NO179710C - Nye fosfolipidderivater av nukleosider, og legemiddel inneholdende disse - Google Patents
Nye fosfolipidderivater av nukleosider, og legemiddel inneholdende disseInfo
- Publication number
- NO179710C NO179710C NO930587A NO930587A NO179710C NO 179710 C NO179710 C NO 179710C NO 930587 A NO930587 A NO 930587A NO 930587 A NO930587 A NO 930587A NO 179710 C NO179710 C NO 179710C
- Authority
- NO
- Norway
- Prior art keywords
- nucleosides
- drug containing
- phospholipid derivatives
- novel phospholipid
- novel
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4026265A DE4026265A1 (de) | 1990-08-20 | 1990-08-20 | Neue phospholipid-derivate von nucleosiden, deren herstellung sowie deren verwendung als antivirale arzneimittel |
PCT/EP1991/001541 WO1992003462A1 (de) | 1990-08-20 | 1991-08-14 | Neue phospholipid-derivate von nucleosiden, deren herstellung sowie deren verwendung als antivirale arzneimittel |
US08/661,038 US5756711A (en) | 1990-08-20 | 1996-06-10 | Phospholipid derivatives of nucleosides and their use as anti-viral medicaments |
Publications (4)
Publication Number | Publication Date |
---|---|
NO930587D0 NO930587D0 (no) | 1993-02-19 |
NO930587L NO930587L (no) | 1993-02-19 |
NO179710B NO179710B (no) | 1996-08-26 |
NO179710C true NO179710C (no) | 1996-12-04 |
Family
ID=25896049
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO930587A NO179710C (no) | 1990-08-20 | 1993-02-19 | Nye fosfolipidderivater av nukleosider, og legemiddel inneholdende disse |
Country Status (15)
Country | Link |
---|---|
US (1) | US5756711A (no) |
EP (1) | EP0545966B1 (no) |
CN (1) | CN1032258C (no) |
AT (1) | ATE114316T1 (no) |
CA (1) | CA2090024C (no) |
DE (2) | DE4026265A1 (no) |
DK (1) | DK0545966T3 (no) |
ES (1) | ES2066461T3 (no) |
FI (1) | FI104176B (no) |
HK (1) | HK35597A (no) |
IE (1) | IE64374B1 (no) |
NO (1) | NO179710C (no) |
PT (1) | PT98720B (no) |
SK (1) | SK281826B6 (no) |
WO (1) | WO1992003462A1 (no) |
Families Citing this family (80)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5817638A (en) * | 1988-07-07 | 1998-10-06 | Nexstar Pharmaceuticals, Inc. | Antiviral liponucleosides: treatment of hepatitis B |
US6252060B1 (en) | 1988-07-07 | 2001-06-26 | Nexstar Pharmaceuticals, Inc. | Antiviral liponucleosides: treatment of hepatitis B |
US6599887B2 (en) | 1988-07-07 | 2003-07-29 | Chimerix, Inc. | Methods of treating viral infections using antiviral liponucleotides |
CA2001401A1 (en) * | 1988-10-25 | 1990-04-25 | Claude Piantadosi | Quaternary amine containing ether or ester lipid derivatives and therapeutic compositions |
DE4204031A1 (de) * | 1992-02-12 | 1993-08-19 | Boehringer Mannheim Gmbh | Neue lipidphosphonsaeure-nucleosid-konjugate sowie deren verwendung als antivirale arzneimittel |
DE4204032A1 (de) * | 1992-02-12 | 1993-08-19 | Boehringer Mannheim Gmbh | Neue liponucleotide, deren herstellunmg sowie deren verwendung als antivirale arzneimittel |
US6080734A (en) * | 1992-08-08 | 2000-06-27 | Roche Diagnostic Gmbh | Liponucleotides of seco-nucleosides, their production as well as their use as antiviral pharmaceutical agents |
