[go: up one dir, main page]

NO164981C - PROCEDURE FOR THE PREPARATION OF DEALKYLATED 14-HYDROXY-MORPHINAN ALKALOIDS. - Google Patents

PROCEDURE FOR THE PREPARATION OF DEALKYLATED 14-HYDROXY-MORPHINAN ALKALOIDS.

Info

Publication number
NO164981C
NO164981C NO852091A NO852091A NO164981C NO 164981 C NO164981 C NO 164981C NO 852091 A NO852091 A NO 852091A NO 852091 A NO852091 A NO 852091A NO 164981 C NO164981 C NO 164981C
Authority
NO
Norway
Prior art keywords
dealkylated
hydroxy
procedure
preparation
formula
Prior art date
Application number
NO852091A
Other languages
Norwegian (no)
Other versions
NO852091L (en
NO164981B (en
Inventor
Christian Hoff
Christian Vergely
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of NO852091L publication Critical patent/NO852091L/en
Publication of NO164981B publication Critical patent/NO164981B/en
Publication of NO164981C publication Critical patent/NO164981C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

1. A process for the dealkylation of 14-hydroxymorphinan alkaloids, characterized in that it consists in : 1) reacting the 14-hydroxy derivative of the formula : see diagramm : EP0164290,P5,F6 in which R' is CH3 or COCH3 , with excess ethyl chloroformate, in the presence of potassium carbonate and in a solvent, 2) subjecting the resulting carbamate of the formula : see diagramm : EP0164290,P5,F2 in which R' is CH3 or COCH3 , to hydrolysis in a strong acid medium to give the corresponding dealkylated derivative of the formula : see diagramm : EP0164290,P5,F3 in which R is CH3 or hydrogen.
NO852091A 1984-05-25 1985-05-24 PROCEDURE FOR THE PREPARATION OF DEALKYLATED 14-HYDROXY-MORPHINAN ALKALOIDS. NO164981C (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8408273A FR2564838B1 (en) 1984-05-25 1984-05-25 PROCESS FOR DEALKYLATION OF ALKALOIDS AND INTERMEDIATES

Publications (3)

Publication Number Publication Date
NO852091L NO852091L (en) 1985-11-26
NO164981B NO164981B (en) 1990-08-27
NO164981C true NO164981C (en) 1990-12-05

Family

ID=9304425

Family Applications (1)

Application Number Title Priority Date Filing Date
NO852091A NO164981C (en) 1984-05-25 1985-05-24 PROCEDURE FOR THE PREPARATION OF DEALKYLATED 14-HYDROXY-MORPHINAN ALKALOIDS.

Country Status (12)

Country Link
EP (1) EP0164290B1 (en)
JP (1) JPS60258183A (en)
AT (1) ATE46163T1 (en)
AU (1) AU577379B2 (en)
CA (1) CA1244825A (en)
DE (1) DE3572819D1 (en)
DK (1) DK160048C (en)
ES (1) ES8603893A1 (en)
FR (1) FR2564838B1 (en)
NO (1) NO164981C (en)
NZ (1) NZ212193A (en)
PT (1) PT80519B (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4795813A (en) * 1981-08-17 1989-01-03 The Florida Board Of Regents On Behalf Of The Florida State University Synthesis of derivatives of codeine and other 3-O-alkylmorphines
US6067749A (en) 1996-07-11 2000-05-30 Tasmanian Alkaloids Pty. Ltd. Papaver somniferum strain with high concentration of thebaine and oripavine
GB2471802B (en) * 2006-05-25 2011-02-16 Alpharma Chemical process
GB2444052A (en) * 2006-05-25 2008-05-28 Alpharma Aps Processes of preparing morphinan derivatives such as naltrexone and naloxone comprising O- and N-demethylation and reductive alkylation steps
GB2471801B (en) * 2006-05-25 2011-02-16 Alpharma Process useful in the preparation of morphine antagonists
US8962841B2 (en) 2007-06-29 2015-02-24 Brock University Methods for one-pot N-demethylation/N-functionalization of morphine and tropane alkaloids
US7999104B2 (en) * 2007-06-29 2011-08-16 Brock University Methods for one-pot N-demethylation/N-acylation of morphine and tropane alkaloids
EP2231674A1 (en) * 2007-12-17 2010-09-29 Mallinckrodt Inc. Processes for the preparation of normorphinan salts
US9131649B2 (en) 2008-03-07 2015-09-15 Tasmanian Alkaloids Pty. Ltd Papaver somniferum strain with high concentration of thebaine
WO2009122436A2 (en) * 2008-03-31 2009-10-08 Sun Pharmaceutical Industries Ltd. An improved process for the preparation of morphinane analogues
CA2802295C (en) 2010-06-11 2016-09-20 Rhodes Technologies Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof
TWI471289B (en) 2010-06-11 2015-02-01 Rhodes Technologies Process for n-dealkylation of tertiary amines
AU2012253188B2 (en) 2011-05-06 2016-12-22 Brock University Process for the preparation of morphine analogs via metal catalyzed N-demethylation/functionalization and intramolecular group transfer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4141807A (en) * 1977-03-01 1979-02-27 Stauffer Chemical Company Photopolymerizable composition stabilized with nitrogen-containing aromatic compounds
DE2727805A1 (en) * 1977-06-21 1979-01-04 Goedecke Ag METHOD FOR PRODUCING OXYNORMORPHONE
US4390699A (en) * 1981-07-16 1983-06-28 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services 6-Keto-morphinans belonging to the 14-hydroxy-series
US4472253A (en) * 1981-08-17 1984-09-18 The Florida Board Of Regents On Behalf Of The Florida State University Process for the preparation of an N-substituted 3-O-alkyl-14-hydroxynormorphinone derivative
ATE52768T1 (en) * 1982-09-24 1990-06-15 Poudres & Explosifs Ste Nale VINYL CARABATES AND MANUFACTURING PROCESSES.

