NO20031006L - Imidazolo-5-yl-2-anilino-pyrimidiner som midler for inhibering av celleproliferasjon - Google Patents

Imidazolo-5-yl-2-anilino-pyrimidiner som midler for inhibering av celleproliferasjon

Info

Publication number: NO20031006L
Authority: NO; Norway
Prior art keywords: imidazolo; anilino; pyrimidines; agents; cell proliferation
Prior art date: 2000-09-05

Application number

NO20031006A

Other languages

English (en)

Other versions

NO20031006D0 (no

NO324059B1 (no

Inventor

Gloria Anne Breault

Nicholas John Newcombe

Andrew Peter Thomas

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-09-05

Filing date

2003-03-04

Publication date

2003-03-04

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9898838&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20031006(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2003-03-04 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2003-03-04 Publication of NO20031006D0 publication Critical patent/NO20031006D0/no

2003-03-04 Publication of NO20031006L publication Critical patent/NO20031006L/no

2007-08-06 Publication of NO324059B1 publication Critical patent/NO324059B1/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Rheumatology (AREA)
Immunology (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Urology & Nephrology (AREA)
Cardiology (AREA)
Oncology (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Ophthalmology & Optometry (AREA)
Dermatology (AREA)
Hematology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Inks, Pencil-Leads, Or Crayons (AREA)
Compositions Of Macromolecular Compounds (AREA)
Adhesives Or Adhesive Processes (AREA)

NO20031006A 2000-09-05 2003-03-04 Imidazolo-5-yl-2-anilino-pyrimidiner, fremstilling, farmasoytisk preparat inneholdende disse, samt anvendelse for fremstilling av medikament for inhibering av celleproliferasjon NO324059B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB0021726.5A GB0021726D0 (en)	2000-09-05	2000-09-05	Chemical compounds
PCT/GB2001/003864 WO2002020512A1 (en)	2000-09-05	2001-08-30	Imidazolo-5-yl-2-anilino-pyrimidines as agents for the inhibition of the cell proliferation

Publications (3)

Publication Number	Publication Date
NO20031006D0 NO20031006D0 (no)	2003-03-04
NO20031006L true NO20031006L (no)	2003-03-04
NO324059B1 NO324059B1 (no)	2007-08-06

Family

ID=9898838

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20031006A NO324059B1 (no)	2000-09-05	2003-03-04	Imidazolo-5-yl-2-anilino-pyrimidiner, fremstilling, farmasoytisk preparat inneholdende disse, samt anvendelse for fremstilling av medikament for inhibering av celleproliferasjon

Country Status (33)

