NO20040113L - Variolinderivater og deres anvendelse som antitumormidler - Google Patents
Variolinderivater og deres anvendelse som antitumormidlerInfo
- Publication number
- NO20040113L NO20040113L NO20040113A NO20040113A NO20040113L NO 20040113 L NO20040113 L NO 20040113L NO 20040113 A NO20040113 A NO 20040113A NO 20040113 A NO20040113 A NO 20040113A NO 20040113 L NO20040113 L NO 20040113L
- Authority
- NO
- Norway
- Prior art keywords
- substituted
- antitumor agents
- unsubstituted
- groups
- alkynyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/38—One sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Steroid Compounds (AREA)
- Saccharide Compounds (AREA)
- Carbon And Carbon Compounds (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0116966.3A GB0116966D0 (en) | 2001-07-11 | 2001-07-11 | Anittumoral compounds |
PCT/GB2002/003197 WO2003006457A1 (en) | 2001-07-11 | 2002-07-11 | Variolin derivatives and their use as antitumor agents |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20040113L true NO20040113L (no) | 2004-03-09 |
NO328848B1 NO328848B1 (no) | 2010-05-31 |
Family
ID=9918335
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20040113A NO328848B1 (no) | 2001-07-11 | 2004-01-12 | Variolinderivater og deres anvendelse som antitumormidler |
Country Status (19)
Country | Link |
---|---|
US (2) | US7495000B2 (no) |
EP (2) | EP1867645B1 (no) |
JP (1) | JP4369225B2 (no) |
KR (1) | KR100929616B1 (no) |
CN (1) | CN1553906B (no) |
AT (2) | ATE396987T1 (no) |
AU (1) | AU2002317329B2 (no) |
CA (1) | CA2453418C (no) |
DE (2) | DE60237652D1 (no) |
ES (2) | ES2307768T3 (no) |
GB (1) | GB0116966D0 (no) |
HU (1) | HUP0402658A2 (no) |
IL (2) | IL159792A0 (no) |
MX (1) | MXPA04000355A (no) |
NO (1) | NO328848B1 (no) |
NZ (1) | NZ530556A (no) |
PL (1) | PL366894A1 (no) |
RU (1) | RU2302419C2 (no) |
WO (1) | WO2003006457A1 (no) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1299388T3 (da) | 2000-07-11 | 2009-08-31 | Pharma Mar Sa | Variolin-derivater som anti-cancermidler |
GB0019117D0 (en) * | 2000-08-03 | 2000-09-27 | Univ Barcelona | Derivatives of variolin B |
GB0116966D0 (en) * | 2001-07-11 | 2001-09-05 | Pharma Mar Sa | Anittumoral compounds |
DK2300475T3 (en) * | 2008-06-11 | 2014-12-08 | Genentech Inc | Diazacarbazoler and methods of using |
JOP20190254A1 (ar) | 2017-04-27 | 2019-10-27 | Pharma Mar Sa | مركبات مضادة للأورام |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1299388T3 (da) | 2000-07-11 | 2009-08-31 | Pharma Mar Sa | Variolin-derivater som anti-cancermidler |
GB0019117D0 (en) * | 2000-08-03 | 2000-09-27 | Univ Barcelona | Derivatives of variolin B |
GB0116966D0 (en) | 2001-07-11 | 2001-09-05 | Pharma Mar Sa | Anittumoral compounds |
-
2001
- 2001-07-11 GB GBGB0116966.3A patent/GB0116966D0/en not_active Ceased
-
2002
- 2002-07-11 KR KR1020047000500A patent/KR100929616B1/ko not_active Expired - Fee Related
- 2002-07-11 AU AU2002317329A patent/AU2002317329B2/en not_active Ceased
- 2002-07-11 AT AT02745614T patent/ATE396987T1/de not_active IP Right Cessation
- 2002-07-11 RU RU2004103857/04A patent/RU2302419C2/ru not_active IP Right Cessation
- 2002-07-11 CA CA2453418A patent/CA2453418C/en not_active Expired - Fee Related
- 2002-07-11 NZ NZ530556A patent/NZ530556A/en not_active IP Right Cessation
- 2002-07-11 DE DE60237652T patent/DE60237652D1/de not_active Expired - Lifetime
- 2002-07-11 MX MXPA04000355A patent/MXPA04000355A/es active IP Right Grant
- 2002-07-11 WO PCT/GB2002/003197 patent/WO2003006457A1/en active IP Right Grant
- 2002-07-11 ES ES02745614T patent/ES2307768T3/es not_active Expired - Lifetime
- 2002-07-11 ES ES07013582T patent/ES2354991T3/es not_active Expired - Lifetime
- 2002-07-11 JP JP2003512229A patent/JP4369225B2/ja not_active Expired - Fee Related
- 2002-07-11 US US10/483,525 patent/US7495000B2/en not_active Expired - Fee Related
- 2002-07-11 AT AT07013582T patent/ATE480533T1/de not_active IP Right Cessation
- 2002-07-11 IL IL15979202A patent/IL159792A0/xx unknown
- 2002-07-11 PL PL02366894A patent/PL366894A1/xx not_active Application Discontinuation
- 2002-07-11 HU HU0402658A patent/HUP0402658A2/hu unknown
- 2002-07-11 CN CN028175298A patent/CN1553906B/zh not_active Expired - Fee Related
- 2002-07-11 DE DE60226869T patent/DE60226869D1/de not_active Expired - Lifetime
- 2002-07-11 EP EP07013582A patent/EP1867645B1/en not_active Expired - Lifetime
- 2002-07-11 EP EP02745614A patent/EP1404668B1/en not_active Expired - Lifetime
-
2004
- 2004-01-11 IL IL159792A patent/IL159792A/en not_active IP Right Cessation
- 2004-01-12 NO NO20040113A patent/NO328848B1/no not_active IP Right Cessation
-
2009
- 2009-01-07 US US12/349,813 patent/US7772241B2/en not_active Expired - Fee Related
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM1K | Lapsed by not paying the annual fees |