DE4226279A1 (de) * | 1992-08-08 | 1994-02-10 | Boehringer Mannheim Gmbh | Liponucleotide von Seco-Nucleosiden, deren Herstellung sowie deren Verwendung als antivirale Arzneimittel |
DE69431596D1 (de) * | 1993-06-10 | 2002-11-28 | Wake Forest University Winston | (phospho)lipide zum bekämpfen einer hepatitis b-infektion |
KR0125779B1 (ko) * | 1993-12-04 | 1997-12-19 | 김승호 | 뉴클레오시드 화합물 및 이의 제조방법 |
DE4418690A1 (de) * | 1994-05-28 | 1996-01-11 | Boehringer Mannheim Gmbh | Neue Lipidester von Nucleosid-Monophosphaten und deren Verwendung als immunsuppressive Arzneimittel |
DE69535758D1 (de) | 1994-08-29 | 2008-07-03 | Univ Wake Forest | Lipid-analoge zur behandlung von viralen infektionen |
US7135584B2 (en) | 1995-08-07 | 2006-11-14 | Wake Forest University | Lipid analogs for treating viral infections |
NZ295682A (en) * | 1994-11-12 | 1999-09-29 | Roche Diagnostics Gmbh Change | Lipid cleavage enzyme complex and use in diagnostic testing to identify compounds that act as a ligand or substrate of the complex |
DE19505168A1 (de) * | 1995-02-16 | 1996-08-22 | Boehringer Mannheim Gmbh | Spezifische Lipidkonjugate von Nucleosid-Diphosphonaten und deren Verwendung als Arzneimittel |
TW343975B (en) * | 1995-12-15 | 1998-11-01 | Boehringer Mannheim Gmbh | New phospholipid derivatives of phosphonocarboxylic acids, the production thereof as well as their use as antiviral pharmaceutical agents |
DE19547022A1 (de) * | 1995-12-15 | 1997-06-19 | Boehringer Mannheim Gmbh | Kovalente Lipid-Phosphonocarbonsäure-Konjugate, deren Herstellung sowie deren Verwendung als antivirale Arzneimittel |
DE19602757A1 (de) | 1996-01-26 | 1997-07-31 | Boehringer Mannheim Gmbh | Feste Instant-Release-Darreichungsformen und Verfahren zu ihrer Herstellung |
US7026469B2 (en) * | 2000-10-19 | 2006-04-11 | Wake Forest University School Of Medicine | Compositions and methods of double-targeting virus infections and cancer cells |
EP1325014B1 (en) | 2000-09-22 | 2012-05-23 | JPI Commercial, LLC | Gamma-hydroxybutyrate compositions containing carbohydrate carriers |
US7309696B2 (en) | 2000-10-19 | 2007-12-18 | Wake Forest University | Compositions and methods for targeting cancer cells |
CN100469131C (zh) | 2001-08-31 | 2009-03-11 | 汤姆森许可公司 | 实现条件存取系统和传输、接收及处理内容的方法和设备 |
US7045543B2 (en) | 2001-11-05 | 2006-05-16 | Enzrel Inc. | Covalent conjugates of biologically-active compounds with amino acids and amino acid derivatives for targeting to physiologically-protected sites |
AU2002356672A1 (en) * | 2001-11-21 | 2003-06-10 | Ganymed 256 Vermogensverwaltungs Gmbh | Phospholipid derivitives of nucleosides as antitumoral medicaments |
DE10156910A1 (de) * | 2001-11-21 | 2003-06-05 | Heidelberg Pharma Holding Gmbh | Phospholipid-Derivate von Nucleosiden als antitumorale Arzneimittel |
EP1460082A1 (en) | 2003-03-19 | 2004-09-22 | Heidelberg Pharma Holding GmbH | Phospholipid esters of clofarabine derivatives |
JP2008520744A (ja) * | 2004-11-19 | 2008-06-19 | ザ・レジェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア | 抗炎症性ピラゾロピリミジン |
ES2401285T3 (es) | 2004-12-16 | 2013-04-18 | The Regents Of The University Of California | Fármacos con el pulmón como diana |
WO2006070004A1 (en) | 2004-12-30 | 2006-07-06 | Medivir Ab | Compounds useful in the treatment of hiv |
EP2842559A3 (en) | 2005-04-08 | 2015-03-18 | Chimerix, Inc. | Compounds, compositions and methods for the treatment of viral infections and other medical disorders |
JP2008535862A (ja) | 2005-04-08 | 2008-09-04 | キメリクス,インコーポレイテッド | ポックスウイルス感染の治療のための化合物、組成物および方法 |
NO324263B1 (no) | 2005-12-08 | 2007-09-17 | Clavis Pharma Asa | Kjemiske forbindelser, anvendelse derav ved behandling av kreft, samt farmasoytiske preparater som omfatter slike forbindelser |
PT2004654E (pt) * | 2006-04-04 | 2013-08-27 | Univ California | Derivados de pirazolopirimidina para utilização como antagonistas da quinase |
GB0608876D0 (en) * | 2006-05-05 | 2006-06-14 | Medivir Ab | Combination therapy |
US7378401B2 (en) | 2006-07-14 | 2008-05-27 | Heidelberg Pharma Gmbh | Use of Fosfluridine Tidoxil (FT) for the treatment of intraepithelial proliferative diseases |
BRPI0817269A2 (pt) | 2007-09-26 | 2014-10-07 | Sinai School Medicine | Análogos de azacitidina e usos dos mesmos |
US20110160232A1 (en) | 2007-10-04 | 2011-06-30 | Pingda Ren | Certain chemical entities and therapeutic uses thereof |
EP2070938A1 (en) | 2007-12-13 | 2009-06-17 | Heidelberg Pharma AG | Clofarabine dietherphospholipid derivatives |
US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
NZ613219A (en) | 2008-01-04 | 2014-11-28 | Intellikine Llc | Heterocyclic containing entities, compositions and methods |
CN105055432A (zh) * | 2008-01-25 | 2015-11-18 | 奇默里克斯公司 | 治疗病毒感染的方法 |
WO2009114874A2 (en) | 2008-03-14 | 2009-09-17 | Intellikine, Inc. | Benzothiazole kinase inhibitors and methods of use |
JP5547099B2 (ja) * | 2008-03-14 | 2014-07-09 | インテリカイン, エルエルシー | キナーゼ阻害剤および使用方法 |
WO2010006072A2 (en) * | 2008-07-08 | 2010-01-14 | The Regents Of The University Of California | Mtor modulators and uses thereof |
MX2011000216A (es) | 2008-07-08 | 2011-03-29 | Intellikine Inc | Inhibidores de cinasa y metodos para su uso. |
CA2738429C (en) | 2008-09-26 | 2016-10-25 | Intellikine, Inc. | Heterocyclic kinase inhibitors |
ES2570429T3 (es) | 2008-10-16 | 2016-05-18 | Univ California | Inhibidores de heteroaril quinasa de anillo condensado |
US8476282B2 (en) * | 2008-11-03 | 2013-07-02 | Intellikine Llc | Benzoxazole kinase inhibitors and methods of use |
JP5789252B2 (ja) | 2009-05-07 | 2015-10-07 | インテリカイン, エルエルシー | 複素環式化合物およびその使用 |
WO2011011519A1 (en) | 2009-07-21 | 2011-01-27 | Chimerix, Inc. | Compounds, compositions and methods for treating ocular conditions |
WO2011047384A2 (en) | 2009-10-16 | 2011-04-21 | The Regents Of The University Of California | Methods of inhibiting ire1 |
HUE032860T2 (en) | 2010-02-12 | 2017-11-28 | Chimerix Inc | A method for treating a virus infection |
CA2797601A1 (en) | 2010-04-26 | 2011-11-10 | Chimerix, Inc. | Methods of treating retroviral infections and related dosage regimes |