Country	Link
US (2)	US6969714B2 (no)
EP (1)	EP1351958B1 (no)
JP (1)	JP3523641B2 (no)
KR (1)	KR100802368B1 (no)
CN (1)	CN1269813C (no)
AR (1)	AR033836A1 (no)
AT (1)	ATE269327T1 (no)
AU (2)	AU2001284192B2 (no)
BG (1)	BG107579A (no)
BR (1)	BR0113496A (no)
CA (1)	CA2417148C (no)
CZ (1)	CZ2003617A3 (no)
DE (1)	DE60103935T2 (no)
DK (1)	DK1351958T3 (no)
EE (1)	EE05430B1 (no)
ES (1)	ES2221904T3 (no)
GB (1)	GB0021726D0 (no)
HK (1)	HK1057553A1 (no)
HU (1)	HUP0302922A3 (no)
IL (1)	IL154292A0 (no)
IS (1)	IS2055B (no)
MX (1)	MXPA03001511A (no)
MY (1)	MY127126A (no)
NO (1)	NO324059B1 (no)
NZ (1)	NZ523787A (no)
PL (1)	PL360627A1 (no)
PT (1)	PT1351958E (no)
RU (1)	RU2284327C2 (no)
SK (1)	SK287277B6 (no)
TW (1)	TWI242559B (no)
UA (1)	UA74206C2 (no)
WO (1)	WO2002020512A1 (no)
ZA (1)	ZA200300612B (no)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9828511D0 (en)	1998-12-24	1999-02-17	Zeneca Ltd	Chemical compounds
GB9919778D0 (en)	1999-08-21	1999-10-27	Zeneca Ltd	Chemical compounds
GB0004887D0 (en)	2000-03-01	2000-04-19	Astrazeneca Uk Ltd	Chemical compounds
GB0004888D0 (en)	2000-03-01	2000-04-19	Astrazeneca Uk Ltd	Chemical compounds
GB0004886D0 (en)	2000-03-01	2000-04-19	Astrazeneca Uk Ltd	Chemical compounds
GB0004890D0 (en)	2000-03-01	2000-04-19	Astrazeneca Uk Ltd	Chemical compounds
GB0007371D0 (en)	2000-03-28	2000-05-17	Astrazeneca Uk Ltd	Chemical compounds
GB0016877D0 (en)	2000-07-11	2000-08-30	Astrazeneca Ab	Chemical compounds
US7122544B2 (en) *	2000-12-06	2006-10-17	Signal Pharmaceuticals, Llc	Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto
US7129242B2 (en)	2000-12-06	2006-10-31	Signal Pharmaceuticals, Llc	Anilinopyrimidine derivatives as JNK pathway inhibitors and compositions and methods related thereto
GB0103926D0 (en)	2001-02-17	2001-04-04	Astrazeneca Ab	Chemical compounds
GB0113041D0 (en)	2001-05-30	2001-07-18	Astrazeneca Ab	Chemical compounds
GB0205688D0 (en) *	2002-03-09	2002-04-24	Astrazeneca Ab	Chemical compounds
WO2003076434A1 (en) *	2002-03-09	2003-09-18	Astrazeneca Ab	4- imidazolyl substuited pyrimidine derivatives with cdk inhibitiory activity
GB0205693D0 (en)	2002-03-09	2002-04-24	Astrazeneca Ab	Chemical compounds
GB0205690D0 (en) *	2002-03-09	2002-04-24	Astrazeneca Ab	Chemical compounds
AR039241A1 (es) *	2002-04-04	2005-02-16	Biogen Inc	Heteroarilos trisustituidos y metodos para su produccion y uso de los mismos
DE10239042A1 (de) *	2002-08-21	2004-03-04	Schering Ag	Makrozyclische Pyrimidine, deren Herstellung und Verwendung als Arzneimittel
UA80295C2 (en) *	2002-09-06	2007-09-10	Biogen Inc	Pyrazolopyridines and using the same
GB0226583D0 (en) *	2002-11-14	2002-12-18	Cyclacel Ltd	Compounds
GB0311276D0 (en)	2003-05-16	2003-06-18	Astrazeneca Ab	Chemical compounds
GB0311274D0 (en)	2003-05-16	2003-06-18	Astrazeneca Ab	Chemical compounds
TW200528101A (en) *	2004-02-03	2005-09-01	Astrazeneca Ab	Chemical compounds
RU2007114080A (ru) *	2004-10-13	2008-11-27	Вайет (Us)	N-бензилсульфонил-замещенные аналоги анилинопиримидина
WO2006050351A2 (en) *	2004-10-28	2006-05-11	Irm Llc	Compounds and compositions as hedgehog pathway modulators
MX2007007272A (es) *	2004-12-17	2007-07-11	Astrazeneca Ab	4-(4-imidazol-4-il)pirimidin-2-ilamino)benzamidas como inhibidores de cdk.
CN1939910A (zh) *	2004-12-31	2007-04-04	孙飘扬	氨基嘧啶类化合物及其盐和其制备方法与药物用途
