NO20055230L - HIV-integraseinhibitorer - Google Patents
HIV-integraseinhibitorerInfo
- Publication number
- NO20055230L NO20055230L NO20055230A NO20055230A NO20055230L NO 20055230 L NO20055230 L NO 20055230L NO 20055230 A NO20055230 A NO 20055230A NO 20055230 A NO20055230 A NO 20055230A NO 20055230 L NO20055230 L NO 20055230L
- Authority
- NO
- Norway
- Prior art keywords
- optionally
- substituted
- multisubstituted
- het2
- nr8r9
- Prior art date
Links
- 108010002459 HIV Integrase Proteins 0.000 title 1
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- 125000000882 C2-C6 alkenyl group Chemical class 0.000 abstract 1
- 125000003601 C2-C6 alkynyl group Chemical class 0.000 abstract 1
- 238000009007 Diagnostic Kit Methods 0.000 abstract 1
- 229940099797 HIV integrase inhibitor Drugs 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 229940124522 antiretrovirals Drugs 0.000 abstract 1
- 239000003903 antiretrovirus agent Substances 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 239000003084 hiv integrase inhibitor Substances 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 230000002250 progressing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- AIDS & HIV (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
A, sammen med de to karbonatomer av fenylringen som den er bundet til, danner monocyklisk aryl eller monocyklisk Het2; R1 er hydrogen, halo, nitro, cyano, sultam, sultim, C3.7-cykloalkyl, C(=O)-R5, S(=O)y-R6, OR7, NR8R9, C(=NR8)-R5, valgfritt flersubstituert C^-alkyl, valgfritt flersubsti-tuert C2.6-alkenyl eller valgfritt flersubstituert C2.6-alkynyl; R2 er hydrogen, C3.7-cykloalkyl, aryl, Het1, Het2, C(=O)-R5, S(=O)y-R6, OR7, NR8R9, C (=NR8) -R5 eller valgfritt flersubstituert C^g-alkyl, valgfritt flersubstituert C2.6-alkenyl eller valgfritt flersubstituert C2.6-alkynyl. Anvendelse derav som HIV-integraseinhibitorer, fremgangs-mater for deres fremstilling samt farmasoytiske sammenset-ninger og diagnostiske sett som inneholder dem. Dessuten kombinasjoner derav med andre anti-retrovirale midler og deres anvendelse i assayer som referanseforbindelser eller som reagensmidler.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46598703P | 2003-04-28 | 2003-04-28 | |
| EP03101164 | 2003-04-28 | ||
| PCT/EP2004/050621 WO2004096807A2 (en) | 2003-04-28 | 2004-04-27 | Hiv integrase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20055230L true NO20055230L (no) | 2005-11-07 |
Family
ID=33420586
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20055230A NO20055230L (no) | 2003-04-28 | 2005-11-07 | HIV-integraseinhibitorer |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20060211724A1 (no) |
| EP (1) | EP1625130A2 (no) |
| KR (1) | KR20060006047A (no) |
| CN (1) | CN1812992A (no) |
| AP (1) | AP2005003451A0 (no) |
| AR (1) | AR044518A1 (no) |
| AU (1) | AU2004234087A1 (no) |
| BR (1) | BRPI0409873A (no) |
| CA (1) | CA2522990A1 (no) |
| MX (1) | MXPA05011726A (no) |
| NO (1) | NO20055230L (no) |
| TW (1) | TW200507848A (no) |
| WO (1) | WO2004096807A2 (no) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006125048A2 (en) * | 2005-05-16 | 2006-11-23 | Gilead Sciences, Inc. | Hiv-integrase inhibitor compounds |
| CA2608214C (en) | 2005-05-19 | 2013-08-20 | Merck Frosst Canada Ltd. | Quinoline derivatives as ep4 antagonists |
| AR057455A1 (es) | 2005-07-22 | 2007-12-05 | Merck & Co Inc | Inhibidores de la transcriptasa reversa de vih y composicion farmaceutica |
| CA2616314A1 (en) * | 2005-07-27 | 2007-02-01 | Gilead Sciences, Inc. | Antiviral phosphonate conjugates for inhibition of hiv |
| EP1973908A2 (en) * | 2005-12-21 | 2008-10-01 | Gilead Sciences, Inc. | Processes and intermediates useful for preparing integrase inhibitor compounds |