Also Published As

Publication number Publication date
NO852091L (en) 1985-11-26
ATE46163T1 (en) 1989-09-15
DK160048C (en) 1991-06-17
DK160048B (en) 1991-01-21
EP0164290A1 (en) 1985-12-11
PT80519A (en) 1985-06-01
FR2564838B1 (en) 1986-11-07
NZ212193A (en) 1988-10-28
AU4284385A (en) 1985-11-28
JPS60258183A (en) 1985-12-20
NO164981B (en) 1990-08-27
EP0164290B1 (en) 1989-09-06
ES543338A0 (en) 1986-01-01
ES8603893A1 (en) 1986-01-01
DK227685D0 (en) 1985-05-22
DE3572819D1 (en) 1989-10-12
CA1244825A (en) 1988-11-15
DK227685A (en) 1985-11-26
PT80519B (en) 1988-01-22
AU577379B2 (en) 1988-09-22
FR2564838A1 (en) 1985-11-29

Similar Documents

Publication Publication Date Title
NO852091L (en) PROCEDURE FOR THE PREPARATION OF ALKALOIDS.
FI852974L (en) NYA N-HYDROXYLGRUPPEN SKYDDANDE GRUPPER OCH FRAMSTAELLNINGSFOERFARANDE FOER 3-ACYLAMINO-1-HYDROXI-2-AZETIDINONER.
PT85943A (en) Antibacterial agents
DE69031534D1 (en) Process for the production of optically active cyclobutane nucleosides
ATE21105T1 (en) 7-OXO-4-THIA-1-AZA(3.2.0)HEPTANE AND 7-OXO-4-THIA-1-AZA-(3.2.0)HEPT-2-EN DERIVATIVES.
KR840001175A (en) Method for preparing [3H] -imidazo [5,1-d] -1,2,3,5-tetrazin-4-one derivative
DK0402339T3 (en) Process for the preparation of carbonate esters
SE8501679L (en) STEREO-CONTROLLED ACETOXIAZETIDINON PROCEDURE
BR8705870A (en) PROCESS FOR THE PRODUCTION OF A URETANE, COMPOUND AND HEALING COMPOSITION
CA1273347C (en)
GB8907008D0 (en) Intermediates useful for the synthesis for delphinidin chloride
ATE9477T1 (en) PROCESS FOR THE PREPARATION OF 1,1'-DIACETALS.
JPS55133325A (en) Manufacture of pentadienol
JPS54109943A (en) Preparation of phenylglycine derivative
ES521004A0 (en) A PROCEDURE FOR PREPARING P-CHLOROPHENOXYACETIL-PIPERONYL PIPERACINE.
ATE26259T1 (en) PROCESS FOR THE PREPARATION OF 3-CYANO-4AMINOACETOPHENONES.
MX170218B (en) PROCEDURE FOR THE PRODUCTION OF 2-THIOCLANOMETILITIOBENZOTIAZOL
ZA874579B (en) Process for preparing 2-methyl-2(methylthio)propionaldehyde 0-(methylcarbomoyl)oxime as a water-wet cake
ES8306757A1 (en) Penicillanic acid derivs prepn.
ES477768A1 (en) A procedure for the preparation of 1 alpha-oxide of penicillin acid. (Machine-translation by Google Translate, not legally binding)
JPS54141715A (en) Synthesis of saccharose by carbon dioxide
KR920007967A (en) Continuous production method of ketal