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NO20063268L - Fremgangsmate til fremstilling av 1-(2S,3S)-2-benzhydryl-N-(5-tert-butyl-2-metoksybenzyl)quinuklidin-3-amin - Google Patents

Fremgangsmate til fremstilling av 1-(2S,3S)-2-benzhydryl-N-(5-tert-butyl-2-metoksybenzyl)quinuklidin-3-amin

Info

Publication number
NO20063268L
NO20063268L NO20063268A NO20063268A NO20063268L NO 20063268 L NO20063268 L NO 20063268L NO 20063268 A NO20063268 A NO 20063268A NO 20063268 A NO20063268 A NO 20063268A NO 20063268 L NO20063268 L NO 20063268L
Authority
NO
Norway
Prior art keywords
quinuclidin
benzhydryl
methoxybenzyl
amine
butyl
Prior art date
Application number
NO20063268A
Other languages
English (en)
Inventor
Patricia Ann Basford
Julian Duncan Smith
Ronald James Post
Geraldine Patricia Taber
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of NO20063268L publication Critical patent/NO20063268L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Det beskrives en forbedret fremgangsmåte for fremstilling av (2S,3S)-2-benzhydryl-A/-(5-teAf-butyl-2-metoksybenzyl)quinuklidin-3-amin, (heretter benevnt "forbindelse av formel I) og dets farmasøytisk akseptable salter. Nærmere bestemt vedrører oppfinnelsen en forbedret syntese av monohydratsitratsaltet av forbindelsen av formel la.
NO20063268A 2004-02-02 2006-07-13 Fremgangsmate til fremstilling av 1-(2S,3S)-2-benzhydryl-N-(5-tert-butyl-2-metoksybenzyl)quinuklidin-3-amin NO20063268L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54132304P 2004-02-02 2004-02-02
PCT/IB2005/000221 WO2005075473A1 (en) 2004-02-02 2005-01-26 Process for preparation of 1-(2s,3s)-2-benzhydr yl-n-(5-tert-butyl-2-methoxybenzyl)quinuclidin-3-amine

Publications (1)

Publication Number Publication Date
NO20063268L true NO20063268L (no) 2006-08-15

Family

ID=34837478

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20063268A NO20063268L (no) 2004-02-02 2006-07-13 Fremgangsmate til fremstilling av 1-(2S,3S)-2-benzhydryl-N-(5-tert-butyl-2-metoksybenzyl)quinuklidin-3-amin

Country Status (22)

Country Link
US (1) US20090099364A1 (no)
EP (1) EP1713801B1 (no)
JP (1) JP2007519710A (no)
KR (1) KR100812046B1 (no)
CN (1) CN1914202A (no)
AR (1) AR047523A1 (no)
AT (1) ATE380811T1 (no)
AU (1) AU2005210259A1 (no)
BR (1) BRPI0507334A (no)
CA (1) CA2554360A1 (no)
CY (1) CY1107141T1 (no)
DE (1) DE602005003791T2 (no)
DK (1) DK1713801T3 (no)
ES (1) ES2296131T3 (no)
IL (1) IL176817A0 (no)
NO (1) NO20063268L (no)
PL (1) PL1713801T3 (no)
PT (1) PT1713801E (no)
RU (1) RU2320659C9 (no)
SI (1) SI1713801T1 (no)
WO (1) WO2005075473A1 (no)
ZA (1) ZA200605784B (no)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1713504T3 (en) 2004-01-30 2017-08-07 Zoetis Services Llc Antimicrobial preservatives to obtain multi-dose formulations using beta-cyclodextrins for liquid dosage forms
JP5956980B2 (ja) 2010-05-19 2016-07-27 サンド・アクチエンゲゼルシヤフト キラル化合物の調製の方法
CA2798010C (en) 2010-05-19 2018-09-25 Sandoz Ag Purification of posaconazole and of posaconazole intermediates
WO2011144656A1 (en) 2010-05-19 2011-11-24 Sandoz Ag Preparation of posaconazole intermediates
US9446029B2 (en) 2010-07-27 2016-09-20 Colorado State University Research Foundation Use of NK-1 receptor antagonists in management of visceral pain
DE102011100534A1 (de) 2011-05-05 2012-11-08 Howaldtswerke-Deutsche Werft Gmbh Verfahren zum Betreiben einer Reformer-Brennstoffzellenanlage
US9493428B2 (en) 2011-06-16 2016-11-15 Sandoz Ag Process for the preparation of a chiral compound
CN108341811A (zh) * 2017-01-23 2018-07-31 科贝源(北京)生物医药科技有限公司 马罗皮坦杂质的制备方法
CN108341812A (zh) * 2017-01-23 2018-07-31 科贝源(北京)生物医药科技有限公司 一种含奎宁环化合物的制备方法
CN106977512B (zh) * 2017-05-04 2019-01-01 海门慧聚药业有限公司 制备马罗匹坦游离碱的方法
CN110577522B (zh) * 2018-06-07 2022-12-27 东莞市东阳光动物保健药品有限公司 马罗匹坦柠檬酸盐新晶型及其制备方法
CN109320510B (zh) * 2018-11-27 2021-04-27 江苏慧聚药业有限公司 一种马罗匹坦游离碱的制备方法
CN112979639A (zh) * 2019-12-16 2021-06-18 四川科瑞德凯华制药有限公司 一种马罗皮坦新晶型及其制备方法
KR102666745B1 (ko) * 2023-09-06 2024-05-17 주식회사 에스아이켐 시선 유도봉 및 표지병의 노면부착용 에폭시계 접착제 조성물 및 이를 이용한 시선 유도봉 및 표지병의 시공방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ281403B6 (cs) * 1991-05-31 1996-09-11 Pfizer Inc. Chinuklidinové deriváty, způsob jejich přípravy a použití.
US5393762A (en) * 1993-06-04 1995-02-28 Pfizer Inc. Pharmaceutical agents for treatment of emesis
PE8798A1 (es) * 1995-07-17 1998-03-02 Pfizer Procedimiento de separacion de los enantiomeros del 1-azabiciclo[2.2.2] octan-3-amina, 2-(difenilmetil) -n- [[2-metoxi-5-(1-metiletil) fenil] metil]
US6255320B1 (en) * 1999-06-01 2001-07-03 Pfizer Inc. Polymorphs of a crystalline azo-bicyclo (2,2,2) octan-3-amine citrate and their pharmaceutical compositions
US6861526B2 (en) * 2002-10-16 2005-03-01 Pfizer Inc. Process for the preparation of (S,S)-cis-2-benzhydryl-3-benzylaminoquinuclidine

Also Published As

Publication number Publication date
US20090099364A1 (en) 2009-04-16
BRPI0507334A (pt) 2007-07-03
DK1713801T3 (da) 2008-03-17
SI1713801T1 (sl) 2008-04-30
CA2554360A1 (en) 2005-08-18
RU2320659C9 (ru) 2008-07-20
DE602005003791T2 (de) 2008-05-29
IL176817A0 (en) 2006-10-31
ZA200605784B (en) 2007-11-28
CN1914202A (zh) 2007-02-14
ATE380811T1 (de) 2007-12-15
KR20060127966A (ko) 2006-12-13
WO2005075473A1 (en) 2005-08-18
ES2296131T3 (es) 2008-04-16
EP1713801A1 (en) 2006-10-25
CY1107141T1 (el) 2012-10-24
AU2005210259A1 (en) 2005-08-18
RU2320659C1 (ru) 2008-03-27
PT1713801E (pt) 2008-02-11
AR047523A1 (es) 2006-01-25
DE602005003791D1 (de) 2008-01-24
EP1713801B1 (en) 2007-12-12
JP2007519710A (ja) 2007-07-19
PL1713801T3 (pl) 2008-04-30
KR100812046B1 (ko) 2008-03-10

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