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NO20061599L - Benzoksazol acetonitriler - Google Patents

Benzoksazol acetonitriler

Info

Publication number
NO20061599L
NO20061599L NO20061599A NO20061599A NO20061599L NO 20061599 L NO20061599 L NO 20061599L NO 20061599 A NO20061599 A NO 20061599A NO 20061599 A NO20061599 A NO 20061599A NO 20061599 L NO20061599 L NO 20061599L
Authority
NO
Norway
Prior art keywords
acetonitriles
benzoxazole
group
insulin resistance
amino
Prior art date
Application number
NO20061599A
Other languages
English (en)
Inventor
Jean-Pierre Gotteland
Pascale Gaillard
Matthias Schwarz
Patrick Page
Thomas J Russell
Original Assignee
Applied Research Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems filed Critical Applied Research Systems
Publication of NO20061599L publication Critical patent/NO20061599L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Foreliggende oppfinnelse angår benzoksazolacetonitriler så vel som farmasøytiske formuleringer som inneholder slike benzoksazolacetonitriler med formel (I). Nevnte benzoksazolacetonitriler kan brukes ved behandlingen av metabolske lidelser som er kontrollert eller forårsaket av insulinresistens eller hyperglykemi, og som omfatter diabetes type II utilstrekkelig glukosetoleranse, insulinresistens, overvekt eller polycystisk eggstokksyndrom (PCOS). Oppfinnelsen angår videre fremgangsmåter for fremstilling av benzoksazolacetonitriler (I). A er pyrimidinyl, L er en sekundær eller tertiær aminogruppe, eller en 3-8-leddet heterosykloalkylgruppe, som inneholder minst ett heteroatom valgt fra N, O eller S, eller L er en acylaminogruppe. R1 er valgt fra gruppen bestående av hydrogen, sulfonyl, amino, Ci-C6-alkyl, C2-Cg-alkenyl, C2-C6-alkynyl eller Ci-C6-alkoksy, aryl, halogen, karboksy, aminokarbonyl, cyano eller hydroksy.
NO20061599A 2003-09-12 2006-04-07 Benzoksazol acetonitriler NO20061599L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03102739 2003-09-12
PCT/EP2004/052141 WO2005026159A1 (en) 2003-09-12 2004-09-10 Benzoxazole acetonitriles

Publications (1)

Publication Number Publication Date
NO20061599L true NO20061599L (no) 2006-06-12

Family

ID=34306920

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20061599A NO20061599L (no) 2003-09-12 2006-04-07 Benzoksazol acetonitriler

Country Status (8)

Country Link
US (1) US20070185104A1 (no)
EP (1) EP1668004A1 (no)
JP (1) JP2007505087A (no)
AU (1) AU2004272307A1 (no)
CA (1) CA2534319A1 (no)
IL (1) IL174252A0 (no)
NO (1) NO20061599L (no)
WO (1) WO2005026159A1 (no)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2258359A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis by muscarinic receptor modulation with sabcomelin
EP1928437A2 (en) 2005-08-26 2008-06-11 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
JP2009512711A (ja) 2005-10-21 2009-03-26 ブレインセルス，インコーポレイティド Ｐｄｅ阻害による神経新生の調節
AU2006308889A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. GABA receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
EP2021000A2 (en) 2006-05-09 2009-02-11 Braincells, Inc. Neurogenesis by modulating angiotensin
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1110957A1 (en) * 1999-12-24 2001-06-27 Applied Research Systems ARS Holding N.V. Benzazole derivatives and their use as JNK modulators
KR100860827B1 (ko) * 2000-09-06 2008-09-30 노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드 글리코겐 합성효소 키나아제 3의 억제제

Also Published As

Publication number Publication date
AU2004272307A1 (en) 2005-03-24
US20070185104A1 (en) 2007-08-09
JP2007505087A (ja) 2007-03-08
IL174252A0 (en) 2006-08-01
CA2534319A1 (en) 2005-03-24
EP1668004A1 (en) 2006-06-14
WO2005026159A1 (en) 2005-03-24

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Legal Events

Date Code Title Description
CREP Change of representative

Representative=s name: ONSAGERS AS, POSTBOKS 6963 ST OLAVS PLASS, 0130 OS

FC2A Withdrawal, rejection or dismissal of laid open patent application