[go: up one dir, main page]

NO20032208L - Benzodiazepinderivater som GABA A reseptormodulatorer - Google Patents

Benzodiazepinderivater som GABA A reseptormodulatorer

Info

Publication number
NO20032208L
NO20032208L NO20032208A NO20032208A NO20032208L NO 20032208 L NO20032208 L NO 20032208L NO 20032208 A NO20032208 A NO 20032208A NO 20032208 A NO20032208 A NO 20032208A NO 20032208 L NO20032208 L NO 20032208L
Authority
NO
Norway
Prior art keywords
gaba
receptor modulators
benzodiazepine derivatives
benzodiazepine
derivatives
Prior art date
Application number
NO20032208A
Other languages
English (en)
Other versions
NO324706B1 (no
NO20032208D0 (no
Inventor
Raffaello Masciadri
Andrew William Thomas
Juergen Wichmann
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO20032208D0 publication Critical patent/NO20032208D0/no
Publication of NO20032208L publication Critical patent/NO20032208L/no
Publication of NO324706B1 publication Critical patent/NO324706B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO20032208A 2000-11-16 2003-05-15 Benzodiazepinderivater, fremstilling av disse, medikament inneholdende slike forbindelser samt anvendelse av disse for fremstilling av medikament for behandling av sykdommer NO324706B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00124332 2000-11-16
PCT/EP2001/012887 WO2002040487A2 (en) 2000-11-16 2001-11-08 Benzodiazepine derivatives as gaba a receptor modulators

Publications (3)

Publication Number Publication Date
NO20032208D0 NO20032208D0 (no) 2003-05-15
NO20032208L true NO20032208L (no) 2003-05-15
NO324706B1 NO324706B1 (no) 2007-12-03

Family

ID=8170315

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20032208A NO324706B1 (no) 2000-11-16 2003-05-15 Benzodiazepinderivater, fremstilling av disse, medikament inneholdende slike forbindelser samt anvendelse av disse for fremstilling av medikament for behandling av sykdommer

Country Status (40)

