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NO180379C - Fremgangsmåte for fremstilling av et vesentlig renset insulinderivat - Google Patents

Fremgangsmåte for fremstilling av et vesentlig renset insulinderivat

Info

Publication number
NO180379C
NO180379C NO895296A NO895296A NO180379C NO 180379 C NO180379 C NO 180379C NO 895296 A NO895296 A NO 895296A NO 895296 A NO895296 A NO 895296A NO 180379 C NO180379 C NO 180379C
Authority
NO
Norway
Prior art keywords
basic
amino acid
preparing
substantially purified
insulin derivative
Prior art date
Application number
NO895296A
Other languages
English (en)
Norwegian (no)
Other versions
NO895296L (no
NO180379B (no
NO895296D0 (no
Inventor
Laszlo Vertesy
Karl Geisen
Guenther Johannes Riess
Klaus Sauber
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of NO895296D0 publication Critical patent/NO895296D0/no
Publication of NO895296L publication Critical patent/NO895296L/no
Publication of NO180379B publication Critical patent/NO180379B/no
Publication of NO180379C publication Critical patent/NO180379C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
NO895296A 1988-12-29 1989-12-28 Fremgangsmåte for fremstilling av et vesentlig renset insulinderivat NO180379C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3844211A DE3844211A1 (de) 1988-12-29 1988-12-29 Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung

Publications (4)

Publication Number Publication Date
NO895296D0 NO895296D0 (no) 1989-12-28
NO895296L NO895296L (no) 1990-07-02
NO180379B NO180379B (no) 1996-12-30
NO180379C true NO180379C (no) 1997-04-09

Family

ID=6370457

Family Applications (1)

Application Number Title Priority Date Filing Date
NO895296A NO180379C (no) 1988-12-29 1989-12-28 Fremgangsmåte for fremstilling av et vesentlig renset insulinderivat

Country Status (20)

