NO20051292L - Fremgangsmate for separasjon av intermediater som kan anvendes for fremstillingen av escitalopram. - Google Patents

Fremgangsmate for separasjon av intermediater som kan anvendes for fremstillingen av escitalopram.

Info

Publication number: NO20051292L
Authority: NO; Norway
Prior art keywords: preparation; escitalopram; intermediates; formula; separating intermediates
Prior art date: 2002-08-12

Application number

NO20051292A

Other languages

English (en)

Norwegian (no)

Inventor

Hans Petersen

Yasuyoshi Ueda

Haleh Ahmadian

Toshihiro Takeda

Naoaki Taoka

Takahisa Kato

Shogo Yamamoto

Takashi Yoshida

Robert Dancer

Lars Ole Lyngso

Original Assignee

Lundbeck & Co As H

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-08-12

Filing date

2005-03-14

Publication date

2005-03-14

2005-03-14 Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H

2005-03-14 Publication of NO20051292L publication Critical patent/NO20051292L/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B57/00—Separation of optically-active compounds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/53—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and hydroxy groups bound to the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/32—Separation; Purification; Stabilisation; Use of additives
- C07C253/34—Separation; Purification
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/34—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring with cyano groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by unsaturated carbon chains
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
- C07C255/59—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/001—Amines; Imines
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/002—Nitriles (-CN)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/008—Preparation of nitrogen-containing organic compounds containing a N-O bond, e.g. nitro (-NO2), nitroso (-NO)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
- C12P41/007—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures by reactions involving acyl derivatives of racemic amines
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/22—Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
Genetics & Genomics (AREA)
Analytical Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Hydrogenated Pyridines (AREA)

NO20051292A 2002-08-12 2005-03-14 Fremgangsmate for separasjon av intermediater som kan anvendes for fremstillingen av escitalopram. NO20051292L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DKPA200201201		2002-08-12
PCT/DK2003/000537 WO2004014821A1 (en)	2002-08-12	2003-08-12	Method for the separation of intermediates which may be used for the preparation of escitalopram

Publications (1)

Publication Number	Publication Date
NO20051292L true NO20051292L (no)	2005-03-14

Family

ID=34717090

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20051292A NO20051292L (no)	2002-08-12	2005-03-14	Fremgangsmate for separasjon av intermediater som kan anvendes for fremstillingen av escitalopram.

Country Status (24)

Country	Link
US (2)	US20070129561A1 (xx)
EP (2)	EP1534654A1 (xx)
JP (3)	JP4694837B2 (xx)
KR (1)	KR20050053618A (xx)
CN (2)	CN100548939C (xx)
AR (1)	AR040970A1 (xx)
AU (1)	AU2003250321B2 (xx)
BR (1)	BR0313114A (xx)
CA (1)	CA2495118C (xx)
EA (1)	EA011762B1 (xx)
HK (2)	HK1131514A1 (xx)
IL (1)	IL166319A0 (xx)
IS (1)	IS7642A (xx)
ME (1)	MEP1608A (xx)
MX (1)	MXPA05001400A (xx)
NO (1)	NO20051292L (xx)
NZ (1)	NZ537785A (xx)
PE (1)	PE20040991A1 (xx)
PL (1)	PL374835A1 (xx)
RS (1)	RS20050092A (xx)
TW (1)	TWI306846B (xx)
UA (1)	UA78840C2 (xx)
WO (1)	WO2004014821A1 (xx)
ZA (1)	ZA200500728B (xx)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20050154052A1 (en) *	2003-03-24	2005-07-14	Hetero Drugs Limited	Novel crystalline forms of (s)-citalopram oxalate
ES2228274B1 (es) *	2003-09-24	2006-06-01	Astur Pharma, S.A.	Sintesis quimioenzimatica de (+)-citalopram y (-)-citalopram.
TWI339651B (en)	2004-02-12	2011-04-01	Lundbeck & Co As H	Method for the separation of intermediates which may be used for the preparation of escitalopram
AU2005218713B2 (en) *	2004-03-05	2009-11-19	H. Lundbeck A/S	Crystalline composition containing escitalopram oxalate
US20050196453A1 (en)	2004-03-05	2005-09-08	H. Lundbeck A/S	Crystalline composition containing escitalopram
ITMI20040717A1 (it) *	2004-04-09	2004-07-09	Adorkem Technology Spa	Procedimento chemo-enzimatico per la preparazione dell'escitalopram
ITMI20041872A1 (it)	2004-10-01	2005-01-01	Adorkem Technology Spa	Processo per la preparazione di citalopram e di scitalopram
EP1736550A1 (en) *	2005-06-22	2006-12-27	Adorkem Technology SpA	Chemoenzymatic process for the synthesis of escitalopram
GB0601286D0 (en)	2006-01-23	2006-03-01	Sandoz Ag	Asymmetric synthesis
WO2008059514A2 (en) *	2006-07-31	2008-05-22	Cadila Healthcare Limited	Process for preparing escitalopram
US7686946B2 (en)	2007-08-17	2010-03-30	Uop Llc	Method of altering a feed to a reaction zone
CN100548974C (zh) *	2007-10-11	2009-10-14	浙江大学	西酞普兰中间体的萃取分离方法
TWI369202B (en) *	2008-01-25	2012-08-01	Xenoport Inc	Enantiomerically resolving acyloxyalkyl thiocarbonates used in synthesizing acyloxyalkyl carbamate prodrugs
ITMI20120448A1 (it)	2012-01-30	2013-07-31	Carthesia Sas	Composizione liofilizzata di escitalopram ossalato per somministrazione sublinguale
ES2554563B2 (es) *	2014-05-05	2016-08-16	Universidad De Sevilla	Cepas bacterianas y sus usos en reacciones de acilación y/o desacilación
WO2017009866A1 (en) *	2015-07-11	2017-01-19	Ipca Laboratories Limited	Novel recovery and recycling process of racemic 4-(4-dimethylamino)-1-(4'-fluorophenyl)-1-(hydroxybutyl)-3-(hydroxymethyl)-benzonitrile

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GB1526331A (en) *	1976-01-14	1978-09-27	Kefalas As	Phthalanes
GB8419963D0 (en) *	1984-08-06	1984-09-12	Lundbeck & Co As H	Intermediate compound and method
EP0285287A3 (en) *	1987-03-23	1990-08-16	Smithkline Beecham Corporation	3-benzazepine compounds for use in treating gastrointestinal motility disorders
GB8814057D0 (en)	1988-06-14	1988-07-20	Lundbeck & Co As H	New enantiomers & their isolation
JP3097145B2 (ja)	1991-02-27	2000-10-10	日産化学工業株式会社	コーリーラクトンジオールの光学分割方法
SE511903C2 (sv)	1996-06-28	1999-12-13	Sca Hygiene Prod Ab	Absorberande alster innefattande en absorptionskropp med förbättrade vätskeinsläppsegenskaper
IT236075Y1 (it)	1997-06-26	2000-07-26	Emilio Brocco	Macchina segatrice per la divisione in lastre di blocchi di materialelapideo
UA62985C2 (en) *	1997-11-10	2004-01-15	Lunnbeck As H	A method for the preparation of citalopram
DE1042310T1 (de)	1997-11-11	2001-04-19	Lundbeck & Co As H	Verfahren zur herstellung von citaloprame
JPH1129418A (ja) *	1998-06-12	1999-02-02	Takeda Chem Ind Ltd	農園芸用殺虫殺菌組成物
DE19832547A1 (de)	1998-07-21	2000-01-27	Basf Ag	Enzymhaltige Polymere
US6294571B1 (en) *	1998-09-11	2001-09-25	Independent Ink, Inc.	Method for using neem extracts and derivatives for protecting wood and other cellulosic composites
PL199423B1 (pl)	1998-10-20	2008-09-30	Lundbeck & Co As H	Sposób wytwarzania citalopramu
AR022329A1 (es)	1999-01-29	2002-09-04	Lundbeck & Co As H	Metodo para la preparacion de 5-cianoftalida
DE69907037T3 (de) *	1999-04-14	2010-02-18	H. Lundbeck A/S	Verfahren zur herstellung von citalopram
ITMI991581A1 (it)	1999-06-25	2001-01-15	Lundbeck & Co As H	Metodo per la preparazione di citalopram
ITMI991579A1 (it)	1999-06-25	2001-01-15	Lundbeck & Co As H	Metodo per la preparazione di citalopram
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IL151566A0 (en)	2000-03-13	2003-04-10	Lundbeck & Co As H	Stepwise alkylation of 5-substituted 1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
HUP0300274A2 (hu)	2000-03-13	2003-06-28	H. Lundbeck A/S	Eljárás citalopram előállítására
SK14512002A3 (sk)	2000-03-14	2003-03-04	H. Lundbeck A/S	Spôsob výroby citalopramu, medziprodukt a citalopram výrobený týmto spôsobom
BR0109180A (pt)	2000-03-16	2003-05-27	Lundbeck & Co As H	Método para a preparação de 5-ciano-1-(4-fluorofenil) -1,3- diidroisobenzofuranos e composição farmacêutica de antidepressivo
FI20011622L (fi) *	2000-08-18	2002-02-19	Lundbeck & Co As H	Menetelmä sitalopraamin valmistamiseksi
AR034612A1 (es) *	2001-06-25	2004-03-03	Lundbeck & Co As H	Proceso para la preparacion del citalopram racemico y/o del s- o r-citalopram mediante la separacion de una mezcla de r- y s-citalopram
AR034759A1 (es)	2001-07-13	2004-03-17	Lundbeck & Co As H	Metodo para la preparacion de escitalopram
AU2002355624B2 (en)	2001-07-31	2006-02-02	H. Lundbeck A/S	Crystalline composition containing escitalopram
IS7239A (is) *	2001-12-14	2004-04-29	H. Lundbeck A/S	Aðferð til framleiðslu á essítalóprami
CA2381341A1 (en) *	2002-04-09	2003-10-09	Torcan Chemical Ltd.	Process and intermediates for preparing escitalopram
CN1510024A (zh) *	2002-12-24	2004-07-07	北京德众万全药物技术开发有限公司	可用于制备西酞普兰(s)-对映异构体的新的化合物及其制备方法

2003
- 2003-08-11 AR ARP030102904A patent/AR040970A1/es unknown
- 2003-08-11 TW TW092121967A patent/TWI306846B/zh not_active IP Right Cessation
- 2003-08-11 PE PE2003000799A patent/PE20040991A1/es not_active Application Discontinuation
- 2003-08-12 EP EP03783962A patent/EP1534654A1/en not_active Withdrawn
- 2003-08-12 EP EP11165320A patent/EP2360150A1/en not_active Withdrawn
- 2003-08-12 AU AU2003250321A patent/AU2003250321B2/en not_active Ceased
- 2003-08-12 NZ NZ537785A patent/NZ537785A/en unknown
- 2003-08-12 RS YUP-2005/0092A patent/RS20050092A/sr unknown
- 2003-08-12 HK HK08103365.3A patent/HK1131514A1/xx not_active IP Right Cessation
- 2003-08-12 IL IL16631903A patent/IL166319A0/xx unknown
- 2003-08-12 CN CNB03819001XA patent/CN100548939C/zh not_active Expired - Lifetime
- 2003-08-12 CA CA2495118A patent/CA2495118C/en not_active Expired - Fee Related
- 2003-08-12 PL PL03374835A patent/PL374835A1/xx unknown
- 2003-08-12 CN CN2007101018055A patent/CN101045664B/zh not_active Expired - Lifetime
- 2003-08-12 MX MXPA05001400A patent/MXPA05001400A/es active IP Right Grant
- 2003-08-12 WO PCT/DK2003/000537 patent/WO2004014821A1/en active Application Filing
- 2003-08-12 KR KR1020057002554A patent/KR20050053618A/ko not_active Application Discontinuation
- 2003-08-12 HK HK06103819.7A patent/HK1083828A1/xx not_active IP Right Cessation
- 2003-08-12 EA EA200500349A patent/EA011762B1/ru not_active IP Right Cessation
- 2003-08-12 BR BR0313114-9A patent/BR0313114A/pt not_active Application Discontinuation
- 2003-08-12 JP JP2004526641A patent/JP4694837B2/ja not_active Expired - Lifetime
- 2003-08-12 ME MEP-16/08A patent/MEP1608A/xx unknown
- 2003-08-12 US US10/524,937 patent/US20070129561A1/en not_active Abandoned
- 2003-12-08 UA UAA200501846A patent/UA78840C2/uk unknown
2005
- 2005-01-12 IS IS7642A patent/IS7642A/is unknown
- 2005-01-25 ZA ZA200500728A patent/ZA200500728B/xx unknown
- 2005-03-14 NO NO20051292A patent/NO20051292L/no not_active Application Discontinuation
2010
- 2010-02-17 JP JP2010032381A patent/JP5520077B2/ja not_active Expired - Lifetime
- 2010-05-17 US US12/781,026 patent/US8067640B2/en not_active Expired - Fee Related
- 2010-11-25 JP JP2010262040A patent/JP2011055842A/ja active Pending

Also Published As

Publication number	Publication date
JP2005535322A (ja)	2005-11-24
HK1083828A1 (en)	2006-07-14
JP5520077B2 (ja)	2014-06-11
AR040970A1 (es)	2005-04-27
UA78840C2 (en)	2007-04-25
PE20040991A1 (es)	2004-12-27
ME00028B (me)	2010-02-10
EA200500349A1 (ru)	2005-08-25
EP1534654A1 (en)	2005-06-01
RS20050092A (xx)	2007-09-21
US8067640B2 (en)	2011-11-29
CA2495118C (en)	2010-11-30
EP2360150A1 (en)	2011-08-24
CA2495118A1 (en)	2004-02-19
CN1675144A (zh)	2005-09-28
CN101045664A (zh)	2007-10-03
TWI306846B (en)	2009-03-01
CN101045664B (zh)	2011-06-15
PL374835A1 (en)	2005-10-31
MEP1608A (xx)	2010-02-10
JP4694837B2 (ja)	2011-06-08
IS7642A (is)	2005-01-12
AU2003250321A1 (en)	2004-02-25
KR20050053618A (ko)	2005-06-08
BR0313114A (pt)	2005-07-12
EA011762B1 (ru)	2009-06-30
MXPA05001400A (es)	2005-04-28
JP2010150270A (ja)	2010-07-08
US20110065937A1 (en)	2011-03-17
HK1131514A1 (en)	2010-01-15
NZ537785A (en)	2006-12-22
ZA200500728B (en)	2006-07-26
CN100548939C (zh)	2009-10-14
US20070129561A1 (en)	2007-06-07
TW200418750A (en)	2004-10-01
IL166319A0 (en)	2006-01-15
JP2011055842A (ja)	2011-03-24
AU2003250321B2 (en)	2009-06-25
WO2004014821A1 (en)	2004-02-19

Publication	Publication Date	Title
NO20051292L (no)	2005-03-14	Fremgangsmate for separasjon av intermediater som kan anvendes for fremstillingen av escitalopram.
BR0307432B1 (pt)	2013-09-10	difluormetiltiazolilcarboxanilidas
DE50200540D1 (de)	2004-07-29	Verfahren zur Herstellung lösungsmittelfreier Suspensionen
NO20041379L (no)	2004-06-01	Enzymatiske prosesser for fremstilling av 4-substituerte 3-hydroksysmorsyrederivater
DE602004019191D1 (de)	2009-03-12	Prozess zur herstellung von antikonvulsiven derivaten von topiramat
ITMI20032050A1 (it)	2005-04-22	Processo per la preparazione di dispersori di fluoropolimeri.
HUP0400446A2 (hu)	2004-09-28	Azitromicin kristályformái
NO20063278L (no)	2006-09-29	Hurtigfremstilling av nukleinsyrer ved enzymatisk fordoyelse
DE60108042D1 (de)	2005-02-03	Prozesse zur Herstellung von pulverförmigen Schlagzäh-Modifizierern
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