GB0504753D0 (en) *	2005-03-08	2005-04-13	Astrazeneca Ab	Chemical compounds
WO2007015064A1 (en) *	2005-07-30	2007-02-08	Astrazeneca Ab	Imidazolyl-pyrimidine compounds for use in the treatment of proliferative disorders
KR100674813B1 (ko) *	2005-08-05	2007-01-29	일양약품주식회사	Ｎ-페닐-2-피리미딘-아민 유도체 및 그의 제조방법
CA2623374A1 (en) *	2005-09-30	2007-04-05	Astrazeneca Ab	Imidazo [1,2-a] pyridine having anti-cell-proliferation activity
US20080214560A1 (en) *	2005-10-03	2008-09-04	Astrazeneca Ab	Use of Pyrimidine Derivatives in the Manufacture of a Medicament for Prevention and/or Treatment of Alzheimer's Disease
AR058073A1 (es) *	2005-10-03	2008-01-23	Astrazeneca Ab	Derivados de imidazol 5-il-pirimidina, procesos de obtencion, composiciones farmaceuticas y usos
CN101426768A (zh) *	2006-04-21	2009-05-06	阿斯利康(瑞典)有限公司	可用作adg受体调节剂的磺酰胺化合物
TW200811169A (en) *	2006-05-26	2008-03-01	Astrazeneca Ab	Chemical compounds
ATE482948T1 (de)	2006-06-21	2010-10-15	Astrazeneca Ab	Chemische verbindungen
TW200815418A (en) *	2006-06-27	2008-04-01	Astrazeneca Ab	New compounds I
TW200815417A (en) *	2006-06-27	2008-04-01	Astrazeneca Ab	New compounds II
CN101970417A (zh) *	2008-03-14	2011-02-09	巴斯夫欧洲公司	作为杀真菌剂使用的取代的吡嗪基甲基磺酰胺
CA2729909A1 (en) *	2008-07-14	2010-01-21	Gilead Sciences, Inc.	Imidazolyl pyrimidine inhibitor compounds
CN101503402B (zh) *	2009-03-10	2014-06-25	沈阳药科大学	2-苯胺嘧啶衍生物及其制备和用途
BRPI1015014A2 (pt)	2009-04-15	2017-06-27	Astrazeneca Ab	composto, composição farmacêutica , e, método de tratamento de distúrbio(s) cognitivo(s) ou indicações com déficit(s) em cognição
CN103038230B (zh)	2010-06-04	2016-05-25	霍夫曼-拉罗奇有限公司	作为lrrk2调节剂的氨基嘧啶衍生物
EP3590933B1 (en)	2010-11-10	2021-01-06	Genentech, Inc.	Pyrazole aminopyrimidine derivatives as lrrk2 modulators
CN106928192B (zh) *	2015-12-29	2020-11-13	中国科学院广州生物医药与健康研究院	一种嘧啶类化合物及其制备方法和应用
US11066404B2 (en)	2018-10-11	2021-07-20	Incyte Corporation	Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors
US11384083B2 (en)	2019-02-15	2022-07-12	Incyte Corporation	Substituted spiro[cyclopropane-1,5′-pyrrolo[2,3-d]pyrimidin]-6′(7′h)-ones as CDK2 inhibitors
US11472791B2 (en)	2019-03-05	2022-10-18	Incyte Corporation	Pyrazolyl pyrimidinylamine compounds as CDK2 inhibitors
WO2020205560A1 (en)	2019-03-29	2020-10-08	Incyte Corporation	Sulfonylamide compounds as cdk2 inhibitors
WO2020223469A1 (en)	2019-05-01	2020-11-05	Incyte Corporation	N-(1-(methylsulfonyl)piperidin-4-yl)-4,5-di hydro-1h-imidazo[4,5-h]quinazolin-8-amine derivatives and related compounds as cyclin-dependent kinase 2 (cdk2) inhibitors for treating cancer
US11447494B2 (en)	2019-05-01	2022-09-20	Incyte Corporation	Tricyclic amine compounds as CDK2 inhibitors
AU2020328025A1 (en)	2019-08-14	2022-03-03	Incyte Corporation	Imidazolyl pyrimidinylamine compounds as CDK2 inhibitors
WO2021072232A1 (en)	2019-10-11	2021-04-15	Incyte Corporation	Bicyclic amines as cdk2 inhibitors
AU2021385745C1 (en) *	2020-11-27	2025-02-20	Allorion Therapeutics Inc	Aminoheteroaryl kinase inhibitors
US11981671B2 (en)	2021-06-21	2024-05-14	Incyte Corporation	Bicyclic pyrazolyl amines as CDK2 inhibitors
CN113999210B (zh) *	2021-12-03	2023-05-23	郑州大学第一附属医院	一组2-苯氨基-4-三氮唑基嘧啶类衍生物及其应用
US11976073B2 (en)	2021-12-10	2024-05-07	Incyte Corporation	Bicyclic amines as CDK2 inhibitors

Family Cites Families (64)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4659363A (en)	1983-07-25	1987-04-21	Ciba-Geigy Corporation	N-(2-nitrophenyl)-2-aminopyrimidine derivatives, the preparation and use thereof
US4946956A (en)	1988-09-21	1990-08-07	Uniroyal Chemical Company, Inc.	Arylenediamine substituted pyrimidines
HU206337B (en)	1988-12-29	1992-10-28	Mitsui Petrochemical Ind	Process for producing pyrimidine derivatives and pharmaceutical compositions
US4983608A (en) *	1989-09-05	1991-01-08	Hoechst-Roussell Pharmaceuticals, Inc.	N-substituted-4-pyrimidinamines and pyrimidinediamines
GB9012592D0 (en)	1990-06-06	1990-07-25	Smithkline Beecham Intercredit	Compounds
ES2108120T3 (es)	1991-05-10	1997-12-16	Rhone Poulenc Rorer Int	Compuestos bis arilicos y heteroarilicos mono- y biciclicos que inhiben tirosina quinasa receptora de egf y/o pdgf.
US5521184A (en) *	1992-04-03	1996-05-28	Ciba-Geigy Corporation	Pyrimidine derivatives and processes for the preparation thereof
US5516775A (en) *	1992-08-31	1996-05-14	Ciba-Geigy Corporation	Further use of pyrimidine derivatives
KR100262254B1 (ko) *	1992-10-05	2000-07-15	나카히로 마오미	피리미딘 화합물
US5543520A (en)	1993-10-01	1996-08-06	Ciba-Geigy Corporation	Pyrimidine derivatives
US5705502A (en)	1993-10-01	1998-01-06	Novartis Corporation	Pharmacologically active pyrimidineamine derivatives and processes for the preparation thereof
AU693475B2 (en)	1993-10-01	1998-07-02	Novartis Ag	Pyrimidineamine derivatives and processes for the preparation thereof
ATE208772T1 (de)	1993-10-01	2001-11-15	Novartis Erfind Verwalt Gmbh	Pharmacologisch wirksame pyridinderivate und verfahren zu deren herstellung
GB9325217D0 (en)	1993-12-09	1994-02-09	Zeneca Ltd	Pyrimidine derivatives
US5494998A (en)	1994-11-14	1996-02-27	Akzo Nobel N.V.	Polymerization of carbon monoxide and ethylene using catalyst containing non-coordinating, non-acidic anion
ATE251141T1 (de)	1995-03-10	2003-10-15	Berlex Lab	Benzamidin-derivate, deren herstellung und deren verwendung als anti-koagulantien
IL118544A (en)	1995-06-07	2001-08-08	Smithkline Beecham Corp	History of imidazole, the process for their preparation and the pharmaceutical preparations containing them
US5739143A (en) *	1995-06-07	1998-04-14	Smithkline Beecham Corporation	Imidazole compounds and compositions
GB9523675D0 (en)	1995-11-20	1996-01-24	Celltech Therapeutics Ltd	Chemical compounds
WO1997035856A1 (en)	1996-03-25	1997-10-02	Smithkline Beecham Corporation	Novel treatment for cns injuries
JP2000511883A (ja)	1996-04-19	2000-09-12	ノボノルディスクアクティーゼルスカブ	ホスホチロシン認識ユニットを有する分子のモジュレーター
TW440563B (en)	1996-05-23	2001-06-16	Hoffmann La Roche	Aryl pyrimidine derivatives and a pharmaceutical composition thereof
EP0906307B1 (en)	1996-06-10	2005-04-27	Merck & Co., Inc.	Substituted imidazoles having cytokine inhibitory activity
GB9619284D0 (en)	1996-09-16	1996-10-30	Celltech Therapeutics Ltd	Chemical compounds
WO1998016230A1 (en)	1996-10-17	1998-04-23	Smithkline Beecham Corporation	Methods for reversibly inhibiting myelopoiesis in mammalian tissue
GB9622363D0 (en)	1996-10-28	1997-01-08	Celltech Therapeutics Ltd	Chemical compounds
ZA9711092B (en)	1996-12-11	1999-07-22	Smithkline Beecham Corp	Novel compounds.
DE69839338T2 (de)	1997-02-05	2008-07-10	Warner-Lambert Company Llc	Pyrido (2,3-d) pyrimidine und 4-amino-pyrimidine als inhibitoren der zellulären proliferation
DE19710435A1 (de)	1997-03-13	1998-09-17	Hoechst Ag	Verwendung von Pyrimidinderivaten zur Prävention von Krebs allein oder in Kombination mit anderen therapeutischen Maßnahmen
GB9705361D0 (en)	1997-03-14	1997-04-30	Celltech Therapeutics Ltd	Chemical compounds
WO1998054093A1 (en)	1997-05-30	1998-12-03	Merck & Co., Inc.	Novel angiogenesis inhibitors
CA2293436C (en)	1997-06-12	2010-10-26	Rhone-Poulenc Rorer Limited	Imidazolyl-cyclic acetals as tnf inhibitors
TW517055B (en)	1997-07-02	2003-01-11	Smithkline Beecham Corp	Novel substituted imidazole compounds
JP2001519345A (ja)	1997-10-02	2001-10-23	メルクエンドカムパニーインコーポレーテッド	プレニルタンパク質トランスフェラーゼの阻害剤
AU9449398A (en)	1997-10-10	1999-05-03	Imperial College Innovations Ltd.	Use of csaidtm compounds for the management of uterine contractions
US6432963B1 (en)	1997-12-15	2002-08-13	Yamanouchi Pharmaceutical Co., Ltd.	Pyrimidine-5-carboxamide derivatives
AR017219A1 (es)	1997-12-19	2001-08-22	Smithkline Beecham Corp	Derivados de imidazol 1,4,5 sustituidos, composiciones que los comprenden, procedimiento para la preparacion de dichos derivados, uso de los derivados parala manufactura de un medicamento
NZ506417A (en)	1998-02-17	2003-05-30	Tularik Inc	Anti-viral pyrimidine derivatives
SI0945443T1 (en)	1998-03-27	2003-08-31	Janssen Pharmaceutica N.V.	HIV inhibiting pyrimidine derivatives
GB9806739D0 (en)	1998-03-28	1998-05-27	Univ Newcastle Ventures Ltd	Cyclin dependent kinase inhibitors
WO2000012485A1 (en)	1998-08-29	2000-03-09	Astrazeneca Ab	Pyrimidine compounds
ES2270612T3 (es)	1998-08-29	2007-04-01	Astrazeneca Ab	Compuestos de pirimidina.
CN1326457A (zh)	1998-09-18	2001-12-12	巴斯福股份公司	作为激酶抑制剂的4－氨基吡咯并嘧啶
GB9828511D0 (en) *	1998-12-24	1999-02-17	Zeneca Ltd	Chemical compounds
GB9903762D0 (en)	1999-02-18	1999-04-14	Novartis Ag	Organic compounds
GB9905075D0 (en)	1999-03-06	1999-04-28	Zeneca Ltd	Chemical compounds
US6627633B2 (en)	1999-03-17	2003-09-30	Albany Molecular Research, Inc.	6-substituted biaryl purine derivatives as potent cyclin/CDK inhibitors and antiproliferative agents
GB9907658D0 (en)	1999-04-06	1999-05-26	Zeneca Ltd	Chemical compounds
GB9914258D0 (en)	1999-06-18	1999-08-18	Celltech Therapeutics Ltd	Chemical compounds
GB9919778D0 (en)	1999-08-21	1999-10-27	Zeneca Ltd	Chemical compounds
GB9924862D0 (en)	1999-10-20	1999-12-22	Celltech Therapeutics Ltd	Chemical compounds
AU7922900A (en)	1999-10-27	2001-05-08	Novartis Ag	Thiazole and imidazo (4,5-b) pyridine compounds and their pharmaceutical use
TR200201364T2 (tr) *	1999-11-22	2002-10-21	Smithkline Beecham P. L. C.	Yeni bileşikler.
EP1242385B1 (en)	1999-12-28	2009-11-25	Pharmacopeia, Inc.	Cytokine, especially tnf-alpha, inhibitors
KR20030024659A (ko)	2000-02-17	2003-03-26	암겐 인코포레이티드	키나제 억제제
GB0004886D0 (en)	2000-03-01	2000-04-19	Astrazeneca Uk Ltd	Chemical compounds
GB0004887D0 (en)	2000-03-01	2000-04-19	Astrazeneca Uk Ltd	Chemical compounds
GB0004888D0 (en)	2000-03-01	2000-04-19	Astrazeneca Uk Ltd	Chemical compounds
GB0004890D0 (en)	2000-03-01	2000-04-19	Astrazeneca Uk Ltd	Chemical compounds
GB0007371D0 (en)	2000-03-28	2000-05-17	Astrazeneca Uk Ltd	Chemical compounds
GB0016877D0 (en)	2000-07-11	2000-08-30	Astrazeneca Ab	Chemical compounds
GB0103926D0 (en)	2001-02-17	2001-04-04	Astrazeneca Ab	Chemical compounds
GB0113041D0 (en)	2001-05-30	2001-07-18	Astrazeneca Ab	Chemical compounds
JP2005511608A (ja) *	2001-11-07	2005-04-28	エフ．ホフマン−ラ　ロシュ　アーゲー	アミノピリミジン類及び−ピリジン類

2000
- 2000-09-05 GB GBGB0021726.5A patent/GB0021726D0/en not_active Ceased
2001
- 2001-08-30 SK SK241-2003A patent/SK287277B6/sk not_active IP Right Cessation
- 2001-08-30 JP JP2002525133A patent/JP3523641B2/ja not_active Expired - Fee Related
- 2001-08-30 EE EEP200300088A patent/EE05430B1/xx not_active IP Right Cessation
- 2001-08-30 NZ NZ523787A patent/NZ523787A/en unknown
- 2001-08-30 CA CA2417148A patent/CA2417148C/en not_active Expired - Fee Related
- 2001-08-30 AU AU2001284192A patent/AU2001284192B2/en not_active Ceased
- 2001-08-30 HU HU0302922A patent/HUP0302922A3/hu unknown
- 2001-08-30 UA UA2003042977A patent/UA74206C2/uk unknown
- 2001-08-30 DK DK01963159T patent/DK1351958T3/da active
- 2001-08-30 DE DE60103935T patent/DE60103935T2/de not_active Expired - Lifetime
- 2001-08-30 EP EP01963159A patent/EP1351958B1/en not_active Expired - Lifetime
- 2001-08-30 US US10/363,655 patent/US6969714B2/en not_active Expired - Fee Related
- 2001-08-30 IL IL15429201A patent/IL154292A0/xx not_active IP Right Cessation
- 2001-08-30 RU RU2003109612/04A patent/RU2284327C2/ru not_active IP Right Cessation
- 2001-08-30 BR BR0113496-5A patent/BR0113496A/pt not_active Application Discontinuation
- 2001-08-30 KR KR1020037003215A patent/KR100802368B1/ko not_active IP Right Cessation
- 2001-08-30 CN CNB018151744A patent/CN1269813C/zh not_active Expired - Fee Related
- 2001-08-30 PT PT01963159T patent/PT1351958E/pt unknown
- 2001-08-30 CZ CZ2003617A patent/CZ2003617A3/cs unknown
- 2001-08-30 AT AT01963159T patent/ATE269327T1/de active
- 2001-08-30 AU AU8419201A patent/AU8419201A/xx active Pending
- 2001-08-30 ES ES01963159T patent/ES2221904T3/es not_active Expired - Lifetime
- 2001-08-30 WO PCT/GB2001/003864 patent/WO2002020512A1/en active IP Right Grant
- 2001-08-30 MX MXPA03001511A patent/MXPA03001511A/es active IP Right Grant
- 2001-08-30 PL PL36062701A patent/PL360627A1/xx not_active Application Discontinuation
- 2001-09-03 MY MYPI20014136 patent/MY127126A/en unknown
- 2001-09-05 AR ARP010104228A patent/AR033836A1/es unknown
- 2001-09-11 TW TW090122494A patent/TWI242559B/zh not_active IP Right Cessation
2003
- 2003-01-22 ZA ZA200300612A patent/ZA200300612B/en unknown
- 2003-02-12 IS IS6715A patent/IS2055B/is unknown
- 2003-02-21 BG BG107579A patent/BG107579A/bg unknown
- 2003-03-04 NO NO20031006A patent/NO324059B1/no not_active IP Right Cessation
2004
- 2004-01-19 HK HK04100403A patent/HK1057553A1/xx not_active IP Right Cessation
2005
- 2005-06-29 US US11/169,197 patent/US20060004033A1/en not_active Abandoned

Also Published As

Publication number	Publication date
JP2004508365A (ja)	2004-03-18
NZ523787A (en)	2004-09-24
SK2412003A3 (en)	2003-09-11
BG107579A (bg)	2003-10-31
IS6715A (is)	2003-02-12
JP3523641B2 (ja)	2004-04-26
ATE269327T1 (de)	2004-07-15
WO2002020512A1 (en)	2002-03-14
IL154292A0 (en)	2003-09-17
CN1452620A (zh)	2003-10-29
AR033836A1 (es)	2004-01-07
CA2417148C (en)	2010-09-21
ZA200300612B (en)	2004-04-22
EP1351958B1 (en)	2004-06-16
US20040014776A1 (en)	2004-01-22
CA2417148A1 (en)	2002-03-14
DE60103935T2 (de)	2005-07-21
MXPA03001511A (es)	2003-06-09
NO20031006D0 (no)	2003-03-04
EP1351958A1 (en)	2003-10-15
TWI242559B (en)	2005-11-01
SK287277B6 (sk)	2010-05-07
DK1351958T3 (da)	2004-09-06
KR20030027109A (ko)	2003-04-03
WO2002020512A9 (en)	2004-05-06
MY127126A (en)	2006-11-30
EE200300088A (et)	2005-02-15
US6969714B2 (en)	2005-11-29
AU2001284192B2 (en)	2006-10-26
HUP0302922A3 (en)	2007-02-28
KR100802368B1 (ko)	2008-02-13
US20060004033A1 (en)	2006-01-05
BR0113496A (pt)	2003-07-01
HUP0302922A2 (hu)	2003-12-29
HK1057553A1 (en)	2004-04-08
EE05430B1 (et)	2011-06-15
NO324059B1 (no)	2007-08-06
RU2284327C2 (ru)	2006-09-27
DE60103935D1 (de)	2004-07-22
AU8419201A (en)	2002-03-22
CN1269813C (zh)	2006-08-16
ES2221904T3 (es)	2005-01-16
CZ2003617A3 (cs)	2003-06-18
IS2055B (is)	2005-10-14
UA74206C2 (uk)	2005-11-15
GB0021726D0 (en)	2000-10-18
PL360627A1 (en)	2004-09-20
PT1351958E (pt)	2004-09-30

Publication	Publication Date	Title
NO20031006L (no)	2003-03-04	Imidazolo-5-yl-2-anilino-pyrimidiner som midler for inhibering av celleproliferasjon
NO20021239D0 (no)	2002-03-13	Pteridinoner som kinase-inhibitorer
DK2253620T3 (da)	2014-03-31	Substituerede 3-cyanoquinoliner som protein-tyrosinkinase-inhibitorer
DK1140840T3 (da)	2006-07-31	omega-carboxyaryl-substituerede diphenylurinstoffer som raf-kinase-inhibitorer
NO20015065D0 (no)	2001-10-18	Pyrazolobenzodiazepiner som CDK2-inhibitorer
DE60040350D1 (de)	2008-11-06	Weichspülerzusammensetzungen
NO20021329L (no)	2002-05-21	Kinaseinhibitorer som terapeutiske midler
DK1244647T3 (da)	2006-09-25	Quinzolinderivater som VIGF-inhibitorer
NO20014642D0 (no)	2001-09-25	Aminopyrimidiner som sorbitol-dehydrogenase-inhibitorer
ATE437862T1 (de)	2009-08-15	Pyrimidin-5-onderivate als ldl-pla2 inhibitoren
NO20026195D0 (no)	2002-12-23	Substituerte-triazolopyrimidiner som anticancer midler
NO20024997D0 (no)	2002-10-17	2-guanidino-4-arylkinazoliner som NHE-3-inhibitorer
AR023440A1 (es)	2002-09-04	Composiciones antitranspirantes
DE60008527D1 (de)	2004-04-01	Zellproliferation inhibitoren
PT1194404E (pt)	2006-08-31	Inibidores de aspartil-protease
ID29785A (id)	2001-10-11	Komposisi-komposisi sampo
ATE257691T1 (de)	2004-01-15	Schweisshemmende zusammensetzungen
NO20016201D0 (no)	2001-12-18	Tienopyrimidiner som fosfodiesteraseinhibitorer
DK1228073T3 (da)	2003-11-03	Imidazolforbindelser som phosphodiesterase VII-inhibitorer
NO20021959L (no)	2002-05-29	Tetrahydrotiopyranftalazinon-derivater som PDE4-inhibitorer
NO20014234D0 (no)	2001-08-31	Pyrazol-3-on-derivater som faktor-Xa-inhibitorer
DE60009260D1 (de)	2004-04-29	Thiopyranderivate as mmp-inhibitoren
DK1222193T3 (da)	2003-12-01	Imidazolderivater som phosphodiesterase VII-inhibitorer
NO20014586D0 (no)	2001-09-21	Resorcinol sammensetninger
DE50012367D1 (de)	2006-05-04	Abrollmaschine

Legal Events

Date	Code	Title	Description
2012-03-26	MM1K	Lapsed by not paying the annual fees