NO175158C - Fremstilling av human livmorsvevplasminogenaktivator med rekombinant-DNA - Google Patents

Fremstilling av human livmorsvevplasminogenaktivator med rekombinant-DNA

Info

Publication number: NO175158C
Authority: NO; Norway
Prior art keywords: preparation; recombinant dna; plasminogen activator; tissue plasminogen; human uterine
Prior art date: 1984-10-01

Application number

NO853851A

Other languages

English (en)

Norwegian (no)

Other versions

NO175158B (no

NO853851L (no

Inventor

Cha-Mer Wei

Nancy Hsiung

Vermuri B Reddy

Jeffrey F Lemontt

William Dackowski

Richard Douglas

Edward S Cole

Jr Richard D Purcell

David Tai-Yui Lau

Original Assignee

Genzyme Corp

Integrated Genetics Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-10-01

Filing date

1985-09-30

Publication date

1994-09-07

1985-09-30 Application filed by Genzyme Corp, Integrated Genetics Inc filed Critical Genzyme Corp

1986-04-02 Publication of NO853851L publication Critical patent/NO853851L/no

1994-05-30 Publication of NO175158B publication Critical patent/NO175158B/no

1994-09-07 Publication of NO175158C publication Critical patent/NO175158C/no

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/14011—Details ssDNA Bacteriophages
- C12N2795/14111—Inoviridae
- C12N2795/14141—Use of virus, viral particle or viral elements as a vector
- C12N2795/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/70—Vector systems having a special element relevant for transcription from fungi
- C12N2830/702—Vector systems having a special element relevant for transcription from fungi yeast
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
- C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
General Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Microbiology (AREA)
Mycology (AREA)
Physics & Mathematics (AREA)
Biophysics (AREA)
Plant Pathology (AREA)
Medicinal Chemistry (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Enzymes And Modification Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Control Of Ac Motors In General (AREA)
Saccharide Compounds (AREA)

NO853851A 1984-10-01 1985-09-30 Fremstilling av human livmorsvevplasminogenaktivator med rekombinant-DNA NO175158C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US65677084A	1984-10-01	1984-10-01

Publications (3)

Publication Number	Publication Date
NO853851L NO853851L (no)	1986-04-02
NO175158B NO175158B (no)	1994-05-30
NO175158C true NO175158C (no)	1994-09-07

Family

ID=24634490

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO853851A NO175158C (no)	1984-10-01	1985-09-30	Fremstilling av human livmorsvevplasminogenaktivator med rekombinant-DNA

Country Status (14)

