NO176915C - Fremgangsmåte for fremstilling av et hirudin-derivat - Google Patents

Fremgangsmåte for fremstilling av et hirudin-derivat

Info

Publication number: NO176915C
Authority: NO; Norway
Prior art keywords: preparation; hirudin derivative; hirudin; derivative
Prior art date: 1988-02-23

Application number

NO890758A

Other languages

English (en)

Other versions

NO890758L (no

NO176915B (no

NO890758D0 (no

Inventor

Peter Crause

Paul Habermann

Dominique Tripier

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-02-23

Filing date

1989-02-22

Publication date

1995-06-21

1989-02-22 Application filed by Hoechst Ag filed Critical Hoechst Ag

1989-02-22 Publication of NO890758D0 publication Critical patent/NO890758D0/no

1989-08-24 Publication of NO890758L publication Critical patent/NO890758L/no

1995-03-13 Publication of NO176915B publication Critical patent/NO176915B/no

1995-06-21 Publication of NO176915C publication Critical patent/NO176915C/no

Links

WQPDUTSPKFMPDP-OUMQNGNKSA-N hirudin Chemical class C([C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC(OS(O)(=O)=O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@H](C(NCC(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N2)=O)CSSC1)C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)[C@@H](C)O)CSSC1)C(C)C)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 WQPDUTSPKFMPDP-OUMQNGNKSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/855—Proteins from animals other than mammals or birds

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Gastroenterology & Hepatology (AREA)
Tropical Medicine & Parasitology (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Diabetes (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Hematology (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Saccharide Compounds (AREA)

NO890758A 1988-02-23 1989-02-22 Fremgangsmåte for fremstilling av et hirudin-derivat NO176915C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE3805540		1988-02-23

Publications (4)

Publication Number	Publication Date
NO890758D0 NO890758D0 (no)	1989-02-22
NO890758L NO890758L (no)	1989-08-24
NO176915B NO176915B (no)	1995-03-13
NO176915C true NO176915C (no)	1995-06-21

Family

ID=6347932

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
NO890758A NO176915C (no)	1988-02-23	1989-02-22	Fremgangsmåte for fremstilling av et hirudin-derivat
NO1998016C NO1998016I1 (no)	1988-02-23	1998-05-26	Lepirudin

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
NO1998016C NO1998016I1 (no)	1988-02-23	1998-05-26	Lepirudin

Country Status (11)

Country	Link
US (1)	US5180668A (no)
JP (1)	JPH0649719B2 (no)
KR (1)	KR970009950B1 (no)
AU (1)	AU604925B2 (no)
CA (1)	CA1339104C (no)
HU (2)	HU210439B (no)
IE (1)	IE65354B1 (no)
NO (2)	NO176915C (no)
NZ (1)	NZ228064A (no)
PH (1)	PH25937A (no)
PT (1)	PT89778B (no)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3835815A1 (de) *	1988-10-21	1990-04-26	Hoechst Ag	Neue isohirudine
DE4009268A1 (de) *	1990-03-22	1991-09-26	Consortium Elektrochem Ind	Sekretion von hirudinderivaten
AU648124B2 (en) *	1990-11-08	1994-04-14	Japan Energy Corporation	Hirudine mutant, production thereof, anticoagulant, secretory vector, microorganism transformed by said vector, and production of product from said microorganism
DE4140381A1 (de) *	1991-12-07	1993-06-09	Hoechst Ag, 6230 Frankfurt, De	Neue synthetische isohirudine mit verbesserter stabilitaet
DE4404168A1 (de) *	1994-02-10	1995-08-17	Hoechst Ag	Hirudinderivate und Verfahren zu deren Herstellung
DE19543737A1 (de) *	1995-11-24	1997-05-28	Hoechst Ag	Verfahren zur Ultrafiltration von Peptide oder Proteine enthaltender biologischer Matrices
DE19544233A1 (de) *	1995-11-28	1997-06-05	Hoechst Ag	Verfahren zur Nutzung des Hefe-ADH II-Promotorsystems zur biotechnologischen Produktion heterologer Proteine in hohen Ausbeuten
DE19944870A1 (de) *	1999-09-18	2001-03-29	Aventis Pharma Gmbh	Signalsequenzen zur Herstellung von Leu-Hirudin über Sekretion durch E. coli in das Kulturmedium
US7795205B2 (en) *	2004-04-12	2010-09-14	Canyon Pharmaceuticals, Inc.	Methods for effecting regression of tumor mass and size in a metastasized pancreatic tumor

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3445517C2 (de) *	1984-12-13	1993-11-18	Ciba Geigy	Für ein Hirudin-ähnliches Protein codierende DNA-Sequenz und Verfahren zur Herstellung eines Hirudin-ähnlichen Proteins
DE3445532A1 (de) *	1984-12-13	1986-06-19	Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn	Hirudin-pa, desulfatohirudine-pa, verfahren zur herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten

1988
- 1988-06-23 AU AU18284/88A patent/AU604925B2/en not_active Expired
1989
- 1989-01-10 US US07/295,422 patent/US5180668A/en not_active Expired - Lifetime
- 1989-02-21 NZ NZ228064A patent/NZ228064A/en unknown
- 1989-02-21 KR KR89002002A patent/KR970009950B1/ko not_active IP Right Cessation
- 1989-02-21 PH PH38226A patent/PH25937A/en unknown
- 1989-02-22 HU HU89854A patent/HU210439B/hu unknown
- 1989-02-22 CA CA000591790A patent/CA1339104C/en not_active Expired - Fee Related
- 1989-02-22 IE IE55989A patent/IE65354B1/en not_active IP Right Cessation
- 1989-02-22 NO NO890758A patent/NO176915C/no not_active IP Right Cessation
- 1989-02-22 PT PT89778A patent/PT89778B/pt not_active IP Right Cessation
- 1989-02-23 JP JP1044980A patent/JPH0649719B2/ja not_active Expired - Lifetime
1995
- 1995-06-29 HU HU95P/P00596P patent/HU211828A9/hu unknown
1998
- 1998-05-26 NO NO1998016C patent/NO1998016I1/no unknown

Also Published As

Publication number	Publication date
HUT50502A (en)	1990-02-28
PH25937A (en)	1991-12-19
US5180668A (en)	1993-01-19
JPH025891A (ja)	1990-01-10
HU211828A9 (en)	1995-12-28
HU210439B (en)	1995-04-28
NO890758L (no)	1989-08-24
PT89778B (pt)	1994-03-31
NZ228064A (en)	1990-12-21
PT89778A (pt)	1989-10-04
KR970009950B1 (en)	1997-06-19
JPH0649719B2 (ja)	1994-06-29
AU604925B2 (en)	1991-01-03
IE890559L (en)	1989-08-23
CA1339104C (en)	1997-07-29
IE65354B1 (en)	1995-10-18
NO176915B (no)	1995-03-13
NO890758D0 (no)	1989-02-22
AU1828488A (en)	1989-08-24
NO1998016I1 (no)	1998-05-26

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Legal Events

Date	Code	Title	Description
2009-03-16	MK1K	Patent expired
2012-04-10	MK1K	Patent expired