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NO20045359L - Hydroksy-tetrahydro-naftalenylureaderivater - Google Patents

Hydroksy-tetrahydro-naftalenylureaderivater

Info

Publication number
NO20045359L
NO20045359L NO20045359A NO20045359A NO20045359L NO 20045359 L NO20045359 L NO 20045359L NO 20045359 A NO20045359 A NO 20045359A NO 20045359 A NO20045359 A NO 20045359A NO 20045359 L NO20045359 L NO 20045359L
Authority
NO
Norway
Prior art keywords
tetrahydro
pain
useful
treatment
naphthalene derivatives
Prior art date
Application number
NO20045359A
Other languages
English (en)
Inventor
Takeshi Yura
Toshio Kokubo
Muneto Mogi
Noriyuki Yamamoto
Nagahiro Yoshida
Tsutomu Masuda
Klaus Urbahns
Hiroshi Fujishima
Toshiya Moriwaki
Masahiro Shiroo
Masaomi Tajimi
Yasuhiro Tsukimi
Original Assignee
Bayer Healthcare Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0210512.0A external-priority patent/GB0210512D0/en
Application filed by Bayer Healthcare Ag filed Critical Bayer Healthcare Ag
Publication of NO20045359L publication Critical patent/NO20045359L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/40—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Foreliggende oppfinnelse angår tefrahydro-naftalenderivater og salter derav som er anvendehge som aktive ingredienser i farmasøytiske preparater. Tefrahydro-naftalenderivatene ifølge oppfmnelsen har en svært god aktivitet som VRI antagonist og anvendelig for profylakse og behandling av sykdorrmier assosiert med VRI aktivitet, særlig for behandling av frengende urininkontinens, overaktiv blære, kronisk smerte, neuropatisk smerte, postoperativ smerte, reumatoid artrittsmerte, neuralgi, neuropati, algesi, nerveskade, ishemi, neurodegenerasjon, slag, inkontinens, inflammasjonsforstyrrelser slike som astina og eOPD.
NO20045359A 2002-05-08 2004-12-07 Hydroksy-tetrahydro-naftalenylureaderivater NO20045359L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0210512.0A GB0210512D0 (en) 2002-05-08 2002-05-08 Tetrahydro-napthalene derivatives
GBGB0227262.3A GB0227262D0 (en) 2002-05-08 2002-11-21 Tetrahydro-naphthalene derivatives
PCT/EP2003/004395 WO2003095420A1 (en) 2002-05-08 2003-04-28 Hydroxy tetrahydro-naphthalenylurea derivatives

Publications (1)

Publication Number Publication Date
NO20045359L true NO20045359L (no) 2004-12-07

Family

ID=29422108

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20045359A NO20045359L (no) 2002-05-08 2004-12-07 Hydroksy-tetrahydro-naftalenylureaderivater

Country Status (21)

Country Link
US (1) US7612113B2 (no)
EP (1) EP1506167B1 (no)
JP (1) JP4335131B2 (no)
CN (1) CN1307150C (no)
AT (1) ATE371641T1 (no)
AU (1) AU2003229734B2 (no)
BR (1) BR0309940A (no)
CA (1) CA2487238C (no)
DE (1) DE60315973T2 (no)
DK (1) DK1506167T3 (no)
ES (1) ES2292959T3 (no)
HK (1) HK1082946A1 (no)
HR (1) HRP20041167A2 (no)
IL (1) IL165004A (no)
MX (1) MXPA04010938A (no)
NO (1) NO20045359L (no)
NZ (1) NZ536418A (no)
PL (1) PL210288B1 (no)
RU (1) RU2331635C2 (no)
TW (1) TWI271396B (no)
WO (1) WO2003095420A1 (no)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003273856A1 (en) * 2002-09-24 2004-04-19 Bayer Healthcare Ag Vr1 antagonists for the treatment of urological disorders
ES2291725T3 (es) * 2002-12-06 2008-03-01 Xention Limited Derivados de tetrahidro-naftaleno.
ES2311744T3 (es) * 2002-12-09 2009-02-16 Xention Limited Derivados de tetrahidronaftaleno como antagonistas del receptor vainilloide.
WO2005035471A1 (ja) 2003-10-14 2005-04-21 Ajinomoto Co., Inc. エーテル誘導体
CA2542494A1 (en) * 2003-10-15 2005-05-06 Bayer Healthcare Ag Tetrahydro-naphthalene and urea derivatives
WO2005044802A2 (en) * 2003-11-08 2005-05-19 Bayer Healthcare Ag Tetrahydro-quinolinylurea derivatives as vrl antagonists
WO2005095329A1 (en) * 2004-03-31 2005-10-13 Pfizer Japan Inc. Substituted benzamide compounds as vr1 receptor antagonists
CA2599778A1 (en) * 2005-03-05 2006-09-14 Bayer Healthcare Ag Use of hydroxy tetrahydro-naphtalene derivates for the treatment of respiratory diseases
BRPI0608714A2 (pt) 2005-03-19 2010-01-26 Amorepacific Corp compostos, isÈmeros dos mesmos, ou sais farmaceuticamente aceitáveis dos mesmos como antagonista do receptor vanilóide, e composições farmacêuticas contendo os mesmos
DE102005017286B3 (de) * 2005-04-14 2006-12-28 Schering Ag Tetrahydronaphthalinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer
DE102005023943A1 (de) 2005-05-20 2006-11-23 Grünenthal GmbH Pentafluorsulfanyl-substituierte Verbindung und deren Verwendung zur Herstellung von Arzneimitteln
EP2450346A1 (en) * 2006-12-20 2012-05-09 Abbott Laboratories Antagonists of the TRPV1 receptor and uses thereof
WO2008096755A1 (ja) * 2007-02-07 2008-08-14 Nippon Suisan Kaisha, Ltd. バニロイド受容体（ｖｒ１）阻害剤及びその用途
DE102009055915A1 (de) * 2009-11-27 2011-06-01 Beiersdorf Ag Verwendung von Zingeron zur Herstellung kosmetischer oder dermatologischer Zubereitungen, welche auf der Haut ein Prickeln hervorrufen
CN114206847B (zh) 2019-08-23 2024-07-16 持田制药株式会社 杂环亚基乙酰胺衍生物的制造方法
WO2021039023A1 (ja) 2019-08-23 2021-03-04 持田製薬株式会社 ヘテロシクリデンアセトアミド誘導体の製造方法
DE102022104759A1 (de) 2022-02-28 2023-08-31 SCi Kontor GmbH Co-Kristall-Screening Verfahren, insbesondere zur Herstellung von Co-Kristallen

