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NO20011966L - Serin-protease-inhibitor - Google Patents

Serin-protease-inhibitor

Info

Publication number
NO20011966L
NO20011966L NO20011966A NO20011966A NO20011966L NO 20011966 L NO20011966 L NO 20011966L NO 20011966 A NO20011966 A NO 20011966A NO 20011966 A NO20011966 A NO 20011966A NO 20011966 L NO20011966 L NO 20011966L
Authority
NO
Norway
Prior art keywords
protease inhibitor
serine protease
serine
inhibitor
protease
Prior art date
Application number
NO20011966A
Other languages
English (en)
Other versions
NO20011966D0 (no
Inventor
Cornelis Marius Timmers
Johannes Bernardus Ma Rewinkel
Original Assignee
Akzo Nobel Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv
Publication of NO20011966D0 publication Critical patent/NO20011966D0/no
Publication of NO20011966L publication Critical patent/NO20011966L/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D237/00Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30Phthalazines
    • C07D237/34Phthalazines with nitrogen atoms directly attached to carbon atoms of the nitrogen-containing ring, e.g. hydrazine radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72Quinazolines; Hydrogenated quinazolines
    • C07D239/86Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94Nitrogen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
NO20011966A 1998-10-23 2001-04-20 Serin-protease-inhibitor NO20011966L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98203559 1998-10-23
PCT/EP1999/007928 WO2000024718A1 (en) 1998-10-23 1999-10-19 Serine protease inhibitor

Publications (2)

Publication Number Publication Date
NO20011966D0 NO20011966D0 (no) 2001-04-20
NO20011966L true NO20011966L (no) 2001-04-23

Family

ID=8234249

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20011966A NO20011966L (no) 1998-10-23 2001-04-20 Serin-protease-inhibitor

Country Status (24)

Country Link
US (1) US6903107B1 (no)
EP (1) EP1123280A1 (no)
JP (1) JP2002528438A (no)
KR (1) KR20010075648A (no)
CN (1) CN1146543C (no)
AR (1) AR020922A1 (no)
AU (1) AU763667B2 (no)
BR (1) BR9914694A (no)
CA (1) CA2346990A1 (no)
CO (1) CO5140114A1 (no)
CZ (1) CZ20011440A3 (no)
HU (1) HUP0103806A3 (no)
ID (1) ID29885A (no)
IL (1) IL142398A0 (no)
NO (1) NO20011966L (no)
NZ (1) NZ511067A (no)
PE (1) PE20001283A1 (no)
PL (1) PL347948A1 (no)
RU (1) RU2232760C2 (no)
SK (1) SK5372001A3 (no)
TR (1) TR200101120T2 (no)
TW (1) TW575567B (no)
WO (1) WO2000024718A1 (no)
ZA (1) ZA200102970B (no)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10046272A1 (de) * 2000-09-19 2002-03-28 Merck Patent Gmbh Aminoheterocyclen (Faktor Xa Inhibitoren 14)
US6924285B2 (en) 2002-03-30 2005-08-02 Boehringer Ingelheim Pharma Gmbh & Co. Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them
HUE025683T2 (hu) 2002-12-03 2016-04-28 Pharmacyclics Llc VIIA faktor inhibitor 2-(2-hidroxi-bifenil-3-il)-1H-benzoimidazol-5-karboxamidin-származékok
GB0309850D0 (en) 2003-04-30 2003-06-04 Astrazeneca Ab Quinazoline derivatives
WO2005026150A1 (en) 2003-09-16 2005-03-24 Astrazeneca Ab Quinazoline derivatives as tyrosine kinase inhibitors
GB0322409D0 (en) 2003-09-25 2003-10-29 Astrazeneca Ab Quinazoline derivatives
GB0326459D0 (en) 2003-11-13 2003-12-17 Astrazeneca Ab Quinazoline derivatives
EP1713781B1 (en) 2004-02-03 2008-11-05 AstraZeneca AB Quinazoline derivatives
DK1899322T3 (da) * 2005-06-28 2009-12-14 Sanofi Aventis Isoquinolin-derivater som hæmmere af Rho-kinase
EP2385047B1 (en) * 2005-07-26 2013-05-29 Sanofi Piperidinyl-substituted isoquinolone derivatives
NI200800024A (es) 2005-07-26 2009-03-03 Derivados de ciclohexilaminisoquinolona en calidad inhibidores de rho-quinasa
TWI389899B (zh) 2006-08-08 2013-03-21 Msd Oss Bv 具口服活性之凝血酶抑制劑
EP1921070A1 (de) 2006-11-10 2008-05-14 Boehringer Ingelheim Pharma GmbH & Co. KG Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstelllung
CA2673922C (en) * 2006-12-27 2015-09-29 Sanofi-Aventis Cycloalkylamine substituted isoquinoline and isoquinolinone derivatives
EP2132194B1 (en) 2006-12-27 2011-03-16 Sanofi-Aventis Substituted isoquinolines and their use as rho-kinase inhibitors
WO2008077550A1 (en) 2006-12-27 2008-07-03 Sanofi-Aventis Substituted isoquinoline and isoquinolinone derivatives as inhibitors of rho-kinase
JP5405315B2 (ja) * 2006-12-27 2014-02-05 サノフイ 置換イソキノリン及びイソキノリノン誘導体
WO2008077554A1 (en) 2006-12-27 2008-07-03 Sanofi-Aventis Cycloalkylamine substituted isoquinoline derivatives
ES2625266T3 (es) * 2006-12-27 2017-07-19 Sanofi Derivados de isoquinolona sustituidos con cicloalquilamina
JP5318778B2 (ja) * 2006-12-27 2013-10-16 サノフイ シクロアルキルアミン置換イソキノロン及びイソキノリノン誘導体
CA2677336A1 (en) 2007-02-06 2008-08-14 Boehringer Ingelheim International Gmbh Bicyclic heterocycles, pharmaceutical compositions containing these compounds, the use thereof and processes for the preparation thereof
DK2245026T3 (da) 2008-02-07 2012-10-15 Boehringer Ingelheim Int Spirocycliske heterocycler, lægemiddel indeholdende disse forbindelser, deres anvendelse og fremgangsmåde til deres fremstilling
AU2009247782C1 (en) 2008-05-13 2013-09-19 Astrazeneca Ab Fumarate salt of 4- (3-chloro-2-fluoroanilino) -7-methoxy-6- { [1- (N-methylcarbamoylmethyl) piperidin- 4-yl] oxy } quinazoline
PT2303846E (pt) * 2008-06-24 2015-09-04 Sanofi Sa Isoquinolinas e isoquinolinonas substituídas como inibidores de rho-quinase
EP2303845B1 (en) * 2008-06-24 2013-09-18 Sanofi Bi-and polycyclic substituted isoquinoline and isoquinoline derivatives as rho kinase inhibitors
PL2313374T3 (pl) * 2008-06-24 2014-03-31 Sanofi Sa 6-podstawione izochinoliny i izochinolinony
JP5539351B2 (ja) 2008-08-08 2014-07-02 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング シクロヘキシルオキシ置換ヘテロ環、これらの化合物を含有する医薬、およびそれらを生成するための方法
WO2013003649A2 (en) * 2011-06-28 2013-01-03 Inhibrx Llc Wap domain fusion polypeptides and methods of use thereof
KR20220003656A (ko) 2011-06-28 2022-01-10 인히브릭스, 인크. 세르핀 융합 폴리펩타이드 및 이의 이용 방법
US10400029B2 (en) 2011-06-28 2019-09-03 Inhibrx, Lp Serpin fusion polypeptides and methods of use thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4473501A (en) * 1981-05-04 1984-09-25 G. D. Searle & Co. Dihydro azino isoquinolines
GB8908229D0 (en) * 1989-04-12 1989-05-24 Smithkline Beckman Intercredit Compounds
EP0892784A1 (en) * 1996-04-13 1999-01-27 Astra Pharmaceuticals Limited Aminoisoquinolines and aminothienopyridine derivatives and their use as anti-inflammatory agents
IL123986A (en) * 1997-04-24 2011-10-31 Organon Nv Medicinal compounds
KR20010042042A (ko) * 1998-03-19 2001-05-25 에가시라 구니오 아미노이소퀴놀린 유도체

Also Published As

Publication number Publication date
SK5372001A3 (en) 2001-11-06
WO2000024718A1 (en) 2000-05-04
CN1146543C (zh) 2004-04-21
TR200101120T2 (tr) 2001-08-21
NZ511067A (en) 2003-03-28
TW575567B (en) 2004-02-11
AU6341399A (en) 2000-05-15
US6903107B1 (en) 2005-06-07
PL347948A1 (en) 2002-04-22
HUP0103806A3 (en) 2002-03-28
BR9914694A (pt) 2001-07-10
AU763667B2 (en) 2003-07-31
CA2346990A1 (en) 2000-05-04
RU2232760C2 (ru) 2004-07-20
NO20011966D0 (no) 2001-04-20
JP2002528438A (ja) 2002-09-03
IL142398A0 (en) 2002-03-10
KR20010075648A (ko) 2001-08-09
CN1348444A (zh) 2002-05-08
ZA200102970B (en) 2002-07-10
EP1123280A1 (en) 2001-08-16
ID29885A (id) 2001-10-18
CO5140114A1 (es) 2002-03-22
PE20001283A1 (es) 2000-11-20
AR020922A1 (es) 2002-06-05
HUP0103806A2 (hu) 2002-02-28
CZ20011440A3 (cs) 2001-09-12

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FC2A Withdrawal, rejection or dismissal of laid open patent application