NO20055312L - Pharmaceutical composition comprising a biospecific antibody for EPCAM - Google Patents
Pharmaceutical composition comprising a biospecific antibody for EPCAMInfo
- Publication number
- NO20055312L NO20055312L NO20055312A NO20055312A NO20055312L NO 20055312 L NO20055312 L NO 20055312L NO 20055312 A NO20055312 A NO 20055312A NO 20055312 A NO20055312 A NO 20055312A NO 20055312 L NO20055312 L NO 20055312L
- Authority
- NO
- Norway
- Prior art keywords
- pharmaceutical composition
- chain antibody
- epcam
- antigen
- prevention
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 102000012804 EPCAM Human genes 0.000 title 1
- 101150084967 EPCAM gene Proteins 0.000 title 1
- 101150057140 TACSTD1 gene Proteins 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 239000000427 antigen Substances 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 230000002265 prevention Effects 0.000 abstract 2
- 102000018651 Epithelial Cell Adhesion Molecule Human genes 0.000 abstract 1
- 108010066687 Epithelial Cell Adhesion Molecule Proteins 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
Landscapes
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
Foreliggende oppfirmelse tilveiebringer en farmasøytisk sammensetning som omfatter en bispesifikk, enkel kjedeantistoffkonstruksjon. Nevnte bispesifikke enkle kjedeantistofiEkonstruksjon er karakterisert til å omfatte, eller bestå av, minst to domener hvor ett av nevnte minst to domener spesifikt binder seg til humant EpCAM og omfatter minst en CDR-H3-region som omfatter aminosyresekvensen NXIL-antigen og et andre domene som binder til humant CD3 -antigen. Oppfirmelsen tilveiebringer videre en prosess for å produsere den farmasøytiske sammensetningen av oppfirmelsen, en fremgangsmåte for forebyggingen, behandlingen eller forbedringen av en tumorsykdom og anvendelsen av det utgreiede, bispesifikke enkeltkjedeantistofifkonstruksjonen og korresponderende måter i forebyggingen, behandlingen eller forbedringen av en tumorsykdom.The present invention provides a pharmaceutical composition comprising a bispecific, simple chain antibody construct. Said bispecific single chain antibody construct is characterized to comprise, or consist of, at least two domains wherein one of said at least two domains specifically binds to human EpCAM and comprises at least one CDR-H3 region comprising the amino acid sequence NXIL antigen and another domain comprising binds to human CD3 antigen. The invention further provides a process for producing the pharmaceutical composition of the invention, a method for the prevention, treatment or amelioration of a tumor disease and the use of the extended, bispecific single chain antibody structure and corresponding ways in the prevention, treatment or enhancement of the tumor.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03012133 | 2003-05-31 | ||
| EP03013134.6A EP1376723A2 (en) | 2002-06-24 | 2003-06-11 | Separator for fuel cells based on graphite, epoxy, phenolic and polycarbodiimide resin |
| PCT/EP2004/005687 WO2004106383A1 (en) | 2003-05-31 | 2004-05-26 | Pharmaceutical composition comprising a bispecific antibody for epcam |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20055312D0 NO20055312D0 (en) | 2005-11-10 |
| NO20055312L true NO20055312L (en) | 2006-02-07 |
Family
ID=35432935
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20055312A NO20055312L (en) | 2003-05-31 | 2005-11-10 | Pharmaceutical composition comprising a biospecific antibody for EPCAM |
Country Status (1)
| Country | Link |
|---|---|
| NO (1) | NO20055312L (en) |
-
2005
- 2005-11-10 NO NO20055312A patent/NO20055312L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO20055312D0 (en) | 2005-11-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |