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NO20014657L - Preparater og fremgangsmåter for å påvirke nivåene av high density lipoprotein (HDL)-kolesterol og apolipoprotein A1, verylow density lipoprotein (VLDL)-kolesterol og low densitylipoprotein (LDL)-kolesterol - Google Patents

Preparater og fremgangsmåter for å påvirke nivåene av high density lipoprotein (HDL)-kolesterol og apolipoprotein A1, verylow density lipoprotein (VLDL)-kolesterol og low densitylipoprotein (LDL)-kolesterol

Info

Publication number
NO20014657L
NO20014657L NO20014657A NO20014657A NO20014657L NO 20014657 L NO20014657 L NO 20014657L NO 20014657 A NO20014657 A NO 20014657A NO 20014657 A NO20014657 A NO 20014657A NO 20014657 L NO20014657 L NO 20014657L
Authority
NO
Norway
Prior art keywords
cholesterol
density lipoprotein
verylow
vldl
apolipoprotein
Prior art date
Application number
NO20014657A
Other languages
English (en)
Other versions
NO331779B1 (no
NO20014657D0 (no
Inventor
Michael Jaye
Kevin J Lynch
Dilip V Amin
Kim-Anh Thi Doan
Dawn Marchadier
Cyrille Maugeais
Daniel J Rader
John A Krawiec
Victoria J South
Original Assignee
Univ Pennsylvania
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/277,401 external-priority patent/US7008776B1/en
Application filed by Univ Pennsylvania filed Critical Univ Pennsylvania
Publication of NO20014657D0 publication Critical patent/NO20014657D0/no
Publication of NO20014657L publication Critical patent/NO20014657L/no
Publication of NO331779B1 publication Critical patent/NO331779B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Biophysics (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
NO20014657A 1999-03-26 2001-09-25 Fremgangsmater for a bestemme hvorvidt en testforbindelse kan inhibere den enzymatiske reaksjonen mellom LIPG polypeptidet og HDL kolesterol og apolipoprotein A1 eller fremme den enzymatiske reaksjonen mellom LIPG polypeptidet og VLDL kolesterol eller LDL kolesterol NO331779B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/277,401 US7008776B1 (en) 1996-12-06 1999-03-26 Compositions and methods for effecting the levels of high density lipoprotein (HDL) cholesterol and apolipoprotein AI very low density lipoprotein (VLDL) cholesterol and low density lipoprotein (LDL) cholesterol
PCT/US2000/007870 WO2000057837A2 (en) 1999-03-26 2000-03-24 Compositions and methods for effecting the levels of cholesterol

Publications (3)

Publication Number Publication Date
NO20014657D0 NO20014657D0 (no) 2001-09-25
NO20014657L true NO20014657L (no) 2001-11-21
NO331779B1 NO331779B1 (no) 2012-03-26

Family

ID=23060703

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20014657A NO331779B1 (no) 1999-03-26 2001-09-25 Fremgangsmater for a bestemme hvorvidt en testforbindelse kan inhibere den enzymatiske reaksjonen mellom LIPG polypeptidet og HDL kolesterol og apolipoprotein A1 eller fremme den enzymatiske reaksjonen mellom LIPG polypeptidet og VLDL kolesterol eller LDL kolesterol
NO20100214A NO331784B1 (no) 1999-03-26 2010-02-11 Anvendelse av et ribozym for fremstilling av et preparat i stand til a redusere den enzymatiske aktiviteten av LIPG hos en pasient.

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO20100214A NO331784B1 (no) 1999-03-26 2010-02-11 Anvendelse av et ribozym for fremstilling av et preparat i stand til a redusere den enzymatiske aktiviteten av LIPG hos en pasient.

Country Status (13)

Country Link
EP (1) EP1171078A4 (no)
JP (1) JP2002540127A (no)
KR (2) KR20050044812A (no)
AU (1) AU776684B2 (no)
BR (1) BR0009333A (no)
CA (1) CA2363486C (no)
HK (1) HK1043309A1 (no)
IL (2) IL145526A0 (no)
MX (1) MXPA01009727A (no)
NO (2) NO331779B1 (no)
NZ (2) NZ531180A (no)
WO (1) WO2000057837A2 (no)
ZA (1) ZA200107598B (no)

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JP5907866B2 (ja) 2009-06-26 2016-04-26 クルナ・インコーポレーテッド ダウン症候群遺伝子に対する天然アンチセンス転写物の抑制によるダウン症候群遺伝子関連疾患の治療
US20120252869A1 (en) 2009-07-24 2012-10-04 Opko Curna, Llc Treatment of sirtuin (sirt) related diseases by inhibition of natural antisense transcript to a sirtuin (sirt)
KR101802536B1 (ko) 2009-08-05 2017-11-28 큐알엔에이, 인크. 인슐린 유전자 (ｉｎｓ)에 대한 자연 안티센스 전사체의 저해에 의한 인슐린 유전자 (ｉｎｓ) 관련된 질환의 치료
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JP5934106B2 (ja) 2009-12-23 2016-06-15 カッパーアールエヌエー，インコーポレイテッド 肝細胞増殖因子（ｈｇｆ）に対する天然アンチセンス転写物の阻害によるｈｇｆ関連性疾患の治療
CA2782375C (en) 2009-12-23 2023-10-31 Opko Curna, Llc Treatment of uncoupling protein 2 (ucp2) related diseases by inhibition of natural antisense transcript to ucp2
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RU2616283C2 (ru) 2009-12-31 2017-04-13 Курна, Инк. Лечение заболеваний, связанных с субстратом рецептора инсулина 2 (irs2), путем ингибирования природного антисмыслового транскрипта к irs2
DK2521784T3 (en) 2010-01-04 2018-03-12 Curna Inc TREATMENT OF INTERFERON REGULATORY FACTOR 8- (IRF8) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENCE TRANSCRIPT TO IRF8
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Also Published As

Publication number Publication date
KR100887164B1 (ko) 2009-03-10
KR20020029651A (ko) 2002-04-19
WO2000057837A2 (en) 2000-10-05
NZ514350A (en) 2004-12-24
NO331779B1 (no) 2012-03-26
CA2363486C (en) 2012-12-18
BR0009333A (pt) 2002-01-08
MXPA01009727A (es) 2002-07-22
JP2002540127A (ja) 2002-11-26
NO20100214L (no) 2001-11-21
AU3918700A (en) 2000-10-16
NO331784B1 (no) 2012-03-26
IL145526A (en) 2010-11-30
HK1043309A1 (zh) 2002-09-13
IL145526A0 (en) 2002-06-30
EP1171078A4 (en) 2002-11-06
NZ531180A (en) 2005-06-24
ZA200107598B (en) 2003-05-28
CA2363486A1 (en) 2000-10-05
EP1171078A2 (en) 2002-01-16
WO2000057837A3 (en) 2001-01-25
NO20014657D0 (no) 2001-09-25
WO2000057837A8 (en) 2001-09-27
AU776684B2 (en) 2004-09-16
WO2000057837A9 (en) 2001-10-18
KR20050044812A (ko) 2005-05-12

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