NO20000811L - Procedure for drug selection - Google Patents
Procedure for drug selectionInfo
- Publication number
- NO20000811L NO20000811L NO20000811A NO20000811A NO20000811L NO 20000811 L NO20000811 L NO 20000811L NO 20000811 A NO20000811 A NO 20000811A NO 20000811 A NO20000811 A NO 20000811A NO 20000811 L NO20000811 L NO 20000811L
- Authority
- NO
- Norway
- Prior art keywords
- library
- members
- identified
- selecting
- amino acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B30/00—Methods of screening libraries
- C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
- G01N2333/24—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- G01N2333/245—Escherichia (G)
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Analytical Chemistry (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Computational Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Genetics & Genomics (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Det er beskrevet en fremgangsmåte for valgt en kandidatmedikament-forbindelse, idet fremgangsmåten omfatter: i) identifisering av et utgangsoligopeptid som har en bindingsaffinitet for en celleoverflate eller annet reseptorsete; ii) dannelse av en mengde homologe oligopeptider som har enkeltsete aminosyre-modifikasjoner relativt til nevnte utgangs oligopeptid; iii) identifisering av komponentene til nevnte utgangsoligopeptid ansvarlig forden sekundære strukturen derav; iv) for modifisering av seter identifisert i trinn (ii) selektering av et sett aminosyrer; v) for komponenter identifisert i trinn (iii) selektering av minst en ikke-naturlig aminosyre som etterligner den sekundære strukturen til komponenten; vi) dannelse av et første kombinatorisk bibliotek av oligopeptider som har det nevnte identifiserte modifikasjonssete aminosyreresidier som korresponderer med nevnte selekterte sett av aminosyrer; vii) identifisering av medlemmer av nevnte første bibliotek som har en bindingsaffinitetverdi over et forutbestemt minimum og dannelse av et ytterligere kombinatorisk bibliotek av oligopeptider som har medlemmer som ikke er tilstede i første bibliotek, og identifisering åv medlemmene til nevnte ytterligere bibliotek som har forbedrede bindingsaffinitetsverdier i forhold til de identifiserte medlemmene av nevnte første bibliotek og med den forutsetningen at minst av nevnte første og ytterligere bibliotek inneholder oligopeptider inneholdende residier av nevnte ikke-naturlige aminosyre eller syrer; og (viii) selektering fra de identifiserte medlemmene av nevnte bibliotek en medikamentkandidat.A method of selecting a candidate drug compound is described, the method comprising: i) identifying a parent oligopeptide having a binding affinity for a cell surface or other receptor site; ii) forming a plurality of homologous oligopeptides having single-site amino acid modifications relative to said parent oligopeptide; iii) identifying the components of said parent oligopeptide responsible for its secondary structure; iv) for modifying sites identified in step (ii) selecting a set of amino acids; v) for components identified in step (iii) selecting at least one non-natural amino acid that mimics the secondary structure of the component; vi) forming a first combinatorial library of oligopeptides having said identified site of modification amino acid residues corresponding to said selected set of amino acids; vii) identifying members of said first library having a binding affinity value above a predetermined minimum and forming an additional combinatorial library of oligopeptides having members not present in the first library, and identifying members of said additional library having enhanced binding affinity values in relative to the identified members of said first library and provided that at least one of said first and further libraries contains oligopeptides containing residues of said unnatural amino acid or acids; and (viii) selecting from the identified members of said library a drug candidate.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9717652.3A GB9717652D0 (en) | 1997-08-20 | 1997-08-20 | Method |