WO2011146882A1 (en) | 2010-05-21 | 2011-11-24 | Intellikine, Inc. | Chemical compounds, compositions and methods for kinase modulation |
WO2012064973A2 (en) | 2010-11-10 | 2012-05-18 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
CA2824197C (en) | 2011-01-10 | 2020-02-25 | Michael Martin | Processes for preparing isoquinolinones and solid forms of isoquinolinones |
JP6130305B2 (ja) | 2011-02-23 | 2017-05-17 | インテリカイン, エルエルシー | キナーゼ阻害剤の組み合わせおよびそれらの使用 |
JP6027610B2 (ja) | 2011-07-19 | 2016-11-16 | インフィニティー ファーマシューティカルズ, インコーポレイテッド | 複素環式化合物及びその使用 |
MX2014000648A (es) | 2011-07-19 | 2014-09-25 | Infinity Pharmaceuticals Inc | Compuestos heterociclicos y sus usos. |
MX2014002542A (es) | 2011-08-29 | 2014-07-09 | Infinity Pharmaceuticals Inc | Compuestos heterociclicos y usos de los mismos. |
JP6342805B2 (ja) | 2011-09-02 | 2018-06-13 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 置換ピラゾロ[3,4−d]ピリミジンおよびその用途 |
US8940742B2 (en) | 2012-04-10 | 2015-01-27 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
US8828998B2 (en) | 2012-06-25 | 2014-09-09 | Infinity Pharmaceuticals, Inc. | Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors |
EP2900673A4 (en) | 2012-09-26 | 2016-10-19 | Univ California | IRE1 MODULATION |
IL291945A (en) | 2012-11-01 | 2022-06-01 | Infinity Pharmaceuticals Inc | Treatment of cancers using pi3 kinase isoform modulators |
US9481667B2 (en) | 2013-03-15 | 2016-11-01 | Infinity Pharmaceuticals, Inc. | Salts and solid forms of isoquinolinones and composition comprising and methods of using the same |
WO2014143643A1 (en) | 2013-03-15 | 2014-09-18 | The Regents Of The University Of California, A California Corporation | Acyclic nucleoside phosphonate diesters |
US9751888B2 (en) | 2013-10-04 | 2017-09-05 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
US9359365B2 (en) | 2013-10-04 | 2016-06-07 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
CN106456628A (zh) | 2014-03-19 | 2017-02-22 | 无限药品股份有限公司 | 用于治疗PI3K‑γ介导的障碍的杂环化合物 |
WO2015160975A2 (en) | 2014-04-16 | 2015-10-22 | Infinity Pharmaceuticals, Inc. | Combination therapies |
AU2015317972B2 (en) | 2014-09-15 | 2019-10-17 | The Regents Of The University Of California | Nucleotide analogs |
WO2016054491A1 (en) | 2014-10-03 | 2016-04-07 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
CA2998469A1 (en) | 2015-09-14 | 2017-03-23 | Infinity Pharmaceuticals, Inc. | Solid forms of isoquinolinones, and process of making, composition comprising, and methods of using the same |
WO2017048956A1 (en) | 2015-09-15 | 2017-03-23 | The Regents Of The University Of California | Nucleotide analogs |
CN105288648B (zh) * | 2015-10-14 | 2018-11-06 | 东南大学 | 一种亲水性药物的磷脂化合物、其药物组合物及应用 |
WO2017161116A1 (en) | 2016-03-17 | 2017-09-21 | Infinity Pharmaceuticals, Inc. | Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors |
US10919914B2 (en) | 2016-06-08 | 2021-02-16 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
CN109640999A (zh) | 2016-06-24 | 2019-04-16 | 无限药品股份有限公司 | 组合疗法 |
