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NO20063676L - Indolderivater og anvendelse derav som kinaseinhibitorer i spesielle IKK2 inhibitorer - Google Patents

Indolderivater og anvendelse derav som kinaseinhibitorer i spesielle IKK2 inhibitorer

Info

Publication number
NO20063676L
NO20063676L NO20063676A NO20063676A NO20063676L NO 20063676 L NO20063676 L NO 20063676L NO 20063676 A NO20063676 A NO 20063676A NO 20063676 A NO20063676 A NO 20063676A NO 20063676 L NO20063676 L NO 20063676L
Authority
NO
Norway
Prior art keywords
inhibitors
indole derivatives
kinase inhibitors
particular ikk2
kinase
Prior art date
Application number
NO20063676A
Other languages
English (en)
Inventor
Paul Bamborough
Lan Robert Baldwin
John Andrew Christopher
Jeffrey K Kerns
Timothy Longstaff
David Drysdale Miller
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of NO20063676L publication Critical patent/NO20063676L/no

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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

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  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
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Abstract

Indolkarboksamid forbindelser med Formel (I) er tilveiebrakt som inhibitorer av kinaseaktivitet, særlig IKK2-aktivitet, så vel som sammensetninger og medikamenter som inneholder dem, for anvendelse ved inflammasjons- og vevsrepareringsforstyrrelser.
NO20063676A 2004-01-15 2006-08-15 Indolderivater og anvendelse derav som kinaseinhibitorer i spesielle IKK2 inhibitorer NO20063676L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0400895.9A GB0400895D0 (en) 2004-01-15 2004-01-15 Chemical compounds
PCT/GB2005/000085 WO2005067923A1 (en) 2004-01-15 2005-01-13 Indole derivatives and use thereof as kinase inhibitors in particular ikk2 inhibitors

Publications (1)

Publication Number Publication Date
NO20063676L true NO20063676L (no) 2006-10-13

Family

ID=31726240

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20063676A NO20063676L (no) 2004-01-15 2006-08-15 Indolderivater og anvendelse derav som kinaseinhibitorer i spesielle IKK2 inhibitorer

Country Status (24)

