NO20070869L - Fremstilling av hydrokloridsalter av tetrazolderivater - Google Patents
Fremstilling av hydrokloridsalter av tetrazolderivaterInfo
- Publication number
- NO20070869L NO20070869L NO20070869A NO20070869A NO20070869L NO 20070869 L NO20070869 L NO 20070869L NO 20070869 A NO20070869 A NO 20070869A NO 20070869 A NO20070869 A NO 20070869A NO 20070869 L NO20070869 L NO 20070869L
- Authority
- NO
- Norway
- Prior art keywords
- irbesartan
- preparation
- anhydrous
- hydrochloride salts
- tetrazole derivatives
- Prior art date
Links
- 150000003840 hydrochlorides Chemical class 0.000 title abstract 2
- 150000003536 tetrazoles Chemical class 0.000 title 1
- 239000002947 C09CA04 - Irbesartan Substances 0.000 abstract 4
- YCPOHTHPUREGFM-UHFFFAOYSA-N irbesartan Chemical compound O=C1N(CC=2C=CC(=CC=2)C=2C(=CC=CC=2)C=2[N]N=NN=2)C(CCCC)=NC21CCCC2 YCPOHTHPUREGFM-UHFFFAOYSA-N 0.000 abstract 4
- 229960002198 irbesartan Drugs 0.000 abstract 4
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 abstract 2
- 239000013078 crystal Substances 0.000 abstract 1
- 239000000706 filtrate Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Den foreliggende oppfinnelse vedrører sesquihydrat hydrokloridsalt av irbesartan og vannfri hydrokloridsalter av irbesartan. Irbesartan anvendt som utgangsmateriale for fremstillingen av de beskrevne hydroklorider av irbesartan kan være i en hvilken som helst form, for eksempel kan det anvendes når det inneholdes i en reaksjonsløsning, i rå form, i et filtrat inneholdende flere løsningsmidler, eller i en vannfri eller en hvilken som helst solvatisert eller hydratisert form, i amorf form eller i en hvilken som helst kjent krystallform eller i en blanding derav.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SI200400220A SI21848A (sl) | 2004-07-29 | 2004-07-29 | Priprava seskvihidratne hidrokloridne soli tetrazolskega derivata |
SI200400292A SI21849A (sl) | 2004-07-29 | 2004-10-22 | Priprava hidrokloridnih soli tetrazolskega derivata |
PCT/SI2005/000023 WO2006011859A2 (en) | 2004-07-29 | 2005-07-29 | Preparation of hydrochloride salts of tetrazole derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20070869L true NO20070869L (no) | 2007-04-19 |
Family
ID=35786598
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20070869A NO20070869L (no) | 2004-07-29 | 2007-02-15 | Fremstilling av hydrokloridsalter av tetrazolderivater |
Country Status (7)
Country | Link |
---|---|
US (1) | US7875641B2 (no) |
EP (1) | EP1773818B1 (no) |
CA (1) | CA2575254A1 (no) |
EA (1) | EA011713B1 (no) |
NO (1) | NO20070869L (no) |
SI (1) | SI21849A (no) |
WO (1) | WO2006011859A2 (no) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI21965A (sl) * | 2005-01-05 | 2006-08-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Priprava tetrazolskega derivata |
FR2886642B1 (fr) * | 2005-06-06 | 2008-05-30 | Sanofi Aventis Sa | Sels alcalino-terreux d'irbesartan et leur preparation |
SI1806130T1 (sl) * | 2006-01-09 | 2010-06-30 | KRKA@@d@d@@@Novo@mesto | Trden farmacevtski sestavek ki obsega irbesartan |
CA2654218C (en) * | 2006-04-07 | 2014-07-22 | Lek Pharmaceuticals D.D. | Process for the preparation of pure irbesartan |
EP2194050A1 (en) | 2008-12-08 | 2010-06-09 | KRKA, tovarna zdravil, d.d., Novo mesto | A new process for the preparation of irbesartan |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT97078B (pt) | 1990-03-20 | 1997-07-31 | Sanofi Sa | Processo para a preparacao de derivados heterociclicos n-substituidos e de composicoes farmaceuticas que os contem |
US5541209A (en) | 1994-08-22 | 1996-07-30 | Bristol-Myers Squibb Company | Method of treating or preventing cardiac arrhythmia employing an N-substituted heterocyclic derivative |
FR2725987B1 (fr) | 1994-10-19 | 1997-01-10 | Sanofi Sa | Procede pour la preparation d'un derive de tetrazole sous deux formes cristallines et nouvelle forme cristalline de ce derive |
FR2780403B3 (fr) | 1998-06-24 | 2000-07-21 | Sanofi Sa | Nouvelle forme de l'irbesartan, procedes pour obtenir ladite forme et compositions pharmaceutiques en contenant |
CA2469656A1 (en) | 2001-12-10 | 2003-06-19 | Dr. Reddy's Laboratories Limited | Amorphous form of 2-n-butyl-3-( (2-(1h-tetrazol-5-yl) (1,1'-biphenyl)-4-yl) methyl) -1,3-diazaspiro (4,4') non-1-en-4-one |
-
2004
- 2004-10-22 SI SI200400292A patent/SI21849A/sl not_active IP Right Cessation
-
2005
- 2005-07-29 EA EA200700198A patent/EA011713B1/ru not_active IP Right Cessation
- 2005-07-29 EP EP05763362.0A patent/EP1773818B1/en active Active
- 2005-07-29 WO PCT/SI2005/000023 patent/WO2006011859A2/en active Application Filing
- 2005-07-29 CA CA002575254A patent/CA2575254A1/en not_active Abandoned
- 2005-07-29 US US11/658,632 patent/US7875641B2/en not_active Expired - Fee Related
-
2007
- 2007-02-15 NO NO20070869A patent/NO20070869L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
US20080306128A1 (en) | 2008-12-11 |
US7875641B2 (en) | 2011-01-25 |
CA2575254A1 (en) | 2006-02-02 |
EP1773818A2 (en) | 2007-04-18 |
EA200700198A1 (ru) | 2007-06-29 |
EP1773818B1 (en) | 2014-09-24 |
EA011713B1 (ru) | 2009-04-28 |
WO2006011859A3 (en) | 2006-07-06 |
WO2006011859A2 (en) | 2006-02-02 |
SI21849A (sl) | 2006-02-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |