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NO20013963D0 - Aromatiske sulfonhydroksaminsyre-metallproteaseinhibitor - Google Patents

Aromatiske sulfonhydroksaminsyre-metallproteaseinhibitor

Info

Publication number
NO20013963D0
NO20013963D0 NO20013963A NO20013963A NO20013963D0 NO 20013963 D0 NO20013963 D0 NO 20013963D0 NO 20013963 A NO20013963 A NO 20013963A NO 20013963 A NO20013963 A NO 20013963A NO 20013963 D0 NO20013963 D0 NO 20013963D0
Authority
NO
Norway
Prior art keywords
protease inhibitor
acid metal
hydroxamic acid
aromatic sulfonic
metal protease
Prior art date
Application number
NO20013963A
Other languages
English (en)
Other versions
NO20013963L (no
Inventor
Thomas E Barta
Daniel P Becker
Louis J Bedell
Terri L Boehm
Jeffery N Carroll
Gary A De Crescenzo
Yvette M Fobian
John N Freskos
Daniel P Getman
Joseph J Mcdonald
Gunnar J Hanson
Susan L Hockerman
Susan C Howard
Steve A Kolodziej
Hui Li
Deborah A Mischke
Joseph G Rico
Nathan W Stehle
Michael B Tollefson
William F Vernier
Original Assignee
Usrao Shashidahar N
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Usrao Shashidahar N filed Critical Usrao Shashidahar N
Publication of NO20013963D0 publication Critical patent/NO20013963D0/no
Publication of NO20013963L publication Critical patent/NO20013963L/no

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
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NO20013963A 1999-02-24 2001-08-15 Aromatiske sulfonhydroksaminsyre-metallproteaseinhibitor NO20013963L (no)

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US09/256,948 US20010039287A1 (en) 1997-11-14 1999-02-24 Aromatic sulfone hydroxamic acid metalloprotease inhibitor
PCT/US2000/002518 WO2000050396A1 (en) 1999-02-24 2000-02-22 Aromatic sulfone hydroxamic acid metalloprotease inhibitor

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Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6747027B1 (en) 1996-07-22 2004-06-08 Pharmacia Corporation Thiol sulfonamide metalloprotease inhibitors
WO1998039315A1 (en) 1997-03-04 1998-09-11 Monsanto Company Aromatic sulfonyl alpha-cycloamino hydroxamic acid compounds
US7115632B1 (en) 1999-05-12 2006-10-03 G. D. Searle & Co. Sulfonyl aryl or heteroaryl hydroxamic acid compounds
US6696449B2 (en) 1997-03-04 2004-02-24 Pharmacia Corporation Sulfonyl aryl hydroxamates and their use as matrix metalloprotease inhibitors
US6794511B2 (en) 1997-03-04 2004-09-21 G. D. Searle Sulfonyl aryl or heteroaryl hydroxamic acid compounds
BR9814643A (pt) * 1997-11-14 2000-10-03 Searle & Co Inibidor de metaloprotease de ácido sulfona hidroxâmico aromático
US20010039287A1 (en) 1997-11-14 2001-11-08 Thomas E Barta Aromatic sulfone hydroxamic acid metalloprotease inhibitor
US6750228B1 (en) 1997-11-14 2004-06-15 Pharmacia Corporation Aromatic sulfone hydroxamic acid metalloprotease inhibitor
US6800646B1 (en) 1999-02-08 2004-10-05 Pharmacia Corporation Sulfamato hydroxamic acid metalloprotease inhibitor
BR0008440A (pt) 1999-02-08 2002-03-26 Searle & Co Inibidor de metaloprotease de sulfamato do ácido hidroxâmico
US20010049449A1 (en) * 1999-12-23 2001-12-06 Becker Daniel P. Aromatic sulfonyl alpha-cycloamino hydroxamates and their use as MMP inhibitors
US6683093B2 (en) * 2000-05-12 2004-01-27 Pharmacia Corporation Aromatic sulfone hydroxamic acids and their use as protease inhibitors
US20040024024A1 (en) * 2001-05-11 2004-02-05 Freskos John N. Aromatic sulfone hydroxamates and their use as protease inhibitors
JP2004530691A (ja) 2001-05-11 2004-10-07 ファルマシア・コーポレーション 芳香族スルホンヒドロキサメートおよびプロテアーゼ阻害剤としてのそれらの使用
US20030139332A1 (en) * 2001-07-09 2003-07-24 The Regents Of The University Of California Use of matrix metalloproteinase inhibitors to mitigate nerve damage
US6683078B2 (en) 2001-07-19 2004-01-27 Pharmacia Corporation Use of sulfonyl aryl or heteroaryl hydroxamic acids and derivatives thereof as aggrecanase inhibitors
WO2003042176A1 (fr) * 2001-11-13 2003-05-22 Shiseido Co., Ltd. Compose azabicyclo, inhibiteur de metalloprotease matricielle et preparation cutanee
US20050209278A1 (en) * 2002-04-25 2005-09-22 Mcdonald Joseph J Piperidinyl- and piperazinyl-sulfonylmethyl hydroxamic acids and their use as protease inhibitors
WO2003091247A2 (en) * 2002-04-25 2003-11-06 Pharmacia Corporation Piperidinyl-and piperazinyl-sulfonylmethyl hydroxamic acids and their use as protease inhibitors
MXPA05000171A (es) * 2002-06-25 2005-04-08 Pharmacia Corp Acido arilsulfonilhidroxamico y derivados de amida y su uso como inhibidores de la proteasa.
US7691843B2 (en) 2002-07-11 2010-04-06 Pfizer Inc. N-hydroxyamide derivatives possessing antibacterial activity
US20050043533A1 (en) * 2003-03-25 2005-02-24 Babiak Kevin A. Process for making alpha-substituted hydroxamic acids
GB0319069D0 (en) * 2003-08-14 2003-09-17 Glaxo Group Ltd Therapeutically useful compounds
DE102004031620A1 (de) * 2004-06-30 2006-02-02 Sanofi-Aventis Deutschland Gmbh 4-Trifluormethoxyphenoxybenzol-4`-sulfonsäuren, Verfahren zu ihrer Herstellung und Verwendung in Arzneimitteln
ATE509956T1 (de) * 2006-06-08 2011-06-15 Helmholtz Zentrum Muenchen Spezifische proteaseinhibitoren und ihre verwendung in der krebstherapie
ITTO20060575A1 (it) 2006-08-02 2008-02-03 Univ Pisa Inibitori di zinco proteinasi tioaril sostituiti e loro usi
WO2013039851A1 (en) 2011-09-12 2013-03-21 Mallinckrodt Llc Optical agents for imaging and visualization of matrix metalloproteinase enzymes
EP3973967A1 (en) 2012-12-21 2022-03-30 Astellas Institute for Regenerative Medicine Methods for production of platelets from pluripotent stem cells and compositions thereof
US11590226B2 (en) 2018-06-29 2023-02-28 Loyola University Of Chicago Carborane hydroxamic acid matrix metalloproteinase inhibitors and agents for boron neutron capture therapy

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4595700A (en) 1984-12-21 1986-06-17 G. D. Searle & Co. Thiol based collagenase inhibitors
US4882434A (en) * 1986-10-29 1989-11-21 Takeda Chemical Industries, Ltd. Gamma-lactonecarboxylic acid derivatives and their use as antibacterial agents or intermediates
GB8827305D0 (en) 1988-11-23 1988-12-29 British Bio Technology Compounds
JP3122161B2 (ja) 1991-05-16 2001-01-09 武田薬品工業株式会社 γ−ラクトン免疫抑制剤
US5525629A (en) 1992-04-07 1996-06-11 British Bio-Technology Limited Inhibition of cytokine production
US5376664A (en) 1992-07-27 1994-12-27 The Du Pont Merck Pharmaceutical Company Unsymmetrical mono-3-nitro bis-naphthalimides as anticancer agents
US5455258A (en) 1993-01-06 1995-10-03 Ciba-Geigy Corporation Arylsulfonamido-substituted hydroxamic acids
GB9307956D0 (en) 1993-04-17 1993-06-02 Walls Alan J Hydroxamic acid derivatives
GB9320660D0 (en) 1993-10-07 1993-11-24 British Bio Technology Inhibition of cytokine production
DE69420859T2 (de) 1993-11-04 2000-01-05 The Liposome Co.,Inc. Multilamellare liposomformulierungen, die einen arachidsäuremetaboliten enthalten
GB9323165D0 (en) 1993-11-10 1994-01-05 Chiros Ltd Compounds
AU2394795A (en) 1994-04-28 1995-11-29 Du Pont Merck Pharmaceutical Company, The Hydroxamic acid and amino acid derivatives and their use as anti-arthritic agents
GB9416897D0 (en) 1994-08-20 1994-10-12 British Biotech Pharm Metalloproteinase inhibitors
AU695796B2 (en) 1994-10-05 1998-08-20 Darwin Discovery Limited Peptidyl compounds and their therapeutic use as inhibitors of metalloproteases
EA003294B1 (ru) 1995-12-08 2003-04-24 Агурон Фармасьютикалс, Инк. Ингибиторы металлопротеиназы, фармацевтические композиции, их содержащие, и их фармацевтические применения
DE69624081T2 (de) * 1995-12-20 2003-06-12 Agouron Pharmaceuticals, Inc. Matrix-metalloprotease Inhibitoren
WO1997024117A1 (en) * 1996-01-02 1997-07-10 Rhone-Poulenc Rorer Pharmaceuticals Inc. Substituted (aryl, heteroaryl, arylmethyl or heteroarylmethyl) hydroxamic acid compounds
WO1997049679A1 (fr) 1996-06-27 1997-12-31 Ono Pharmaceutical Co., Ltd. Derives d'aryle (sulfure, oxyde sulfonique et sulfone) et medicaments les contenant en tant que principe actif
BR9710758A (pt) 1996-07-22 1999-08-17 Monsanto Co Inibidores da metaloprotease de tiol sulfona
ES2212274T3 (es) * 1997-02-27 2004-07-16 Wyeth Holdings Corporation Alquil, aril o heteroarilamidas n-hidroxi-2-(alquil, aril o heteroaril sulfanil, sulfinil o sulfonil)-3-sustituidas, como inhibidores de las metaloproteinasas de la matriz.
US6300514B1 (en) 1997-06-25 2001-10-09 Ono Pharmaceutical Co., Ltd. Aryl (sulfide, sulfoxide and sulfone) derivatives and drugs containing the same as the active ingredient
US6576664B1 (en) 1997-08-18 2003-06-10 Bristol-Myers Squibb Pharma Company Inhibitors of aggrecanase and matrix metalloproteinases for the treatment of arthritis
US6750228B1 (en) 1997-11-14 2004-06-15 Pharmacia Corporation Aromatic sulfone hydroxamic acid metalloprotease inhibitor
BR9814643A (pt) * 1997-11-14 2000-10-03 Searle & Co Inibidor de metaloprotease de ácido sulfona hidroxâmico aromático
US20010039287A1 (en) 1997-11-14 2001-11-08 Thomas E Barta Aromatic sulfone hydroxamic acid metalloprotease inhibitor
IL127496A0 (en) 1997-12-19 1999-10-28 Pfizer Prod Inc The use of MMP inhibitors for the treatment of ocular angiogenesis
GEP20022797B (en) * 1998-02-19 2002-09-25 American Cyanamid Co N-Hydroxy-2-(Alkyl, Aryl, or Heteroaryl Sulfanyl, Sulfinil or Sulfonyl)-3-Substituted Alkyl, Aryl or Heteroarylamides as Matrix Metalloproteinase Inhibitors
BR0008440A (pt) 1999-02-08 2002-03-26 Searle & Co Inibidor de metaloprotease de sulfamato do ácido hidroxâmico
AU4180900A (en) 1999-04-02 2000-10-23 Du Pont Pharmaceuticals Company Novel amide derivatives as inhibitors of matrix metalloproteinases, tnf-alpha, and aggrecanase

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CN1370144A (zh) 2002-09-18
EA200100804A1 (ru) 2002-04-25
ZA200106780B (en) 2002-08-16
US20010039287A1 (en) 2001-11-08
NO20013963L (no) 2001-10-23
AU3478500A (en) 2000-09-14
KR20020092157A (ko) 2002-12-11
AR043676A1 (es) 2005-08-10
CA2371876A1 (en) 2000-08-31
WO2000050396A1 (en) 2000-08-31
PL351204A1 (en) 2003-03-24
HUP0200239A3 (en) 2003-04-28
JP2002537378A (ja) 2002-11-05
EP1230219A1 (en) 2002-08-14
US20020177588A1 (en) 2002-11-28
MXPA01008568A (es) 2002-04-08
BR0008491A (pt) 2002-09-17
US6750233B2 (en) 2004-06-15
NZ513648A (en) 2004-02-27
HUP0200239A2 (en) 2002-06-29
CZ20013038A3 (cs) 2002-07-17

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