|
US6908744B1
(en)
*
|
2000-03-14 |
2005-06-21 |
Regeneron Pharmaceuticals, Inc. |
Methods of stimulating cartilage formation
|
|
DK1311661T3
(da)
*
|
2000-08-14 |
2012-11-26 |
Us Gov Health & Human Serv |
Forøget homolog rekombination medieret ved lambda-rekombinationsproteiner
|
|
US6586251B2
(en)
*
|
2000-10-31 |
2003-07-01 |
Regeneron Pharmaceuticals, Inc. |
Methods of modifying eukaryotic cells
|
|
US20050144655A1
(en)
|
2000-10-31 |
2005-06-30 |
Economides Aris N. |
Methods of modifying eukaryotic cells
|
|
US6596541B2
(en)
|
2000-10-31 |
2003-07-22 |
Regeneron Pharmaceuticals, Inc. |
Methods of modifying eukaryotic cells
|
|
GB0110029D0
(en)
|
2001-04-24 |
2001-06-13 |
Grosveld Frank |
Transgenic animal
|
|
SG141296A1
(en)
|
2002-05-17 |
2008-04-28 |
Sinai School Medicine |
Mesoderm and definitive endoderm cell populations
|
|
ES2442615T5
(es)
|
2002-07-18 |
2023-03-16 |
Merus Nv |
Producción recombinante de mezclas de anticuerpos
|
|
USRE47770E1
(en)
|
2002-07-18 |
2019-12-17 |
Merus N.V. |
Recombinant production of mixtures of antibodies
|
|
WO2004022738A1
(en)
*
|
2002-09-09 |
2004-03-18 |
California Institute Of Technology |
Methods and compositions for the generation of humanized mice
|
|
WO2004067725A2
(en)
*
|
2003-01-30 |
2004-08-12 |
Regeneron Pharmaceuticals, Inc. |
Methods of identifying modulators of nmur2-mediated activity
|
|
US20100069614A1
(en)
|
2008-06-27 |
2010-03-18 |
Merus B.V. |
Antibody producing non-human mammals
|
|
EP1639009B1
(en)
|
2003-05-30 |
2013-02-27 |
Merus B.V. |
Fab library for the preparation of a mixture of antibodies
|
|
PT1802193E
(pt)
|
2004-10-19 |
2014-06-23 |
Regeneron Pharma |
Método para gerar um murganho homozigótico para uma modificação genética
|
|
US20060117396A1
(en)
*
|
2004-11-30 |
2006-06-01 |
Murphy Andrew J |
Assay methods for identifying modulators of OPSDL3 and transgenic knockouts
|
|
US20090263900A1
(en)
*
|
2008-04-14 |
2009-10-22 |
Sangamo Biosciences, Inc. |
Linear donor constructs for targeted integration
|
|
BRPI0809042B1
(pt)
|
2007-03-22 |
2021-08-31 |
Biogen Ma Inc. |
Proteína de ligação a cd154 isolada, seu uso, e composição
|
|
SG10201509853UA
(en)
|
2007-06-01 |
2015-12-30 |
Omt Inc |
Compositions and methods for inhibiting endogenous immunoglobulin genes and producing transgenic human idiotype antibodies
|
|
CA2708776A1
(en)
*
|
2007-12-10 |
2009-06-18 |
Aliva Biopharmaceuticals, Inc. |
Methods for sequential replacement of targeted region by homologous recombination
|
|
US20090328240A1
(en)
*
|
2008-06-24 |
2009-12-31 |
Sing George L |
Genetically modified mice as predictors of immune response
|
|
DE102008002715A1
(de)
*
|
2008-06-27 |
2009-12-31 |
Evonik Röhm Gmbh |
2-Hydroxyisobuttersäure produzierende rekombinante Zelle
|
|
KR101826224B1
(ko)
|
2008-09-30 |
2018-02-06 |
아블렉시스, 엘엘씨 |
키메라 항체의 제조를 위한 인간 이외의 포유동물
|
|
US9445581B2
(en)
|
2012-03-28 |
2016-09-20 |
Kymab Limited |
Animal models and therapeutic molecules
|
|
NZ597481A
(en)
|
2009-07-08 |
2013-10-25 |
Kymab Ltd |
Animal models and therapeutic molecules
|
|
ES2908587T3
(es)
|
2009-10-06 |
2022-05-03 |
Regeneron Pharma |
Ratones modificados genéticamente e injerto
|
|
PT3147362T
(pt)
|
2009-10-29 |
2019-04-02 |
Regeneron Pharma |
Alelos multifuncionais
|
|
SG181477A1
(en)
|
2009-12-10 |
2012-07-30 |
Regeneron Pharma |
Mice that make heavy chain antibodies
|
|
NO2516457T3
(no)
|
2009-12-21 |
2018-08-11 |
|
|
|
NZ631363A
(en)
|
2010-02-08 |
2016-05-27 |
Regeneron Pharma |
Common light chain mouse
|
|
US20130045492A1
(en)
|
2010-02-08 |
2013-02-21 |
Regeneron Pharmaceuticals, Inc. |
Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain
|
|
US9796788B2
(en)
|
2010-02-08 |
2017-10-24 |
Regeneron Pharmaceuticals, Inc. |
Mice expressing a limited immunoglobulin light chain repertoire
|
|
US20120021409A1
(en)
|
2010-02-08 |
2012-01-26 |
Regeneron Pharmaceuticals, Inc. |
Common Light Chain Mouse
|
|
NZ601171A
(en)
|
2010-03-31 |
2014-11-28 |
Ablexis Llc |
Genetic engineering of non-human animals for the production of chimeric antibodies
|
|
US9242014B2
(en)
|
2010-06-15 |
2016-01-26 |
The Regents Of The University Of California |
Receptor tyrosine kinase-like orphan receptor 1 (ROR1) single chain Fv antibody fragment conjugates and methods of use thereof
|
|
PL2480676T3
(pl)
|
2010-06-22 |
2016-10-31 |
|
Mysz wykazująca ekspresję hybrydowego łańcucha lekkiego immunoglobuliny
|
|
US10662256B2
(en)
|
2010-07-26 |
2020-05-26 |
Trianni, Inc. |
Transgenic mammals and methods of use thereof
|
|
US10793829B2
(en)
|
2010-07-26 |
2020-10-06 |
Trianni, Inc. |
Transgenic mammals and methods of use thereof
|
|
US10881084B2
(en)
|
2010-07-26 |
2021-01-05 |
Trianni, Inc |
Transgenic animals and methods of use
|
|
NZ707327A
(en)
|
2010-08-02 |
2017-01-27 |
Regeneron Pharma |
Mice that make binding proteins comprising vl domains
|
|
WO2012063048A1
(en)
|
2010-11-08 |
2012-05-18 |
Kymab Limited |
Cells & vertebrates for enhanced somatic hypermutation and class switch recombination
|
|
DK3604339T3
(da)
|
2011-01-14 |
2021-04-12 |
Univ California |
Terapeutiske antistoffer mod ror-1-protein og fremgangsmåder til anvendelse af samme
|
|
EP3375284B1
(en)
|
2011-02-15 |
2023-03-29 |
Regeneron Pharmaceuticals, Inc. |
Humanized m-csf mice and uses thereof
|
|
JP2014507137A
(ja)
|
2011-02-25 |
2014-03-27 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
Adam6マウス
|
|
US10920242B2
(en)
|
2011-02-25 |
2021-02-16 |
Recombinetics, Inc. |
Non-meiotic allele introgression
|
|
DK2527842T3
(da)
|
2011-05-12 |
2013-09-08 |
Regeneron Pharma |
Neuropeptidfrisætningsanalyse til natriumkanaler
|
|
LT3572517T
(lt)
|
2011-08-05 |
2021-04-26 |
Regeneron Pharmaceuticals, Inc. |
Humanizuotos universalios lengvosios grandinės pelės
|
|
EP3839049A3
(en)
|
2011-09-19 |
2021-10-20 |
Kymab Limited |
Antibodies, variable domains & chains tailored for human use
|
|
JP2014531452A
(ja)
|
2011-09-19 |
2014-11-27 |
カイマブ・リミテッド |
動物、レパートリーおよび方法
|
|
EP2761008A1
(en)
|
2011-09-26 |
2014-08-06 |
Kymab Limited |
Chimaeric surrogate light chains (slc) comprising human vpreb
|
|
SI3216871T1
(sl)
|
2011-10-17 |
2022-04-29 |
Regeneron Pharmaceuticals, Inc. |
Miš z omejeno težko verigo imunoglobulina
|
|
KR102295746B1
(ko)
|
2011-10-28 |
2021-09-01 |
리제너론 파아마슈티컬스, 인크. |
유전자 변형된 주요 조직적합성 복합체 마우스
|
|
US9043996B2
(en)
|
2011-10-28 |
2015-06-02 |
Regeneron Pharmaceuticals, Inc. |
Genetically modified major histocompatibility complex animals
|
|
GB2496375A
(en)
|
2011-10-28 |
2013-05-15 |
Kymab Ltd |
A non-human assay vertebrate comprising human antibody loci and human epitope knock-in, and uses thereof
|
|
US9591835B2
(en)
|
2011-10-28 |
2017-03-14 |
Regeneron Pharmaceuticals, Inc. |
Genetically modified major histocompatibility complex animals
|
|
US9113616B2
(en)
|
2011-10-28 |
2015-08-25 |
Regeneron Pharmaceuticals, Inc. |
Genetically modified mice having humanized TCR variable genes
|
|
LT3590332T
(lt)
|
2011-10-28 |
2022-08-10 |
Regeneron Pharmaceuticals, Inc. |
Genetiškai modifikuotos pelės, ekspresuojančios chimerines pagrindinio audinių dermės komplekso (mhc) ii molekules
|
|
US9381518B2
(en)
|
2011-10-31 |
2016-07-05 |
Merck Sharp & Dohme Corp. |
Nano-suspension process
|
|
GB201122047D0
(en)
|
2011-12-21 |
2012-02-01 |
Kymab Ltd |
Transgenic animals
|
|
US9253965B2
(en)
|
2012-03-28 |
2016-02-09 |
Kymab Limited |
Animal models and therapeutic molecules
|
|
EP3527070B1
(en)
|
2011-12-20 |
2025-12-03 |
Regeneron Pharmaceuticals, Inc. |
Humanized light chain mice
|
|
NZ734504A
(en)
|
2012-02-01 |
2022-10-28 |
Regeneron Pharma |
Humanized rodents that express heavy chains containing vl domains
|
|
EP3165086A1
(en)
|
2012-03-06 |
2017-05-10 |
Regeneron Pharmaceuticals, Inc. |
Common light chain mouse
|
|
US20140013456A1
(en)
|
2012-03-16 |
2014-01-09 |
Regeneron Pharmaceuticals, Inc. |
Histidine Engineered Light Chain Antibodies and Genetically Modified Non-Human Animals for Generating the Same
|
|
DK2825037T3
(da)
|
2012-03-16 |
2019-07-29 |
Regeneron Pharma |
Gnavere, der udtrykker pH-sensitive immunoglobulinsekvenser
|
|
HK1200271A1
(en)
|
2012-03-16 |
2015-08-07 |
瑞泽恩制药公司 |
Mice that produce antigen-binding proteins with ph-dependent binding characteristics
|
|
SMT201800229T1
(it)
|
2012-03-16 |
2018-07-17 |
Regeneron Pharma |
Anticorpi a catena leggera ingegnerizzati con istidina e roditori modificati geneticamente per la generazione degli stessi
|
|
US10251377B2
(en)
|
2012-03-28 |
2019-04-09 |
Kymab Limited |
Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies
|
|
JP2015512635A
(ja)
|
2012-03-28 |
2015-04-30 |
カイマブ・リミテッド |
クラススイッチした完全ヒト抗体の発現のためのトランスジェニック非−ヒト脊椎動物
|
|
GB2502127A
(en)
|
2012-05-17 |
2013-11-20 |
Kymab Ltd |
Multivalent antibodies and in vivo methods for their production
|
|
AU2013251558B2
(en)
|
2012-04-25 |
2019-01-03 |
Regeneron Pharmaceuticals, Inc. |
Nuclease-mediated targeting with large targeting vectors
|
|
MX379274B
(es)
|
2012-06-12 |
2025-03-10 |
Regeneron Pharma |
Animales no humanos humanizados con loci de cadena pesada de inmunoglobulina restringidos.
|
|
AR091482A1
(es)
*
|
2012-06-21 |
2015-02-04 |
Recombinetics Inc |
Celulas modificadas geneticamente y metodos par su obtencion
|
|
EP2887959B1
(en)
|
2012-08-23 |
2018-12-19 |
Agensys, Inc. |
Antibody drug conjugates (adc) that bind to 158p1d7 proteins
|
|
AU2013306390B2
(en)
|
2012-08-24 |
2018-07-05 |
The Regents Of The University Of California |
Antibodies and vaccines for use in treating ROR1 cancers and inhibiting metastasis
|
|
CA2881468C
(en)
|
2012-09-07 |
2023-03-21 |
Yale University |
Genetically modified mice which express human cytokines and methods of use thereof, including engraftment
|
|
UA118090C2
(uk)
*
|
2012-09-07 |
2018-11-26 |
ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі |
Спосіб інтегрування послідовності нуклеїнової кислоти, що представляє інтерес, у ген fad2 у клітині сої та специфічний для локусу fad2 білок, що зв'язується, здатний індукувати спрямований розрив
|
|
NZ724353A
(en)
|
2012-11-05 |
2022-05-27 |
Regeneron Pharma |
Genetically modified non-human animals and methods of use thereof
|
|
US20140245468A1
(en)
|
2013-02-20 |
2014-08-28 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals with modified immunoglobulin heavy chain sequences
|
|
JP6444895B2
(ja)
|
2013-02-20 |
2018-12-26 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. |
ヒト化t細胞補助受容体を発現するマウス
|
|
CN109913495B
(zh)
|
2013-02-20 |
2022-11-25 |
瑞泽恩制药公司 |
大鼠的遗传修饰
|
|
DK2958937T3
(en)
|
2013-02-22 |
2018-11-26 |
Regeneron Pharma |
Mice expressing humanized major histocompatibility complex
|
|
US20150342163A1
(en)
|
2013-02-22 |
2015-12-03 |
Regeneron Pharmaceuticals, Inc. |
Genetically modified major histocompatibility complex mice
|
|
KR102313053B1
(ko)
|
2013-03-11 |
2021-10-18 |
리제너론 파아마슈티컬스, 인크. |
키메라 주요 조직적합성 복합체(mhc) 제i 부류 분자를 발현하는 유전자전이 마우스
|
|
CN105208855B
(zh)
|
2013-03-11 |
2018-04-27 |
瑞泽恩制药公司 |
表达嵌合的主要组织相容性复合物(mhc)ii类分子的转基因小鼠
|
|
CN105189545A
(zh)
|
2013-03-13 |
2015-12-23 |
瑞泽恩制药公司 |
常见轻链小鼠
|
|
ES2712207T3
(es)
|
2013-03-13 |
2019-05-09 |
Regeneron Pharma |
Ratones que expresan un repertorio limitado de cadenas ligeras de inmunoglobulina
|
|
US9788534B2
(en)
|
2013-03-18 |
2017-10-17 |
Kymab Limited |
Animal models and therapeutic molecules
|
|
SI2986729T1
(sl)
*
|
2013-04-16 |
2019-02-28 |
Regeneron Pharmaceuticals, Inc. |
Ciljana sprememba genoma podgane
|
|
US9783618B2
(en)
|
2013-05-01 |
2017-10-10 |
Kymab Limited |
Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics
|
|
US9783593B2
(en)
|
2013-05-02 |
2017-10-10 |
Kymab Limited |
Antibodies, variable domains and chains tailored for human use
|
|
US11707056B2
(en)
|
2013-05-02 |
2023-07-25 |
Kymab Limited |
Animals, repertoires and methods
|
|
SG11201600587VA
(en)
|
2013-08-01 |
2016-02-26 |
Agensys Inc |
Antibody drug conjugates (adc) that bind to cd37 proteins
|
|
DK3178928T3
(da)
|
2013-08-07 |
2020-08-24 |
Regeneron Pharma |
Pint-knockout-mus med en præmatur, aldersassocieret fænotype
|
|
ES2738679T3
(es)
|
2013-09-18 |
2020-01-24 |
Regeneron Pharma |
Anticuerpos de cadena ligera diseñados genéticamente con histidina y animales no humanos modificados genéticamente para generar los mismos
|
|
KR102407354B1
(ko)
|
2013-09-23 |
2022-06-10 |
리제너론 파마슈티칼스 인코포레이티드 |
인간화된 신호-조절 단백질 유전자를 가지는 비-인간 동물
|
|
DE112014004537T5
(de)
|
2013-10-01 |
2016-07-21 |
Kymab Limited |
Tiermodelle und therapeutische Moleküle
|
|
AU2014353347B2
(en)
|
2013-11-19 |
2020-07-02 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals having a humanized a proliferation-inducing ligand gene
|
|
SG10201900003WA
(en)
|
2013-11-19 |
2019-02-27 |
Regeneron Pharma |
Non-human animals having a humanized b-cell activating factor gene
|
|
CN110951779B
(zh)
*
|
2013-12-11 |
2024-04-16 |
瑞泽恩制药公司 |
用于靶向修饰基因组的方法和组合物
|
|
EP3460063B1
(en)
|
2013-12-11 |
2024-03-13 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions for the targeted modification of a genome
|
|
US11160879B2
(en)
|
2014-01-15 |
2021-11-02 |
Masamichi Yamamoto |
Transgenic animal for visualization of ATP and use thereof
|
|
TWI681969B
(zh)
*
|
2014-01-23 |
2020-01-11 |
美商再生元醫藥公司 |
針對pd-1的人類抗體
|
|
KR20160131118A
(ko)
|
2014-03-21 |
2016-11-15 |
리제너론 파마슈티칼스 인코포레이티드 |
상이한 결합 특징을 전시하는 vl 항원 결합 단백질
|
|
EP3895528A1
(en)
|
2014-03-21 |
2021-10-20 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals that make single domain binding proteins
|
|
KR20250096864A
(ko)
|
2014-05-19 |
2025-06-27 |
리제너론 파마슈티칼스 인코포레이티드 |
인간 epo를 발현하는 유전자 변형된 비-인간 동물
|
|
JP6212659B2
(ja)
|
2014-05-30 |
2017-10-11 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. |
ヒト化ジペプチジルペプチダーゼiv(dpp4)動物
|
|
DK3152312T3
(da)
|
2014-06-06 |
2020-04-06 |
Regeneron Pharma |
Fremgangsmåder og sammensætninger til modifikation af et mållocus
|
|
BR112016029650A2
(pt)
|
2014-06-19 |
2017-10-24 |
Regeneron Pharma |
roedor, polipeptídeo pd-1, célula isolada ou tecido de roedor, célula-tronco embrionária de roedor, métodos de produzir um roedor, de reduzir o crescimento de tumor em um roedor, de matar células tumorais em um roedor e de avaliar as propriedades farmacocinéticas de uma droga que direciona pd-1 humano, e, modelo de tumor de roedor?
|
|
ES2666179T3
(es)
|
2014-06-23 |
2018-05-03 |
Regeneron Pharmaceuticals, Inc. |
Montaje de ADN mediado por nucleasas
|
|
JP6752158B2
(ja)
|
2014-06-26 |
2020-09-09 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. |
標的化された遺伝子修飾のための方法及び組成物、並びに使用方法
|
|
CA2959428A1
(en)
|
2014-09-19 |
2016-03-24 |
Regeneron Pharmaceuticals, Inc. |
Chimeric antigen receptors
|
|
ES2741387T3
(es)
|
2014-10-15 |
2020-02-10 |
Regeneron Pharma |
Métodos y composiciones para generar o mantener células pluripotentes
|
|
ES3013183T3
(en)
*
|
2014-11-21 |
2025-04-11 |
Regeneron Pharma |
Methods for targeted genetic modification using paired guide rnas
|
|
MX2017006802A
(es)
|
2014-11-24 |
2018-01-30 |
Regeneron Pharma |
Animales no humanos que expresan el complejo cd3 humanizado.
|
|
WO2016089692A1
(en)
|
2014-12-05 |
2016-06-09 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals having a humanized cluster of differentiation 47 gene
|
|
CA2968675C
(en)
|
2014-12-09 |
2023-10-17 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals having a humanized cluster of differentiation 274 gene
|
|
CN107208113A
(zh)
|
2014-12-19 |
2017-09-26 |
瑞泽恩制药公司 |
用于通过单步多重靶向进行靶向遗传修饰的方法和组合物
|
|
ES2884844T3
(es)
|
2015-03-09 |
2021-12-13 |
Agensys Inc |
Conjugados de anticuerpo fármaco (ADC) que se unen a proteínas FLT3
|
|
SG10201912899QA
(en)
|
2015-03-16 |
2020-02-27 |
Regeneron Pharma |
Non-human animal exhibiting diminished upper and lower motor neuron function and sensory perception
|
|
EP3271403A1
(en)
|
2015-03-19 |
2018-01-24 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals that select for light chain variable regions that bind antigen
|
|
PT3280257T
(pt)
|
2015-04-06 |
2023-09-12 |
Regeneron Pharma |
Respostas imunes mediadas por células t humanizadas em animais não humanos
|
|
CN115943929B
(zh)
|
2015-04-13 |
2025-01-10 |
再生元制药公司 |
人源化SIRPα-IL15敲入小鼠及其使用方法
|
|
US10787516B2
(en)
|
2015-05-18 |
2020-09-29 |
Agensys, Inc. |
Antibodies that bind to AXL proteins
|
|
US10395759B2
(en)
|
2015-05-18 |
2019-08-27 |
Regeneron Pharmaceuticals, Inc. |
Methods and systems for copy number variant detection
|
|
EP4679095A2
(en)
|
2015-05-18 |
2026-01-14 |
Agensys, Inc. |
Antibodies that bind to axl proteins
|
|
ES3009538T3
(en)
|
2015-05-29 |
2025-03-27 |
Regeneron Pharma |
Rodent cells having a disruption in a c9orf72 locus
|
|
JP2018526005A
(ja)
|
2015-09-02 |
2018-09-13 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. |
前立腺がんのげっ歯類モデル
|
|
TWI824372B
(zh)
|
2015-10-12 |
2023-12-01 |
美商再生元醫藥公司 |
活化瘦素受體的抗原結合蛋白
|
|
US10306874B2
(en)
*
|
2015-11-20 |
2019-06-04 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals having a humanized lymphocyte-activation gene 3
|
|
CA3006288A1
(en)
*
|
2015-11-24 |
2017-06-01 |
Glaxosmithkline Intellectual Property Development Limited |
Stable cell lines for retroviral production
|
|
DE102016122317A1
(de)
*
|
2015-11-24 |
2017-05-24 |
Glaxosmithkline Intellectual Property Development Limited |
Transientes transfektionsverfahren für retrovirale produktion
|
|
US10813346B2
(en)
|
2015-12-03 |
2020-10-27 |
Trianni, Inc. |
Enhanced immunoglobulin diversity
|
|
AU2017206785C1
(en)
|
2016-01-13 |
2023-09-07 |
Regeneron Pharmaceuticals, Inc. |
Rodents having an engineered heavy chain diversity region
|
|
US20170218398A1
(en)
*
|
2016-01-30 |
2017-08-03 |
Markus Alexander Brown |
Method to selectively target cancerous cells for genetic manipulation
|
|
IL260743B2
(en)
|
2016-02-04 |
2024-03-01 |
Trianni Inc |
Advanced production of antibodies
|
|
MX2018009513A
(es)
|
2016-02-04 |
2019-01-31 |
Regeneron Pharma |
Animales no humanos que tienen un gen angptl8 modificado genéticamente.
|
|
SG11201806812SA
(en)
|
2016-02-12 |
2018-09-27 |
Regeneron Pharma |
Methods and systems for detection of abnormal karyotypes
|
|
MA44242A
(fr)
|
2016-02-16 |
2018-12-26 |
Regeneron Pharma |
Animaux non humains ayant un gène de kynuréninase mutant
|
|
EP3422845B1
(en)
|
2016-02-29 |
2021-06-02 |
Regeneron Pharmaceuticals, Inc. |
Rodents having a humanized tmprss gene
|
|
WO2017172958A1
(en)
|
2016-03-29 |
2017-10-05 |
Regeneron Pharmaceuticals, Inc. |
Genetic variant-phenotype analysis system and methods of use
|
|
RU2745563C2
(ru)
|
2016-05-20 |
2021-03-29 |
Регенерон Фармасьютикалс, Инк. |
Способы преодоления иммунологической толерантности с использованием множества направляющих рнк
|
|
RS66700B1
(sr)
|
2016-06-03 |
2025-05-30 |
Regeneron Pharma |
Glodari koji eksprimiraju egzogenu terminalnu dezoksinukleotidil transferazu
|
|
CN109996544A
(zh)
|
2016-06-27 |
2019-07-09 |
加利福尼亚大学董事会 |
癌症治疗组合
|
|
US10912287B2
(en)
|
2016-06-28 |
2021-02-09 |
Biocytogen Pharmaceuticals (Beijing) Co., Ltd |
Genetically modified mice expressing humanized PD-1
|
|
EP3490373B1
(en)
|
2016-07-29 |
2023-10-25 |
Regeneron Pharmaceuticals, Inc. |
Mice comprising mutations resulting in expression of c-truncated fibrillin-1
|
|
WO2018064600A1
(en)
*
|
2016-09-30 |
2018-04-05 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals having a hexanucleotide repeat expansion in a c9orf72 locus
|
|
SI3766343T1
(sl)
|
2016-11-04 |
2022-06-30 |
Regeneron Pharmaceuticals, Inc. |
Nehumane živali z modificiranim lokusom lahke verige lambda imunoglobulina
|
|
CA3050715A1
(en)
|
2017-01-19 |
2018-07-26 |
Open Monoclonal Technology, Inc. |
Human antibodies from transgenic rodents with multiple heavy chain immunoglobulin loci
|
|
WO2018157058A1
(en)
|
2017-02-27 |
2018-08-30 |
Regeneron Pharmaceuticals, Inc. |
Non-human animal models of retinoschisis
|
|
EP3585160A2
(en)
|
2017-07-31 |
2020-01-01 |
Regeneron Pharmaceuticals, Inc. |
Crispr reporter non-human animals and uses thereof
|
|
EP3585159B1
(en)
|
2017-07-31 |
2025-05-14 |
Regeneron Pharmaceuticals, Inc. |
Method of testing the ability of a crispr/cas9 nuclease to modify a target genomic locus in vivo, by making use of a cas-transgenic mouse or rat which comprises a cas9 expression cassette in its genome
|
|
CN111386039B
(zh)
|
2017-09-29 |
2023-02-28 |
瑞泽恩制药公司 |
经基因修饰的啮齿动物基因组
|
|
ES2962277T3
(es)
|
2017-09-29 |
2024-03-18 |
Regeneron Pharma |
Roedores que comprenden un locus Ttr humanizado y métodos de uso
|
|
CN109666701B
(zh)
*
|
2017-10-13 |
2021-08-24 |
百奥赛图(北京)医药科技股份有限公司 |
一种pd-1基因修饰人源化动物模型的构建方法及其应用
|
|
WO2019072241A1
(en)
|
2017-10-13 |
2019-04-18 |
Beijing Biocytogen Co., Ltd |
NON-HUMAN ANIMAL GENETICALLY MODIFIED WITH PD-1 HUMAN OR CHIMERIC
|
|
CN116064611A
(zh)
|
2017-11-30 |
2023-05-05 |
瑞泽恩制药公司 |
包含人源化trkb基因座的非人动物
|
|
ES2928995T3
(es)
|
2017-12-05 |
2022-11-24 |
Regeneron Pharma |
Ratones que tienen una cadena ligera lambda de inmunoglobulina genomanipulada y usos de los mismos
|
|
KR102647714B1
(ko)
|
2018-03-19 |
2024-03-18 |
리제너론 파마슈티칼스 인코포레이티드 |
CRISPR/Cas 시스템을 사용한 동물에서의 전사 조절
|
|
WO2019190990A1
(en)
|
2018-03-26 |
2019-10-03 |
Regeneron Pharmaceuticals, Inc. |
Humanized rodents for testing therapeutic agents
|
|
CA3094400A1
(en)
|
2018-04-06 |
2019-10-10 |
Regeneron Pharmaceuticals, Inc. |
A leptin receptor agonist antibody for use in treating a metabolic dysfunction or hypoleptinemia
|
|
MX2020013043A
(es)
|
2018-06-01 |
2021-07-16 |
Regeneron Pharma |
Métodos y sistemas para transformaciones de matrices dispersas basadas en vectores.