DE112020006626A5 (de) | 2020-03-30 | 2022-12-08 | Chiracon Gmbh | Fosalvudin und Fozivudintidoxil zur Anwendung bei der Behandlung der Krankheit Covid-19 und die Verwendung von deren strukturvereinfachten Derivaten |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4291024A (en) * | 1978-04-10 | 1981-09-22 | Turcotte Joseph G | Cytotoxic liponucleotide analogs |
US4283394A (en) * | 1979-08-06 | 1981-08-11 | Research Corporation | Cytotoxic nucleoside-corticosteroid phosphodiesters |
US4622392A (en) * | 1984-06-21 | 1986-11-11 | Health Research Inc. (Roswell Park Division) | Thiophospholipid conjugates of antitumor agents |
US5223263A (en) * | 1988-07-07 | 1993-06-29 | Vical, Inc. | Liponucleotide-containing liposomes |
EP0262876B1 (en) * | 1986-09-27 | 1992-04-29 | Toyo Jozo Kabushiki Kaisha | Nucleoside-phospholipid conjugate |
US5194654A (en) * | 1989-11-22 | 1993-03-16 | Vical, Inc. | Lipid derivatives of phosphonoacids for liposomal incorporation and method of use |
-
1990
- 1990-08-20 DE DE4026265A patent/DE4026265A1/de not_active Withdrawn
-
1991
- 1991-08-14 CA CA002090024A patent/CA2090024C/en not_active Expired - Fee Related
- 1991-08-14 DE DE59103595T patent/DE59103595D1/de not_active Expired - Fee Related
- 1991-08-14 ES ES91914553T patent/ES2066461T3/es not_active Expired - Lifetime
- 1991-08-14 AT AT91914553T patent/ATE114316T1/de not_active IP Right Cessation
- 1991-08-14 EP EP91914553A patent/EP0545966B1/de not_active Expired - Lifetime
- 1991-08-14 WO PCT/EP1991/001541 patent/WO1992003462A1/de active IP Right Grant
- 1991-08-14 SK SK92-93A patent/SK281826B6/sk not_active IP Right Cessation
- 1991-08-14 DK DK91914553.2T patent/DK0545966T3/da active
- 1991-08-20 CN CN91105815A patent/CN1032258C/zh not_active Expired - Fee Related
- 1991-08-20 PT PT98720A patent/PT98720B/pt not_active IP Right Cessation
-
1993
- 1993-02-19 FI FI930753A patent/FI104176B/fi active
- 1993-02-19 IE IE293091A patent/IE64374B1/en not_active IP Right Cessation
- 1993-02-19 NO NO930587A patent/NO179710C/no not_active IP Right Cessation
-
1996
- 1996-06-10 US US08/661,038 patent/US5756711A/en not_active Expired - Lifetime
-
1997
- 1997-03-20 HK HK35597A patent/HK35597A/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0545966A1 (de) | 1993-06-16 |
DE4026265A1 (de) | 1992-02-27 |
IE912930A1 (en) | 1992-02-26 |
ATE114316T1 (de) | 1994-12-15 |
CA2090024C (en) | 2000-05-02 |
SK281826B6 (sk) | 2001-08-06 |
CN1032258C (zh) | 1996-07-10 |
SK9293A3 (en) | 1993-07-07 |
US5756711A (en) | 1998-05-26 |
DK0545966T3 (da) | 1995-05-08 |
AU654670B2 (en) | 1994-11-17 |
NO179710B (no) | 1996-08-26 |
FI104176B1 (fi) | 1999-11-30 |
AU8325191A (en) | 1992-03-17 |
CN1059149A (zh) | 1992-03-04 |
IE64374B1 (en) | 1995-07-26 |
ES2066461T3 (es) | 1995-03-01 |
DE59103595D1 (de) | 1995-01-05 |
FI104176B (fi) | 1999-11-30 |
FI930753A0 (fi) | 1993-02-19 |
HK35597A (en) | 1997-03-27 |
PT98720A (pt) | 1992-07-31 |
EP0545966B1 (de) | 1994-11-23 |
FI930753A (fi) | 1993-02-19 |
NO930587D0 (no) | 1993-02-19 |
WO1992003462A1 (de) | 1992-03-05 |
NO930587L (no) | 1993-02-19 |
PT98720B (pt) | 1999-02-26 |
CA2090024A1 (en) | 1992-02-21 |
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