Country Link
US (1) US20080269200A1 (no)
EP (1) EP1703905B1 (no)
JP (2) JP4975447B2 (no)
KR (1) KR20070026357A (no)
CN (1) CN1933830A (no)
AT (1) ATE413877T1 (no)
AU (1) AU2005205090A1 (no)
BR (1) BRPI0506802A (no)
CA (1) CA2552953A1 (no)
DE (1) DE602005010970D1 (no)
DK (1) DK1703905T3 (no)
ES (1) ES2317184T3 (no)
GB (1) GB0400895D0 (no)
HK (1) HK1098047A1 (no)
HR (1) HRP20090071T3 (no)
IL (1) IL176739A0 (no)
MA (1) MA28279A1 (no)
NO (1) NO20063676L (no)
PL (1) PL1703905T3 (no)
PT (1) PT1703905E (no)
RU (1) RU2006129492A (no)
SI (1) SI1703905T1 (no)
WO (1) WO2005067923A1 (no)
ZA (1) ZA200604855B (no)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200616967A (en) * 2004-06-24 2006-06-01 Smithkline Beecham Corp Novel indazole carboxamides and their use
PE20060748A1 (es) 2004-09-21 2006-10-01 Smithkline Beecham Corp Derivados de indolcarboxamida como inhibidores de quinasa ikk2
US8063071B2 (en) 2007-10-31 2011-11-22 GlaxoSmithKline, LLC Chemical compounds
WO2007005534A2 (en) * 2005-06-30 2007-01-11 Smithkline Beecham Corporation Chemical compounds
EP1940296A2 (en) * 2005-10-25 2008-07-09 SmithKline Beecham Corporation Chemical compounds
EP1948187A4 (en) * 2005-11-18 2010-11-03 Glaxosmithkline Llc CHEMICAL COMPOUNDS
US20080293802A1 (en) * 2005-12-16 2008-11-27 Smithline Beecham Corporation Chemical Compounds
RU2470918C2 (ru) * 2007-01-15 2012-12-27 Сантен Фармасьютикал Ко., Лтд. НОВЫЕ ПРОИЗВОДНЫЕ ИНДОЛА, ОБЛАДАЮЩИЕ ИНГИБИРУЮЩЕЙ АКТИВНОСТЬЮ В ОТНОШЕНИИ IκB КИНАЗЫ β
AR065804A1 (es) * 2007-03-23 2009-07-01 Smithkline Beecham Corp Compuesto de indol carboxamida, composicion farmaceutica que lo comprende y uso de dicho compuesto para preparar un medicamento
WO2009100130A1 (en) * 2008-02-04 2009-08-13 Mercury Therapeutics, Inc. Ampk modulators
US20110009421A1 (en) * 2008-02-27 2011-01-13 Takeda Pharmaceutical Company Limited Compound having 6-membered aromatic ring
WO2010007972A1 (ja) * 2008-07-14 2010-01-21 参天製薬株式会社 カルバモイル基、ウレイド基及び置換オキシ基を有する新規インドール誘導体
US20110313197A1 (en) * 2009-03-05 2011-12-22 Sumitomo Chemical Company, Limited Method for producing halogen-substituted benzene dimethanol
WO2010102968A1 (en) 2009-03-10 2010-09-16 Glaxo Group Limited Indole derivatives as ikk2 inhibitors
JP5908493B2 (ja) * 2010-12-01 2016-04-26 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーＧｌａｘｏＳｍｉｔｈＫｌｉｎｅ ＬＬＣ インドール
WO2014036268A2 (en) * 2012-08-29 2014-03-06 Mount Sinai School Of Medicine Indole derivatives as sumo activators
FR3001219A1 (fr) * 2013-01-22 2014-07-25 Centre Nat Rech Scient Inhibiteurs de kinases
TWI644899B (zh) 2013-02-04 2018-12-21 健生藥品公司 Ｆｌａｐ調節劑
EP2951170B1 (en) 2013-02-04 2018-10-24 Janssen Pharmaceutica NV Flap modulators
KR102273997B1 (ko) * 2013-06-26 2021-07-08 애브비 인코포레이티드 Btk 억제제로서 1급 카복스아미드
JP6644792B2 (ja) * 2014-12-18 2020-02-12 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト ベンザゼピンスルホンアミド化合物
US20170158702A1 (en) * 2015-12-02 2017-06-08 Kyras Therapeutics, Inc. Multivalent ras binding compounds
WO2018013430A2 (en) 2016-07-12 2018-01-18 Arisan Therapeutics Inc. Heterocyclic compounds for the treatment of arenavirus infection
US11008360B2 (en) 2017-06-07 2021-05-18 Institute Of Chinese Materia Medica, China Academy Of Chinese Medical Sciences Indoleacetic acid derivative and preparation method and pharmaceutical use thereof
WO2024059220A2 (en) * 2022-09-15 2024-03-21 Vanderbilt University 6,5 southwestern core compounds as mglu5 negative allosteric modulators and methods of making and using the same