| PCT/GB1998/002504 WO1999009416A2 (en) | 1997-08-20 | 1998-08-20 | Method of drug selection |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20000811D0 NO20000811D0 (en) | 2000-02-18 |
| NO20000811L true NO20000811L (en) | 2000-04-12 |
Family
ID=10817781
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20000811A NO20000811L (en) | 1997-08-20 | 2000-02-18 | Procedure for drug selection |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1005655A2 (en) |
| JP (1) | JP2001516029A (en) |
| AU (2) | AU8816898A (en) |
| CA (1) | CA2300903A1 (en) |
| GB (1) | GB9717652D0 (en) |
| NO (1) | NO20000811L (en) |
| WO (2) | WO1999009416A2 (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9809776D0 (en) * | 1998-05-07 | 1998-07-08 | Nycomed Imaging As | Method |
| GB9809780D0 (en) * | 1998-05-07 | 1998-07-08 | Nycomed Imaging As | Method |
| GB9809782D0 (en) * | 1998-05-07 | 1998-07-08 | Nycomed Imaging As | Method |
| WO2008106429A2 (en) | 2007-02-26 | 2008-09-04 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of heart failure and other disorders |
| CA2707840A1 (en) | 2007-08-20 | 2009-02-26 | Allozyne, Inc. | Amino acid substituted molecules |
| WO2014128555A2 (en) * | 2013-02-20 | 2014-08-28 | Bergen Teknologioverføring As | Vaccine |
| WO2020039387A1 (en) * | 2018-08-24 | 2020-02-27 | Vestlandets Innovasjonsselskap As (Vis) | Heat-stable enterotoxins mutants as antidiarrheal vaccine antigens |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5075211A (en) * | 1986-03-26 | 1991-12-24 | Genetic Systems Corporation | Synthetic antigen for the detection of AIDS-related disease |
| US4965343A (en) * | 1988-01-28 | 1990-10-23 | Hoffmann-La Roche Inc. | Method of peptide synthesis |
| JPH0768271B2 (en) * | 1989-08-31 | 1995-07-26 | 三菱化学株式会社 | Method for producing human osteocalcin |
| CS89491A3 (en) * | 1990-04-09 | 1992-01-15 | Chugai Pharmaceutical Co Ltd | Hybrid calcitonin |
| US5723286A (en) * | 1990-06-20 | 1998-03-03 | Affymax Technologies N.V. | Peptide library and screening systems |
| US5824483A (en) * | 1994-05-18 | 1998-10-20 | Pence Inc. | Conformationally-restricted combinatiorial library composition and method |
| US5911997A (en) * | 1995-06-07 | 1999-06-15 | Connetics Corporation | Relaxin-like factor and methods and uses thereof |
| DE69628194T2 (en) * | 1995-12-18 | 2004-04-01 | Praecis Pharmaceuticals, Inc., Cambridge | METHOD FOR DETECTING COMPOUNDS BINDING SPECIFIC TARGET MOLECULES |
-
1997
- 1997-08-20 GB GBGB9717652.3A patent/GB9717652D0/en active Pending
-
1998
- 1998-08-20 AU AU88168/98A patent/AU8816898A/en not_active Abandoned
- 1998-08-20 WO PCT/GB1998/002504 patent/WO1999009416A2/en not_active Application Discontinuation
- 1998-08-20 AU AU88173/98A patent/AU8817398A/en not_active Abandoned
- 1998-08-20 EP EP98939765A patent/EP1005655A2/en not_active Withdrawn
- 1998-08-20 JP JP2000510029A patent/JP2001516029A/en not_active Withdrawn
- 1998-08-20 CA CA002300903A patent/CA2300903A1/en not_active Abandoned
- 1998-08-20 WO PCT/GB1998/002510 patent/WO1999009417A2/en active Application Filing
-
2000
- 2000-02-18 NO NO20000811A patent/NO20000811L/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB9717652D0 (en) | 1997-10-22 |
| CA2300903A1 (en) | 1999-02-25 |
| WO1999009417A9 (en) | 1999-05-27 |
| AU8816898A (en) | 1999-03-08 |
| WO1999009416A3 (en) | 1999-10-21 |
| AU8817398A (en) | 1999-03-08 |
| EP1005655A2 (en) | 2000-06-07 |
| WO1999009417A2 (en) | 1999-02-25 |
| WO1999009417A3 (en) | 1999-08-12 |
| WO1999009416A2 (en) | 1999-02-25 |
| JP2001516029A (en) | 2001-09-25 |
| NO20000811D0 (en) | 2000-02-18 |
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