NO20054397L - Cycloalkyl derivatives with bioisosteric carboxylic acid groups, processes for their preparation and their use as a drug - Google Patents
Cycloalkyl derivatives with bioisosteric carboxylic acid groups, processes for their preparation and their use as a drugInfo
- Publication number
- NO20054397L NO20054397L NO20054397A NO20054397A NO20054397L NO 20054397 L NO20054397 L NO 20054397L NO 20054397 A NO20054397 A NO 20054397A NO 20054397 A NO20054397 A NO 20054397A NO 20054397 L NO20054397 L NO 20054397L
- Authority
- NO
- Norway
- Prior art keywords
- processes
- preparation
- carboxylic acid
- acid groups
- drug
- Prior art date
Links
- 125000002843 carboxylic acid group Chemical group 0.000 title abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 206010022489 Insulin Resistance Diseases 0.000 abstract 1
- 230000004129 fatty acid metabolism Effects 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
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- A61P25/16—Anti-Parkinson drugs
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P3/06—Antihyperlipidemics
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- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A61P9/12—Antihypertensives
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
- Ophthalmology & Optometry (AREA)
- Virology (AREA)
- Psychology (AREA)
- Reproductive Health (AREA)
Abstract
Oppfinnelsen beskriver sykloalkylderivater med bioisostere karboksylsyregrupper, samt deres fysiologisk godtagbare salter og fysiologisk funksjonelle derivater. Oppfinnelsen angår forbindelser med formel I der gruppene er definert som angitt i beskrivelsen, samt til deres fysiologisk godtagbare salter og fremgangsmåter til deres fremstilling. Forbindelsene er egnede for terapi og/eller prevensjon av forstyrrelser av fettsyrestoffskiftet og glukoseutnyttelses-forstyrrelser, samt forstyrrelser der insulinresistens spiller en rolle.The invention describes cycloalkyl derivatives with bioisostere carboxylic acid groups, as well as their physiologically acceptable salts and physiologically functional derivatives. The invention relates to compounds of formula I wherein the groups are defined as described in the specification, as well as to their physiologically acceptable salts and processes for their preparation. The compounds are suitable for the therapy and / or prevention of fatty acid metabolism and glucose utilization disorders, as well as disorders in which insulin resistance plays a role.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10308354A DE10308354A1 (en) | 2003-02-27 | 2003-02-27 | Cycloalkyl derivatives with biostear carboxylic acid groups, process for their preparation and their use as medicaments |
| PCT/EP2004/001585 WO2004076447A1 (en) | 2003-02-27 | 2004-02-19 | Cycloalkyl derivatives comprising bioisosteric carboxylic acid groups, method for the production thereof, and use thereof as a medicament |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20054397D0 NO20054397D0 (en) | 2005-09-22 |
| NO20054397L true NO20054397L (en) | 2005-11-23 |
Family
ID=32920628
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20054397A NO20054397L (en) | 2003-02-27 | 2005-09-22 | Cycloalkyl derivatives with bioisosteric carboxylic acid groups, processes for their preparation and their use as a drug |
Country Status (30)
| Country | Link |
|---|---|
| EP (1) | EP1601671B1 (en) |
| JP (1) | JP2006519198A (en) |
| KR (1) | KR20050106464A (en) |
| CN (1) | CN100398537C (en) |
| AR (1) | AR043426A1 (en) |
| AT (1) | ATE437874T1 (en) |
| AU (1) | AU2004215676B2 (en) |
| BR (1) | BRPI0407867A (en) |
| CA (1) | CA2516657A1 (en) |
| CL (1) | CL2004000399A1 (en) |
| CO (1) | CO5690552A2 (en) |
| DE (2) | DE10308354A1 (en) |
| DK (1) | DK1601671T3 (en) |
| EC (1) | ECSP055984A (en) |
| ES (1) | ES2330848T3 (en) |
| HR (1) | HRP20050738A2 (en) |
| MA (1) | MA27739A1 (en) |
| MX (1) | MXPA05008989A (en) |
| NO (1) | NO20054397L (en) |
| OA (1) | OA13036A (en) |
| PA (1) | PA8596601A1 (en) |
| PE (1) | PE20050294A1 (en) |
| PL (1) | PL377754A1 (en) |
| PT (1) | PT1601671E (en) |
| RU (1) | RU2005129996A (en) |
| TN (1) | TNSN05205A1 (en) |
| TW (1) | TW200508229A (en) |
| UY (1) | UY28208A1 (en) |
| WO (1) | WO2004076447A1 (en) |
| ZA (1) | ZA200505764B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0515015A (en) | 2004-08-11 | 2008-07-01 | Kyorin Seiyaku Kk | cyclic aminobenzoic acid derivative; medicine; ppar (alpha) agonist; ppar (alpha) double agonist, y; ppar double agonist (alpha), (delta); par modulator; lipid agent; prophylactic or therapeutic agent comprising at least one of the pharmaceutically acceptable cyclic derivatives of aminobenzoic acid or salt thereof |
| CA2624102A1 (en) | 2005-09-29 | 2007-04-12 | Sanofi-Aventis | Phenyl- and pyridinyl- 1, 2 , 4 - oxadiazolone derivatives, processes for their preparation and their use as pharmaceuticals |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPO713297A0 (en) * | 1997-06-02 | 1997-06-26 | Fujisawa Pharmaceutical Co., Ltd. | Oxazole compound |
| EP1067109B1 (en) * | 1998-03-10 | 2009-12-09 | Ono Pharmaceutical Co., Ltd. | Carboxylic acid derivatives and drugs containing the same as the active ingredient |
| YU74701A (en) * | 1999-04-28 | 2005-07-19 | Aventis Pharma Deutschland Gmbh. | Tri-aryl acid derivatives as ppar receptor ligands |
| GB9914977D0 (en) * | 1999-06-25 | 1999-08-25 | Glaxo Group Ltd | Chemical compounds |
| EP1182251A1 (en) * | 2000-08-11 | 2002-02-27 | Yissum Research Development Company of the Hebrew University of Jerusalem | Methods for identifying compounds that inhibit ubiquitin-mediated proteolysis of IkB |
| ATE370130T1 (en) * | 2000-12-25 | 2007-09-15 | Ono Pharmaceutical Co | DIHYDRONAPHTHALINE DERIVATIVE COMPOUNDS AND DRUGS CONTAINING THESE COMPOUNDS AS THE ACTIVE INGREDIENTS |
-
2003
- 2003-02-27 DE DE10308354A patent/DE10308354A1/en not_active Withdrawn
-
2004
- 2004-02-19 CA CA002516657A patent/CA2516657A1/en not_active Abandoned
- 2004-02-19 KR KR1020057016054A patent/KR20050106464A/en not_active Ceased
- 2004-02-19 MX MXPA05008989A patent/MXPA05008989A/en active IP Right Grant
- 2004-02-19 DK DK04712484T patent/DK1601671T3/en active
- 2004-02-19 RU RU2005129996/04A patent/RU2005129996A/en not_active Application Discontinuation
- 2004-02-19 ES ES04712484T patent/ES2330848T3/en not_active Expired - Lifetime
- 2004-02-19 PL PL377754A patent/PL377754A1/en not_active Application Discontinuation
- 2004-02-19 EP EP04712484A patent/EP1601671B1/en not_active Expired - Lifetime
- 2004-02-19 AT AT04712484T patent/ATE437874T1/en not_active IP Right Cessation
- 2004-02-19 HR HR20050738A patent/HRP20050738A2/en not_active Application Discontinuation
- 2004-02-19 AU AU2004215676A patent/AU2004215676B2/en not_active Ceased
- 2004-02-19 OA OA1200500249A patent/OA13036A/en unknown
- 2004-02-19 PT PT04712484T patent/PT1601671E/en unknown
- 2004-02-19 CN CNB2004800054491A patent/CN100398537C/en not_active Expired - Fee Related
- 2004-02-19 DE DE502004009823T patent/DE502004009823D1/en not_active Expired - Lifetime
- 2004-02-19 BR BRPI0407867-5A patent/BRPI0407867A/en not_active IP Right Cessation
- 2004-02-19 JP JP2006501891A patent/JP2006519198A/en active Pending
- 2004-02-19 WO PCT/EP2004/001585 patent/WO2004076447A1/en active Application Filing
- 2004-02-25 TW TW093104696A patent/TW200508229A/en unknown
- 2004-02-27 PE PE2004000207A patent/PE20050294A1/en not_active Application Discontinuation
- 2004-02-27 UY UY28208A patent/UY28208A1/en unknown
- 2004-02-27 CL CL200400399A patent/CL2004000399A1/en unknown
- 2004-02-27 AR ARP040100628A patent/AR043426A1/en not_active Application Discontinuation
- 2004-02-27 PA PA20048596601A patent/PA8596601A1/en unknown
-
2005
- 2005-07-19 ZA ZA200505764A patent/ZA200505764B/en unknown
- 2005-08-26 CO CO05085513A patent/CO5690552A2/en not_active Application Discontinuation
- 2005-08-26 MA MA28462A patent/MA27739A1/en unknown
- 2005-08-26 EC EC2005005984A patent/ECSP055984A/en unknown
- 2005-08-26 TN TNP2005000205A patent/TNSN05205A1/en unknown
- 2005-09-22 NO NO20054397A patent/NO20054397L/en unknown
Also Published As
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