Country Link
US (1) US6743789B2 (no)
EP (1) EP1337535B1 (no)
JP (1) JP4088151B2 (no)
KR (1) KR100504300B1 (no)
CN (1) CN1191255C (no)
AR (1) AR031345A1 (no)
AT (1) ATE268776T1 (no)
AU (2) AU1700702A (no)
BG (1) BG107817A (no)
BR (1) BR0115393A (no)
CA (1) CA2427576C (no)
CZ (1) CZ295256B6 (no)
DE (1) DE60103776T2 (no)
DK (1) DK1337535T3 (no)
EC (1) ECSP034607A (no)
ES (1) ES2220831T3 (no)
GC (1) GC0000375A (no)
GT (1) GT200100230A (no)
HR (1) HRP20030360A2 (no)
HU (1) HUP0303281A3 (no)
IL (1) IL155813A0 (no)
JO (1) JO2359B1 (no)
MA (1) MA26962A1 (no)
MX (1) MXPA03004251A (no)
MY (1) MY141675A (no)
NO (1) NO324706B1 (no)
NZ (1) NZ525413A (no)
PA (1) PA8532401A1 (no)
PE (1) PE20020583A1 (no)
PL (1) PL362925A1 (no)
PT (1) PT1337535E (no)
RU (1) RU2278865C2 (no)
SI (1) SI1337535T1 (no)
SK (1) SK7232003A3 (no)
TR (1) TR200402073T4 (no)
TW (1) TWI239333B (no)
UY (1) UY27026A1 (no)
WO (1) WO2002040487A2 (no)
YU (1) YU35603A (no)
ZA (1) ZA200303435B (no)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6686352B2 (en) 2001-05-18 2004-02-03 Hoffmann-La Roche Inc. Substituted imidazo [1,5-a] pyrimido [5,4-d] [1] benzazepine derivatives
JP4616770B2 (ja) * 2003-06-19 2011-01-19 第一三共株式会社 選択的なアミノ置換基導入法
PL1691811T3 (pl) 2003-12-11 2014-12-31 Sunovion Pharmaceuticals Inc Skojarzenie leku uspokajającego i modulatora neuroprzekaźnikowego oraz sposoby poprawy jakości snu i leczenia depresji
US7572783B2 (en) 2004-08-13 2009-08-11 Amgen Inc. Substituted benzofused heterocycles
JP5117192B2 (ja) 2004-10-12 2013-01-09 エフ．ホフマン−ラ ロシュ アーゲー 置換ベンゾジアゼピン誘導体
JP4783375B2 (ja) 2004-10-20 2011-09-28 エフ．ホフマン−ラ ロシュ アーゲー イミダゾベンゾジゼピン誘導体
BRPI0516244A (pt) * 2004-10-20 2008-08-26 Hoffmann La Roche derivados de benzodiazepina substituìda por halogênio
RU2393161C2 (ru) * 2004-12-14 2010-06-27 Ф. Хоффманн-Ля Рош Аг Тетрациклические имидазо-бензодиазепины в качестве модуляторов гамк-рецепторов
EP2682481A3 (en) * 2005-08-03 2014-09-17 The Johns-Hopkins University Methods for characterizing and treating cognitive impairment in aging and disease
US8510055B2 (en) 2005-08-03 2013-08-13 The Johns Hopkins University Methods for characterizing and treating cognitive impairment in aging and disease
WO2007042421A1 (en) * 2005-10-11 2007-04-19 F. Hoffmann-La Roche Ag Imidazo benzodiazepine derivatives
WO2007053596A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
WO2009139916A1 (en) * 2008-05-16 2009-11-19 Synta Pharmaceuticals Corp. Tricyclic triazole compounds that modulate hsp90 activity
WO2010057795A1 (en) 2008-11-18 2010-05-27 F. Hoffmann-La Roche Ag Alkylcyclohexylethers of dihydrotetraazabenzoazulenes
EP2370441B1 (en) * 2008-11-28 2013-09-11 F. Hoffmann-La Roche AG Arylcyclohexylethers of dihydrotetraazabenzoazulenes for use as vasopressin v1a receptor antagonists
CU20090172A7 (es) 2009-10-09 2011-10-05 Ct De Investigación Y Desarrollo De Medicamentos Sistemas tricíclicos y tetracíclicos con actividad sobre el sistema nervioso central y vascular
EP3034079B1 (en) 2010-11-15 2018-01-10 Agenebio, Inc. Pyridazine derivatives, compositions and methods for treating cognitive impairment
US20150374705A1 (en) 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain
US9879020B2 (en) * 2012-09-21 2018-01-30 Uwm Research Foundation, Inc. GABAA agonists and methods of using to control airway hyperresponsiveness and inflammation in asthma
WO2015095783A1 (en) * 2013-12-20 2015-06-25 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
WO2016205739A1 (en) 2015-06-19 2016-12-22 Belew Mekonnen Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
US10059718B2 (en) * 2016-01-04 2018-08-28 Tabomedex Biosciences, LLC Fused quadracyclic compounds, compositions and uses thereof
US10973479B2 (en) 2016-05-16 2021-04-13 Canon Medical Systems Corporation X-ray diagnosis apparatus, X-ray diagnosis apparatus controlling method, and X-ray diagnosis system
US11505555B2 (en) 2016-12-19 2022-11-22 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
US20180170941A1 (en) * 2016-12-19 2018-06-21 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
KR102512548B1 (ko) 2017-12-22 2023-03-22 삼성디스플레이 주식회사 유기 전계 발광 소자 및 유기 전계 발광 소자용 함질소 화합물
BR112020026062B1 (pt) * 2018-06-19 2023-04-04 Agenebio, Inc Compostos derivados de benzodiazepina ou um sal farmaceuticamente aceitavel, isômero ou combinação dos mesmos, composição farmacêutica compreendendo os mesmos e usos dos mesmos para o tratamento de comprometimento cognitivo, câncer cerebral e psicose da doença de parkinson
KR102151969B1 (ko) * 2019-12-11 2020-09-04 주식회사 지투비 투과도 가변창의 제조방법 및 그에 의해 제조된 투과도 가변창
CN112979658B (zh) * 2021-02-22 2022-05-31 南湖实验室 一种氟马西尼的制备方法
AU2023324882A1 (en) 2022-08-19 2025-03-20 Agenebio, Inc. Benzazepine derivatives, compositions, and methods for treating cognitive impairment

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK174086D0 (da) 1986-04-16 1986-04-16 Ferrosan As Nye benzodiazepinderivater samt fremgangsmaade til fremstilling af samme
TW201311B (no) 1991-06-17 1993-03-01 Hoffmann La Roche

