NO20021846D0 - Imidazolderivater som fosfodiesterase VII-inhibitorer - Google Patents

Imidazolderivater som fosfodiesterase VII-inhibitorer

Info

Publication number: NO20021846D0
Authority: NO; Norway
Prior art keywords: imidazole derivatives; phosphodiesterase vii; vii inhibitors; inhibitors; phosphodiesterase
Prior art date: 1999-10-21

Application number

NO20021846A

Other languages

English (en)

Other versions

NO20021846L (no

Inventor

Hans-Michael Eggenweiler

Jonas Rochus

Michael Wolf

Michael Gassen

Oliver Poeschke

Original Assignee

Merck Patent Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-10-21

Filing date

2002-04-19

Publication date

2002-04-19

2002-04-19 Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh

2002-04-19 Publication of NO20021846L publication Critical patent/NO20021846L/no

2002-04-19 Publication of NO20021846D0 publication Critical patent/NO20021846D0/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Diabetes (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Pulmonology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Hematology (AREA)
Dermatology (AREA)
Cardiology (AREA)
Pain & Pain Management (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Obesity (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Transplantation (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Epidemiology (AREA)

NO20021846A 1999-10-21 2002-04-19 Imidazolderivater som fosfodiesterase VII-inhibitorer NO20021846D0 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19950647A DE19950647A1 (de)	1999-10-21	1999-10-21	Imidazolderivate als Phosphodiesterase VII-Hemmer
PCT/EP2000/009926 WO2001029049A2 (de)	1999-10-21	2000-10-10	Imidazolderivate als phosphodiesterase vii-hemmer

Publications (2)

Publication Number	Publication Date
NO20021846L NO20021846L (no)	2002-04-19
NO20021846D0 true NO20021846D0 (no)	2002-04-19

Family

ID=7926352

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20021846A NO20021846D0 (no)	1999-10-21	2002-04-19	Imidazolderivater som fosfodiesterase VII-inhibitorer

Country Status (22)

Country	Link
EP (1)	EP1222193B1 (no)
JP (1)	JP2003512381A (no)
KR (1)	KR20020060201A (no)
CN (1)	CN1382146A (no)
AR (1)	AR026198A1 (no)
AT (1)	ATE247121T1 (no)
AU (1)	AU780788B2 (no)
BR (1)	BR0014922A (no)
CA (1)	CA2388314C (no)
CZ (1)	CZ293751B6 (no)
DE (2)	DE19950647A1 (no)
DK (1)	DK1222193T3 (no)
ES (1)	ES2200957T3 (no)
HU (1)	HUP0203139A3 (no)
MX (1)	MXPA02003952A (no)
NO (1)	NO20021846D0 (no)
PL (1)	PL355020A1 (no)
PT (1)	PT1222193E (no)
RU (1)	RU2259199C2 (no)
SK (1)	SK4922002A3 (no)
WO (1)	WO2001029049A2 (no)
ZA (1)	ZA200203995B (no)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BR0207215A (pt)	2001-12-13	2004-02-10	Daiichi Suntory Pharma Co Ltd	Derivados de pirazolopiriminona tendo ação de inibição de pde7
DE10163991A1 (de) *	2001-12-24	2003-07-03	Merck Patent Gmbh	Pyrrolo-pyrimidine
JP2006219374A (ja)	2003-06-13	2006-08-24	Daiichi Asubio Pharma Co Ltd	Ｐｄｅ７阻害作用を有するイミダゾトリアジノン誘導体
JP2006219373A (ja)	2003-06-13	2006-08-24	Daiichi Asubio Pharma Co Ltd	Ｐｄｅ７阻害作用を有するピリジニルピラゾロピリミジノン誘導体
CA2569530C (en)	2004-07-01	2013-07-30	Daiichi Asubio Pharma Co.,Ltd.	Thienopyrazole derivative having pde 7 inhibitory activity
ES2533206T3 (es)	2007-03-27	2015-04-08	Omeros Corporation	Inhibidores de PDE7 para uso en el tratamiento de trastornos del movimiento
US8637528B2 (en)	2007-03-27	2014-01-28	Omeros Corporation	Use of PDE7 inhibitors for the treatment of movement disorders
KR20130124333A (ko)	2010-11-08	2013-11-13	오메로스 코포레이션	Pde7 억제제를 사용한 중독 및 충동-조절 장애의 치료
US9220715B2 (en)	2010-11-08	2015-12-29	Omeros Corporation	Treatment of addiction and impulse-control disorders using PDE7 inhibitors
IL318817A (en)	2022-08-18	2025-04-01	Mitodicure Gmbh	Use of a therapeutic agent with PHOSPHODIESTERASE-7 inhibitory activity for the treatment and prevention of diseases associated with chronic fatigue, exhaustion and/or exercise intolerance

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4305954A (en) *	1981-02-11	1981-12-15	E. I. Du Pont De Nemours And Company	Antiinflammatory 3,4-dihydro(or 1,4-dihydro)-2-[(substituted)thio]-[1]benzopyrano[3,4-d]imidazoles and their corresponding sulfoxides and sulfones
WO2000023091A2 (en) *	1998-10-15	2000-04-27	Bioimage A/S	Specific therapeutic interventions obtained by interference with redistribution and/or targeting of cyclic nucleotide phosphodiesterases of i-kappa-b kinases
AU4589800A (en) *	1999-05-05	2000-11-21	Darwin Discovery Limited	9-(1,2,3,4-tetrahydronaphthalen-1-yl)-1,9-dihydropurin-6-one derivatives as pde7inhibitors

1999
- 1999-10-21 DE DE19950647A patent/DE19950647A1/de not_active Withdrawn
2000
- 2000-10-10 JP JP2001531847A patent/JP2003512381A/ja active Pending
- 2000-10-10 DK DK00972714T patent/DK1222193T3/da active
- 2000-10-10 AT AT00972714T patent/ATE247121T1/de not_active IP Right Cessation
- 2000-10-10 MX MXPA02003952A patent/MXPA02003952A/es unknown
- 2000-10-10 ES ES00972714T patent/ES2200957T3/es not_active Expired - Lifetime
- 2000-10-10 PT PT00972714T patent/PT1222193E/pt unknown
- 2000-10-10 SK SK492-2002A patent/SK4922002A3/sk unknown
- 2000-10-10 WO PCT/EP2000/009926 patent/WO2001029049A2/de active IP Right Grant
- 2000-10-10 AU AU11356/01A patent/AU780788B2/en not_active Ceased
- 2000-10-10 KR KR1020027004903A patent/KR20020060201A/ko not_active Application Discontinuation
- 2000-10-10 PL PL00355020A patent/PL355020A1/xx unknown
- 2000-10-10 CZ CZ20021251A patent/CZ293751B6/cs not_active IP Right Cessation
- 2000-10-10 DE DE50003309T patent/DE50003309D1/de not_active Expired - Lifetime
- 2000-10-10 BR BR0014922-5A patent/BR0014922A/pt not_active IP Right Cessation
- 2000-10-10 HU HU0203139A patent/HUP0203139A3/hu unknown
- 2000-10-10 CN CN00814402A patent/CN1382146A/zh active Pending
- 2000-10-10 RU RU2002111413/15A patent/RU2259199C2/ru not_active IP Right Cessation
- 2000-10-10 CA CA002388314A patent/CA2388314C/en not_active Expired - Fee Related
- 2000-10-10 EP EP00972714A patent/EP1222193B1/de not_active Expired - Lifetime
- 2000-10-20 AR ARP000105542A patent/AR026198A1/es unknown
2002
- 2002-04-19 NO NO20021846A patent/NO20021846D0/no not_active Application Discontinuation
- 2002-05-20 ZA ZA200203995A patent/ZA200203995B/en unknown

Also Published As

Publication number	Publication date
DE19950647A1 (de)	2001-04-26
AU780788B2 (en)	2005-04-14
CN1382146A (zh)	2002-11-27
KR20020060201A (ko)	2002-07-16
DE50003309D1 (de)	2003-09-18
ES2200957T3 (es)	2004-03-16
DK1222193T3 (da)	2003-12-01
HUP0203139A2 (hu)	2003-01-28
WO2001029049A2 (de)	2001-04-26
AR026198A1 (es)	2003-01-29
EP1222193A2 (de)	2002-07-17
NO20021846L (no)	2002-04-19
RU2259199C2 (ru)	2005-08-27
CZ293751B6 (cs)	2004-07-14
MXPA02003952A (es)	2004-09-06
CZ20021251A3 (cs)	2002-07-17
WO2001029049A3 (de)	2001-11-01
SK4922002A3 (en)	2002-09-10
PT1222193E (pt)	2003-12-31
ATE247121T1 (de)	2003-08-15
CA2388314A1 (en)	2001-04-26
PL355020A1 (en)	2004-03-22
ZA200203995B (en)	2003-10-29
CA2388314C (en)	2009-06-16
BR0014922A (pt)	2002-06-11
AU1135601A (en)	2001-04-30
JP2003512381A (ja)	2003-04-02
EP1222193B1 (de)	2003-08-13
HUP0203139A3 (en)	2004-12-28

Publication	Publication Date	Title
NO20021239D0 (no)	2002-03-13	Pteridinoner som kinase-inhibitorer
NO20023828L (no)	2002-09-30	Pyrimidin-4-on derivater som LDL-PLA2 inhibitorer
ATE256127T1 (de)	2003-12-15	Betacarbolinderivate als phosphodiesterase- inhibitoren
IS6662A (is)	2002-12-19	Imídasól afleiður
DK1244647T3 (da)	2006-09-25	Quinzolinderivater som VIGF-inhibitorer
ATE360620T1 (de)	2007-05-15	Imidazolderivate
DE60106252D1 (de)	2004-11-11	Substituierte pyprolopyridinonderivate als phosphodiesterase-inhibitoren
DK1185529T3 (da)	2005-02-07	Pyrazolbenzodiazepiner som CDK2-inhibitorer
NL300242I1 (nl)	2006-12-01	Mega-carboxyaryl gesubstitueerde difenylureums alsraf kinaseremmers.
ATE425147T1 (de)	2009-03-15	Imidazolderivate
NO20022125D0 (no)	2002-05-03	Pyrrolderivater som inhibitorer for fosfodiesterase VII
DK1226143T3 (da)	2003-06-30	Imidazopyridinderivater som phosphodiesterase VII-inhibitorer
DK1228073T3 (da)	2003-11-03	Imidazolforbindelser som phosphodiesterase VII-inhibitorer
NO20016201D0 (no)	2001-12-18	Tienopyrimidiner som fosfodiesteraseinhibitorer
NO20021959L (no)	2002-05-29	Tetrahydrotiopyranftalazinon-derivater som PDE4-inhibitorer
NO20022123D0 (no)	2002-05-03	Osoksazolderivater for anvendelse som inhibitorer for fosfodiesterase VII
DK1222193T3 (da)	2003-12-01	Imidazolderivater som phosphodiesterase VII-inhibitorer
NO20014234D0 (no)	2001-08-31	Pyrazol-3-on-derivater som faktor-Xa-inhibitorer
ATE262517T1 (de)	2004-04-15	Thiopyranderivate as mmp-inhibitoren
DE60009296D1 (de)	2004-04-29	Substituierte purine-derivate als zell-adhäsionhemmer
NO20020592D0 (no)	2002-02-06	Fluorenderivater som integrininhibitorer
ATE264308T1 (de)	2004-04-15	Aminoalkyl-3,4-dihydrochinolin-derivate als no synthase inhibitoren
DK1296981T3 (da)	2005-07-25	Substituerede pyrrolopyridinonderivater som phosphodiesteraseinhibitorer

Legal Events

Date	Code	Title	Description
2004-10-18	FC2A	Withdrawal, rejection or dismissal of laid open patent application