|
|
IL318469A
(en)
|
2018-06-14 |
2025-03-01 |
Regeneron Pharma |
Non-human animals capable of reorganizing transgenic DH-DH, and their uses
|
|
AU2019308205B2
(en)
|
2018-07-16 |
2025-11-06 |
Regeneron Pharmaceuticals, Inc. |
Non-human animal models of DITRA disease and uses thereof
|
|
CN109504708A
(zh)
*
|
2018-12-03 |
2019-03-22 |
江苏集萃药康生物科技有限公司 |
一种筛选标记自我删除的基因打靶载体及方法
|
|
JP7449291B2
(ja)
|
2018-12-20 |
2024-03-13 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
ヌクレアーゼ媒介リピート伸長
|
|
US20220104468A1
(en)
|
2019-01-22 |
2022-04-07 |
St. Jude Children's Research Hospital |
Modulation of lc3-associated endocytosis pathway and genetically modified non-human animals as a model of neuroinflammation and neurodegeneration
|
|
AU2020226445B2
(en)
|
2019-02-18 |
2025-05-29 |
Biocytogen Pharmaceuticals (Beijing) Co., Ltd. |
Genetically modified non-human animals with humanized immunoglobulin locus
|
|
AU2020226865A1
(en)
|
2019-02-22 |
2021-07-29 |
Regeneron Pharmaceuticals, Inc. |
Rodents having genetically modified sodium channels and methods of use thereof
|
|
CN113795588B
(zh)
|
2019-04-04 |
2025-02-25 |
瑞泽恩制药公司 |
用于在靶向性载体中无瘢痕引入靶向修饰的方法
|
|
CN117178959A
(zh)
|
2019-04-04 |
2023-12-08 |
瑞泽恩制药公司 |
包括人源化凝血因子12基因座的非人动物
|
|
CA3136602A1
(en)
|
2019-04-15 |
2020-10-22 |
Qwixel Therapeutics Llc |
Fusion protein composition(s) comprising targeted masked type i interferons (ifna and ifnb) and an antibody against tumor antigen, for use in the treatment of cancer
|
|
EP3801011A1
(en)
|
2019-06-04 |
2021-04-14 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals comprising a humanized ttr locus with a beta-slip mutation and methods of use
|
|
CA3136478A1
(en)
|
2019-06-05 |
2020-12-10 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals having a limited lambda light chain repertoire expressed from the kappa locus and uses thereof
|
|
US11622547B2
(en)
|
2019-06-07 |
2023-04-11 |
Regeneran Pharmaceuticals, Inc. |
Genetically modified mouse that expresses human albumin
|
|
CN114008193A
(zh)
|
2019-06-27 |
2022-02-01 |
瑞泽恩制药公司 |
Tdp-43蛋白病的建模
|
|
MX2022000133A
(es)
|
2019-07-01 |
2022-04-27 |
Tonix Pharma Ltd |
Anticuerpos anti-cd154 y usos de los mismos.
|
|
CA3154710A1
(en)
|
2019-10-04 |
2021-04-08 |
TAE Life Sciences |
Antibody compositions comprising fc mutations and site-specific conjugation properties
|
|
WO2021108363A1
(en)
|
2019-11-25 |
2021-06-03 |
Regeneron Pharmaceuticals, Inc. |
Crispr/cas-mediated upregulation of humanized ttr allele
|
|
CA3169272A1
(en)
|
2020-01-28 |
2021-08-05 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals comprising a humanized pnpla3 locus and methods of use
|
|
WO2021158883A1
(en)
|
2020-02-07 |
2021-08-12 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals comprising a humanized klkb1 locus and methods of use
|
|
WO2021195079A1
(en)
|
2020-03-23 |
2021-09-30 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals comprising a humanized ttr locus comprising a v30m mutation and methods of use
|
|
CA3167557A1
(en)
|
2020-04-21 |
2021-10-28 |
Davor Frleta |
Non-human animals having a humanized cxcl13 gene
|
|
AU2021283564B2
(en)
|
2020-06-02 |
2025-05-29 |
Biocytogen Pharmaceuticals (Beijing) Co., Ltd. |
Genetically modified non-human animals with common light chain immunoglobulin locus
|
|
RU2751237C1
(ru)
*
|
2020-06-10 |
2021-07-12 |
Регенерон Фармасьютикалс, Инк. |
Способы и композиции для направленной модификации генома
|
|
KR20230024822A
(ko)
|
2020-06-25 |
2023-02-21 |
주식회사 휴맵 |
이형접합성 형질전환 동물
|
|
AU2021342159A1
(en)
|
2020-09-11 |
2023-03-02 |
Regeneron Pharmaceuticals, Inc. |
Identification and production of antigen-specific antibodies
|
|
CN116323651A
(zh)
|
2020-10-01 |
2023-06-23 |
瑞泽恩制药公司 |
表达人cr1的啮齿动物
|
|
US12012441B2
(en)
|
2020-10-26 |
2024-06-18 |
Neptune Biosciences Llc |
Engineered human IL-21 cytokines and methods for using the same
|
|
CN116848254A
(zh)
|
2020-12-16 |
2023-10-03 |
瑞泽恩制药公司 |
表达人源化Fcα受体的小鼠
|
|
CN116802200A
(zh)
|
2020-12-21 |
2023-09-22 |
瑞泽恩制药公司 |
具有人源化tslp基因、人源化tslp受体基因和/或人源化il7ra基因的非人动物
|
|
MX2023007401A
(es)
|
2020-12-23 |
2023-07-06 |
Regeneron Pharma |
Acidos nucleicos que codifican anticuerpos modificados por anclaje y usos de los mismos.