| US20090306054A1 (en) | 2006-05-16 | 2009-12-10 | Gilead Sciences ,Inc. | Integrase inhibitors |
| EP1916249A1 (en) * | 2006-10-10 | 2008-04-30 | LEK Pharmaceuticals D.D. | 3-(benzo[d][1,3]dioxol-5-ylmethyl)-4-(thio)oxo-2-(thio)oxo-azolidin-5-ylidene derivatives as antibacterial agents |
| CN101686680B (zh) | 2007-03-09 | 2015-12-09 | 伊沃泰克美国股份有限公司 | 作为p2x7调节剂的双环杂芳基化合物及其用途 |
| WO2009067541A2 (en) * | 2007-11-20 | 2009-05-28 | Gilead Sciences, Inc. | Integrase inhibitors |
| CN105055432A (zh) | 2008-01-25 | 2015-11-18 | 奇默里克斯公司 | 治疗病毒感染的方法 |
| US9249147B2 (en) | 2008-03-19 | 2016-02-02 | Chembridge Corporation | Tyrosine kinase inhibitors |
| AU2009226153B2 (en) | 2008-03-19 | 2014-02-20 | Chembridge Corporation | Novel tyrosine kinase inhibitors |
| WO2010115264A1 (en) * | 2009-04-09 | 2010-10-14 | Boehringer Ingelheim International Gmbh | Inhibitors of hiv replication |
| US8283366B2 (en) | 2010-01-22 | 2012-10-09 | Ambrilia Biopharma, Inc. | Derivatives of pyridoxine for inhibiting HIV integrase |
| PL2534150T3 (pl) | 2010-02-12 | 2017-09-29 | Chimerix, Inc. | Sposoby leczenia infekcji wirusowej |
| WO2012037155A2 (en) | 2010-09-13 | 2012-03-22 | Gtx, Inc. | Tyrosine kinase inhibitors |
| US10513515B2 (en) | 2017-08-25 | 2019-12-24 | Biotheryx, Inc. | Ether compounds and uses thereof |
| EP3830093A1 (en) | 2018-07-27 | 2021-06-09 | Biotheryx, Inc. | Bifunctional compounds as cdk modulators |
| EP4143329A4 (en) | 2020-04-28 | 2024-10-16 | Anwita Biosciences, Inc. | Interleukin-2 polypeptides and fusion proteins thereof, and their pharmaceutical compositions and therapeutic applications |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6544732B1 (en) * | 1999-05-20 | 2003-04-08 | Illumina, Inc. | Encoding and decoding of array sensors utilizing nanocrystals |
| JP2004517860A (ja) * | 2000-10-12 | 2004-06-17 | メルク エンド カムパニー インコーポレーテッド | Ｈｉｖインテグラーゼ阻害薬として有用なアザ−およびポリアザ−ナフタレニルカルボキサミド類 |
| AU2003301439A1 (en) * | 2002-10-16 | 2004-05-04 | Gilead Sciences, Inc. | Pre-organized tricyclic integrase inhibitor compounds |
| US7442773B2 (en) * | 2004-01-23 | 2008-10-28 | The Board Of Trustees Of The University Of Illinois | Universal peptide-binding scaffolds and protein chips |
-
2004
- 2004-04-27 AU AU2004234087A patent/AU2004234087A1/en not_active Abandoned
- 2004-04-27 EP EP04741485A patent/EP1625130A2/en not_active Withdrawn
- 2004-04-27 CA CA002522990A patent/CA2522990A1/en not_active Abandoned
- 2004-04-27 AP AP2005003451A patent/AP2005003451A0/xx unknown
- 2004-04-27 MX MXPA05011726A patent/MXPA05011726A/es unknown
- 2004-04-27 BR BRPI0409873-0A patent/BRPI0409873A/pt not_active IP Right Cessation
- 2004-04-27 KR KR1020057020004A patent/KR20060006047A/ko not_active Application Discontinuation
- 2004-04-27 US US10/554,712 patent/US20060211724A1/en not_active Abandoned
- 2004-04-27 CN CNA2004800180526A patent/CN1812992A/zh active Pending
- 2004-04-27 WO PCT/EP2004/050621 patent/WO2004096807A2/en active Application Filing
- 2004-04-28 TW TW093111823A patent/TW200507848A/zh unknown
- 2004-04-28 AR ARP040101446A patent/AR044518A1/es not_active Application Discontinuation
-
2005
- 2005-11-07 NO NO20055230A patent/NO20055230L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AR044518A1 (es) | 2005-09-14 |
| EP1625130A2 (en) | 2006-02-15 |
| WO2004096807A3 (en) | 2005-01-06 |
| US20060211724A1 (en) | 2006-09-21 |
| KR20060006047A (ko) | 2006-01-18 |
| CN1812992A (zh) | 2006-08-02 |
| MXPA05011726A (es) | 2006-01-23 |
| AU2004234087A1 (en) | 2004-11-11 |
| WO2004096807A8 (en) | 2005-09-22 |
| WO2004096807A2 (en) | 2004-11-11 |
| BRPI0409873A (pt) | 2006-05-16 |
| TW200507848A (en) | 2005-03-01 |
| CA2522990A1 (en) | 2004-11-11 |
| AP2005003451A0 (en) | 2005-12-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |