NO20011381L - Streptococcal C <beta> protein preparations - Google Patents
Streptococcal C <beta> protein preparationsInfo
- Publication number
- NO20011381L NO20011381L NO20011381A NO20011381A NO20011381L NO 20011381 L NO20011381 L NO 20011381L NO 20011381 A NO20011381 A NO 20011381A NO 20011381 A NO20011381 A NO 20011381A NO 20011381 L NO20011381 L NO 20011381L
- Authority
- NO
- Norway
- Prior art keywords
- relates
- peptides
- protein fragments
- animal
- protein
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 5
- 108090000623 proteins and genes Proteins 0.000 title abstract 5
- 238000002360 preparation method Methods 0.000 title 1
- 239000012634 fragment Substances 0.000 abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 102000040430 polynucleotide Human genes 0.000 abstract 2
- 108091033319 polynucleotide Proteins 0.000 abstract 2
- 239000002157 polynucleotide Substances 0.000 abstract 2
- 229960005486 vaccine Drugs 0.000 abstract 2
- 241000192125 Firmicutes Species 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 230000000295 complement effect Effects 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 230000000625 opsonophagocytic effect Effects 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1275—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Streptococcus (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Foreliggende oppfinnelse gjelder proteinfragmenter eller peptider som frembringer antistoffer mot gramposi-tive bakterier som er baktericide med komplement alene, uten at en opsono-fagocyttisk mekanisme inngår, samt vaksiner og konjugater som omfatter disse. Proteinfragmentene eller peptidene omfatter et immunogent IgG-bindende område som omfatter en peptid-sekvens på minst 8 aminosyrer mellom posisjonene 828 og 1027 i aminosyre-sekvensen vist i fig. 1. Oppfinnelsen gjelder også et polynukleotidmolekyl som koder for proteinfragmentene eller peptidene, vektorer som omfatter slike polynukleotidmolekyler og vertsceller transformert med disse. Oppfinnelsen gjelder også en fremgangsmåte for erholdelse av et i det vesentlige rent C(3-protein eller et fragment og/eller en mutant derav. Oppfinnelsen gjelder også en fremgangsmåte for induksjon av en immunrespons i et dyr, som omfatter tilførsel av vaksinen ifølge oppfinnelsen til et dyr i en terapeutisk effek-tiv mengde i et farmasøytisk aksep-tabelt bærerstoff.The present invention relates to protein fragments or peptides which produce antibodies to gram-positive bacteria which are bactericidal with complement alone, without the involvement of an opsonophagocytic mechanism, and to vaccines and conjugates comprising them. The protein fragments or peptides comprise an immunogenic IgG binding region comprising a peptide sequence of at least 8 amino acids between positions 828 and 1027 of the amino acid sequence shown in FIG. The invention also relates to a polynucleotide molecule encoding the protein fragments or peptides, vectors comprising such polynucleotide molecules and host cells transformed therewith. The invention also relates to a method for obtaining a substantially pure C (3 protein or a fragment and / or a mutant thereof. The invention also relates to a method for inducing an immune response in an animal, which comprises administering the vaccine according to the invention to an animal in a therapeutically effective amount in a pharmaceutically acceptable carrier.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10085998P | 1998-09-17 | 1998-09-17 | |
| US14432499P | 1999-07-19 | 1999-07-19 | |
| US15401799P | 1999-09-15 | 1999-09-15 | |
| PCT/US1999/021643 WO2000015760A1 (en) | 1998-09-17 | 1999-09-17 | Streptococcal c beta protein compositions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20011381L true NO20011381L (en) | 2001-03-19 |
| NO20011381D0 NO20011381D0 (en) | 2001-03-19 |
Family
ID=27379089
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20011381A NO20011381D0 (en) | 1998-09-17 | 2001-03-19 | Streptococcal C <beta> protein preparations |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP1114143A4 (en) |
| JP (1) | JP2002525041A (en) |
| AU (1) | AU6049599A (en) |
| CA (1) | CA2343051A1 (en) |
| CZ (1) | CZ2001951A3 (en) |
| HU (1) | HUP0103502A2 (en) |
| NO (1) | NO20011381D0 (en) |
| PL (1) | PL347058A1 (en) |
| SK (1) | SK3482001A3 (en) |
| WO (1) | WO2000015760A1 (en) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPQ899700A0 (en) | 2000-07-25 | 2000-08-17 | Borody, Thomas Julius | Probiotic recolonisation therapy |
| KR102216603B1 (en) | 2010-08-04 | 2021-02-17 | 크레스토보 홀딩스 엘엘씨 | Compositions for fecal floral transplantation and methods for making and using them and devices for delivering them |
| MX2013010343A (en) | 2011-03-09 | 2014-04-30 | Univ Minnesota | Compositions and methods for transplantation of colon microbiota. |
| BR112014021388A2 (en) | 2012-02-29 | 2017-07-18 | Ethicon Endo Surgery Inc | microbiota compositions and methods related thereto |
| WO2013176774A1 (en) | 2012-05-25 | 2013-11-28 | Arizona Board Of Regents | Microbiome markers and therapies for autism spectrum disorders |
| CN113730442A (en) | 2014-10-31 | 2021-12-03 | 潘德勒姆治疗公司 | Methods and compositions relating to microbial treatment and diagnosis of disorders |
| US9901603B2 (en) | 2015-05-14 | 2018-02-27 | Crestovo Holdings Llc | Compositions for fecal floral transplantation and methods for making and using them and device for delivering them |
| ES2909456T3 (en) | 2015-05-22 | 2022-05-06 | Univ Arizona State | Methods to treat autism spectrum disorder and associated symptoms |
| US20170360848A1 (en) | 2016-06-15 | 2017-12-21 | Arizona Board Of Regents On Behalf Of Arizona State University | Methods for treating autism spectrum disorder and associated symptoms |
| US10849936B2 (en) | 2016-07-01 | 2020-12-01 | Regents Of The University Of Minnesota | Compositions and methods for C. difficile treatment |
| US20180036352A1 (en) | 2016-08-03 | 2018-02-08 | Crestovo Holdings Llc | Methods for treating ulcerative colitis |
| US11213549B2 (en) | 2016-10-11 | 2022-01-04 | Finch Therapeutics Holdings Llc | Compositions and method for treating primary sclerosing cholangitis and related disorders |
| WO2018071537A1 (en) | 2016-10-11 | 2018-04-19 | Crestovo Holdings Llc | Compositions and methods for treating multiple sclerosis and related disorders |
| US10092601B2 (en) | 2016-10-11 | 2018-10-09 | Crestovo Holdings Llc | Compositions and methods for treating multiple sclerosis and related disorders |
| AU2018250206A1 (en) | 2017-04-05 | 2019-10-31 | Crestovo Holdings Llc | Compositions and methods for treating parkinson's disease (PD) and related disorders |
| WO2018187464A1 (en) | 2017-04-05 | 2018-10-11 | Crestovo Holdings Llc | Compositions and methods for treating diverticulitis and related disorders |
| WO2018218159A1 (en) | 2017-05-26 | 2018-11-29 | Crestovo Holdings Llc | Lyophilized compositions comprising fecal microbe-based therapeutic agents and methods for making and using same |
| WO2019032573A1 (en) | 2017-08-07 | 2019-02-14 | Finch Therapeutics, Inc. | Compositions and methods for maintaining and restoring a healthy gut barrier |
| EP3675882A4 (en) | 2017-08-30 | 2021-07-28 | Pendulum Therapeutics, Inc. | METHODS AND COMPOSITIONS FOR TREATMENT OF DISEASES RELATED TO MICROBIOMS |
| US11166990B2 (en) | 2018-07-13 | 2021-11-09 | Finch Therapeutics Holdings Llc | Methods and compositions for treating ulcerative colitis |
| KR20210065969A (en) | 2018-09-27 | 2021-06-04 | 핀치 테라퓨틱스 홀딩스 엘엘씨 | Compositions and methods for treating epilepsy and related disorders |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4757134A (en) * | 1982-12-02 | 1988-07-12 | The Rockefeller University | IgA binding protein |
| US5595740A (en) * | 1994-05-16 | 1997-01-21 | University Of Florida | Cloning of non-IgA FC binding forms of the group B streptococcal beta antigens |
| JP2001500010A (en) * | 1996-09-06 | 2001-01-09 | ノース アメリカン バクシン，インコーポレイテッド | Non-IgA Fc binding forms of group B streptococcal beta antigen |
-
1999
- 1999-09-17 EP EP99969108A patent/EP1114143A4/en not_active Withdrawn
- 1999-09-17 SK SK348-2001A patent/SK3482001A3/en unknown
- 1999-09-17 AU AU60495/99A patent/AU6049599A/en not_active Abandoned
- 1999-09-17 CA CA002343051A patent/CA2343051A1/en not_active Abandoned
- 1999-09-17 JP JP2000570287A patent/JP2002525041A/en not_active Withdrawn
- 1999-09-17 WO PCT/US1999/021643 patent/WO2000015760A1/en not_active Application Discontinuation
- 1999-09-17 PL PL99347058A patent/PL347058A1/en not_active Application Discontinuation
- 1999-09-17 HU HU0103502A patent/HUP0103502A2/en unknown
- 1999-09-17 CZ CZ2001951A patent/CZ2001951A3/en unknown
-
2001
- 2001-03-19 NO NO20011381A patent/NO20011381D0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU6049599A (en) | 2000-04-03 |
| SK3482001A3 (en) | 2002-02-05 |
| WO2000015760A1 (en) | 2000-03-23 |
| EP1114143A1 (en) | 2001-07-11 |
| JP2002525041A (en) | 2002-08-13 |
| CZ2001951A3 (en) | 2001-11-14 |
| NO20011381D0 (en) | 2001-03-19 |
| HUP0103502A2 (en) | 2002-01-28 |
| CA2343051A1 (en) | 2000-03-23 |
| EP1114143A4 (en) | 2003-05-07 |
| PL347058A1 (en) | 2002-03-11 |
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