Country	Link
US (1)	US5344773A (de)
EP (1)	EP0178105B1 (de)
JP (1)	JPS61149094A (de)
AT (1)	ATE151111T1 (de)
AU (1)	AU599576B2 (de)
DE (1)	DE3588149T2 (de)
DK (1)	DK175327B1 (de)
ES (3)	ES8702945A1 (de)
FI (1)	FI89723C (de)
IE (1)	IE81135B1 (de)
NO (1)	NO175158C (de)
NZ (1)	NZ213647A (de)
PT (1)	PT81231B (de)
ZA (1)	ZA857574B (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3479520D1 (en) *	1983-11-21	1989-09-28	Ciba Geigy Ag	Synthesis of tissue plasminogen activator(tpa) by yeast
US5073494A (en) *	1985-04-22	1991-12-17	Genentech, Inc.	Human tissue plasminogen activator substituted at position 275 or at positions 275 and 277
GB8528321D0 (en) *	1985-11-18	1985-12-24	Ciba Geigy Ag	Modified fibrinolytic agents
JP2581668B2 (ja) *	1985-11-27	1997-02-12	三井東圧化学株式会社	ヒト正常細胞由来のヒト組織プラスミノ−ゲン活性化因子をコ−ドする新しいｄｎａ配列とそれを含むベクタ−及び細胞
ES2031826T3 (es) *	1985-12-23	1993-01-01	Chiron Corporation	Procedimiento para producir nuevos peptidos activadores del plasminogeno.
US5837518A (en) *	1986-01-31	1998-11-17	Genetics Institute, Inc.	Thrombolytic proteins
US5258298A (en) *	1986-01-31	1993-11-02	Genetics Institute, Inc.	Deletion and glycosylation mutant of human tissue plasminogen activator
DE3789664T3 (de) *	1986-01-31	2004-09-16	Genetics Institute, LLC, Cambridge	Neue thrombolytische proteine.
US5589361A (en) *	1986-03-18	1996-12-31	Genentech, Inc.	Human tissue-type plasminogen activator variant
IE81073B1 (en) *	1986-03-18	2000-01-12	Genentech Inc	Modified human tissue-type plasminogen activator and its preparation
ATE141646T1 (de)	1986-04-09	1996-09-15	Genzyme Corp	Genetisch transformierte tiere, die ein gewünschtes protein in milch absondern
US5047241A (en) *	1986-07-11	1991-09-10	American Home Products Corporation	Tris-Kringle plasminogen activator with novel K2 insert
WO1988000615A1 (en) *	1986-07-16	1988-01-28	Celltech Limited	Process for purifying a plasminogen activator
US5580559A (en) *	1986-12-05	1996-12-03	Ciba-Geigy Corporation	Hybrid plasminogen activator
US5242819A (en) *	1986-12-05	1993-09-07	Ciba-Geigy Corporation	DNA molecules encoding hybrid proteins of tissue plasminogen activator and urokinase
EP0276846A3 (de) *	1987-01-29	1989-07-26	Zymogenetics, Inc.	Derivate des koloniestimulierenden Faktors
IE880255L (en) *	1987-01-30	1988-07-30	American Home Prod	Des-epidermal growth factor activators.
JPH084501B2 (ja) *	1987-03-20	1996-01-24	エーザイ株式会社	糖鎖に関する変異ｔＰＡ
DK275788A (da) *	1987-05-22	1989-02-03	Zymogenetics Inc	Fibrinolytiske proteiner
AU1668988A (en) *	1987-06-03	1988-12-08	Smithkline Beckman Corporation	Purification of tpa
US6682733B1 (en) *	1987-06-18	2004-01-27	Roche Diagnostics, Gmbh	Fibrinolytic enzymes
DE3726019A1 (de) *	1987-08-05	1989-02-16	Boehringer Mannheim Gmbh	Verfahren zur abtrennung und reinigung von t-pa
US4963357A (en) *	1987-10-09	1990-10-16	Monsanto Company	Tissue plasminogen activator modified by the substitution of Arg for Cys at position 73, methods and pharmaceutical compositions therefor
US5244676A (en) *	1987-10-09	1993-09-14	Monsanto Company	Modified tissue plasminogen activator with modified glycosylation site
US5100666A (en) *	1987-10-09	1992-03-31	Monsanto Company	Modified tissue plasminogen activator K2K2SP
US5037752A (en) *	1987-10-09	1991-08-06	Monsanto Company	Modified tissue plasminogen activator substituted at cysteine-73 and lysine-277
US5270198A (en) *	1988-05-20	1993-12-14	Genentech, Inc.	DNA molecules encoding variants of tissue plasminogen activators, vectors, and host cells
US5665583A (en)	1988-08-12	1997-09-09	Arch Dev Corp	Methods and materials relating to IMPDH and GMP production
US5262170A (en) *	1988-09-02	1993-11-16	Genentech, Inc.	Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells
US5714145A (en) *	1988-09-02	1998-02-03	Genentech, Inc.	Tissue plasminogen activator having zymogenic or fibrin specific properties
US5070021A (en) *	1989-01-10	1991-12-03	Monsanto Company	Method of modifying oligosaccharide structure of tissue plasminogen activator
US5268273A (en) *	1990-12-14	1993-12-07	Phillips Petroleum Company	Pichia pastoris acid phosphatase gene, gene regions, signal sequence and expression vectors comprising same
PT786257E (pt) *	1992-06-03	2003-12-31	Genentech Inc	Variantes de glicosilacao do activador de plasminogenio tissular com propriedades terapeuticas meloradas
US7299805B2 (en)	2002-06-07	2007-11-27	Marctec, Llc	Scaffold and method for implanting cells
US10160813B2 (en)	2013-01-22	2018-12-25	University Of Tennessee Research Foundation	Tissue plasminogen activator antibodies and methods of use

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4370417A (en) *	1980-04-03	1983-01-25	Abbott Laboratories	Recombinant deoxyribonucleic acid which codes for plasminogen activator
US4419446A (en) *	1980-12-31	1983-12-06	The United States Of America As Represented By The Department Of Health And Human Services	Recombinant DNA process utilizing a papilloma virus DNA as a vector
ZA833174B (en) *	1982-05-05	1984-08-29	Genentech Inc	Human tissue plasminogen activator
IL68561A (en) *	1982-05-05	1991-01-31	Genentech Inc	Preparation of polypeptide with human tissue plasminogen activator function,processes for making it,and dna and transformed cell intermediates thereof
EP0125254A1 (de) *	1982-10-28	1984-11-21	Beecham Group Plc	Enzymderivate und deren verwendung bei der behandlung von trombosen
AU554862B2 (en) *	1982-12-14	1986-09-04	Implico B.V.	Plasminogen activator isolated by affinity chromatography
IE56716B1 (en) *	1983-01-19	1991-11-20	Genentech Inc	Method for producing human tpa and expression vectors therefor
DE3479520D1 (en) *	1983-11-21	1989-09-28	Ciba Geigy Ag	Synthesis of tissue plasminogen activator(tpa) by yeast
US4753879A (en) *	1984-08-27	1988-06-28	Biogen N.V.	Modified tissue plasminogen activators
GB8528321D0 (en) *	1985-11-18	1985-12-24	Ciba Geigy Ag	Modified fibrinolytic agents
ES2031826T3 (es) *	1985-12-23	1993-01-01	Chiron Corporation	Procedimiento para producir nuevos peptidos activadores del plasminogeno.
IE81073B1 (en) *	1986-03-18	2000-01-12	Genentech Inc	Modified human tissue-type plasminogen activator and its preparation

1985
- 1985-09-30 AT AT85306957T patent/ATE151111T1/de not_active IP Right Cessation
- 1985-09-30 EP EP85306957A patent/EP0178105B1/de not_active Expired - Lifetime
- 1985-09-30 FI FI853761A patent/FI89723C/fi not_active IP Right Cessation
- 1985-09-30 DK DK198504415A patent/DK175327B1/da not_active IP Right Cessation
- 1985-09-30 NO NO853851A patent/NO175158C/no not_active IP Right Cessation
- 1985-09-30 NZ NZ213647A patent/NZ213647A/xx unknown
- 1985-09-30 DE DE3588149T patent/DE3588149T2/de not_active Expired - Lifetime
- 1985-09-30 ES ES547416A patent/ES8702945A1/es not_active Expired
- 1985-09-30 IE IE239485A patent/IE81135B1/en not_active IP Right Cessation
- 1985-10-01 ZA ZA857574A patent/ZA857574B/xx unknown
- 1985-10-01 US US06/782,686 patent/US5344773A/en not_active Expired - Lifetime
- 1985-10-01 PT PT81231A patent/PT81231B/pt unknown
- 1985-10-01 AU AU48148/85A patent/AU599576B2/en not_active Expired
- 1985-10-01 JP JP60216313A patent/JPS61149094A/ja active Pending
1986
- 1986-04-28 ES ES554449A patent/ES8706726A1/es not_active Expired
- 1986-04-28 ES ES554450A patent/ES8801306A1/es not_active Expired

Also Published As

Publication number	Publication date
DK441585A (da)	1986-04-02
ES554449A0 (es)	1987-07-01
FI89723B (fi)	1993-07-30
NO175158B (no)	1994-05-30
US5344773A (en)	1994-09-06
DE3588149D1 (de)	1997-05-07
ES8801306A1 (es)	1988-01-01
ATE151111T1 (de)	1997-04-15
AU4814885A (en)	1986-04-10
FI853761L (fi)	1986-04-02
IE852394L (en)	1986-04-01
FI853761A0 (fi)	1985-09-30
ES547416A0 (es)	1987-01-16
EP0178105B1 (de)	1997-04-02
EP0178105A3 (de)	1988-11-17
JPS61149094A (ja)	1986-07-07
IE81135B1 (en)	2000-03-22
DE3588149T2 (de)	1997-10-09
PT81231B (pt)	1987-10-20
DK175327B1 (da)	2004-08-23
NO853851L (no)	1986-04-02
ZA857574B (en)	1986-06-25
ES8706726A1 (es)	1987-07-01
NZ213647A (en)	1989-05-29
ES554450A0 (es)	1988-01-01
EP0178105A2 (de)	1986-04-16
ES8702945A1 (es)	1987-01-16
FI89723C (fi)	1993-11-10
AU599576B2 (en)	1990-07-26
DK441585D0 (da)	1985-09-30
PT81231A (en)	1985-11-01

Publication	Publication Date	Title
NO175158C (no)	1994-09-07	Fremstilling av human livmorsvevplasminogenaktivator med rekombinant-DNA
NO831575L (no)	1983-11-07	Menneskevev-plasminogenaktivator
IL80659A (en)	1991-12-15	Modified tissue plasminogen activators,their preparation and pharmaceutical compositions containing them
MX197183A (es)	1994-02-28	Activador de plasminogeno de tejido humano
NO171344C (no)	1993-03-03	Fremgangsmaate for fremstilling av farmasoeytiske preparater inneholdende vevsplasminogenaktivator
NO862096L (no)	1986-12-01	Fremgangsmaate for fremstilling av farmasoeytiske preparater inneholdende vevsplasminogenaktivator.
ES2000743A6 (es)	1988-03-16	Estuche y procedimiento para preparar una unidad de dosificacion de activador de plasminogeno de tejidos humanos.
DK96787A (da)	1987-10-23	Human vaevs-plasminogenaktivator
NO864674D0 (no)	1986-11-21	Fremgangsmaate for fremstilling av terapeutisk aktive cefemforbindelser.
DK50987D0 (da)	1987-01-30	Polypeptid med plasminogenaktivatorvirkning
NO168055C (no)	1992-01-08	Fremgangsmaate for fremstilling av human vevplasminogenaktivator og urokinase-type plasminogenaktivator.
DE3764697D1 (de)	1990-10-11	T-pa enthaltende medizinische zubereitung und deren verwendung.
DE3675063D1 (de)	1990-11-29	Mischungen von polycaprolactonpolyolen und polyepoxyden.
NO880831D0 (no)	1988-02-25	Rekombinant human vevsplasminogen-aktivatorblanding.
EP0225177A3 (en)	1987-11-25	Dna sequence coding for human tissue plasminogen activator
ZA863956B (en)	1988-04-27	Pharmaceutical formulations containing tissue plasminogen activator
DK96888A (da)	1988-04-22	Rekombinant humant vaevsplasminogen aktivatormateriale
ZA884012B (en)	1989-02-22	Tissue plasminogen activator analogs having modified growth factor domains
LV5289A3 (lv)	1993-10-10	Plazminogena audu aktivatora aktivacijas panemiens (varianti)
IT8819559A0 (it)	1988-02-26	Impiego terapeutico dell'acido uridinfosfoglucuronico (udpg_a)come attivatore della glucuronconiugazione del trattamento di epatopie ed itteri.
SE8605572D0 (sv)	1986-12-29	Terapeutisk indikation for kend substans
ATE70971T1 (de)	1992-01-15	Foerderung der heilung von meniskusgewebe.
IE870208L (en)	1987-07-29	Modified tissue plasminogen activator
GB8726683D0 (en)	1987-12-16	Tissue plasminogen activator
GB8725052D0 (en)	1987-12-02	Tissue plasminogen activator

Legal Events

Date	Code	Title	Description
2005-11-21	MK1K	Patent expired