Country Link
US (1) US5506202A (pt)
EP (1) EP0376156B1 (pt)
JP (1) JP3129722B2 (pt)
KR (1) KR900009698A (pt)
AT (1) ATE136038T1 (pt)
AU (1) AU623963B2 (pt)
CA (1) CA2006818C (pt)
DE (2) DE3844211A1 (pt)
DK (1) DK173178B1 (pt)
ES (1) ES2085271T3 (pt)
FI (1) FI102843B (pt)
GR (1) GR3019560T3 (pt)
HU (1) HU205172B (pt)
IE (1) IE73672B1 (pt)
IL (1) IL92905A (pt)
NO (1) NO180379C (pt)
NZ (1) NZ231944A (pt)
PH (1) PH27425A (pt)
PT (1) PT92757B (pt)
ZA (1) ZA899946B (pt)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK134189D0 (da) * 1989-03-20 1989-03-20 Nordisk Gentofte Insulinforbindelser
DE3936876A1 (de) * 1989-11-06 1991-05-23 Hoechst Ag Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
TW224471B (pt) * 1991-11-26 1994-06-01 Lilly Co Eli
US6251856B1 (en) 1995-03-17 2001-06-26 Novo Nordisk A/S Insulin derivatives
CA2215694A1 (en) * 1995-03-17 1996-09-26 Novo Nordisk A/S Insulin derivatives
US6444641B1 (en) 1997-10-24 2002-09-03 Eli Lilly Company Fatty acid-acylated insulin analogs
US6746853B1 (en) 1999-05-19 2004-06-08 Xencor, Inc. Proteins with insulin-like activity useful in the treatment of diabetes
US6323311B1 (en) 1999-09-22 2001-11-27 University Of Utah Research Foundation Synthesis of insulin derivatives
KR20040070237A (ko) * 2001-12-20 2004-08-06 일라이 릴리 앤드 캄파니 연장된 작용 시간을 갖는 인슐린 분자
CA2518776A1 (en) * 2003-04-29 2004-11-11 Eli Lilly And Company Insulin analogs having protracted time action
CA2587985C (en) * 2004-11-24 2016-05-10 Neopro Labs, Llc Peptides for use in treatment in fever or pain
US7833513B2 (en) 2004-12-03 2010-11-16 Rhode Island Hospital Treatment of Alzheimer's Disease
TWI376234B (en) * 2005-02-01 2012-11-11 Msd Oss Bv Conjugates of a polypeptide and an oligosaccharide
PL373543A1 (pl) * 2005-03-10 2006-09-18 Instytut Biotechnologii i Antybiotyków Kompozycja farmaceutyczna zawierająca biosyntetyczny analog insuliny ludzkiej, oraz jej zastosowanie w terapii cukrzycy
US20060212009A1 (en) * 2005-03-16 2006-09-21 Accisano Nicholas G Iii Drainage catheter hub with rotatable lever handle
US7824367B2 (en) * 2005-08-17 2010-11-02 Merit Medical Systems, Inc. Drainage catheter with locking hub
WO2007081824A2 (en) * 2006-01-06 2007-07-19 Case Western Reserve University Fibrillation resistant proteins
WO2007112453A2 (en) * 2006-03-28 2007-10-04 Neopro Labs, Llc Methods amd compositions for treating conditions
DE102006031955A1 (de) 2006-07-11 2008-01-17 Sanofi-Aventis Deutschland Gmbh Verfahren zur Herstellung von Insulinanaloga mit dibasischem B-Kettenende
DE102006031962A1 (de) 2006-07-11 2008-01-17 Sanofi-Aventis Deutschland Gmbh Amidiertes Insulin Glargin
US20090306337A1 (en) * 2006-07-31 2009-12-10 Novo Nordisk A/S Pegylated, Extended Insulins
US9233226B2 (en) * 2006-08-22 2016-01-12 Merit Medical Systems, Inc. Drainage catheter with pig-tail straightener
ES2601839T3 (es) 2006-09-22 2017-02-16 Novo Nordisk A/S Análogos de insulina resistentes a proteasas
EP2074140B8 (en) 2006-10-04 2015-10-28 Case Western Reserve University Fibrillation-resistant insulin and insulin analogues
JP5496082B2 (ja) 2007-04-30 2014-05-21 ノボ・ノルデイスク・エー／エス タンパク質組成物を乾燥させる方法、乾燥タンパク質組成物、及び乾燥タンパク質を含有する薬学的組成物
US8217141B2 (en) 2007-05-17 2012-07-10 Neopro Labs, Llc Crystalline and amorphous forms of peptide
US20100144592A1 (en) * 2007-06-01 2010-06-10 Nove Nordisk A/S Stable Non-Aqueous Pharmaceutical Compositions
US20090069237A1 (en) * 2007-07-18 2009-03-12 Hanna Skubatch Methods and compositions for treating conditions
WO2009112583A2 (en) 2008-03-14 2009-09-17 Novo Nordisk A/S Protease-stabilized insulin analogues
ES2609288T3 (es) 2008-03-18 2017-04-19 Novo Nordisk A/S Análogos de insulina acilada, estabilizados frente a proteasas
WO2009129250A2 (en) * 2008-04-14 2009-10-22 Case Western Reserve University Meal-time insulin analogues of enhanced stability
AU2009240636A1 (en) * 2008-04-22 2009-10-29 Case Western Reserve University Isoform-specific insulin analogues
PL219335B1 (pl) * 2008-07-04 2015-04-30 Inst Biotechnologii I Antybiotyków Pochodna insuliny lub jej farmaceutycznie dopuszczalna sól, jej zastosowanie oraz zawierająca ją kompozycja farmaceutyczna
US9200053B2 (en) 2008-07-31 2015-12-01 Case Western Reserve University Insulin analogues containing penta-fluoro-Phenylalanine at position B24
KR20120129875A (ko) 2008-07-31 2012-11-28 케이스 웨스턴 리저브 유니버시티 염소화 아미노산을 갖는 인슐린 유사체
US8399407B2 (en) * 2009-09-17 2013-03-19 Case Western Reserve University Non-standard insulin analogues
RU2012123642A (ru) 2009-12-11 2014-01-20 Кейз Вестерн Ризев Юнивесити Аналоги инсулина, содержащие хлорированные аминокислоты
BR112014025132A2 (pt) 2012-04-11 2017-07-11 Novo Nordisk As formulações de insulina
BR112016007166A2 (pt) 2013-10-07 2017-09-12 Novo Nordisk As derivado de um análogo de insulina
WO2016057529A2 (en) 2014-10-06 2016-04-14 Case Western Reserve University Biphasic single-chain insulin analogues
GB2549275B (en) * 2016-04-11 2018-05-09 Tectonic Facades Ltd Construction assembly
CN110087674B (zh) 2016-12-16 2023-01-03 诺和诺德股份有限公司 含胰岛素的药物组合物
WO2024137820A1 (en) * 2022-12-20 2024-06-27 The Board Of Trustees Of The Leland Stanford Junior University Insulin receptor antagonist