Also Published As

Publication number Publication date
HK1062442A1 (en) 2004-11-05
US20020103371A1 (en) 2002-08-01
PA8532401A1 (es) 2002-08-26
JP4088151B2 (ja) 2008-05-21
GT200100230A (es) 2002-07-04
CA2427576C (en) 2007-11-06
CZ20031597A3 (cs) 2003-11-12
DE60103776D1 (de) 2004-07-15
ES2220831T3 (es) 2004-12-16
UY27026A1 (es) 2002-06-20
NO324706B1 (no) 2007-12-03
ZA200303435B (en) 2004-08-05
AU1700702A (en) 2002-05-27
HRP20030360A2 (en) 2005-04-30
JO2359B1 (en) 2006-12-12
ATE268776T1 (de) 2004-06-15
RU2003116895A (ru) 2005-02-20
CN1474820A (zh) 2004-02-11
NO20032208D0 (no) 2003-05-15
HUP0303281A3 (en) 2005-05-30
PL362925A1 (en) 2004-11-02
EP1337535B1 (en) 2004-06-09
SI1337535T1 (en) 2004-10-31
GC0000375A (en) 2007-03-31
AR031345A1 (es) 2003-09-17
RU2278865C2 (ru) 2006-06-27
BG107817A (bg) 2004-07-30
BR0115393A (pt) 2004-07-06
US6743789B2 (en) 2004-06-01
CZ295256B6 (cs) 2005-06-15
IL155813A0 (en) 2003-12-23
EP1337535A2 (en) 2003-08-27
CA2427576A1 (en) 2002-05-23
HUP0303281A2 (hu) 2004-01-28
KR20030045192A (ko) 2003-06-09
DK1337535T3 (da) 2004-10-25
CN1191255C (zh) 2005-03-02
ECSP034607A (es) 2003-06-25
YU35603A (sh) 2006-05-25
AU2002217007B2 (en) 2006-11-30
TWI239333B (en) 2005-09-11
PE20020583A1 (es) 2002-07-06
MY141675A (en) 2010-06-15
MA26962A1 (fr) 2004-12-20
KR100504300B1 (ko) 2005-07-28
SK7232003A3 (en) 2004-03-02
WO2002040487A2 (en) 2002-05-23
JP2004517070A (ja) 2004-06-10
NZ525413A (en) 2005-02-25
TR200402073T4 (tr) 2004-10-21
DE60103776T2 (de) 2005-07-14
MXPA03004251A (es) 2003-09-22
WO2002040487A3 (en) 2002-09-26
PT1337535E (pt) 2004-09-30

Similar Documents

Publication Publication Date Title
DK1337535T3 (da) Benzodiazepinderivater som GABA A-receptormodulatorer
DK1526134T3 (da) Triazolyltropanderivater som CCR5-modulatorer
ATE293962T1 (de) Adenosin-rezeptor modulatoren
AU2003290778A8 (en) Non-steroidal farnesoid x receptor modulators
DE50007817D1 (de) Mikrospiegel
DK1444215T3 (da) 1,2,4-Thiadiazoliumderivater som melanocortinreceptormodulatorer
DK1224175T3 (da) Benzodiazepinderivater som metabotropiske glutamatreceptorantagonister
NO20002585L (no) Fremgangsmåte for komplettering av en brönn
NO20032834L (no) Benzimidazol- og pyridylimidazol-derivater som ligander for GABA-reseptorer
NO20051042L (no) Pyrimidylsulfonamidderivater som kemokinreseptormodulatorer
NO20003730L (no) Triazolo-pyridazinderivater som ligander for GABA reseptorer
DE60104910D1 (de) Druckeinrichtung
DE60133250D1 (de) Optischer Modulator
DK1165547T3 (da) Substituerede benzoylpyrazoler som herbicider
NO20000822D0 (no) Substituerte 4-okso-3-karboksamider som GABA- hjernereseptorligander
DE60110517D1 (de) Lichtgesteuerter Lichtmodulator
DK1347974T3 (da) Aminotriazolopyridinderivater som adenosinreceptorligander
DK1467998T3 (da) Tetracykliske hetaroforbindelser som östrogenreceptormodulatorer
NO20006279L (no) Innretning for generering av en fotonantalltilstand
ES1049394Y (es) Dispositivo para la fijacion de una lampara
PT1175576E (pt) Acessorio de entrada para um autoclismo
DE60031109D1 (de) Übertragsicherstellungsaddierer
NO20015378L (no) Cyklokarbamatderivater som progesteronreseptormodulatorer
NO20032415D0 (no) Forbindelser som er aktive på glukokortikoidreseptor II
EE200300566A (et) AMPA retseptori allosteerilised positiivsed naftotiasiin-modulaatorid