|
|
WO2022150452A1
(en)
|
2021-01-06 |
2022-07-14 |
Seth Lederman |
Methods of inducing immune tolerance with modified anti-cd154 antibodies
|
|
CN118511853A
(zh)
|
2021-03-31 |
2024-08-20 |
瑞泽恩制药公司 |
包含具有改善的tcrb组库多样性的人源化细胞免疫系统组分的基因修饰的小鼠
|
|
US20240199725A1
(en)
|
2021-04-16 |
2024-06-20 |
Korea University Research And Business Foundation |
Human antibody targeting covid-19 virus
|
|
WO2022265679A2
(en)
|
2021-06-18 |
2022-12-22 |
Nammi Therapeutics, Inc. |
FUSION PROTEIN COMPOSITION(S) COMPRISING MASKED TYPE I INTERFERONS (IFNα AND IFNβ) FOR USE IN THE TREATMENT OF CANCER AND METHODS THEREOF
|
|
US20240415980A1
(en)
|
2021-10-28 |
2024-12-19 |
Regeneron Pharmaceuticals, Inc. |
Crispr/cas-related methods and compositions for knocking out c5
|
|
CN118632622A
(zh)
|
2021-12-08 |
2024-09-10 |
瑞泽恩制药公司 |
突变型肌纤蛋白疾病模型及其用途
|
|
US20250049006A1
(en)
|
2021-12-20 |
2025-02-13 |
C/O Regeneron Pharmaceuticals, Inc. |
Non-human animals comprising humanized ace2 and tmprss loci
|
|
US20250194571A1
(en)
|
2022-02-07 |
2025-06-19 |
Regeneron Pharmaceuticals, Inc. |
Compositions and methods for defining optimal treatment timeframes in lysosomal disease
|
|
US20230257432A1
(en)
|
2022-02-11 |
2023-08-17 |
Regeneron Pharmaceuticals, Inc. |
Compositions and methods for screening 4r tau targeting agents
|
|
WO2023212560A1
(en)
|
2022-04-26 |
2023-11-02 |
Regeneron Pharmaceuticals, Inc. |
A rodent model of fibrodysplasia ossificans progressiva
|
|
WO2023235725A2
(en)
|
2022-05-31 |
2023-12-07 |
Regeneron Pharmaceuticals, Inc. |
Crispr-based therapeutics for c9orf72 repeat expansion disease
|
|
EP4531554A1
(en)
|
2022-05-31 |
2025-04-09 |
Regeneron Pharmaceuticals, Inc. |
Animal model of tdp-43 proteinopathy
|
|
US20230417899A1
(en)
|
2022-06-27 |
2023-12-28 |
Oshkosh Corporation |
Position tracking for a lift device
|
|
EP4557944A1
(en)
|
2022-07-19 |
2025-05-28 |
Regeneron Pharmaceuticals, Inc. |
Genetically modified animal model and its use to model the human immune system
|
|
CA3265746A1
(en)
|
2022-09-22 |
2024-03-28 |
Regeneron Pharmaceuticals, Inc. |
GENETICALLY MODIFIED MICE EXPRESSING COMPONENTS OF A HUMAN CELLULAR IMMUNE SYSTEM
|
|
US20240224964A9
(en)
|
2022-09-29 |
2024-07-11 |
Regeneron Pharmaceuticals, Inc. |
Correction of hepatosteatosis in humanized liver animals through restoration of il6/il6r/gp130 signaling in human hepatocytes
|
|
IL322105A
(en)
|
2023-02-01 |
2025-09-01 |
Regeneron Pharma |
Animals comprising a modified klhdc7b locus
|
|
AU2024304180A1
(en)
|
2023-06-13 |
2026-01-08 |
Adcentrx Therapeutics, Inc. |
Methods and compositions related to antibodies and antibody drug conjugates (adcs) that bind nectin-4 proteins
|
|
CN121335619A
(zh)
|
2023-06-16 |
2026-01-13 |
瑞泽恩制药公司 |
载体、经基因修饰的细胞和包含其的经基因修饰的非人动物
|
|
WO2025122669A1
(en)
|
2023-12-05 |
2025-06-12 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals having a humanized complement factor b gene
|
|
WO2025171307A1
(en)
|
2024-02-08 |
2025-08-14 |
Regeneron Pharmaceuticals, Inc. |
Vectors, genetically modified cells, and genetically modified non-human animals comprising the same
|
|
WO2025212991A1
(en)
|
2024-04-05 |
2025-10-09 |
Regeneron Pharmaceuticals, Inc. |
Rodent models of disease
|
|
WO2025235388A1
(en)
|
2024-05-06 |
2025-11-13 |
Regeneron Pharmaceuticals, Inc. |
Transgene genomic identification by nuclease-mediated long read sequencing
|
|
WO2025250495A1
(en)
|
2024-05-28 |
2025-12-04 |
Regeneron Pharmaceuticals, Inc. |
Acceleration of human hepatocyte engraftment in humanized liver animals by supplementing paracrine ligands or agonists that activate human liver regeneration signals
|
|
WO2025264533A1
(en)
|
2024-06-17 |
2025-12-26 |
Adcentrx Therapeutics Inc. |
Methods and compositions related to antibody drug conjugates (adcs) that bind steap-1 proteins
|
|
WO2026030428A2
(en)
|
2024-08-01 |
2026-02-05 |
Regeneron Pharmaceuticals, Inc. |
Prostate-specific antigen peptides and uses thereof
|