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4775761A (en) * 1983-08-22 1988-10-04 Hoechst-Roussel Pharmaceuticals, Inc. 3-(piperidinyl)- and 3-(pyrrolidinyl)-1H-indazoles
US5256673A (en) * 1983-11-25 1993-10-26 Merck Patent Gesellschaft Mit Beschrankter Haftung Indole-3-yl-A-tetrahydropyridyl or piperidyl compounds
DE3342632A1 (de) * 1983-11-25 1985-06-05 Merck Patent Gmbh, 6100 Darmstadt Indolderivate
JPH0262875A (ja) * 1988-05-23 1990-03-02 Wakunaga Pharmaceut Co Ltd 新規イソインドリン誘導体
US5254473A (en) * 1990-03-16 1993-10-19 Jp Laboratories Solid state device for monitoring integral values of time and temperature of storage of perishables
US5330986A (en) * 1992-11-24 1994-07-19 Hoechst-Roussel Pharmaceuticals Inc. Indole-7-carboxamide derivatives
ZA951822B (en) * 1994-12-23 1996-09-26 Glaxo Group Ltd Chemical compounds
DE19756036A1 (de) * 1997-12-17 1999-06-24 Merck Patent Gmbh Amid- und Harnstoffderivate
US6589954B1 (en) * 1998-05-22 2003-07-08 Scios, Inc. Compounds and methods to treat cardiac failure and other disorders
MXPA02001568A (es) * 1999-08-13 2002-07-02 Vela Pharmaceuticals Inc Ciclobenzaprina para tratar trastornos de ansiedad generalizada y composiciones de la misma.
US6245799B1 (en) * 1999-11-08 2001-06-12 American Home Products Corp [(Indol-3-yl)-cycloalkyl]-3-substituted azetidines for the treatment of central nervous system disorders
CA2407370A1 (en) * 2000-04-24 2001-11-01 Bristol-Myers Squibb Company Heterocycles that are inhibitors of impdh enzyme
US20050009876A1 (en) * 2000-07-31 2005-01-13 Bhagwat Shripad S. Indazole compounds, compositions thereof and methods of treatment therewith
US6897231B2 (en) * 2000-07-31 2005-05-24 Signal Pharmaceuticals, Inc. Indazole derivatives as JNK inhibitors and compositions and methods related thereto
MXPA03001960A (es) * 2000-09-06 2004-03-18 Johnson & Johnson Un metodo para tratar alergias.
US6869956B2 (en) * 2000-10-03 2005-03-22 Bristol-Myers Squibb Company Methods of treating inflammatory and immune diseases using inhibitors of IκB kinase (IKK)
ES2305125T3 (es) * 2000-10-26 2008-11-01 Amgen Inc. Agentes anti-inflamatorios.
CA2449874C (en) * 2001-06-07 2009-06-23 F. Hoffmann-La Roche Ag New indole derivatives with 5-ht6 receptor affinity
CA2460942A1 (en) * 2001-09-19 2003-03-27 Pharmacia Corporation Substituted pyrazolyl compounds for the treatment of inflammation
CA2464924A1 (en) * 2001-10-30 2003-05-08 Pharmacia Corporation Heteroaromatic carboxamide derivatives for the treatment of inflammation
JP2005526831A (ja) * 2002-04-09 2005-09-08 アステックス テクノロジー リミテッド 医薬化合物
AR039280A1 (es) * 2002-04-11 2005-02-16 Smithkline Beecham Corp Compuesto de aminotiofeno y su uso para preparar una composicion farmaceutica
AU2003286180B2 (en) * 2002-12-02 2009-11-12 F. Hoffmann-La Roche Ag Indazole derivatives as CRF antagonists
JP2006510676A (ja) * 2002-12-06 2006-03-30 スミスクライン・ビーチャム・コーポレイション ＮＦ−κＢ阻害剤
US7572914B2 (en) * 2003-12-19 2009-08-11 Takeda Pharmaceutical Company Limited Kinase inhibitors
DE102004012069A1 (de) * 2004-03-12 2005-09-29 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue aryl-haltige 5-Acylindolinone, deren Herstellung und deren Verwendung als Arzneimittel
TW200616967A (en) * 2004-06-24 2006-06-01 Smithkline Beecham Corp Novel indazole carboxamides and their use
PE20060748A1 (es) * 2004-09-21 2006-10-01 Smithkline Beecham Corp Derivados de indolcarboxamida como inhibidores de quinasa ikk2
EA013123B1 (ru) * 2005-04-13 2010-02-26 Ньюрэксон, Инк. Замещенные индолы, обладающие активностью ингибирования nos
US8063071B2 (en) * 2007-10-31 2011-11-22 GlaxoSmithKline, LLC Chemical compounds
JP5072594B2 (ja) * 2005-07-22 2012-11-14 塩野義製薬株式会社 Ｐｇｄ２受容体アンタゴニスト活性を有するインドール誘導体
EP1940296A2 (en) * 2005-10-25 2008-07-09 SmithKline Beecham Corporation Chemical compounds
EP1940394A4 (en) * 2005-10-25 2009-07-08 Smithkline Beecham Corp CHEMICAL COMPOUNDS
EP1948187A4 (en) * 2005-11-18 2010-11-03 Glaxosmithkline Llc CHEMICAL COMPOUNDS
US20080293802A1 (en) * 2005-12-16 2008-11-27 Smithline Beecham Corporation Chemical Compounds
MX2008012482A (es) * 2006-03-31 2008-10-10 Abbott Lab Compuestos de indazol.
CL2007002708A1 (es) * 2006-09-22 2008-04-04 Glaxo Group Ltd Compuestos derivados de pirrolo[2,3-b]piridina; procedimiento de preparacion; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, caquexia, trastornos inflamatorios, entre otros.
AR065804A1 (es) * 2007-03-23 2009-07-01 Smithkline Beecham Corp Compuesto de indol carboxamida, composicion farmaceutica que lo comprende y uso de dicho compuesto para preparar un medicamento
GB0710528D0 (en) * 2007-06-01 2007-07-11 Glaxo Group Ltd Novel compounds

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ZA200604855B (en) 2007-11-28
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DE602005010970D1 (de) 2008-12-24
ATE413877T1 (de) 2008-11-15
ES2317184T3 (es) 2009-04-16
SI1703905T1 (sl) 2009-04-30
KR20070026357A (ko) 2007-03-08
EP1703905A1 (en) 2006-09-27
AU2005205090A1 (en) 2005-07-28
GB0400895D0 (en) 2004-02-18
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CN1933830A (zh) 2007-03-21
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CA2552953A1 (en) 2005-07-28
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