammadex
US10233263B1 (en) * 2017-08-23 2019-03-19 Formosa Laboratories, Inc. Method for preparation of sugammadex sodium
TWI703163B (zh) * 2017-08-23 2020-09-01 台耀化學股份有限公司 舒更葡糖鈉之製備方法及其晶型
CN107892727B (zh) * 2017-11-27 2019-12-24 合肥博思科创医药科技有限公司 一种舒更葡糖钠的纯化方法
US11104746B2 (en) 2017-11-27 2021-08-31 Medichem, S.A. Process for the synthesis of a cyclodextrin derivative
EP3775026B1 (en) 2018-04-06 2022-03-16 Synthon B.V. Purification of sugammadex
KR102054228B1 (ko) 2018-05-28 2019-12-10 연성정밀화학(주) 슈가마덱스 나트륨염의 제조방법
JP7461304B2 (ja) * 2018-06-07 2024-04-03 メルク・シャープ・アンド・ドーム・エルエルシー スガマデクスの製造方法
CN110615860A (zh) * 2018-06-20 2019-12-27 江苏恒瑞医药股份有限公司 一种舒更葡糖钠的纯化方法
EP3830184A1 (en) * 2018-08-02 2021-06-09 Pliva Hrvatska D.O.O. Solid state forms of sugammadex sodium
WO2020058987A1 (en) * 2018-09-20 2020-03-26 Natco Pharma Limited An improved process for the preparation of sugammadex sodium and its novel polymorphic form
EP3856791A1 (en) 2018-09-27 2021-08-04 Werthenstein Biopharma GmbH Novel crystalline forms of sugammadex
JP6950966B2 (ja) * 2018-11-01 2021-10-13 丸石製薬株式会社 スガマデクス又はその薬理学的に許容される塩含有液剤及びその製造方法
CN109438591B (zh) * 2018-12-29 2021-02-09 博瑞生物医药(苏州)股份有限公司 舒更葡糖钠的制备工艺
CN109824800A (zh) * 2018-12-29 2019-05-31 鼎元(天津)生物医药科技有限公司 一种选择性肌松拮抗药舒更葡萄糖钠的制备方法
WO2020201930A1 (en) 2019-03-29 2020-10-08 Hospira, Inc. An improved process for preparation of sugammadex acid and sugammadex sodium
CN111978435B (zh) 2019-05-22 2021-05-25 合肥博思科创医药科技有限公司 一种高纯度舒更葡糖钠的制备方法
US11324692B2 (en) 2019-07-03 2022-05-10 Galenicum Health S.L.U. Method to prepare pharmaceutical compositions of suggamadex
JP7617844B2 (ja) 2019-08-30 2025-01-20 テルモ株式会社 注射液製剤
RU2724900C1 (ru) * 2019-10-24 2020-06-26 Маруиси Фармасьютикал Ко., Лтд. Препарат рокурония с улучшенной стабильностью
CN111019016B (zh) * 2019-12-27 2022-02-18 武汉嘉诺康医药技术有限公司 一种舒更葡糖钠杂质的合成方法
CN115348974B (zh) 2020-02-28 2024-03-08 摩迪康公司 用于干燥舒更葡糖的方法
CN111714459B (zh) * 2020-06-18 2022-06-14 广州瑞尔医药科技有限公司 一种注射用舒更葡糖钠粉针剂及其制备方法
US11097023B1 (en) 2020-07-02 2021-08-24 Par Pharmaceutical, Inc. Pre-filled syringe containing sugammadex
EP3932391A1 (en) 2020-07-03 2022-01-05 Galenicum Health S.L.U. Method to prepare pharmaceutical compositions
US11446325B2 (en) * 2020-09-30 2022-09-20 Cyclolab Cyclodextrin Research And Development Laboratory Ltd. Cyclodextrin derivatives in the treatment or prevention of lysosomal neurodegenerative diseases
US11945788B2 (en) 2021-06-07 2024-04-02 Nuray Chemicals Private Limited Process for preparing pitolisant hydrochloride and solid-state forms thereof
CN113637097A (zh) * 2021-08-10 2021-11-12 北京恒创星远医药科技有限公司 6-全脱氧-6-全碘代-γ-环糊精晶体及其制备方法和应用
CN115708777A (zh) 2021-08-19 2023-02-24 北京费森尤斯卡比医药有限公司 包含巯基环糊精衍生物或其可药用盐的包装药品和保存方法

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3929813A (en) * 1973-12-26 1975-12-30 Interx Research Corp Novel pro-drug derivatives of pyridinium aldoxime type cholinesterase reactivators and process for preparing same
JPS52108027A (en) 1976-03-09 1977-09-10 Rikagaku Kenkyusho Anticarcinogen
US4816462A (en) 1982-05-18 1989-03-28 Nowicky Wassili Method for diagnosing and for the therapeutic treatment of tumors and/or infectious diseases of different types with alkaloid-compounds
HU194858B (en) 1982-12-03 1988-03-28 Chinoin Gyogyszer Es Vegyeszet Process for producing dibenzo/b,d/pirane derivatives and pharmaceutical compositions containing them
IT1196033B (it) 1984-02-22 1988-11-10 Chiesi Farma Spa Composto ad attivita' antiinfiammatoria ottenuto per complessazione con beta-ciclodestrina e relative formulazioni farmaceutiche
US4727064A (en) 1984-04-25 1988-02-23 The United States Of America As Represented By The Department Of Health And Human Services Pharmaceutical preparations containing cyclodextrin derivatives
GB8506792D0 (en) 1985-03-15 1985-04-17 Janssen Pharmaceutica Nv Derivatives of y-cyclodextrin
GB8613688D0 (en) 1986-06-05 1986-07-09 Euro Celtique Sa Pharmaceutical composition
JPH0819004B2 (ja) 1986-12-26 1996-02-28 日清製粉株式会社 徐放性医薬製剤
HU201783B (en) 1987-10-13 1990-12-28 Chinoin Gyogyszer Es Vegyeszet Process for producing partially methylized carboxy-acyl-beta-cyclodextrines and salts
US5017566A (en) 1987-12-30 1991-05-21 University Of Florida Redox systems for brain-targeted drug delivery
US5002935A (en) 1987-12-30 1991-03-26 University Of Florida Improvements in redox systems for brain-targeted drug delivery
HUT58770A (en) 1989-04-03 1992-03-30 Janssen Pharmaceutica Nv Process for producing regioselective substituted cyclodextrines
US5173481A (en) 1989-04-03 1992-12-22 The United States Of America As Represented By The Department Of Health And Human Services Preparation of specifically substituted cyclodextrins
DK0447171T3 (da) * 1990-03-15 1994-12-12 Tanabe Seiyaku Co Polysulfat af cyclodextrinderivat og fremgangsmåde til fremstilling deraf
US5180716A (en) 1990-08-01 1993-01-19 The Regents Of The University Of California Cyclodextrin complexes for neuraxial administration of drugs
JP2556236B2 (ja) 1991-08-29 1996-11-20 田辺製薬株式会社 β−シクロデキストリン誘導体のポリ硫酸エステル及びその製法
US5840881A (en) 1992-11-27 1998-11-24 Takeda Chemical Industries, Ltd. Composition containing a water-insoluble or slightly water-soluble compound with enhanced water-solubility
US5767112A (en) 1994-10-21 1998-06-16 Poli Industria Chimica, S.P.A. Muscle relaxant pharmaceutical compositions
AU708107B2 (en) 1994-11-04 1999-07-29 Commonwealth Scientific And Industrial Research Organisation Method for treating animals
GB2307176A (en) * 1995-11-15 1997-05-21 Todd Selwyn Everest Anti-inflammatory clathrating agents for topical use
US5935941A (en) 1997-10-24 1999-08-10 Pitha; Josef Alkylations of cyclodextrins leading to derivatives which have a ridgidly extended cavity
US5834446A (en) * 1996-06-21 1998-11-10 Queen's University At Kingston Nerve process growth modulators
JP4249282B2 (ja) 1998-02-27 2009-04-02 日本食品化工株式会社 新規シクロデキストリン誘導体及びその製造方法
US6348498B1 (en) 1998-05-29 2002-02-19 Neurosciences Research Foundation, Inc. Control of pain with endogenous cannabinoids
WO2001012202A2 (en) 1999-08-13 2001-02-22 Akzo Nobel N.V. Use of chemical chelators as reversal agents for drug-induced neuromuscular block
TWI242015B (en) 1999-11-29 2005-10-21 Akzo Nobel Nv 6-mercapto-cyclodextrin derivatives: reversal agents for drug-induced neuromuscular block
US20020111377A1 (en) 2000-12-22 2002-08-15 Albany College Of Pharmacy Transdermal delivery of cannabinoids
JP4313041B2 (ja) 2001-02-14 2009-08-12 ナームローゼ・フエンノートチヤツプ・オルガノン 2−アルキル化−シクロデキストリン誘導体:薬物性神経筋遮断に対する拮抗薬
TW200402417A (en) 2002-06-21 2004-02-16 Akzo Nobel Nv 1-[(Indol-3-yl)carbonyl]piperazine derivatives

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