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55138393A (en) * 1979-04-13 1980-10-29 Shionogi & Co Ltd Semisynthesis of insulin
IE50892B1 (en) * 1980-02-11 1986-08-06 Novo Industri As Process for preparing insulin esters
DE3327709A1 (de) * 1983-07-29 1985-02-07 Hoechst Ag, 6230 Frankfurt Insulin-derivat-kristallsuspensionen, verfahren zu deren herstellung und deren verwendung
DK58285D0 (da) * 1984-05-30 1985-02-08 Novo Industri As Peptider samt fremstilling og anvendelse deraf
US4946828A (en) * 1985-03-12 1990-08-07 Novo Nordisk A/S Novel insulin peptides
DK129385A (da) * 1985-03-22 1986-09-23 Novo Industri As Peptider og fremstilling deraf
DE3636903A1 (de) * 1985-12-21 1987-07-02 Hoechst Ag Fusionsproteine mit eukaryotischem ballastanteil
DE3541856A1 (de) * 1985-11-27 1987-06-04 Hoechst Ag Eukaryotische fusionsproteine, ihre herstellung und verwendung sowie mittel zur durchfuehrung des verfahrens
DE3545595A1 (de) * 1985-12-21 1987-06-25 Behringwerke Ag Dispersionspolymere, verfahren zu ihrer herstellung und ihre verwendung
DK437786D0 (da) * 1986-09-12 1986-09-12 Nordisk Gentofte Insulinprecursorer
DE3805150A1 (de) * 1987-04-11 1988-10-20 Hoechst Ag Gentechnologisches verfahren zur herstellung von polypeptiden
DE3714866A1 (de) * 1987-05-05 1988-11-24 Hoechst Ag Verfahren zur herstellung von fremdproteinen in streptomyceten
DK134189D0 (da) * 1989-03-20 1989-03-20 Nordisk Gentofte Insulinforbindelser

Also Published As

Publication number Publication date
AU623963B2 (en) 1992-05-28
HUT53150A (en) 1990-09-28
JPH02225498A (ja) 1990-09-07
EP0376156A2 (de) 1990-07-04
FI102843B1 (fi) 1999-02-26
NO895296L (no) 1990-07-02
ES2085271T3 (es) 1996-06-01
US5506202A (en) 1996-04-09
JP3129722B2 (ja) 2001-01-31
AU4733289A (en) 1990-07-05
IE894200L (en) 1990-06-29
IL92905A0 (en) 1990-09-17
DK173178B1 (da) 2000-03-06
GR3019560T3 (en) 1996-07-31
DE58909633D1 (de) 1996-05-02
IE73672B1 (en) 1997-07-02
DK669889A (da) 1990-06-30
IL92905A (en) 1994-10-21
DK669889D0 (da) 1989-12-28
CA2006818A1 (en) 1990-06-29
EP0376156B1 (de) 1996-03-27
NO180379B (no) 1996-12-30
EP0376156A3 (de) 1991-05-02
FI102843B (fi) 1999-02-26
ATE136038T1 (de) 1996-04-15
PT92757A (pt) 1990-06-29
KR900009698A (ko) 1990-07-05
NZ231944A (en) 1993-02-25
DE3844211A1 (de) 1990-07-05
FI896279A0 (fi) 1989-12-27
PH27425A (en) 1993-06-21
CA2006818C (en) 2000-05-23
HU205172B (en) 1992-03-30
ZA899946B (en) 1990-09-26
NO895296D0 (no) 1989-12-28
HU896781D0 (en) 1990-03-28
PT92757B (pt) 1995-12-29

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Publication Publication Date Title
NO180379C (no) Fremgangsmåte for fremstilling av et vesentlig renset insulinderivat
IE893576L (en) Insulin derivatives
FI905439A0 (fi) Nya insulinderivat, foerfarande foer deras framstaellning, deras anvaendning och dessa innehaollande farmaceutisk produkt.

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees

Free format text: LAPSED IN JUNE 2003