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9713484D0 (en) 1997-06-27 1997-09-03 Smithkline Beecham Plc Neuroprotective vanilloid compounds
US6333337B1 (en) * 1998-01-27 2001-12-25 Icagen, Inc. Potassium channel inhibitors
DE60024785T2 (de) * 1999-02-22 2006-09-14 Amorepacific Corp. Vanilloid-analoge die resiniferatoxin-pharmacophore enthalten als wirksame vanilloid rezeptor agonisten und analgetika, zusammensetzungen und ihre verwendung
CA2369971A1 (en) 1999-04-07 2000-10-19 Sankyo Company, Limited Aryl or heteroaryl fused imidazole derivatives, their pharmaceutical compositions and agents, and uses thereof
US6294694B1 (en) 1999-06-04 2001-09-25 Wisconsin Alumni Research Foundation Matrix metalloproteinase inhibitors and method of using same
ES2291725T3 (es) * 2002-12-06 2008-03-01 Xention Limited Derivados de tetrahidro-naftaleno.
EP1493438A1 (en) * 2003-07-03 2005-01-05 Bayer HealthCare AG Vanilloid receptor (VR) inhibitors for treatment of Human Immunodeficiency Virus (HIV)-mediated pain states
CA2542494A1 (en) * 2003-10-15 2005-05-06 Bayer Healthcare Ag Tetrahydro-naphthalene and urea derivatives
US20080058377A1 (en) * 2003-11-08 2008-03-06 Bayer Healthcare Ag Bicyclic Amide, Carbamate or Urea Derivatives as Vanilloid Receptor Modulators

Also Published As

Publication number Publication date
CA2487238A1 (en) 2003-11-20
WO2003095420A1 (en) 2003-11-20
RU2004136281A (ru) 2005-07-10
NZ536418A (en) 2006-04-28
CN1665778A (zh) 2005-09-07
CN1307150C (zh) 2007-03-28
BR0309940A (pt) 2005-02-09
IL165004A0 (en) 2005-12-18
AU2003229734B2 (en) 2009-02-19
ES2292959T3 (es) 2008-03-16
DK1506167T3 (da) 2008-01-02
CA2487238C (en) 2011-03-22
JP4335131B2 (ja) 2009-09-30
EP1506167B1 (en) 2007-08-29
AU2003229734A1 (en) 2003-11-11
DE60315973D1 (de) 2007-10-11
DE60315973T2 (de) 2008-05-21
PL210288B1 (pl) 2011-12-30
EP1506167A1 (en) 2005-02-16
JP2005524717A (ja) 2005-08-18
TW200404052A (en) 2004-03-16
US20060258742A1 (en) 2006-11-16
RU2331635C2 (ru) 2008-08-20
PL373257A1 (en) 2005-08-22
IL165004A (en) 2010-12-30
HRP20041167A2 (en) 2005-08-31
ATE371641T1 (de) 2007-09-15
MXPA04010938A (es) 2005-02-14
US7612113B2 (en) 2009-11-03
TWI271396B (en) 2007-01-21
HK1082946A1 (en) 2006-06-23

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Legal Events

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